Collated Gene Ontology terms

Biological process: serine-type endopeptidase inhibitor activity(2017, 2025) peptidase inhibitor activity(2025) toxin activity(2025) ion channel inhibitor activity(2025) calcium ion binding(2025) extracellular matrix structural constituent(2003, 2025) transmembrane transporter activity(2025) enzyme inhibitor activity(2025) endopeptidase inhibitor activity(2003)

Molecular function: blood coagulation2003, 2025 hemostasis2025 modulation of process of another organism2025 negative regulation of blood coagulation2017, 2025 cellular response to lipid2025 cellular response to steroid hormone stimulus2017, 2025 venom-mediated perturbation of hemostasis2025 mechanosensory behavior2004, 2005, 2017 extracellular matrix organization2025 cell migration2025
anatomical structure morphogenesis2025 venom-mediated inhibition of voltage-gated potassium channel activity2025 response to mechanical stimulus2004, 2005 nematode larval development2009, 2025 lactation2025 embryonic morphogenesis2009, 2025 embryo development ending in birth or egg hatching2009, 2025 distal tip cell migration2023, 2025 detection of mechanical stimulus involved in sensory perception of touch2017 cuticle development involved in collagen and cuticulin-based cuticle molting cycle2024, 2025 cell morphogenesis2009, 2025 transmembrane transport2025 sarcomere organization2015 response to lipopolysaccharide2016 response to estradiol2016 response to bacterium2018 regulation of hemopoiesis2015 positive regulation of mechanosensory behavior2017 positive regulation of detection of mechanical stimulus involved in sensory perception of touch2017 insemination2025 heart development2015 extracellular structure organization2005 cognition2018 central nervous system development2013 cellular response to lipopolysaccharide2016 cellular response to interleukin-12016 cellular response to fluid shear stress2016

Cellular component: extracellular space2009, 2012, 2016, 2017, 2018, 2025 extracellular region2004, 2025 nematocyst2025 cell surface2014, 2017, 2025 caveola2017, 2025 basement membrane2013, 2025 plasma membrane2004, 2025 membrane2025 extracellular matrix2003, 2025 early endosome2018, 2025
side of membrane2025 recycling endosome2018 perikaryon2025 growth cone2025 cytoplasmic vesicle2025 clathrin-coated pit2025 Golgi-associated vesicle2018

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 1/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
TFPI1_HUMAN
Ensembl»
3.9
TFPI Tissue factor pathway inhibitor (TFPI) (Extrinsic
pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI)		 Homo sapiens
TI:9606 None
 
TFPI1_RAT
RGD»
4.7
Tfpi Tissue factor pathway inhibitor (TFPI) (Extrinsic
pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI)		 Rattus norvegicus
TI:10116 None
 
TFPI1_MOUSE
Ensembl»
1.0
Tfpi Tissue factor pathway inhibitor (TFPI) (Extrinsic
pathway inhibitor) (EPI) (Lipoprotein-associated coagulation inhibitor) (LACI)		 Mus musculus
TI:10090 None
 
Q18761_CAEEL
WormBase»
5.3
mec-9 Kunitz/Bovine pancreatic trypsin
inhibitor domain protein		 Caenorhabditis elegans
TI:6239 None
 
A0A8V0YDC8_CHICK
Ensembl»
0.5
TFPI Tissue factor pathway inhibitor (Extrinsic
pathway inhibitor) (Lipoprotein-associated coagulation inhibitor)		 Gallus gallus
TI:9031 None
   
Q5ZR42_CAEEL
WormBase»
4.5
mec-1 Papilin Caenorhabditis elegans
TI:6239 None
 
PPN1_CAEEL
WormBase»
4.0
mig-6 Papilin (Abnormal cell migration protein 6) Caenorhabditis elegans
TI:6239 None
 
Q1WCN6_DANRE
ZFIN»
3.7
tfpi2 Tissue factor pathway inhibitor Danio rerio
TI:7955 None
 
Q9VCM5_DROME
FlyBase»
1.0
Dmel\CG31515 BPTI/Kunitz inhibitor domain-containing protein Drosophila melanogaster
TI:7227 None
 
TFPI2_HUMAN
Ensembl»
1.4
TFPI2 Tissue factor pathway inhibitor 2
(TFPI-2) (Placental protein 5) (PP5)		 Homo sapiens
TI:9606 None
 
Q9VQT8_DROME
FlyBase»
1.0
IM33 Immune induced molecule 33, isoform A (Immune
induced molecule 33, isoform B) (RH05411p) (RH38008p)		 Drosophila melanogaster
TI:7227 None
 
A0A3Q3A7D8_CHICK
Ensembl»
0.5
TFPI2 Tissue factor pathway inhibitor Gallus gallus
TI:9031 None
   
A1Z7L2_DROME
FlyBase»
0.5
Dmel\CG13748 IP20435p Drosophila melanogaster
TI:7227 None
 
B0S6C1_DANRE
ZFIN»
0.5
tfpia Tissue factor pathway inhibitor Danio rerio
TI:7955 None
 
Q9VQT1_DROME
FlyBase»
0.5
Dmel\CG15418 GEO10309p1 (TA01751p) Drosophila melanogaster
TI:7227 None
 
TFPI2_MOUSE
Ensembl»
0.5
Tfpi2 Tissue factor pathway inhibitor 2 (TFPI-2) Mus musculus
TI:10090 None
 
E7FAB1_DANRE
ZFIN»
0.5
tfpil Uncharacterized protein
LOC322379 precursor (Wu:fb59d01)		 Danio rerio
TI:7955 None
 
A0A0G2K680_RAT
RGD»
0.5
Spint3 Serine peptidase inhibitor, Kunitz type, 3 Rattus norvegicus
TI:10116 None
   
B9WRT9_CAEEL
WormBase»
1.3
mlt-11 Papilin Caenorhabditis elegans
TI:6239 None
 
G5ED57_CAEEL
WormBase»
0.5
CELE_F22E12.1 F22E12.1 BPTI/Kunitz inhibitor domain-containing protein Caenorhabditis elegans
TI:6239 None
 
I2HAB0_CAEEL
WormBase»
0.5
C49H3.16 CELE_C49H3.16 BPTI/Kunitz inhibitor domain-containing protein Caenorhabditis elegans
TI:6239 None
 
M9MS11_DROME
FlyBase»
0.5
Dmel\CG42716 BPTI/Kunitz inhibitor domain-containing protein Drosophila melanogaster
TI:7227 None
 
Q3UW09_MOUSE
Ensembl»
0.5
Spint3 Serine peptidase inhibitor, Kunitz type, 3 Mus musculus
TI:10090 None
 
Q4V608_DROME
FlyBase»
0.5
Dmel\CG42827 CG42827-PC, CG42827-PD (IP06046p) (IP06146p) (Uncharacterized protein,
isoform C) (Uncharacterized protein, isoform D)		 Drosophila melanogaster
TI:7227 None
 
Q8IPF1_DROME
FlyBase»
0.0
anon-AE003623.1 BPTI/Kunitz inhibitor domain-containing protein Drosophila melanogaster
TI:7227 None
 
Q9VCM3_DROME
FlyBase»
0.5
Dmel\CG17380 BPTI/Kunitz inhibitor domain-containing protein Drosophila melanogaster
TI:7227 None
 
G3V7D5_RAT
RGD»
1.3
Tfpi2 Tissue factor pathway inhibitor 2 Rattus norvegicus
TI:10116 None
   
Q9VF11_DROME
FlyBase»
0.5
CG5470 Uncharacterized protein, isoform A
(Uncharacterized protein, isoform B)		 Drosophila melanogaster
TI:7227 None
 
Q9VQT9_DROME
FlyBase»
0.5
Dmel\CG3604 LP04037p Drosophila melanogaster
TI:7227 None
 
A0A8V0Z096_CHICK
Ensembl»
0.0
SPINT4 Serine peptidase inhibitor, Kunitz type 4 Gallus gallus
TI:9031 None
   
SPIT3_HUMAN
Ensembl»
0.0
SPINT3 Kunitz-type protease inhibitor 3 (HKIB9) Homo sapiens
TI:9606 None
 
A0AB13A905_DANRE
ZFIN»
0.0
si:dkeyp-73b11.8 BPTI/Kunitz domain-containing protein precursor Danio rerio
TI:7955 None
   
M9NDD9_DROME
FlyBase»
0.0
Dmel\CG43165 BPTI/Kunitz inhibitor domain-containing protein Drosophila melanogaster
TI:7227 None
 
Q32ZM2_MOUSE
Ensembl»
0.0
Spint5 KUNITZ5 (Predicted gene, OTTMUSG00000016293) (Serine
protease inhibitor, Kunitz type 5)		 Mus musculus
TI:10090 None
 
Q4V4A5_DROME
FlyBase»
0.0
Dmel\CG2816 GEO13386p1 (IP03754p) (IP03854p) Drosophila melanogaster
TI:7227 None
 
Q9VQT6_DROME
FlyBase»
0.0
Dmel\CG3513 IP03784p Drosophila melanogaster
TI:7227 None
 
Q9VQU0_DROME
FlyBase»
0.0
Dmel\CG10031 BPTI/Kunitz inhibitor domain-containing protein Drosophila melanogaster
TI:7227 None
 
A0A8V0YTE6_CHICK
Ensembl»
0.0
BPTI/Kunitz inhibitor domain-containing protein Gallus gallus
TI:9031 None
   
E9PTI0_RAT
RGD»
0.0
Spint5p Serine peptidase inhibitor, Kunitz type 5 Rattus norvegicus
TI:10116 None
   
Q1LYP0_DANRE
ZFIN»
0.0
si:dkey-117n7.5 Si:dkey-117n7.5 (Uncharacterized
protein LOC559444)		 Danio rerio
TI:7955 None