Collated Gene Ontology terms

Biological process: metal ion binding(2024) phosphatidylinositol binding(2024) zinc ion binding(2024) small GTPase binding(2024) RNA polymerase II cis-regulatory region sequence-specific DNA binding(2024) DNA-binding transcription factor activity(2024) ATP hydrolysis activity(2024) ATP binding(2024)

Molecular function: lysosome localization2017, 2021, 2024 positive regulation of ruffle assembly2017, 2024 positive regulation of bone resorption2017, 2024 autophagy2024 myoblast differentiation2018, 2024 late endosome to lysosome transport2021, 2024 autophagosome-lysosome fusion2021, 2024 protein transport2024 regulation of DNA-templated transcription2024 lysosome organization2017

Cellular component: endosome2024 membrane2024 lysosome2021, 2024 cytoplasm2018, 2024 Golgi apparatus2018, 2024 plasma membrane2018, 2024 autolysosome2021, 2024 nucleolus2023, 2024 intracellular membrane-bounded organelle2023, 2024 late endosome membrane2024
autolysosome membrane2024

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 1/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 18/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A803T7V7_ANOCA
Ensembl»
0.0
DEF8 Differentially expressed in FDCP 8 homolog Anolis carolinensis
TI:28377 None
   
G1KN51_ANOCA
Ensembl»
0.0
plekhm1 Pleckstrin homology and RUN domain containing M1 Anolis carolinensis
TI:28377 None
   
H9GFM3_ANOCA
Ensembl»
0.0
PLEKHM3 Pleckstrin homology domain containing M3 Anolis carolinensis
TI:28377 None
   
Q7Q6B8_ANOGA
EnsemblMetazoa»
0.0
1276599 AGAP005931-PA Anopheles gambiae
TI:7165 None
 
F4JDV4_ARATH
TAIR»
0.0
SNX5 Phox (PX) domain-containing protein Arabidopsis thaliana
TI:3702 None
 
DEFI8_BOVIN
Ensembl»
0.0
DEF8 Differentially expressed in
FDCP 8 homolog (DEF-8)		 Bos taurus
TI:9913 None
 
A0A9J7LX37_BRAFL
CTD»
0.0
LOC118425769 Differentially expressed in
FDCP 8 homolog B-like		 Branchiostoma floridae
TI:7739 None
   
A0A9J7M8M6_BRAFL
CTD»
0.0
LOC118429890 Uncharacterized protein LOC118429890 isoform X1 Branchiostoma floridae
TI:7739 None
   
A0A078JJN2_BRANA
EnsemblPlants»
0.0
BnaC01g42970D BnaC01g42970D protein Brassica napus
TI:3708 None
 
A0A078JWJ9_BRANA
EnsemblPlants»
0.0
BnaAnng31860D BnaAnng31860D protein Brassica napus
TI:3708 None
 
M4EY70_BRACM
EnsemblPlants»
0.0
PX domain-containing protein Brassica campestris
TI:3711 None
   
M4EY71_BRACM
EnsemblPlants»
0.0
PX domain-containing protein Brassica campestris
TI:3711 None
   
M4EY72_BRACM
EnsemblPlants»
0.0
PX domain-containing protein Brassica campestris
TI:3711 None
   
A8WLQ1_CAEBR
WormBase»
0.0
CBG24893 CBG_24893 Protein CBG24893 Caenorhabditis briggsae
TI:6238 None
 
A8XLN6_CAEBR
WormBase»
0.0
CBG15211 CBG_15211 Protein CBG15211 Caenorhabditis briggsae
TI:6238 None
 
A8XYD1_CAEBR
WormBase»
0.0
cup-14 Protein CBG20681 Caenorhabditis briggsae
TI:6238 None
 
DEFI8_CAEEL
WormBase»
0.0
F20H11.1 Differentially expressed in FDCP 8 homolog Caenorhabditis elegans
TI:6239 None
 
K8ESM7_CAEEL
WormBase»
0.8
cup-14 RUN domain-containing protein Caenorhabditis elegans
TI:6239 None
 
A0A8I3MH28_CANLF
Ensembl»
0.0
DEF8 Differentially expressed in FDCP 8 homolog Canis lupus
TI:9612 None
   
A0A8I3RU75_CANLF
Ensembl»
0.0
PLEKHM1 Pleckstrin homology and RUN domain containing M1 Canis lupus
TI:9612 None
   
A0A8I3S5S4_CANLF
Ensembl»
0.0
PLEKHM3 Pleckstrin homology domain containing M3 Canis lupus
TI:9612 None
   
A0A2G2XZH6_CAPAN
EnsemblPlants»
0.0
T459_33394 PX domain-containing protein Capsicum annuum
TI:4072 None
 
F6WFF8_CIOIN
Ensembl»
0.0
Phorbol-ester/DAG-type domain-containing protein Ciona intestinalis
TI:7719 None
   
F6ZK14_CIOIN
Ensembl»
0.0
LOC100181521 Pleckstrin homology domain-containing
family M member 1-like		 Ciona intestinalis
TI:7719 None
   
A0A0A0LP51_CUCSA
EnsemblPlants»
0.0
Csa_1G004890 PX domain-containing protein Cucumis sativus
TI:3659 None
 
A0A0R4IHS8_DANRE
ZFIN»
0.0
zgc:101815 Differentially expressed in FDCP 8 homolog Danio rerio
TI:7955 None
 
A0A8M9Q8H1_DANRE
ZFIN»
0.0
wu:fc17c08 Pleckstrin homology domain-containing family M member 1 isoform 1 (Pleckstrin homology domain-containing family M
member 1 isoform X1) (Pleckstrin homology domain-containing, family M (with RUN domain) member 1)		 Danio rerio
TI:7955 None
 
B0UYC9_DANRE
ZFIN»
0.0
plekhm3 Novel protein (Pleckstrin homology
domain-containing family M member 3)		 Danio rerio
TI:7955 None
 
E9FRK4_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_39904 Phorbol-ester/DAG-type domain-containing protein Daphnia pulex
TI:6669 None
 
E9H211_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_57290 Rubicon Homology domain-containing protein Daphnia pulex
TI:6669 None
 
E9I431_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_274317 Phorbol-ester/DAG-type domain-containing protein Daphnia pulex
TI:6669 None
 
DEFI8_DROME
FlyBase»
0.0
DEF8 Differentially expressed in FDCP 8 homolog Drosophila melanogaster
TI:7227 None
 
Q9W293_DROME
FlyBase»
0.8
Plekhm1 Pleckstrin homology and RUN domain containing M1 Drosophila melanogaster
TI:7227 None
 
A0A5F5PVZ7_HORSE
Ensembl»
0.0
PLEKHM1 Pleckstrin homology and RUN domain containing M1 Equus caballus
TI:9796 None
   
A0A022Q6I4_ERYGU
EnsemblFungi»
0.0
MIMGU_mgv1a000597mg PX domain-containing protein Erythranthe guttata
TI:4155 None
 
A0A2I2UKI7_FELCA
Ensembl»
0.0
PLEKHM1 Pleckstrin homology and RUN domain containing M1 Felis catus
TI:9685 None
 
A0A2I2UWJ4_FELCA
Ensembl»
0.0
PLEKHM3 Pleckstrin homology domain containing M3 Felis catus
TI:9685 None
 
M3W100_FELCA
Ensembl»
0.0
DEF8 Differentially expressed in FDCP 8 homolog Felis catus
TI:9685 None
 
A0A8V0Y0K9_CHICK
Ensembl»
0.0
DEF8 Differentially expressed in FDCP 8 homolog Gallus gallus
TI:9031 None
   
A0A8V0ZT76_CHICK
Ensembl»
0.0
Pleckstrin homology domain-containing
family M member 1		 Gallus gallus
TI:9031 None
   
A0A8V1A4M8_CHICK
Ensembl»
0.0
PLEKHM3 Pleckstrin homology domain containing M3 Gallus gallus
TI:9031 None
   
A0A8V1A7J0_CHICK
Ensembl»
0.0
PLEKHM1 Pleckstrin homology and RUN domain containing M1 Gallus gallus
TI:9031 None
   
K7KKY2_SOYBN
EnsemblPlants»
0.0
100800081 PX domain-containing protein Glycine max
TI:3847 None
 
K7KVR7_SOYBN
EnsemblPlants»
0.0
100778899 PX domain-containing protein Glycine max
TI:3847 None
 
G3QFB7_GORGO
Ensembl»
0.0
PLEKHM3 Pleckstrin homology domain containing M3 Gorilla gorilla
TI:9593 None
 
G3R769_GORGO
Ensembl»
0.0
DEF8 Differentially expressed in FDCP 8 homolog Gorilla gorilla
TI:9593 None
 
G3RAS6_GORGO
Ensembl»
0.0
Phorbol-ester/DAG-type domain-containing protein Gorilla gorilla
TI:9593 None
 
G3RPX2_GORGO
Ensembl»
0.0
Rubicon Homology domain-containing protein Gorilla gorilla
TI:9593 None
 
A0A251US21_HELAN
EnsemblPlants»
0.0
HannXRQ_Chr05g0155771 Putative phox domain, Multihem
cytochrome, Putative zinc-RING and/or ribbon		 Helianthus annuus
TI:4232 None
 
T1EHB4_HELRO
EnsemblMetazoa»
0.0
20195964 Rubicon Homology domain-containing protein Helobdella robusta
TI:6412 None
 
T1FZW2_HELRO
EnsemblMetazoa»
0.0
20214360 Phorbol-ester/DAG-type domain-containing protein Helobdella robusta
TI:6412 None
 
DEFI8_HUMAN
Ensembl»
1.5
DEF8 Differentially expressed in
FDCP 8 homolog (DEF-8)		 Homo sapiens
TI:9606 None
 
PKHM1_HUMAN
Ensembl»
3.9
PLEKHM1 Pleckstrin homology domain-containing family M member 1 (PH domain-containing
family M member 1) (162 kDa adapter protein) (AP162)		 Homo sapiens
TI:9606 None
 
PKHM3_HUMAN
Ensembl»
0.5
PLEKHM3 Pleckstrin homology domain-containing family M member 3 (PH
domain-containing family M member 3) (Differentiation associated protein)		 Homo sapiens
TI:9606 None
 
B7Q1L9_IXOSC
EnsemblMetazoa»
0.0
8034556 Phorbol-ester/DAG-type domain-containing protein Ixodes scapularis
TI:6945 None
 
B7Q8K7_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW011518 RUN domain-containing protein Ixodes scapularis
TI:6945 None
 
A0A2I4EPE8_JUGRE
EnsemblPlants»
0.0
LOC108991471 Uncharacterized protein LOC108991471 Juglans regia
TI:51240 None
 
A0A1Y1HT47_KLENI
EnsemblPlants»
0.0
KFL_000220390 PX domain-containing protein Klebsormidium nitens
TI:105231 None
 
W5LYV9_LEPOC
Ensembl»
0.0
Differentially expressed in FDCP 8 homolog Lepisosteus oculatus
TI:7918 None
 
W5M9M1_LEPOC
Ensembl»
0.0
Pleckstrin homology domain containing M3 Lepisosteus oculatus
TI:7918 None
 
W5N6D5_LEPOC
Ensembl»
0.0
Pleckstrin homology and RUN domain containing M1 Lepisosteus oculatus
TI:7918 None
 
F6UUH3_MACMU
Ensembl»
0.0
PLEKHM1 Pleckstrin homology and RUN domain containing M1 Macaca mulatta
TI:9544 None
   
F6X5P1_MACMU
Ensembl»
0.0
DEF8 Differentially expressed in FDCP 8 homolog Macaca mulatta
TI:9544 None
   
H9ERP5_MACMU
Ensembl»
0.0
PLEKHM3 Pleckstrin homology domain containing M3 (Pleckstrin
homology domain-containing family M member 3)		 Macaca mulatta
TI:9544 None
 
A0A2C9UJI5_MANES
EnsemblPlants»
0.0
MANES_14G064400 PX domain-containing protein Manihot esculenta
TI:3983 None
 
A0A2R6XC71_MARPO
EnsemblPlants»
0.0
MARPO_0023s0026 PX domain-containing protein Marchantia polymorpha
TI:3197 None
 
G7J5E3_MEDTR
EnsemblPlants»
0.0
11428174 Phox (PX) domain protein
(Putative Phox domain-containing protein)		 Medicago truncatula
TI:3880 None
 
F7BB60_MONDO
Ensembl»
0.0
PLEKHM1 Pleckstrin homology and RUN domain containing M1 Monodelphis domestica
TI:13616 None
   
F7CTD5_MONDO
Ensembl»
0.0
DEF8 Differentially expressed in FDCP 8 homolog Monodelphis domestica
TI:13616 None
   
K7E2A7_MONDO
Ensembl»
0.0
PLEKHM3 Pleckstrin homology domain containing M3 Monodelphis domestica
TI:13616 None
   
A9UU05_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_18112 Phorbol-ester/DAG-type domain-containing protein Monosiga brevicollis
TI:81824 None
 
A9UVG2_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_31799 ABC transporter domain-containing protein Monosiga brevicollis
TI:81824 None
 
DEFI8_MOUSE
Ensembl»
2.4
Def8 Differentially expressed in FDCP 8 (DEF-8) Mus musculus
TI:10090 None
 
PKHM1_MOUSE
Ensembl»
3.9
Plekhm1 Pleckstrin homology domain-containing family M member
1 (PH domain-containing family M member 1)		 Mus musculus
TI:10090 None
 
PKHM3_MOUSE
Ensembl»
0.8
Plekhm3 Pleckstrin homology domain-containing family M member 3
(PH domain-containing family M member 3) (Differentiation-associated protein)		 Mus musculus
TI:10090 None
 
A0A1U7ZJM1_NELNU
EnsemblBacteria»
0.0
LOC104591417 Uncharacterized protein LOC104591417 isoform X1 Nelumbo nucifera
TI:4432 None
   
A7RRC1_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g90855 Phorbol-ester/DAG-type domain-containing protein Nematostella vectensis
TI:45351 None
 
A7SVS4_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g13517 Rubicon Homology domain-containing protein Nematostella vectensis
TI:45351 None
 
A0A6I8NG62_ORNAN
Ensembl»
0.0
PLEKHM3 Pleckstrin homology domain containing M3 Ornithorhynchus anatinus
TI:9258 None
   
F6TMX5_ORNAN
Ensembl»
0.0
DEF8 Differentially expressed in FDCP 8 homolog Ornithorhynchus anatinus
TI:9258 None
   
H2M0B6_ORYLA
Ensembl»
0.0
def8 Differentially expressed in FDCP 8 homolog Oryzias latipes
TI:8090 None
   
H2M3L0_ORYLA
Ensembl»
0.0
plekhm3 Pleckstrin homology domain containing M3 Oryzias latipes
TI:8090 None
   
H2M7Y1_ORYLA
Ensembl»
0.0
plekhm1 Pleckstrin homology and RUN domain containing M1 Oryzias latipes
TI:8090 None
   
A0A2I3SVT5_PANTR
Ensembl»
0.0
PLEKHM3 Pleckstrin homology domain containing M3 (Pleckstrin
homology domain containing, family M, member 3)		 Pan troglodytes
TI:9598 None
 
A0A2J8J014_PANTR
Ensembl»
0.0
DEF8 Differentially expressed in FDCP 8 homolog Pan troglodytes
TI:9598 None
 
H2QD91_PANTR
Ensembl»
0.0
PLEKHM1 Pleckstrin homology and RUN domain containing M1 (Pleckstrin homology
domain containing, family M (With RUN domain) member 1)		 Pan troglodytes
TI:9598 None
 
A0BU97_PARTE
EnsemblProtists»
0.0
GSPATT00032346001 Chromosome undetermined scaffold_129,
whole genome shotgun sequence		 Paramecium tetraurelia
TI:5888 None
 
A0BWI8_PARTE
EnsemblProtists»
0.0
GSPATT00032757001 Chromosome undetermined scaffold_132,
whole genome shotgun sequence		 Paramecium tetraurelia
TI:5888 None
 
A0CJL8_PARTE
EnsemblProtists»
0.0
GSPATT00000697001 Chromosome undetermined scaffold_2,
whole genome shotgun sequence		 Paramecium tetraurelia
TI:5888 None
 
A0A2K1IBF3_PHYPA
EnsemblPlants»
0.0
PHYPA_030080 PX domain-containing protein Physcomitrium patens
TI:3218 None
 
A0A3N7G1P7_POPTR
EnsemblPlants»
0.0
POPTR_015G078250 PX domain-containing protein Populus trichocarpa
TI:3694 None
 
A0A2A6B440_PRIPA
EnsemblMetazoa»
0.0
WBGene00111174 C1 domain containing protein Pristionchus pacificus
TI:54126 None
 
A0A2A6CWH7_PRIPA
EnsemblMetazoa»
0.0
WBGene00096311 RUN domain-containing protein Pristionchus pacificus
TI:54126 None
 
A0A2A6CZU2_PRIPA
EnsemblMetazoa»
0.0
WBGene00111218 Nhr-32 Pristionchus pacificus
TI:54126 None
 
D4A959_RAT
RGD»
0.5
Plekhm3 Pleckstrin homology domain containing M3 Rattus norvegicus
TI:10116 None
   
DEFI8_RAT
RGD»
3.0
Def8 Differentially expressed in
FDCP 8 homolog (DEF-8)		 Rattus norvegicus
TI:10116 None
 
PKHM1_RAT
RGD»
5.0
Plekhm1 Pleckstrin homology domain-containing family M member
1 (PH domain-containing family M member 1)		 Rattus norvegicus
TI:10116 None
 
D8QPZ9_SELML
EnsemblPlants»
0.0
SELMODRAFT_74498 PX domain-containing protein Selaginella moellendorffii
TI:88036 None
 
D8SKH7_SELML
EnsemblPlants»
0.0
SELMODRAFT_119129 PX domain-containing protein Selaginella moellendorffii
TI:88036 None
 
A0A7M7N655_STRPU
EnsemblMetazoa»
0.0
Differentially expressed in FDCP 8 homolog Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7NRM0_STRPU
EnsemblMetazoa»
0.0
Differentially expressed in FDCP 8 homolog Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7SZB0_STRPU
EnsemblMetazoa»
0.0
RUN domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A8W4FPV5_PIG
Ensembl»
0.0
PLEKHM1 Pleckstrin homology and RUN domain containing M1 Sus scrofa
TI:9823 None
   
F1S6M6_PIG
Ensembl»
0.0
DEF8 Differentially expressed in FDCP 8 homolog Sus scrofa
TI:9823 None
   
I3L6K9_PIG
Ensembl»
0.0
PLEKHM3 Pleckstrin homology domain containing M3 (Pleckstrin
homology domain-containing family M member 3)		 Sus scrofa
TI:9823 None
 
D6W845_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_30686 RUN domain-containing protein Tribolium castaneum
TI:7070 None
 
D6WGG5_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_03420 Differentially expressed in
FDCP 8 homolog-like Protein		 Tribolium castaneum
TI:7070 None
 
B3RVJ0_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_23786 Phorbol-ester/DAG-type domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B3S7P2_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_60242 Rubicon Homology domain-containing protein Trichoplax adhaerens
TI:10228 None
 
Q38BR7_TRYB2
VEuPathDB»
0.0
Tb10.70.4140 Rubicon Homology domain-containing protein Trypanosoma brucei
TI:5691 None
 
A0A1L8ELD0_XENLA
Xenbase»
0.0
plekhm1.S Pleckstrin homology domain-containing
family M member 1		 Xenopus laevis
TI:8355 None
   
A0A1L8EPW5_XENLA
Xenbase»
0.0
plekhm3.S Pleckstrin homology domain-containing
family M member 3-like		 Xenopus laevis
TI:8355 None
   
A0A6I8SJK7_XENTR
Ensembl»
0.0
plekhm1 Pleckstrin homology and RUN domain containing M1
(Pleckstrin homology domain-containing family M member 1)		 Xenopus tropicalis
TI:8364 None
   
A0A8J0UYB7_XENLA
Xenbase»
0.0
def8.L Differentially expressed in FDCP
8 homolog A isoform X1		 Xenopus laevis
TI:8355 None
   
A0A8J1LS80_XENLA
Xenbase»
0.0
plekhm1.L Pleckstrin homology domain-containing
family M member 1		 Xenopus laevis
TI:8355 None
   
DEFI8_XENTR
Xenbase»
0.0
def8 Differentially expressed in
FDCP 8 homolog (DEF-8)		 Xenopus tropicalis
TI:8364 None
 
DFI8A_XENLA
Xenbase»
0.0
def8-a Differentially expressed in FDCP
8 homolog A (DEF-8-A)		 Xenopus laevis
TI:8355 None
 
DFI8B_XENLA
Xenbase»
0.0
def8-b Differentially expressed in FDCP
8 homolog B (DEF-8-B)		 Xenopus laevis
TI:8355 None
 
F6QBG2_XENTR
Xenbase»
0.0
plekhm3 Pleckstrin homology domain-containing M3 (Pleckstrin homology
domain-containing family M member 3 isoform X1)		 Xenopus tropicalis
TI:8364 None
   
PKHM3_XENLA
Xenbase»
0.0
plekhm3 Pleckstrin homology domain-containing family M member
3 (PH domain-containing family M member 3)		 Xenopus laevis
TI:8355 None
 
A0A0K9NQP8_ZOSMR
EnsemblPlants»
0.0
ZOSMA_721G00050 PX domain-containing protein Zostera marina
TI:29655 None
 
A0A0K9PQL6_ZOSMR
EnsemblPlants»
0.0
ZOSMA_19G01050 PX domain-containing protein Zostera marina
TI:29655 None