Collated Gene Ontology terms

Biological process: ubiquitin-like ligase-substrate adaptor activity(2021, 2022, 2025) RNA binding(2025) ATP hydrolysis activity(2025)

Molecular function: ubiquitin-dependent protein catabolic process via the C-end degron rule pathway2021, 2022, 2025 T cell activation2022, 2025 regulation of autophagy2021, 2025 protein ubiquitination2024 Wnt signaling pathway2025 spermatogenesis2025 regulation of miRNA-mediated gene silencing2025 regulation of cell population proliferation2025 protein polyubiquitination2024 proteasome-mediated ubiquitin-dependent protein catabolic process2024
positive regulation of hippo signaling2024 miRNA-mediated gene silencing by mRNA destabilization2025 evoked neurotransmitter secretion2021 autophagic cell death2024

Cellular component: Cul4-RING E3 ubiquitin ligase complex2017, 2021, 2025 nucleus2021, 2025 centrosome2009, 2025 cytoplasm2021, 2022, 2025 cytosol2007, 2022, 2025 presynapse2021, 2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 2/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 1/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
D3ZKN9_RAT
RGD»
0.0
Dcaf12l2 DDB1 and CUL4 associated factor 12-like 2 Rattus norvegicus
TI:10116 None
   
D4ABX0_RAT
RGD»
0.0
Dcaf12l1 DDB1 and CUL4 associated factor 12-like 1 Rattus norvegicus
TI:10116 None
   
DC121_HUMAN
Ensembl»
0.0
DCAF12L1 DDB1- and CUL4-associated factor 12-like
protein 1 (WD repeat-containing protein 40B)		 Homo sapiens
TI:9606 None
 
DC121_MOUSE
Ensembl»
0.0
Dcaf12l1 DDB1- and CUL4-associated factor 12-like
protein 1 (WD repeat-containing protein 40B)		 Mus musculus
TI:10090 None
 
DC122_HUMAN
Ensembl»
0.0
DCAF12L2 DDB1- and CUL4-associated factor 12-like
protein 2 (WD repeat-containing protein 40C)		 Homo sapiens
TI:9606 None
 
DC122_MOUSE
Ensembl»
0.0
Dcaf12l2 DDB1- and CUL4-associated factor 12-like
protein 2 (WD repeat-containing protein 40C)		 Mus musculus
TI:10090 None
 
DCA12_CHICK
Ensembl»
1.5
DCAF12 DDB1- and CUL4-associated factor
12 (WD repeat-containing protein 40A)		 Gallus gallus
TI:9031 None
 
DCA12_DANRE
ZFIN»
1.5
dcaf12 DDB1- and CUL4-associated factor
12 (WD repeat-containing protein 40A)		 Danio rerio
TI:7955 None
 
DCA12_DROME
FlyBase»
4.8
DCAF12 DDB1- and CUL4-associated factor 12 homolog Drosophila melanogaster
TI:7227 None
 
DCA12_HUMAN
Ensembl»
5.0
DCAF12 DDB1- and CUL4-associated factor 12 (Centrosome-related protein TCC52)
(Testis cancer centrosome-related protein) (WD repeat-containing protein 40A)		 Homo sapiens
TI:9606 None
 
DCA12_MOUSE
Ensembl»
4.5
Dcaf12 DDB1- and CUL4-associated factor
12 (WD repeat-containing protein 40A)		 Mus musculus
TI:10090 None
 
M0RC41_RAT
RGD»
2.0
Dcaf12 DDB1- and CUL4-associated factor
12 (WD repeat-containing protein 40A)		 Rattus norvegicus
TI:10116 None
   
Q54CE3_DICDI
dictyBase»
0.0
DDB_G0293032 NACHT domain-containing protein Dictyostelium discoideum
TI:44689 None
 
Q54D26_DICDI
dictyBase»
0.0
DDB_G0292714 BRCT domain-containing protein Dictyostelium discoideum
TI:44689 None 		 
 
TTC41_HUMAN
AG»
0.0
TTC41P Putative tetratricopeptide repeat protein 41
(TPR repeat protein 41) (Grp94-neighboring nucleotidase)		 Homo sapiens
TI:9606 None
 
TTC41_MOUSE
AG»
0.0
Ttc41 Tetratricopeptide repeat protein 41 (TPR
repeat protein 41) (Grp94-neighboring nucleotidase)		 Mus musculus
TI:10090 None
 
TTC41_RAT
RGD»
0.0
Ttc41 Tetratricopeptide repeat protein 41 (TPR
repeat protein 41) (Grp94-neighboring nucleotidase)		 Rattus norvegicus
TI:10116 None
 
U4PAR2_CAEEL
WormBase»
0.0
CELE_F15E6.9 F15E6.9 RING-type domain-containing protein Caenorhabditis elegans
TI:6239 None
 
Y7407_DICDI
dictyBase»
0.0
DDB_G0287407 TPR repeat-containing protein DDB_G0287407 Dictyostelium discoideum
TI:44689 None