Collated Gene Ontology terms

Biological process: guanyl-nucleotide exchange factor activity(2013, 2021, 2022, 2024) glycine-tRNA ligase activity(2024) ATP binding(2024)

Molecular function: axon guidance2021 regulation of small GTPase mediated signal transduction2024 intracellular signal transduction2024 regulation of locomotor rhythm2015 positive regulation of Rho protein signal transduction2013 neuron projection morphogenesis2015 mesoderm morphogenesis2004 imaginal disc-derived leg morphogenesis2012 glycyl-tRNA aminoacylation2024 cell-cell adhesion2024
animal organ morphogenesis2004 activation of GTPase activity2013

Cellular component: plasma membrane2022, 2023, 2024 cytosol2017, 2020, 2021, 2023, 2024 cytoplasm2022, 2024 extrinsic component of membrane2023 nucleus2024 basal plasma membrane2024 membrane2024 cell-cell junction2024 anchoring junction2024

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
G1KJ14_ANOCA
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Anolis carolinensis
TI:28377 None
   
H9G6D4_ANOCA
Ensembl»
0.0
plekhg4 Pleckstrin homology and
RhoGEF domain containing G4		 Anolis carolinensis
TI:28377 None
   
H9G943_ANOCA
Ensembl»
0.0
Uncharacterized protein Anolis carolinensis
TI:28377 None
     
H9GSS0_ANOCA
Ensembl»
0.0
Rho guanine nucleotide exchange factor 40 Anolis carolinensis
TI:28377 None 		       
A0A453Z0F1_ANOGA
EnsemblMetazoa»
0.0
Uncharacterized protein Anopheles gambiae
TI:7165 None
 
F1MPM8_BOVIN
Ensembl»
0.0
KIAA1755 KIAA1755 Bos taurus
TI:9913 None 		       
G3MXG4_BOVIN
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Bos taurus
TI:9913 None
   
A0A9J7LFE0_BRAFL
CTD»
0.0
LOC118418693 glycine--tRNA ligase (EC 6.1.1.14) Branchiostoma floridae
TI:7739 None
   
A0A8I3NKW6_CANLF
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Canis lupus
TI:9612 None
   
A0A8I3PMN2_CANLF
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Canis lupus
TI:9612 None
   
A0A8I3Q078_CANLF
Ensembl»
0.0
KIAA1755 KIAA1755 Canis lupus
TI:9612 None 		       
A0A8I3RWE5_CANLF
Ensembl»
0.0
PLEKHG4 Pleckstrin homology and
RhoGEF domain containing G4		 Canis lupus
TI:9612 None
   
F6SMX2_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None 		 
 
F6SSR3_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None
 
A2RV33_DANRE
ZFIN»
0.0
zgc:158766 Uncharacterized protein
LOC100009641 (Zgc:158766 protein)		 Danio rerio
TI:7955 None 		 
   
E7F579_DANRE
ZFIN»
0.0
arhgef40 Pleckstrin homology domain-containing family G member 4B
(Rho guanine nucleotide exchange factor (GEF) 40)		 Danio rerio
TI:7955 None
 
E7FCG7_DANRE
ZFIN»
0.0
si:dkey-65j6.2 Pleckstrin homology domain-containing family G
member 4B isoform X1 (Si:dkey-65j6.2)		 Danio rerio
TI:7955 None
 
E7FEK1_DANRE
ZFIN»
0.0
plekhg4 Pleckstrin homology domain-containing, family G (with RhoGef
domain) member 4 (Uncharacterized protein plekhg4 isoform X1)		 Danio rerio
TI:7955 None
 
Q6DN89_DANRE
ZFIN»
1.6
sb:cb9 Quattro Danio rerio
TI:7955 None
 
E9HAC2_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_308942 CRAL-TRIO domain-containing protein Daphnia pulex
TI:6669 None 		 
   
E9HAC4_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_201819 Uncharacterized protein Daphnia pulex
TI:6669 None
 
Q7KU89_DROME
FlyBase»
3.4
Pura Puratrophin-1-like, isoform A Drosophila melanogaster
TI:7227 None
 
A0A3Q2GWW4_HORSE
Ensembl»
0.0
PLEKHG4 Pleckstrin homology and
RhoGEF domain containing G4		 Equus caballus
TI:9796 None
   
F6RVW8_HORSE
Ensembl»
0.0
KIAA1755 KIAA1755 Equus caballus
TI:9796 None 		       
F6YY39_HORSE
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Equus caballus
TI:9796 None
   
F7DIS5_HORSE
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Equus caballus
TI:9796 None
   
A0A337SDP0_FELCA
Ensembl»
0.0
PLEKHG4 Pleckstrin homology and
RhoGEF domain containing G4		 Felis catus
TI:9685 None
 
M3W2W6_FELCA
Ensembl»
0.0
KIAA1755 KIAA1755 Felis catus
TI:9685 None 		 
   
M3W8U5_FELCA
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Felis catus
TI:9685 None
 
M3WLJ4_FELCA
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Felis catus
TI:9685 None
 
A0A8V0YIP1_CHICK
Ensembl»
0.0
KIAA1755 KIAA1755 Gallus gallus
TI:9031 None 		       
A0A8V0ZJ14_CHICK
Ensembl»
0.0
PLEKHG4 Pleckstrin homology and
RhoGEF domain containing G4		 Gallus gallus
TI:9031 None
   
A0A2I2YG21_GORGO
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Gorilla gorilla
TI:9593 None
 
G3QUF7_GORGO
Ensembl»
0.0
KIAA1755 KIAA1755 Gorilla gorilla
TI:9593 None 		 
   
G3QW68_GORGO
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Gorilla gorilla
TI:9593 None
 
G3RIQ0_GORGO
Ensembl»
0.0
PLEKHG4 Pleckstrin homology and
RhoGEF domain containing G4		 Gorilla gorilla
TI:9593 None
 
T1EDQ6_HELRO
EnsemblMetazoa»
0.0
20194708 DH domain-containing protein Helobdella robusta
TI:6412 None
 
ARH40_HUMAN
Ensembl»
2.8
ARHGEF40 Rho guanine nucleotide exchange
factor 40 (Protein SOLO)		 Homo sapiens
TI:9606 None
 
K1755_HUMAN
Ensembl»
1.0
KIAA1755 Uncharacterized protein KIAA1755 Homo sapiens
TI:9606 None
   
PKH4B_HUMAN
Ensembl»
4.4
PLEKHG4B Pleckstrin homology domain-containing family G member
4B (PH domain-containing family G member 4B)		 Homo sapiens
TI:9606 None
 
PKHG4_HUMAN
Ensembl»
2.8
PLEKHG4 Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH
domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1)		 Homo sapiens
TI:9606 None
 
B7Q624_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW021423 Uncharacterized protein Ixodes scapularis
TI:6945 None 		 
   
B7Q626_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW021426 Uncharacterized protein Ixodes scapularis
TI:6945 None
 
W5LZ15_LEPOC
Ensembl»
0.0
Si:dkey-65j6.2 Lepisosteus oculatus
TI:7918 None
 
W5M3G8_LEPOC
Ensembl»
0.0
BRCT domain-containing protein Lepisosteus oculatus
TI:7918 None 		 
   
W5MNE2_LEPOC
Ensembl»
0.0
Pleckstrin homology and
RhoGEF domain containing G4B		 Lepisosteus oculatus
TI:7918 None
 
W5MNQ9_LEPOC
Ensembl»
0.0
Pleckstrin homology domain containing, family
G (with RhoGef domain) member 4		 Lepisosteus oculatus
TI:7918 None
 
A0A5F7ZQE5_MACMU
Ensembl»
0.0
KIAA1755 KIAA1755 Macaca mulatta
TI:9544 None 		       
A0A5F8ARR5_MACMU
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Macaca mulatta
TI:9544 None
   
F7HDS2_MACMU
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Macaca mulatta
TI:9544 None
   
A0A5F8G1R6_MONDO
Ensembl»
0.0
Pleckstrin homology and
RhoGEF domain containing G4		 Monodelphis domestica
TI:13616 None
   
F6QBY5_MONDO
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Monodelphis domestica
TI:13616 None
   
F6TFN3_MONDO
Ensembl»
0.0
KIAA1755 KIAA1755 ortholog Monodelphis domestica
TI:13616 None 		       
F7FTM4_MONDO
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Monodelphis domestica
TI:13616 None
   
ARH40_MOUSE
Ensembl»
0.0
Arhgef40 Rho guanine nucleotide exchange
factor 40 (Protein SOLO)		 Mus musculus
TI:10090 None
 
F8VPS6_MOUSE
Ensembl»
0.8
Plekhg4 Pleckstrin homology domain containing, family
G (with RhoGef domain) member 4		 Mus musculus
TI:10090 None
   
K1755_MOUSE
Ensembl»
0.0
Uncharacterized protein KIAA1755 homolog Mus musculus
TI:10090 None 		 
   
A7SXZ7_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g137344 Uncharacterized protein Nematostella vectensis
TI:45351 None
 
A7T683_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g222901 Uncharacterized protein Nematostella vectensis
TI:45351 None 		 
   
A8DVW5_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g225828 Uncharacterized protein Nematostella vectensis
TI:45351 None 		 
   
A0A6I8N489_ORNAN
Ensembl»
0.0
Pleckstrin homology and
RhoGEF domain containing G4		 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8NZG2_ORNAN
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Ornithorhynchus anatinus
TI:9258 None
   
F7E158_ORNAN
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Ornithorhynchus anatinus
TI:9258 None
   
A0A3B3HA98_ORYLA
Ensembl»
0.0
Rho guanine nucleotide exchange factor (GEF) 40 Oryzias latipes
TI:8090 None 		       
A0A3B3HIB1_ORYLA
Ensembl»
0.0
Uncharacterized protein Oryzias latipes
TI:8090 None 		       
A0A3B3I6L7_ORYLA
Ensembl»
0.0
DH domain-containing protein Oryzias latipes
TI:8090 None
   
A0A3B3IKG3_ORYLA
Ensembl»
0.0
PLEKHG4B Pleckstrin homology domain-containing
family G member 4B		 Oryzias latipes
TI:8090 None
   
A0A3B3ILV4_ORYLA
Ensembl»
0.0
LOC101173785 Rho guanine nucleotide exchange factor 40 Oryzias latipes
TI:8090 None
   
H2MPV1_ORYLA
Ensembl»
0.0
LOC101173699 Uncharacterized LOC101173699 Oryzias latipes
TI:8090 None
   
H2QQK1_PANTR
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and
RhoGEF domain containing G4B		 Pan troglodytes
TI:9598 None
 
H2R3U5_PANTR
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Pan troglodytes
TI:9598 None
 
H2R8Z1_PANTR
Ensembl»
0.0
KIAA1755 KIAA1755 Pan troglodytes
TI:9598 None 		 
   
K7BJC3_PANTR
Ensembl»
0.0
PLEKHG4 Pleckstrin homology and RhoGEF domain containing G4 (Pleckstrin homology
domain containing, family G (With RhoGef domain) member 4)		 Pan troglodytes
TI:9598 None
 
A0A0G2JZE7_RAT
RGD»
0.0
Arhgef40 Rho guanine nucleotide exchange factor 40 Rattus norvegicus
TI:10116 None
   
A0A8I6AG98_RAT
RGD»
0.0
Plekhg4 Pleckstrin homology and
RhoGEF domain containing G4		 Rattus norvegicus
TI:10116 None
   
F1M4P5_RAT
RGD»
0.0
Kiaa1755 RIKEN cDNA D630003M21 gene Rattus norvegicus
TI:10116 None 		       
A0A7M7N615_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A287ACJ6_PIG
Ensembl»
0.0
PLEKHG4B Pleckstrin homology and RhoGEF domain containing G4B (Pleckstrin
homology domain-containing family G member 4B isoform X1)		 Sus scrofa
TI:9823 None 		 
   
A0A8W4FKU2_PIG
Ensembl»
0.0
PLEKHG4 Pleckstrin homology and
RhoGEF domain containing G4		 Sus scrofa
TI:9823 None
   
F1SDX5_PIG
Ensembl»
0.0
KIAA1755 KIAA1755 Sus scrofa
TI:9823 None 		       
I3LFZ9_PIG
Ensembl»
0.0
ARHGEF40 Rho guanine nucleotide exchange factor 40 Sus scrofa
TI:9823 None
   
A0A139WJY6_TRICA
EnsemblMetazoa»
0.0
GLEAN_04018 Uncharacterized protein Tribolium castaneum
TI:7070 None
 
A0A1L8HZN3_XENLA
Xenbase»
0.0
arhgef40.L Rho guanine nucleotide exchange factor 40 Xenopus laevis
TI:8355 None
   
A0A6I8PZ35_XENTR
Ensembl»
0.0
kiaa1755 KIAA1755 ortholog (Uncharacterized
protein KIAA1755 homolog)		 Xenopus tropicalis
TI:8364 None
   
A0A8J0QD64_XENTR
Xenbase»
0.0
plekhg4 Puratrophin-1 Xenopus tropicalis
TI:8364 None
   
A0A8J0QLB3_XENTR
Xenbase»
0.0
arhgef40 Rho guanine nucleotide exchange
factor 40 isoform X1		 Xenopus tropicalis
TI:8364 None
   
A0A8J0U528_XENLA
Xenbase»
0.0
LOC108704601 Uncharacterized protein LOC108704601 Xenopus laevis
TI:8355 None
   
A0A8J0V378_XENLA
Xenbase»
0.0
plekhg4.L Uncharacterized protein plekhg4.L isoform X1 Xenopus laevis
TI:8355 None
   
A0A8J1KKE5_XENLA
Xenbase»
0.0
plekhg4.S Uncharacterized protein plekhg4.S isoform X1 Xenopus laevis
TI:8355 None
   
A0A8J1LTZ6_XENLA
Xenbase»
0.0
arhgef40.S Rho guanine nucleotide exchange
factor 40 isoform X1		 Xenopus laevis
TI:8355 None
   
A0A8J1LYG5_XENLA
Xenbase»
0.0
LOC108702747 Pleckstrin homology domain-containing
family G member 4B-like		 Xenopus laevis
TI:8355 None