Collated Gene Ontology terms

Biological process: actin filament binding(2024, 2025) microtubule binding(2024, 2025) protein phosphatase 2A binding(2014, 2025) actin binding(2025) ATP hydrolysis activity(2025) ATP binding(2025) SH3 domain binding(2025)

Molecular function: protein localization to actin cytoskeleton2020, 2024 negative regulation of cilium assembly2024, 2025 stress fiber assembly2024, 2025 contractile ring contraction2024, 2025 regulation of synapse organization2021, 2025 regulation of protein complex stability2024, 2025 modification of postsynaptic structure2024, 2025 apical constriction2024, 2025 neural fold bending2012, 2025 protein dephosphorylation2014
ventricular septum development2012 protein secretion2024 proteasomal protein catabolic process2024 neuron migration2024 negative regulation of transporter activity2014 negative regulation of transmembrane transport2014 intracellular protein localization2024 hindgut development2024 gene expression2024 corpus callosum development2024 cerebral cortex development2024 artery development2012 regulation of modification of postsynaptic actin cytoskeleton2025 regulation of hippo signaling2024 positive regulation of neuron projection arborization2020 positive regulation of lamellipodium morphogenesis2020 positive regulation of Arp2/3 complex-mediated actin nucleation2020 actin filament bundle retrograde transport2020

Cellular component: actin cytoskeleton2010, 2024, 2025 glutamatergic synapse2021, 2024, 2025 centrosome2022, 2024, 2025 cytoplasm2012, 2025 stress fiber2020, 2024, 2025 FAR/SIN/STRIPAK complex2020, 2024, 2025 cell projection2025 dendritic spine2024, 2025 midbody2024, 2025 chromosome, centromeric region2024, 2025
cell cortex2025 spindle midzone2024, 2025 nucleus2006, 2025 ciliary basal body2024, 2025 actin filament2024, 2025 tight junction2024, 2025 CERF complex2024, 2025 postsynaptic actin cytoskeleton2024, 2025 lamellipodium2020, 2025 spindle2025 postsynapse2024, 2025 perikaryon2025 microtubule2025 membrane2014, 2025 dendrite2025 cytoskeleton2025 bicellular tight junction2025 synaptic vesicle2025 plasma membrane2025 nucleolus2025 extracellular exosome2014 cytosol2020

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A803TLW8_ANOCA
Ensembl»
0.0
Cortactin-binding protein-2
N-terminal domain-containing protein		 Anolis carolinensis
TI:28377 None
   
A0A803TMT0_ANOCA
Ensembl»
0.0
filip1l Cortactin-binding protein-2
N-terminal domain-containing protein		 Anolis carolinensis
TI:28377 None
   
A0A803TNQ0_ANOCA
Ensembl»
0.0
FILIP1 Filamin A interacting protein 1 Anolis carolinensis
TI:28377 None
   
A0A803TXP9_ANOCA
Ensembl»
0.0
CTTNBP2NL CTTNBP2 N-terminal like Anolis carolinensis
TI:28377 None
   
H9GNT5_ANOCA
Ensembl»
0.0
luzp1 Leucine zipper protein 1 Anolis carolinensis
TI:28377 None
   
A0A1S4H6A7_ANOGA
EnsemblMetazoa»
0.0
CortBP2 domain-containing protein Anopheles gambiae
TI:7165 None
 
A0A3Q1LT16_BOVIN
Ensembl»
0.0
CTTNBP2 Cortactin-binding protein 2 Bos taurus
TI:9913 None
   
A0A3Q1MZP2_BOVIN
Ensembl»
0.0
FILIP1 Filamin A interacting protein 1 Bos taurus
TI:9913 None
   
A0AAA9S794_BOVIN
Ensembl»
0.0
Leucine zipper protein 1 Bos taurus
TI:9913 None
   
F1MJB0_BOVIN
Ensembl»
0.0
FILIP1L Filamin A interacting protein 1 like Bos taurus
TI:9913 None
   
F1MUH9_BOVIN
Ensembl»
0.0
CTTNBP2NL CTTNBP2 N-terminal like Bos taurus
TI:9913 None
   
A0A9J7MRI5_BRAFL
euHCVdb»
0.0
LOC118416091 Cortactin-binding protein 2 Branchiostoma floridae
TI:7739 None
   
A8XRH6_CAEBR
WormBase»
0.0
CBG17702 CBG_17702 Protein CBG17702 Caenorhabditis briggsae
TI:6238 None 		 
 
Q95QQ9_CAEEL
WormBase»
0.0
C49H3.6 CELE_C49H3.6 Cortactin-binding protein-2
N-terminal domain-containing protein		 Caenorhabditis elegans
TI:6239 None
 
A0A8I3N9D2_CANLF
Ensembl»
0.0
FILIP1 Filamin A interacting protein 1 Canis lupus
TI:9612 None
   
A0A8I3NIB8_CANLF
Ensembl»
0.0
CTTNBP2NL CTTNBP2 N-terminal like Canis lupus
TI:9612 None
   
A0A8I3P0F9_CANLF
Ensembl»
0.0
LUZP1 Leucine zipper protein 1 Canis lupus
TI:9612 None
   
A0A8I3P957_CANLF
Ensembl»
0.0
FILIP1L Filamin A interacting protein 1 like Canis lupus
TI:9612 None
   
F7AR21_CIOIN
Ensembl»
0.0
Cortactin-binding protein-2
N-terminal domain-containing protein		 Ciona intestinalis
TI:7719 None 		 
 
H2Y1Y4_CIOIN
Ensembl»
0.0
Cortactin-binding protein-2
N-terminal domain-containing protein		 Ciona intestinalis
TI:7719 None
   
A0A8N7UVR0_DANRE
ZFIN»
0.5
luzp1 Leucine zipper protein 1 Danio rerio
TI:7955 None
 
A0AB13AB69_DANRE
CTD»
0.0
filip1a Filamin A interacting protein 1a Danio rerio
TI:7955 None 		     
A0AB40E9R1_DANRE
ZFIN»
0.0
cttnbp2nlb CTTNBP2 N-terminal like b isoform 2 Danio rerio
TI:7955 None
   
F1Q9J8_DANRE
ZFIN»
0.5
cttnbp2nla CTTNBP2 N-terminal-like a
(CTTNBP2 N-terminal-like protein)		 Danio rerio
TI:7955 None
 
F1QFV1_DANRE
ZFIN»
0.5
cttnbp2 Cortactin-binding protein 2 Danio rerio
TI:7955 None
 
FIL1L_DANRE
ZFIN»
0.5
filip1l Filamin A-interacting protein 1-like Danio rerio
TI:7955 None
 
E9HAA9_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_201796 Cortactin-binding protein-2
N-terminal domain-containing protein		 Daphnia pulex
TI:6669 None 		 
 
CT2NL_DROME
FlyBase»
5.1
Naus CTTNBP2 N-terminal-like
protein (Protein Nausicaa)		 Drosophila melanogaster
TI:7227 None
 
A0A9L0R3Y8_HORSE
Ensembl»
0.0
FILIP1 Filamin A interacting protein 1 Equus caballus
TI:9796 None
   
A0A9L0TPY7_HORSE
Ensembl»
0.0
LUZP1 Leucine zipper protein 1 Equus caballus
TI:9796 None
   
CTTB2_HORSE
CTD»
0.0
CTTNBP2 Cortactin-binding protein 2 (CortBP2) Equus caballus
TI:9796 None
 
F6Q620_HORSE
Ensembl»
0.0
CTTNBP2 Cortactin-binding protein 2 Equus caballus
TI:9796 None
   
F6Y517_HORSE
Ensembl»
0.0
FILIP1L Filamin A interacting protein 1 like Equus caballus
TI:9796 None 		     
F7DQH8_HORSE
Ensembl»
0.0
CTTNBP2NL CTTNBP2 N-terminal like Equus caballus
TI:9796 None
   
A0ABI7W3N8_FELCA
Ensembl»
0.0
CTTNBP2 Cortactin-binding protein 2 Felis catus
TI:9685 None
   
A0ABI7XIJ8_FELCA
Ensembl»
0.0
FILIP1 Cortactin-binding protein-2
N-terminal domain-containing protein		 Felis catus
TI:9685 None 		     
A0ABI7XM41_FELCA
Ensembl»
0.0
FILIP1L Cortactin-binding protein-2
N-terminal domain-containing protein		 Felis catus
TI:9685 None 		     
A0ABI7ZYW3_FELCA
Ensembl»
0.0
LUZP1 Leucine zipper protein 1 Felis catus
TI:9685 None 		     
A0ABI8A7B2_FELCA
Ensembl»
0.0
CTTNBP2NL Cortactin-binding protein-2
N-terminal domain-containing protein		 Felis catus
TI:9685 None
   
A0A8V0XMV6_CHICK
Ensembl»
0.5
FILIP1 Filamin A interacting protein 1 Gallus gallus
TI:9031 None
   
A0A8V0XPR3_CHICK
Ensembl»
0.0
FILIP1L Filamin A interacting protein 1 like Gallus gallus
TI:9031 None 		     
A0A8V0YPS1_CHICK
Ensembl»
0.5
LUZP1 Leucine zipper protein 1 Gallus gallus
TI:9031 None
   
A0A8V1A3G3_CHICK
Ensembl»
0.0
CTTNBP2NL CTTNBP2 N-terminal like Gallus gallus
TI:9031 None
   
A0M8U5_CHICK
Ensembl»
0.5
CORTBP2 Cortactin-binding protein 2 Gallus gallus
TI:9031 None
 
A0A2I2YDR4_GORGO
Ensembl»
0.0
FILIP1L Cortactin-binding protein-2
N-terminal domain-containing protein		 Gorilla gorilla
TI:9593 None
   
A0A2I2YLY2_GORGO
Ensembl»
0.0
LUZP1 Leucine zipper protein 1 Gorilla gorilla
TI:9593 None
 
A0A2I2YSX6_GORGO
Ensembl»
0.0
Cortactin-binding protein-2
N-terminal domain-containing protein		 Gorilla gorilla
TI:9593 None 		 
 
CTTB2_GORGO
euHCVdb»
0.0
CTTNBP2 Cortactin-binding protein 2 (CortBP2) Gorilla gorilla
TI:9593 None
 
G3QII3_GORGO
Ensembl»
0.0
CTTNBP2NL CTTNBP2 N-terminal like Gorilla gorilla
TI:9593 None
 
G3RG49_GORGO
Ensembl»
0.0
CTTNBP2 Cortactin-binding protein 2 Gorilla gorilla
TI:9593 None
 
G3RLU5_GORGO
Ensembl»
0.0
FILIP1 Filamin A interacting protein 1 Gorilla gorilla
TI:9593 None
 
T1EUE2_HELRO
EnsemblMetazoa»
0.0
20200192 Cortactin-binding protein-2
N-terminal domain-containing protein		 Helobdella robusta
TI:6412 None 		 
 
CT2NL_HUMAN
Ensembl»
3.7
CTTNBP2NL CTTNBP2 N-terminal-like protein Homo sapiens
TI:9606 None
 
CTTB2_HUMAN
Ensembl»
0.5
CTTNBP2 Cortactin-binding protein 2 (CortBP2) Homo sapiens
TI:9606 None
 
FIL1L_HUMAN
Ensembl»
0.5
FILIP1L Filamin A-interacting protein 1-like (130 kDa GPBP-interacting protein) (90
kDa GPBP-interacting protein) (Protein down-regulated in ovarian cancer 1) (DOC-1)		 Homo sapiens
TI:9606 None
 
FLIP1_HUMAN
Ensembl»
0.5
FILIP1 Filamin-A-interacting protein 1 (FILIP) Homo sapiens
TI:9606 None
 
LUZP1_HUMAN
Ensembl»
5.2
LUZP1 Leucine zipper protein 1 (Filamin
mechanobinding actin cross-linking protein) (Fimbacin)		 Homo sapiens
TI:9606 None
 
B7PGS8_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW018299 Cortactin-binding protein-2
N-terminal domain-containing protein		 Ixodes scapularis
TI:6945 None 		 
 
W5MA87_LEPOC
Ensembl»
0.0
Leucine zipper protein 1 Lepisosteus oculatus
TI:7918 None
 
W5MSW4_LEPOC
Ensembl»
0.0
Filamin A interacting protein 1 like Lepisosteus oculatus
TI:7918 None
 
W5MWB5_LEPOC
Ensembl»
0.0
CTTNBP2 N-terminal like a Lepisosteus oculatus
TI:7918 None
 
W5NEX6_LEPOC
Ensembl»
0.0
Cortactin-binding protein 2 Lepisosteus oculatus
TI:7918 None
 
W5NJT4_LEPOC
Ensembl»
0.0
Filamin A interacting protein 1 Lepisosteus oculatus
TI:7918 None
 
A0A1D5Q724_MACMU
Ensembl»
0.0
LUZP1 Leucine zipper protein 1 Macaca mulatta
TI:9544 None
   
A0A1D5RIS6_MACMU
Ensembl»
0.0
CTTNBP2 Cortactin-binding protein 2 Macaca mulatta
TI:9544 None
   
F6SBM7_MACMU
Ensembl»
0.0
FILIP1 Filamin A interacting protein 1 Macaca mulatta
TI:9544 None
   
F6YTC8_MACMU
Ensembl»
0.0
FILIP1L Filamin A interacting protein 1 like Macaca mulatta
TI:9544 None
   
F7HER6_MACMU
Ensembl»
0.0
CTTNBP2NL CTTNBP2 N-terminal like
(CTTNBP2 N-terminal-like protein)		 Macaca mulatta
TI:9544 None
 
A0A5F8GJD0_MONDO
Ensembl»
0.0
FILIP1 Filamin A interacting protein 1 Monodelphis domestica
TI:13616 None
   
A0A5F8GWP1_MONDO
Ensembl»
0.0
CTTNBP2NL CTTNBP2 N-terminal like Monodelphis domestica
TI:13616 None
   
F7D7F7_MONDO
Ensembl»
0.0
LUZP1 Leucine zipper protein 1 Monodelphis domestica
TI:13616 None
   
F7GHN1_MONDO
Ensembl»
0.0
FILIP1L Filamin A interacting protein 1 like Monodelphis domestica
TI:13616 None
   
CT2NL_MOUSE
Ensembl»
3.3
Cttnbp2nl CTTNBP2 N-terminal-like protein Mus musculus
TI:10090 None
 
FIL1L_MOUSE
Ensembl»
4.5
Filip1l Filamin A-interacting protein 1-like (Protein down-regulated
in ovarian cancer 1 homolog) (DOC-1)		 Mus musculus
TI:10090 None
 
FLIP1_MOUSE
Ensembl»
4.5
Filip1 Filamin-A-interacting protein 1 (FILIP) Mus musculus
TI:10090 None
 
LUZP1_MOUSE
Ensembl»
10.1
Luzp1 Leucine zipper protein 1 (Filamin mechanobinding actin
cross-linking protein) (Fimbacin) (Leucine zipper motif-containing protein)		 Mus musculus
TI:10090 None
 
A0A6I8N9X0_ORNAN
Ensembl»
0.0
FILIP1 Filamin A interacting protein 1 Ornithorhynchus anatinus
TI:9258 None 		     
A0A6I8N9Z1_ORNAN
Ensembl»
0.0
LUZP1 Leucine zipper protein 1 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8NSN2_ORNAN
Ensembl»
0.0
CTTNBP2 Cortactin-binding protein 2 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8NXV1_ORNAN
Ensembl»
0.0
CTTNBP2NL CTTNBP2 N-terminal like Ornithorhynchus anatinus
TI:9258 None
   
F7CH88_ORNAN
Ensembl»
0.0
FILIP1L Filamin A interacting protein 1 like Ornithorhynchus anatinus
TI:9258 None 		     
A0A3B3HDK9_ORYLA
Ensembl»
0.0
LOC101167844 Cortactin-binding protein-2
N-terminal domain-containing protein		 Oryzias latipes
TI:8090 None
   
A0A3B3IHS7_ORYLA
Ensembl»
0.0
CTTNBP2NL CTTNBP2 N-terminal like b Oryzias latipes
TI:8090 None
   
A0A3B3IKM2_ORYLA
Ensembl»
0.0
luzp1 Leucine zipper protein 1 Oryzias latipes
TI:8090 None
   
H2L9C0_ORYLA
Ensembl»
0.0
FILIP1L Filamin A interacting protein 1 like Oryzias latipes
TI:8090 None
   
H2LMU7_ORYLA
Ensembl»
0.0
CTTNBP2NL CTTNBP2 N-terminal like Oryzias latipes
TI:8090 None
   
H2MSD3_ORYLA
Ensembl»
0.0
FILIP1 Filamin A interacting protein 1 Oryzias latipes
TI:8090 None
   
H2MT12_ORYLA
Ensembl»
0.0
FILIP1 Filamin A interacting protein 1 Oryzias latipes
TI:8090 None
   
H2MZ27_ORYLA
Ensembl»
0.0
CTTNBP2 Cortactin-binding protein 2 Oryzias latipes
TI:8090 None
   
A0A2I3RMT5_PANTR
Ensembl»
0.0
FILIP1L Filamin A interacting protein 1 like Pan troglodytes
TI:9598 None 		 
 
A0A2I3RPT2_PANTR
Ensembl»
0.0
LUZP1 Leucine zipper protein 1 Pan troglodytes
TI:9598 None
 
H2PZN9_PANTR
Ensembl»
0.0
CTTNBP2NL CTTNBP2 N-terminal like Pan troglodytes
TI:9598 None
 
H2QTA6_PANTR
Ensembl»
0.0
FILIP1 Filamin A interacting protein 1 Pan troglodytes
TI:9598 None
 
H2QV97_PANTR
Ensembl»
0.0
CTTNBP2 Cortactin-binding protein 2 Pan troglodytes
TI:9598 None
 
A0A8R1YIM4_PRIPA
EnsemblMetazoa»
0.0
WBGene00110496 Cortactin-binding protein-2
N-terminal domain-containing protein		 Pristionchus pacificus
TI:54126 None 		     
D4A8X8_RAT
RGD»
0.5
Cttnbp2nl CTTNBP2 N-terminal like Rattus norvegicus
TI:10116 None
   
D4A900_RAT
RGD»
3.0
Filip1l Filamin A interacting protein 1-like Rattus norvegicus
TI:10116 None
   
FLIP1_RAT
RGD»
2.5
Filip1 Filamin-A-interacting protein 1 (FILIP) Rattus norvegicus
TI:10116 None
 
LUZP1_RAT
RGD»
9.0
Luzp1 Leucine zipper protein 1 (Filamin mechanobinding actin
cross-linking protein) (Fimbacin) (Leucine zipper motif-containing protein)		 Rattus norvegicus
TI:10116 None
 
A0A7M7MZ37_STRPU
EnsemblMetazoa»
0.0
Cortactin-binding protein 2 Strongylocentrotus purpuratus
TI:7668 None
   
A0A287A8F1_PIG
Ensembl»
0.0
FILIP1 Filamin A interacting protein 1
(Filamin-A-interacting protein 1 isoform X1)		 Sus scrofa
TI:9823 None
 
A0A287AM29_PIG
Ensembl»
0.0
FILIP1L Filamin A interacting protein 1 like
(Filamin A-interacting protein 1-like isoform 3)		 Sus scrofa
TI:9823 None
 
F1SBP5_PIG
Ensembl»
0.0
CTTNBP2NL CTTNBP2 N-terminal like (CTTNBP2
N-terminal-like protein isoform X1)		 Sus scrofa
TI:9823 None
 
F1SJF2_PIG
Ensembl»
0.0
CTTNBP2 Cortactin-binding protein 2 Sus scrofa
TI:9823 None
   
I3LNF8_PIG
Ensembl»
0.0
LUZP1 Leucine zipper protein 1 Sus scrofa
TI:9823 None
 
A0A139WPT5_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_04607 Uncharacterized protein CG10915-like Protein Tribolium castaneum
TI:7070 None 		 
 
A0A1L8G3D7_XENLA
Xenbase»
0.0
filip1.S Filamin-A-interacting protein 1 isoform X1 Xenopus laevis
TI:8355 None
   
A0A1L8H7V8_XENLA
Xenbase»
0.0
luzp1.S Leucine zipper protein 1 S homeolog isoform X1 Xenopus laevis
TI:8355 None
   
A0A1L8HFN2_XENLA
Xenbase»
0.0
luzp1.L Leucine zipper protein 1 Xenopus laevis
TI:8355 None
   
A0A5S6KF84_XENTR
Xenbase»
0.0
filip1l Diablo homolog, mitochondrial (Filamin A interacting protein
1-like) (Filamin A-interacting protein 1-like isoform X1)		 Xenopus tropicalis
TI:8364 None 		     
A0A8J0QMD7_XENTR
Xenbase»
0.0
luzp1 Leucine zipper protein 1 Xenopus tropicalis
TI:8364 None
   
A0A8J0U3Z3_XENLA
Xenbase»
0.0
filip1.L Filamin-A-interacting protein 1 isoform X1 Xenopus laevis
TI:8355 None
   
A0A8J0UB71_XENLA
Xenbase»
0.0
cmss1.S Filamin A-interacting protein 1-like isoform X1 Xenopus laevis
TI:8355 None
   
A0A8J0UGB4_XENLA
CTD»
0.0
LOC108707914 Filamin A-interacting protein 1-like isoform X3 Xenopus laevis
TI:8355 None
   
A0A8J0UHI6_XENLA
Xenbase»
0.0
cttnbp2nl.L CTTNBP2 N-terminal-like protein isoform X2 Xenopus laevis
TI:8355 None
   
F6XM98_XENTR
Xenbase»
0.0
cttnbp2nl CTTNBP2 N-terminal-like Xenopus tropicalis
TI:8364 None