Collated Gene Ontology terms

Biological process: protein-macromolecule adaptor activity(2024, 2025) oxidoreductase activity(2025) cytochrome-c oxidase activity(2003, 2024, 2025)

Molecular function: mitochondrial electron transport, cytochrome c to oxygen2025 oxidative phosphorylation2024, 2025 mitochondrial respirasome assembly2024, 2025 regulation of oxidative phosphorylation2024, 2025 proton transmembrane transport2025 respiratory chain complex IV assembly2025 regulation of cardiac muscle tissue regeneration2025 generation of precursor metabolites and energy2003 cellular respiration2025

Cellular component: mitochondrial inner membrane2005, 2013, 2016, 2023, 2024, 2025 respiratory chain complex IV2013, 2024, 2025 mitochondrial membrane2024, 2025 respiratory chain complex2025 mitochondrion2003, 2007, 2009, 2014, 2024, 2025 nucleolus2025

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
CX7A2_HUMAN
Ensembl»
2.2
COX7A2 Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c oxidase subunit
VIIa-liver/heart) (Cytochrome c oxidase subunit VIIa-L) (Cytochrome c oxidase subunit VIIaL)		 Homo sapiens
TI:9606 None
 
CX7A1_HUMAN
Ensembl»
3.3
COX7A1 Cytochrome c oxidase subunit 7A1, mitochondrial (Cytochrome c oxidase subunit VIIa-heart) (Cytochrome c
oxidase subunit VIIa-H) (Cytochrome c oxidase subunit VIIa-muscle) (Cytochrome c oxidase subunit VIIa-M)		 Homo sapiens
TI:9606 None
 
CX7A2_MOUSE
Ensembl»
1.0
Cox7a2 Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c
oxidase subunit VIIa-liver/heart) (Cytochrome c oxidase subunit VIIa-L)		 Mus musculus
TI:10090 None
 
Q6IHY5_DROME
FlyBase»
2.6
COX7AL2 Cytochrome c oxidase subunit 7A-like 2, isoform A (Cytochrome c oxidase subunit 7A-like 2, isoform B) (Cytochrome
c oxidase subunit 7A-like 2, isoform C) (Cytochrome c oxidase subunit 7A-like 2, isoform D) (HDC00331) (IP16915p) (IP17015p)		 Drosophila melanogaster
TI:7227 None
 
CO72L_HUMAN
Ensembl»
4.6
COX7A2L Cytochrome c oxidase subunit 7A2-like, mitochondrial (Cytochrome c oxidase subunit 7A-related protein)
(COX7a-related protein) (Cytochrome c oxidase subunit VIIa-related protein) (EB1) (Supercomplex assembly factor 1)		 Homo sapiens
TI:9606 None
 
CX7A1_MOUSE
Ensembl»
3.1
Cox7a1 Cytochrome c oxidase subunit 7A1, mitochondrial (Cytochrome c oxidase subunit VIIa-heart) (Cytochrome c
oxidase subunit VIIa-H) (Cytochrome c oxidase subunit VIIa-muscle) (Cytochrome c oxidase subunit VIIa-M)		 Mus musculus
TI:10090 None
 
H2QG60_PANTR
Ensembl»
0.0
COX7A1 Cytochrome c oxidase subunit 7A1,
mitochondrial (Cytochrome c oxidase subunit VIIa-heart)		 Pan troglodytes
TI:9598 None
 
H2QHT3_PANTR
Ensembl»
0.0
COX7A2L Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Pan troglodytes
TI:9598 None
 
CO72L_DANRE
ZFIN»
2.9
cox7a2l Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Danio rerio
TI:7955 None
 
CX7A1_BOVIN
Ensembl»
0.0
COX7A1 Cytochrome c oxidase subunit 7A1, mitochondrial (Cytochrome c oxidase subunit VIIIc) (VIIIC) (Cytochrome c oxidase subunit
VIIa-heart) (Cytochrome c oxidase subunit VIIa-H) (Cytochrome c oxidase subunit VIIa-muscle) (Cytochrome c oxidase subunit VIIa-M)		 Bos taurus
TI:9913 None
 
CX7A1_DANRE
ZFIN»
4.2
cox7a1 Cytochrome c oxidase subunit 7A1, mitochondrial Danio rerio
TI:7955 None
 
CX7A2_BOVIN
Ensembl»
0.0
COX7A2 Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c
oxidase subunit VIIa-liver/heart) (Cytochrome c oxidase subunit VIIa-L)		 Bos taurus
TI:9913 None
 
Q4PM38_IXOSC
EnsemblMetazoa»
0.0
8029840 Cytochrome C oxidase subunit VIIa (EC 1.9.3.1) Ixodes scapularis
TI:6945 None
 
Q53CF7_MACMU
Ensembl»
0.0
COX7A1 Cytochrome c oxidase subunit 7A1,
mitochondrial (Cytochrome c oxidase subunit VIIa-heart)		 Macaca mulatta
TI:9544 None
 
CO72L_MOUSE
Ensembl»
2.6
Cox7a2l Cytochrome c oxidase subunit 7A2-like, mitochondrial (Cytochrome c
oxidase subunit 7A-related protein) (Supercomplex assembly factor 1)		 Mus musculus
TI:10090 None
 
COX7A_DROME
FlyBase»
2.6
COX7A Cytochrome c oxidase subunit 7A,
mitochondrial (Cytochrome c oxidase subunit VIIa)		 Drosophila melanogaster
TI:7227 None
 
Q07FY4_XENTR
Xenbase»
0.0
XB5730115 Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Xenopus tropicalis
TI:8364 None
 
Q504B4_DANRE
ZFIN»
1.0
cox7a2a Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Danio rerio
TI:7955 None
 
Q9VHR9_DROME
FlyBase»
1.6
COX7AL Cytochrome c oxidase subunit 7A-like (IP06967p) Drosophila melanogaster
TI:7227 None
 
A0A2I2ZKR6_GORGO
Ensembl»
0.0
Cytochrome c oxidase subunit 7A2 Gorilla gorilla
TI:9593 None
 
A0A2R8Q5H6_DANRE
ZFIN»
1.0
cox7a2b Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Danio rerio
TI:7955 None
 
A0AUU3_XENLA
Xenbase»
0.0
cox7a2.L Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Xenopus laevis
TI:8355 None
 
A4QND9_XENTR
Xenbase»
0.0
cox7a2 Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Xenopus tropicalis
TI:8364 None
 
A7SL41_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g233333 Uncharacterized protein Nematostella vectensis
TI:45351 None
 
C3Z4S5_BRAFL
euHCVdb»
0.0
LOC118420103 Cytochrome c oxidase
subunit 7A-related protein, mitochondrial-like		 Branchiostoma floridae
TI:7739 None
 
CO72L_BOVIN
Ensembl»
0.0
COX7A2L Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Bos taurus
TI:9913 None
 
COX7S_HUMAN
AG»
1.0
COX7A2P2 Putative cytochrome c oxidase subunit 7A3,
mitochondrial (Cytochrome c oxidase subunit VIIa 3)		 Homo sapiens
TI:9606 None
 
CX7A1_PIG
Ensembl»
0.0
COX7A1 Cytochrome c oxidase subunit 7A1, mitochondrial (Cytochrome c
oxidase subunit VIIa-heart) (Cytochrome c oxidase subunit VIIa-H)		 Sus scrofa
TI:9823 None
 
CX7A2_RAT
RGD»
1.0
Cox7a2 Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c
oxidase subunit VIIa-liver/heart) (Cytochrome c oxidase subunit VIIa-L)		 Rattus norvegicus
TI:10116 None
 
D6WU18_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_15888 Cytochrome c oxidase
subunit 7A1, mitochondrial-like Protein		 Tribolium castaneum
TI:7070 None
 
F7GAF4_MACMU
Ensembl»
0.0
COX7A2L Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Macaca mulatta
TI:9544 None
 
G3R5A0_GORGO
Ensembl»
0.0
LOC101144032 Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Gorilla gorilla
TI:9593 None
 
G3RVC1_GORGO
Ensembl»
0.0
LOC101129299 Cytochrome c oxidase subunit 7A1,
mitochondrial (Cytochrome c oxidase subunit VIIa-heart)		 Gorilla gorilla
TI:9593 None
 
H2RDY1_PANTR
Ensembl»
0.0
Uncharacterized protein Pan troglodytes
TI:9598 None
 
H9Z5D2_MACMU
Ensembl»
0.0
COX7A2 Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Macaca mulatta
TI:9544 None
 
Q2VPF0_XENLA
Xenbase»
0.0
cox7a2l.S Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Xenopus laevis
TI:8355 None
 
Q4V9Y2_XENTR
Xenbase»
0.0
cox7a2l Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Xenopus tropicalis
TI:8364 None
 
Q66KP1_XENLA
Xenbase»
0.0
cox7a2.S Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Xenopus laevis
TI:8355 None
 
Q7QER2_ANOGA
EnsemblMetazoa»
0.0
1272159 AGAP000109-PA Anopheles gambiae
TI:7165 None
 
Q7QG65_ANOGA
EnsemblMetazoa»
0.0
AgaP_AGAP009526 AGAP009526-PA Anopheles gambiae
TI:7165 None
 
W5NJT0_LEPOC
Ensembl»
0.0
Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Lepisosteus oculatus
TI:7918 None
 
A0A140T857_BOVIN
Ensembl»
0.0
COX7A2 Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Bos taurus
TI:9913 None
   
A0A1L8F0L2_XENLA
CTD»
0.0
LOC108700492 Cytochrome c oxidase subunit 7A1, mitochondrial Xenopus laevis
TI:8355 None
   
A0A1L8F980_XENLA
CTD»
0.0
LOC108698667 Cytochrome c oxidase subunit 7A1, mitochondrial Xenopus laevis
TI:8355 None
   
A0A1L8FB54_XENLA
CTD»
0.0
LOC108699281 Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Xenopus laevis
TI:8355 None
   
A0A1L8G671_XENLA
Xenbase»
0.0
cox7a2l.L Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Xenopus laevis
TI:8355 None
   
A0A3B3H8D8_ORYLA
Ensembl»
0.0
COX7A2L Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Oryzias latipes
TI:8090 None
   
A0A3B3I3I1_ORYLA
Ensembl»
0.0
LOC101164577 Cytochrome c oxidase subunit 7A1, mitochondrial Oryzias latipes
TI:8090 None
   
A0A3Q1LGX7_BOVIN
Ensembl»
0.0
Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Bos taurus
TI:9913 None
   
A0A3Q1MP07_BOVIN
Ensembl»
0.0
LOC132346172 Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Bos taurus
TI:9913 None
   
A0A3Q1MSG2_BOVIN
Ensembl»
0.0
LOC132343906 Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Bos taurus
TI:9913 None
   
A0A4X1SP87_PIG
Ensembl»
0.0
COX7A2L Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Sus scrofa
TI:9823 None
   
A0A5F8GG74_MONDO
Ensembl»
0.0
Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Monodelphis domestica
TI:13616 None
   
A0A6I8NFV4_ORNAN
Ensembl»
0.0
LOC100091985 Uncharacterized protein Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8NP17_ORNAN
Ensembl»
0.0
COX7A2 Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8PAY5_ORNAN
Ensembl»
0.0
LOC114811991 Cytochrome c oxidase subunit 7A1,
mitochondrial (Cytochrome c oxidase subunit VIIa-heart)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7G0Q9_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7RGV2_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A803SMD7_ANOCA
Ensembl»
0.0
COX7A2L Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Anolis carolinensis
TI:28377 None
   
A0A803TT32_ANOCA
Ensembl»
0.0
COX7A2 Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Anolis carolinensis
TI:28377 None
   
A0A8I3MA85_CANLF
Ensembl»
0.0
COX7A1 Cytochrome c oxidase subunit 7A1,
mitochondrial (Cytochrome c oxidase subunit VIIa-heart)		 Canis lupus
TI:9612 None
   
A0A8I3MLJ4_CANLF
Ensembl»
0.0
Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Canis lupus
TI:9612 None
   
A0A8I3NPM4_CANLF
Ensembl»
0.0
Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Canis lupus
TI:9612 None
   
A0A8I3PDM7_CANLF
Ensembl»
0.0
Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Canis lupus
TI:9612 None
   
A0A8I3PNU0_CANLF
Ensembl»
0.0
COX7A2L Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Canis lupus
TI:9612 None
   
A0A8I3RVF9_CANLF
Ensembl»
0.0
LOC119863903 Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Canis lupus
TI:9612 None
   
A0A8I6A6K4_RAT
RGD»
0.0
AABR07012587.1 Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Rattus norvegicus
TI:10116 None
   
A0A8I6GHX2_RAT
RGD»
1.0
Cox7a2l Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Rattus norvegicus
TI:10116 None
   
A0A8J0QPY5_XENTR
Xenbase»
0.0
cox7a1 Cytochrome c oxidase subunit 7A1, mitochondrial Xenopus tropicalis
TI:8364 None
   
A0A8V0YFA0_CHICK
Ensembl»
0.0
Uncharacterized protein Gallus gallus
TI:9031 None
   
A0A8V0Z6B5_CHICK
Ensembl»
0.0
COX7A2L Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Gallus gallus
TI:9031 None
   
A0A9J7L4Z6_BRAFL
neXtProt»
0.0
LOC118415245 Cytochrome c oxidase
subunit 7A2, mitochondrial-like		 Branchiostoma floridae
TI:7739 None
   
A0ABI0P3C0_BOVIN
Ensembl»
0.0
LOC132343845 Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Bos taurus
TI:9913 None
   
A0ABI7XI52_FELCA
Ensembl»
0.0
Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Felis catus
TI:9685 None
   
A0ABI7ZTB0_FELCA
Ensembl»
0.0
SAMD13 Cytochrome c oxidase subunit 7A1,
mitochondrial (Cytochrome c oxidase subunit VIIa-heart)		 Felis catus
TI:9685 None
   
A0ABK0L816_RAT
Ensembl»
1.0
Cox7a1 Cytochrome c oxidase subunit 7A1,
mitochondrial (Cytochrome c oxidase subunit VIIa-heart)		 Rattus norvegicus
TI:10116 None
   
CX7A2_CANLF
euHCVdb»
0.0
COX7A2 Cytochrome c oxidase subunit 7A2, mitochondrial (Cytochrome c
oxidase subunit VIIa-liver/heart) (Cytochrome c oxidase subunit VIIa-L)		 Canis lupus
TI:9612 None
   
F1NWK2_CHICK
Ensembl»
0.0
COX7A2 Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Gallus gallus
TI:9031 None
   
F6RV04_MONDO
Ensembl»
0.0
COX7A2L Cytochrome c oxidase subunit 7A2-like,
mitochondrial (Supercomplex assembly factor 1)		 Monodelphis domestica
TI:13616 None
   
F6U2Q2_MONDO
Ensembl»
0.0
Cytochrome c oxidase subunit 7A1,
mitochondrial (Cytochrome c oxidase subunit VIIa-heart)		 Monodelphis domestica
TI:13616 None
   
F7AKP1_HORSE
Ensembl»
0.0
COX7A1 Cytochrome c oxidase subunit 7A1,
mitochondrial (Cytochrome c oxidase subunit VIIa-heart)		 Equus caballus
TI:9796 None
   
F7CBF8_HORSE
Ensembl»
0.0
COX7A2L Cytochrome c oxidase subunit 7A2 like Equus caballus
TI:9796 None
   
H2MT09_ORYLA
Ensembl»
0.0
COX7A2 Cytochrome c oxidase subunit 7A2,
mitochondrial (Cytochrome c oxidase subunit VIIa-liver/heart)		 Oryzias latipes
TI:8090 None