Collated Gene Ontology terms

Biological process: methylmalonyl-CoA epimerase activity(2004, 2010, 2018, 2025) metal ion binding(2025) isomerase activity(2025) lyase activity(2025) lactoylglutathione lyase activity(2025) oxidoreductase activity(2025) dioxygenase activity(2025)

Molecular function: L-methylmalonyl-CoA metabolic process2004, 2010, 2018, 2025 succinyl-CoA biosynthetic process2025 ubiquinone biosynthetic process2025 short-chain fatty acid catabolic process2025

Cellular component: mitochondrion2009, 2012, 2024, 2025 mitochondrial matrix2013

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 2/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 5/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 2/39 
Archea: 4/8 
Bacteria: 16/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
MCEE_HUMAN
Ensembl»
5.2
MCEE Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Homo sapiens
TI:9606 None
 
MCEE_MOUSE
Ensembl»
2.5
Mcee Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Mus musculus
TI:10090 None
 
MCEE_DICDI
dictyBase»
2.0
mcee Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Dictyostelium discoideum
TI:44689 None
 
A0A8I6AMQ5_RAT
RGD»
1.5
Mcee Methylmalonyl CoA epimerase Rattus norvegicus
TI:10116 None
   
A0A8V1A245_CHICK
Ensembl»
1.0
MCEE Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Gallus gallus
TI:9031 None
   
G5EEG4_CAEEL
WormBase»
1.0
mce-1 Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Caenorhabditis elegans
TI:6239 None
 
Q502B7_DANRE
ZFIN»
1.0
mcee Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Danio rerio
TI:7955 None
 
A0A1Y1IJJ6_KLENI
euHCVdb»
0.0
KFL_004680100 Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Klebsormidium nitens
TI:105231 None
 
A0A2A6C9X7_PRIPA
EnsemblMetazoa»
0.0
WBGene00278219 Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Pristionchus pacificus
TI:54126 None
   
A0A2K1IJX2_PHYPA
EnsemblPlants»
0.0
LOC112275493 VOC domain-containing protein Physcomitrium patens
TI:3218 None
 
A0A3B3HV50_ORYLA
Ensembl»
0.0
MCEE Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Oryzias latipes
TI:8090 None
   
A0A5F7ZLR6_MACMU
Ensembl»
0.0
MCEE Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Macaca mulatta
TI:9544 None
   
A0A5F7ZST7_MACMU
Ensembl»
0.0
Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Macaca mulatta
TI:9544 None
   
A0A5F8H490_MONDO
Ensembl»
0.0
MCEE Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Monodelphis domestica
TI:13616 None
   
A0A7I4C233_PHYPA
EnsemblPlants»
0.0
LOC112273455 Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Physcomitrium patens
TI:3218 None
 
A0A7I4CG42_PHYPA
EnsemblPlants»
0.0
LOC112275469 VOC domain-containing protein Physcomitrium patens
TI:3218 None
 
A0A7M7N8Q5_STRPU
EnsemblMetazoa»
0.0
Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7U2HZM1_PHANO
TubercuList»
0.0
JI435_151420 VOC domain-containing protein Phaeosphaeria nodorum
TI:13684 None
 
A0A7U2I788_PHANO
TubercuList»
0.0
JI435_113440 VOC domain-containing protein Phaeosphaeria nodorum
TI:13684 None
 
A0A8I3PG62_CANLF
Ensembl»
0.0
MCEE Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Canis lupus
TI:9612 None
   
A0A9J7KMU9_BRAFL
euHCVdb»
0.0
LOC118409746 Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Branchiostoma floridae
TI:7739 None
   
A0A9L0R373_HORSE
Ensembl»
0.0
MCEE Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Equus caballus
TI:9796 None
   
A0ABI7X4Y2_FELCA
Ensembl»
0.0
MCEE VOC domain-containing protein Felis catus
TI:9685 None
   
A1XQS7_PIG
Ensembl»
0.0
MCEE Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Sus scrofa
TI:9823 None
 
A2DM71_TRIV3
TubercuList»
0.0
TVAG_083440 VOC domain-containing protein Trichomonas vaginalis
TI:5722 None
 
A2E293_TRIV3
TubercuList»
0.0
TVAG_097630 Glyoxalase family protein Trichomonas vaginalis
TI:5722 None
 
A5I208_CLOBH
euHCVdb»
0.0
CBO1531 Glyoxylase-family protein Clostridium botulinum
TI:1491 None
 
A8XEP1_CAEBR
WormBase»
0.0
mce-1 Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Caenorhabditis briggsae
TI:6238 None
 
A9A2D8_NITMS
EnsemblBacteria»
0.0
Nmar_0953 Glyoxalase/bleomycin
resistance protein/dioxygenase		 Nitrosopumilus maritimus
TI:338192 None
 
A9URJ5_MONBE
euHCVdb»
0.0
MONBRDRAFT_14532 Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Monosiga brevicollis
TI:81824 None
 
A9WGS0_CHLAA
EnsemblBacteria»
0.0
Caur_3037 Glyoxalase/bleomycin
resistance protein/dioxygenase		 Chloroflexus aurantiacus
TI:1108 None
 
B3RRT7_TRIAD
CTD»
0.0
TRIADDRAFT_54362 Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Trichoplax adhaerens
TI:10228 None
 
B7PF37_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW003889 Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Ixodes scapularis
TI:6945 None
 
B8BYE7_THAPS
euHCVdb»
0.0
THAPSDRAFT_3661 VOC domain-containing protein Thalassiosira pseudonana
TI:35128 None
 
B8E0B0_DICTD
EnsemblBacteria»
0.0
Dtur_1277 Lactoylglutathione lyase or related lyase Dictyoglomus turgidum
TI:513050 None
 
C8V2C5_EMENI
TubercuList»
0.0
ANIA_10787 VOC domain-containing protein Emericella nidulans
TI:162425 None
 
C8V838_EMENI
TubercuList»
0.0
ANIA_10624 VOC domain-containing protein Emericella nidulans
TI:162425 None
 
C8VB38_EMENI
TubercuList»
0.0
ANIA_10883 Oxidoreductase, putative
(AFU_orthologue AFUA_7G06950)		 Emericella nidulans
TI:162425 None
 
E9FVV0_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_41153 Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Daphnia pulex
TI:6669 None
 
F0ZE17_DICPU
TubercuList»
0.0
DICPUDRAFT_149546 Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Dictyostelium purpureum
TI:5786 None
 
F6UJX4_XENTR
Xenbase»
0.0
mcee Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Xenopus tropicalis
TI:8364 None
 
F7AAX8_ORNAN
Ensembl»
0.0
MCEE Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Ornithorhynchus anatinus
TI:9258 None
   
G3RZF8_GORGO
Ensembl»
0.0
MCEE Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Gorilla gorilla
TI:9593 None
 
H2QI34_PANTR
Ensembl»
0.0
MCEE Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Pan troglodytes
TI:9598 None
 
H2XQG7_CIOIN
Ensembl»
0.0
Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Ciona intestinalis
TI:7719 None
 
H3G7L9_PHYRM
EnsemblProtists»
0.0
VOC domain-containing protein Phytophthora ramorum
TI:164328 None
 
H9G6G3_ANOCA
Ensembl»
0.0
Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Anolis carolinensis
TI:28377 None
   
L7N6B1_MYCTU
PseudoCAP»
0.0
Rv1322A Conserved protein Mycobacterium tuberculosis
TI:1773 None
 
MCEE_BOVIN
CTD»
0.0
MCEE Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Bos taurus
TI:9913 None
 
O86701_STRCO
neXtProt»
0.0
SCO6519 Lyase Streptomyces coelicolor
TI:1902 None
 
Q4FZP6_XENLA
Xenbase»
0.0
mcee.S Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Xenopus laevis
TI:8355 None
 
Q4Q9I9_LEIMA
TubercuList»
0.0
LMJF_26_0020 Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Leishmania major
TI:5664 None
 
Q4WBJ1_ASPFU
TubercuList»
0.0
AFUA_8G02470 Trihydroxytoluene oxygenase (EC 1.13.-.-) Aspergillus fumigatus
TI:746128 None
 
Q4WH14_ASPFU
TubercuList»
0.0
AFUA_7G06950 Oxidoreductase, putative (EC 1.13.-.-) Aspergillus fumigatus
TI:746128 None
 
Q5JG02_THEKO
EnsemblBacteria»
0.0
TK0330 Methylmalonyl-CoA epimerase Thermococcus kodakarensis
TI:311400 None
 
Q747G3_GEOSL
EnsemblBacteria»
0.0
mceE Methylmalonyl-CoA epimerase Geobacter sulfurreducens
TI:35554 None
 
Q7NE21_GLOVI
EnsemblBacteria»
0.0
gll4059 Gll4059 protein Gloeobacter violaceus
TI:33072 None
 
Q7NGH6_GLOVI
EnsemblBacteria»
0.0
gll3193 Gll3193 protein Gloeobacter violaceus
TI:33072 None
 
Q7NLG3_GLOVI
EnsemblBacteria»
0.0
glr1161 Glr1161 protein Gloeobacter violaceus
TI:33072 None
 
Q7SA40_NEUCR
TubercuList»
0.0
NCU07322 Glyoxalase Neurospora crassa
TI:5141 None
 
Q7UTJ8_RHOBA
EnsemblBacteria»
0.0
RB3840 Similar to dioxygenase superfamily Rhodopirellula baltica
TI:265606 None
 
Q7UTN4_RHOBA
EnsemblBacteria»
0.0
RB3774 VOC domain-containing protein Rhodopirellula baltica
TI:265606 None
 
Q81BH9_BACCR
euHCVdb»
0.0
BC_3178 Lactoylglutathione lyase (EC 4.4.1.5) Bacillus cereus
TI:1396 None
 
Q81EX4_BACCR
neXtProt»
0.0
BC_1837 Methylmalonyl CoA epimerase (EC 5.1.99.1) Bacillus cereus
TI:1396 None
 
Q81F54_BACCR
euHCVdb»
0.0
BC_1747 Glyoxalase family protein Bacillus cereus
TI:1396 None
 
Q89BG5_BRADU
EnsemblBacteria»
0.0
blr8189 Blr8189 protein Bradyrhizobium diazoefficiens
TI:1355477 None
 
Q89JF8_BRADU
EnsemblBacteria»
0.0
blr5325 Blr5325 protein Bradyrhizobium diazoefficiens
TI:1355477 None
 
Q89KK4_BRADU
EnsemblBacteria»
0.0
bll4901 methylmalonyl-CoA epimerase (EC 5.1.99.1) Bradyrhizobium diazoefficiens
TI:1355477 None
 
Q89RD8_BRADU
EnsemblBacteria»
0.0
blr2834 Blr2834 protein Bradyrhizobium diazoefficiens
TI:1355477 None
 
Q8A740_BACTN
EnsemblBacteria»
0.0
BT_1685 Lactoylglutathione lyase and related protein Bacteroides thetaiotaomicron
TI:818 None
 
Q8A8J6_BACTN
EnsemblBacteria»
0.0
BT_1171 Glyoxalase family-like protein Bacteroides thetaiotaomicron
TI:818 None
 
Q8EI54_SHEON
neXtProt»
0.0
SO_0996 Lactoylglutathione lyase family protein Shewanella oneidensis
TI:70863 None
 
Q8F692_LEPIN
EnsemblBacteria»
0.0
LA_1417 Lactoylglutathione lyase Leptospira interrogans
TI:173 None
 
Q93RT7_STRCO
euHCVdb»
0.0
SCO6304 Oxidoreductase Streptomyces coelicolor
TI:1902 None
 
Q97W20_SACS2
EnsemblBacteria»
0.0
SSO2426 Lactoylglutathione lyase (Glyoxalase
I), putative (EC 4.4.1.5)		 Saccharolobus solfataricus
TI:2287 None
 
Q9HRZ3_HALSA
neXtProt»
0.0
VNG_0478C VOC domain-containing protein Halobacterium salinarum
TI:2242 None
 
Q9HYL4_PSEAE
PharmGKB»
0.0
PA3389 Probable ring-cleaving dioxygenase Pseudomonas aeruginosa
TI:287 None
 
Q9L2C2_STRCO
neXtProt»
0.0
SCO5398 VOC domain-containing protein Streptomyces coelicolor
TI:1902 None
 
Q9RL13_STRCO
euHCVdb»
0.0
SCO0304 VOC domain-containing protein Streptomyces coelicolor
TI:1902 None
 
Q9RSV0_DEIRA
EnsemblBacteria»
0.0
DR_2022 VOC domain-containing protein Deinococcus radiodurans
TI:1299 None
 
Q9RTR1_DEIRA
EnsemblBacteria»
0.0
DR_1695 Lactoylglutathione lyase-related protein Deinococcus radiodurans
TI:1299 None
 
Q9S1P9_STRCO
neXtProt»
0.0
SCO0242 VOC domain-containing protein Streptomyces coelicolor
TI:1902 None
 
Q9X9X9_STRCO
neXtProt»
0.0
SCO1893 Lyase Streptomyces coelicolor
TI:1902 None
 
Q9XA78_STRCO
neXtProt»
0.0
SCO0847 Lyase Streptomyces coelicolor
TI:1902 None
 
T1EUC2_HELRO
EnsemblMetazoa»
0.0
20200172 Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Helobdella robusta
TI:6412 None
 
W5N8B7_LEPOC
Ensembl»
0.0
Methylmalonyl-CoA epimerase, mitochondrial
(EC 5.1.99.1) (DL-methylmalonyl-CoA racemase)		 Lepisosteus oculatus
TI:7918 None
 
YQJC_BACSU
EnsemblBacteria»
0.0
yqjC Uncharacterized protein YqjC Bacillus subtilis
TI:1423 None
 
YRAH_BACSU
EnsemblBacteria»
0.0
yraH Uncharacterized protein YraH Bacillus subtilis
TI:1423 None
 
YWBC_BACSU
EnsemblBacteria»
0.0
ywbC Uncharacterized protein YwbC Bacillus subtilis
TI:1423 None