Collated Gene Ontology terms

Biological process: guanyl-nucleotide exchange factor activity(2013, 2021, 2024, 2025) nucleotide binding(2025) glycine-tRNA ligase activity(2025) ATP binding(2025)

Molecular function: cell-cell adhesion2024, 2025 axon guidance2021 regulation of small GTPase mediated signal transduction2025 intracellular signal transduction2025 regulation of locomotor rhythm2015 positive regulation of Rho protein signal transduction2013 neuron projection morphogenesis2015 mesoderm morphogenesis2004 imaginal disc-derived leg morphogenesis2012 glycyl-tRNA aminoacylation2025
animal organ morphogenesis2004

Cellular component: cytosol2017, 2020, 2021, 2025 cytoplasm2024, 2025 nucleus2024, 2025 basal plasma membrane2024, 2025 plasma membrane2024, 2025 cell-cell junction2024, 2025 extrinsic component of membrane2024 anchoring junction2025 hemidesmosome2025 cytoskeleton2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A3B3I6L7_ORYLA
Ensembl»
0.0
DH domain-containing protein Oryzias latipes
TI:8090 None
   
T1EDQ6_HELRO
EnsemblMetazoa»
0.0
20194708 DH domain-containing protein Helobdella robusta
TI:6412 None
 
A0A5F7ZQE5_MACMU
Ensembl»
0.0
KIAA1755 KIAA1755 Macaca mulatta
TI:9544 None 		     
A0A8I3Q078_CANLF
Ensembl»
0.0
KIAA1755 KIAA1755 Canis lupus
TI:9612 None 		     
A0A8V0YIP1_CHICK
Ensembl»
0.0
KIAA1755 KIAA1755 Gallus gallus
TI:9031 None 		     
A0ABI8A4D8_FELCA
Ensembl»
0.0
KIAA1755 KIAA1755 Felis catus
TI:9685 None 		     
F1MPM8_BOVIN
Ensembl»
0.0
KIAA1755 KIAA1755 Bos taurus
TI:9913 None 		     
F1SDX5_PIG
Ensembl»
0.0
KIAA1755 KIAA1755 Sus scrofa
TI:9823 None 		     
F6RVW8_HORSE
Ensembl»
0.0
KIAA1755 KIAA1755 Equus caballus
TI:9796 None 		     
G3QUF7_GORGO
Ensembl»
0.0
KIAA1755 KIAA1755 Gorilla gorilla
TI:9593 None 		 
 
H2R8Z1_PANTR
Ensembl»
0.0
KIAA1755 KIAA1755 Pan troglodytes
TI:9598 None 		 
 
F6TFN3_MONDO
Ensembl»
0.0
KIAA1755 KIAA1755 ortholog Monodelphis domestica
TI:13616 None 		     
A0A6I8PZ35_XENTR
Xenbase»
0.0
KIAA1755 KIAA1755 ortholog (Uncharacterized
protein KIAA1755 homolog)		 Xenopus tropicalis
TI:8364 None
   
A0A2I2YG21_GORGO
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Gorilla gorilla
TI:9593 None
 
A0A3B3IKG3_ORYLA
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Oryzias latipes
TI:8090 None
   
A0A3Q2GWW4_HORSE
Ensembl»
0.0
PLEKHG4 Pleckstrin homology and
RhoGEF domain containing G4		 Equus caballus
TI:9796 None
   
A0A5F8ARR5_MACMU
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Macaca mulatta
TI:9544 None
   
A0A5F8G1R6_MONDO
Ensembl»
0.0
Pleckstrin homology and
RhoGEF domain containing G4		 Monodelphis domestica
TI:13616 None
   
A0A8I3NKW6_CANLF
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Canis lupus
TI:9612 None
   
A0A8I3RWE5_CANLF
Ensembl»
0.0
PLEKHG4 Pleckstrin homology and
RhoGEF domain containing G4		 Canis lupus
TI:9612 None
   
A0A8V0ZJ14_CHICK
Ensembl»
0.0
PLEKHG4 Pleckstrin homology and
RhoGEF domain containing G4		 Gallus gallus
TI:9031 None
   
A0A8W4FKU2_PIG
Ensembl»
0.0
PLEKHG4 Pleckstrin homology and
RhoGEF domain containing G4		 Sus scrofa
TI:9823 None
   
A0ABI7VPP8_FELCA
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Felis catus
TI:9685 None
   
A0ABI7W7T3_FELCA
Ensembl»
0.0
PLEKHG4 Pleckstrin homology and
RhoGEF domain containing G4		 Felis catus
TI:9685 None
   
A0ABK0LL84_RAT
RGD»
0.0
Plekhg4 Pleckstrin homology and
RhoGEF domain containing G4		 Rattus norvegicus
TI:10116 None
   
E1BEX3_BOVIN
Ensembl»
0.0
PLEKHG4 Pleckstrin homology and
RhoGEF domain containing G4		 Bos taurus
TI:9913 None
   
F6QBY5_MONDO
Ensembl»
0.0
Pleckstrin homology and
RhoGEF domain containing G4B		 Monodelphis domestica
TI:13616 None
   
F7DIS5_HORSE
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Equus caballus
TI:9796 None
   
F7E158_ORNAN
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Ornithorhynchus anatinus
TI:9258 None
   
G1KJ14_ANOCA
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Anolis carolinensis
TI:28377 None
   
G3RIQ0_GORGO
Ensembl»
0.0
PLEKHG4 Pleckstrin homology and
RhoGEF domain containing G4		 Gorilla gorilla
TI:9593 None
 
H2QQK1_PANTR
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Pan troglodytes
TI:9598 None
 
H9G6D4_ANOCA
Ensembl»
0.0
plekhg4 Pleckstrin homology and
RhoGEF domain containing G4		 Anolis carolinensis
TI:28377 None
   
W5MNE2_LEPOC
Ensembl»
0.0
Pleckstrin homology and
RhoGEF domain containing G4B		 Lepisosteus oculatus
TI:7918 None
 
W5MNQ9_LEPOC
Ensembl»
0.0
Pleckstrin homology and
RhoGEF domain containing G4		 Lepisosteus oculatus
TI:7918 None
 
K7BJC3_PANTR
Ensembl»
0.0
PLEKHG4 Pleckstrin homology and RhoGEF domain containing G4 (Pleckstrin homology
domain containing, family G (With RhoGef domain) member 4)		 Pan troglodytes
TI:9598 None
 
A0A287ACJ6_PIG
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and RhoGEF domain containing G4B (Pleckstrin
homology domain-containing family G member 4B isoform X1)		 Sus scrofa
TI:9823 None 		 
 
A0A3B3ILV4_ORYLA
Ensembl»
0.0
LOC101173785 Pleckstrin homology domain containing, family
G (with RhoGef domain) member 4		 Oryzias latipes
TI:8090 None
   
F8VPS6_MOUSE
Ensembl»
0.8
Plekhg4 Pleckstrin homology domain containing, family
G (with RhoGef domain) member 4		 Mus musculus
TI:10090 None
   
A0A8J1LYG5_XENLA
CTD»
0.0
LOC108702747 Pleckstrin homology domain-containing
family G member 4B-like		 Xenopus laevis
TI:8355 None
   
E7FCG7_DANRE
ZFIN»
0.0
quoa Pleckstrin homology domain-containing family G
member 4B isoform X1 (Si:dkey-65j6.2)		 Danio rerio
TI:7955 None
 
PKH4B_HUMAN
Ensembl»
4.4
PLEKHG4B Pleckstrin homology domain-containing family G member
4B (PH domain-containing family G member 4B)		 Homo sapiens
TI:9606 None
 
A0A6I8N489_ORNAN
Ensembl»
0.0
PLEKHG4 Puratrophin-1 Ornithorhynchus anatinus
TI:9258 None
   
A0A8J0QD64_XENTR
Xenbase»
0.0
plekhg4 Puratrophin-1 Xenopus tropicalis
TI:8364 None
   
PKHG4_HUMAN
Ensembl»
2.8
PLEKHG4 Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH
domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1)		 Homo sapiens
TI:9606 None
 
Q7KU89_DROME
FlyBase»
3.4
Pura Puratrophin-1-like, isoform A Drosophila melanogaster
TI:7227 None
 
H2MPV1_ORYLA
Ensembl»
0.0
quo Quattro Oryzias latipes
TI:8090 None
   
A0AB32TQS0_DANRE
ZFIN»
1.6
quob Quattro isoform X1 Danio rerio
TI:7955 None
   
A0A8J0QLB3_XENTR
Xenbase»
0.0
arhgef40 Rho guanine nucleotide exchange
factor 40 isoform X1		 Xenopus tropicalis
TI:8364 None
   
A0A8J1LTZ6_XENLA
CTD»
0.0
arhgef40.S Rho guanine nucleotide exchange
factor 40 isoform X1		 Xenopus laevis
TI:8355 None
   
ARH40_CANLF
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange
factor 40 (Protein SOLO)		 Canis lupus
TI:9612 None
   
ARH40_HUMAN
Ensembl»
2.8
ARHGEF40 Rho guanine nucleotide exchange factor
40 (Protein SOLO) (Scambio) (Sabi)		 Homo sapiens
TI:9606 None
 
ARH40_MOUSE
Ensembl»
0.0
Arhgef40 Rho guanine nucleotide exchange factor
40 (Protein SOLO) (Scambio) (Sabi)		 Mus musculus
TI:10090 None
 
E7F579_DANRE
ZFIN»
0.0
arhgef40 Rho guanine nucleotide exchange factor (GEF)
40 (Rho guanine nucleotide exchange factor 40)		 Danio rerio
TI:7955 None
 
A0A3B3HA98_ORYLA
Ensembl»
0.0
Rho guanine nucleotide exchange factor (GEF) 40 Oryzias latipes
TI:8090 None 		     
A0A1L8HZN3_XENLA
Xenbase»
0.0
arhgef40.L Rho guanine nucleotide exchange factor 40 Xenopus laevis
TI:8355 None
   
A0A6I8NZG2_ORNAN
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Ornithorhynchus anatinus
TI:9258 None
   
A0A8I5ZUE2_RAT
RGD»
0.0
Arhgef40 Rho guanine nucleotide exchange factor 40 Rattus norvegicus
TI:10116 None
   
A0ABI7Y4L9_FELCA
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Felis catus
TI:9685 None
   
F6YY39_HORSE
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Equus caballus
TI:9796 None
   
F7FTM4_MONDO
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Monodelphis domestica
TI:13616 None
   
F7HDS2_MACMU
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Macaca mulatta
TI:9544 None
   
G3QW68_GORGO
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Gorilla gorilla
TI:9593 None
 
H2R3U5_PANTR
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Pan troglodytes
TI:9598 None
 
H9GSS0_ANOCA
Ensembl»
0.0
Rho guanine nucleotide exchange factor 40 Anolis carolinensis
TI:28377 None 		     
I3LFZ9_PIG
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Sus scrofa
TI:9823 None
   
W5LZ15_LEPOC
Ensembl»
0.0
Si:dkey-65j6.2 Lepisosteus oculatus
TI:7918 None
 
A0A139WJY6_TRICA
euHCVdb»
0.0
GLEAN_04018 Uncharacterized protein Tribolium castaneum
TI:7070 None
 
A0A3B3HIB1_ORYLA
Ensembl»
0.0
Uncharacterized protein Oryzias latipes
TI:8090 None 		     
A0A453Z0F1_ANOGA
EnsemblMetazoa»
0.0
Uncharacterized protein Anopheles gambiae
TI:7165 None
 
A0A7M7N615_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
A7SXZ7_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g137344 Uncharacterized protein Nematostella vectensis
TI:45351 None
 
A7T683_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g222901 Uncharacterized protein Nematostella vectensis
TI:45351 None 		 
 
A8DVW5_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g225828 Uncharacterized protein Nematostella vectensis
TI:45351 None 		 
 
B7Q624_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW021423 Uncharacterized protein Ixodes scapularis
TI:6945 None 		 
 
B7Q626_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW021426 Uncharacterized protein Ixodes scapularis
TI:6945 None
 
E9HAC2_DAPPU
neXtProt»
0.0
DAPPUDRAFT_308942 Uncharacterized protein Daphnia pulex
TI:6669 None 		 
 
E9HAC4_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_201819 Uncharacterized protein Daphnia pulex
TI:6669 None
 
F6SMX2_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None 		 
 
F6SSR3_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None
 
H9G943_ANOCA
Ensembl»
0.0
Uncharacterized protein Anolis carolinensis
TI:28377 None 		     
W5M3G8_LEPOC
Ensembl»
0.0
Uncharacterized protein Lepisosteus oculatus
TI:7918 None 		 
 
K1755_HUMAN
Ensembl»
1.0
KIAA1755 Uncharacterized protein KIAA1755 Homo sapiens
TI:9606 None
 
K1755_MOUSE
Ensembl»
0.0
Uncharacterized protein KIAA1755 homolog Mus musculus
TI:10090 None 		 
 
A0A8J0U528_XENLA
CTD»
0.0
LOC108704601 Uncharacterized protein LOC108704601 Xenopus laevis
TI:8355 None
   
A0A9J7LFE0_BRAFL
euHCVdb»
0.0
LOC118418693 Uncharacterized protein LOC118418693 isoform X1 Branchiostoma floridae
TI:7739 None
   
A0A8J0V378_XENLA
Xenbase»
0.0
plekhg4.L Uncharacterized protein plekhg4.L isoform X1 Xenopus laevis
TI:8355 None
   
A0A8J1KKE5_XENLA
CTD»
0.0
plekhg4.S Uncharacterized protein plekhg4.S isoform X1 Xenopus laevis
TI:8355 None