Collated Gene Ontology terms

Biological process: propionate-CoA ligase activity(2012, 2017, 2019, 2022, 2024) acetate-CoA ligase activity(2005, 2008, 2019, 2024) acid-thiol ligase activity(2024) CoA-ligase activity(2024) ligase activity(2024) nucleotide binding(2024) ATP binding(2024) medium-chain fatty acid-CoA ligase activity(2019, 2024) AMP binding(2005, 2024) short-chain fatty acid-CoA ligase activity(2018)
oxidoreductase activity2024 long-chain fatty acid-CoA ligase activity2024

Molecular function: lipid metabolic process2024 propionate catabolic process, 2-methylcitrate cycle2024 long-chain fatty acid metabolic process2024 lipid biosynthetic process2008 ketone body biosynthetic process2024 fumagillin biosynthetic process2013 fatty acid biosynthetic process2018 acetyl-CoA biosynthetic process from acetate2024 acetyl-CoA biosynthetic process2005 acetate fermentation2004

Cellular component: mitochondrial matrix2016, 2019, 2022, 2024 mitochondrion2009, 2023, 2024 intracellular membrane-bounded organelle2023, 2024

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 5/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 1/39 
Archea: 0/8 
Bacteria: 8/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
ACSS3_HUMAN
Ensembl»
4.1
ACSS3 Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase
3) (Acyl-CoA synthetase short-chain family member 3) (Propionate--CoA ligase) (EC 6.2.1.17)		 Homo sapiens
TI:9606 None
 
ACSS3_RAT
RGD»
3.4
Acss3 Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC 6.2.1.1) (Acetate--CoA ligase
3) (Acyl-CoA synthetase short-chain family member 3) (Propionate--CoA ligase) (EC 6.2.1.17)		 Rattus norvegicus
TI:10116 None
 
Q557X0_DICDI
dictyBase»
2.5
aslA-1 Uncharacterized protein Dictyostelium discoideum
TI:44689 None
 
Q9VC92_DROME
FlyBase»
2.3
Dmel\CG6432 GH15945p (Uncharacterized protein, isoform A)
(Uncharacterized protein, isoform B (EC 6.2.1.3))		 Drosophila melanogaster
TI:7227 None
 
ACSB_DICDI
dictyBase»
1.5
aslB Acyl-CoA synthetase short-chain family
member B, mitochondrial (EC 6.2.1.1)		 Dictyostelium discoideum
TI:44689 None
 
ACSS3_MOUSE
Ensembl»
1.5
Acss3 Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC
6.2.1.1) (Acetate--CoA ligase 3) (Propionate--CoA ligase) (EC 6.2.1.17)		 Mus musculus
TI:10090 None
 
PRPE_ECOLI
EnsemblBacteria»
1.3
prpE Propionate--CoA ligase (EC
6.2.1.17) (Propionyl-CoA synthetase)		 Escherichia coli
TI:562 None
 
A0A8N7TBI0_DANRE
CTD»
0.5
acss3 propionate--CoA ligase (EC
6.2.1.17) (Propionate--CoA ligase)		 Danio rerio
TI:7955 None
   
Q54YU1_DICDI
dictyBase»
0.5
DDB_G0278083 Uncharacterized protein Dictyostelium discoideum
TI:44689 None
 
Q556Z4_DICDI
dictyBase»
0.5
aslD-2 Uncharacterized protein Dictyostelium discoideum
TI:44689 None
 
Q556Z8_DICDI
dictyBase»
0.5
aslG-2 Uncharacterized protein Dictyostelium discoideum
TI:44689 None
 
Q557A3_DICDI
dictyBase»
0.5
aslO-2 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium discoideum
TI:44689 None
 
Q557A4_DICDI
dictyBase»
0.5
aslC-2 Uncharacterized protein Dictyostelium discoideum
TI:44689 None
 
Q557A5_DICDI
dictyBase»
0.5
aslI-2 Uncharacterized protein Dictyostelium discoideum
TI:44689 None
 
Q557A7_DICDI
dictyBase»
0.5
aslJ-2 Acetyl-CoA synthetase-like protein Dictyostelium discoideum
TI:44689 None
 
Q557A8_DICDI
dictyBase»
0.5
aslK-2 Uncharacterized protein Dictyostelium discoideum
TI:44689 None
 
Q557A9_DICDI
dictyBase»
0.5
aslL-2 Uncharacterized protein Dictyostelium discoideum
TI:44689 None
 
Q559P5_DICDI
dictyBase»
0.5
aslE Acetyl-CoA synthetase-like protein Dictyostelium discoideum
TI:44689 None
 
Q55GR9_DICDI
dictyBase»
0.5
aslM AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium discoideum
TI:44689 None
 
Q55GS0_DICDI
dictyBase»
0.5
aslN AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium discoideum
TI:44689 None
 
Q55GU6_DICDI
dictyBase»
0.5
aslH Uncharacterized protein Dictyostelium discoideum
TI:44689 None
 
Q75JX7_DICDI
dictyBase»
0.5
aslF Acetyl-CoA synthetase-like protein Dictyostelium discoideum
TI:44689 None
 
A0A1L8GY84_XENLA
Xenbase»
0.0
acss3.L Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC
6.2.1.1) (EC 6.2.1.17) (Acetate--CoA ligase 3) (Propionate--CoA ligase)		 Xenopus laevis
TI:8355 None
   
A0A287B4R8_PIG
Ensembl»
0.0
ACSS3 propionate--CoA ligase (EC
6.2.1.17) (Propionate--CoA ligase)		 Sus scrofa
TI:9823 None
   
A0A3B3H6H1_ORYLA
Ensembl»
0.0
acss3 Acyl-CoA synthetase short chain family member 3 Oryzias latipes
TI:8090 None
   
A0A6I8R1C2_XENTR
Xenbase»
0.0
acss3 propionate--CoA ligase (EC
6.2.1.17) (Propionate--CoA ligase)		 Xenopus tropicalis
TI:8364 None
   
A0A7M7P3E0_STRPU
EnsemblMetazoa»
0.0
Propionate--CoA ligase Strongylocentrotus purpuratus
TI:7668 None
   
A0A8I3NC94_CANLF
Ensembl»
0.0
ACSS3 propionate--CoA ligase (EC
6.2.1.17) (Propionate--CoA ligase)		 Canis lupus
TI:9612 None
   
A0A8V0YE50_CHICK
Ensembl»
0.0
ACSS3 propionate--CoA ligase (EC
6.2.1.17) (Propionate--CoA ligase)		 Gallus gallus
TI:9031 None
   
A0A9J7MPP2_BRAFL
CTD»
0.0
LOC118414488 Acyl-CoA synthetase short-chain
family member 3, mitochondrial-like		 Branchiostoma floridae
TI:7739 None
   
A0EBR0_PARTE
EnsemblProtists»
0.0
GSPATT00025461001 Chromosome undetermined scaffold_88,
whole genome shotgun sequence		 Paramecium tetraurelia
TI:5888 None
 
A7RH51_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g158601 Propionate--CoA ligase Nematostella vectensis
TI:45351 None
 
A9UNX0_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_13709 Propionate--CoA ligase Monosiga brevicollis
TI:81824 None
 
A9WAN2_CHLAA
EnsemblBacteria»
0.0
Caur_0002 AMP-dependent synthetase and ligase Chloroflexus aurantiacus
TI:1108 None
 
ACSS3_BOVIN
Ensembl»
0.0
ACSS3 Acyl-CoA synthetase short-chain family member 3, mitochondrial (EC
6.2.1.1) (Acetate--CoA ligase 3) (Propionate--CoA ligase) (EC 6.2.1.17)		 Bos taurus
TI:9913 None
 
B7P7P6_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW002566 Acyl-CoA synthetase, putative (EC
6.2.1.1) (Acyl-CoA synthetase, putative (Fragment))		 Ixodes scapularis
TI:6945 None
 
B9TC46_RICCO
EnsemblBacteria»
0.0
RCOM_1850940 Acetyl-CoA synthetase, putative (EC 6.2.1.1) Ricinus communis
TI:3988 None
 
D7EIL8_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_01434 Acetyl-coenzyme A synthetase-like Protein Tribolium castaneum
TI:7070 None
 
E9FTL0_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_303190 Propionate--CoA ligase Daphnia pulex
TI:6669 None
 
F0ZAK1_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_27694 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZBV3_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_75854 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZCY4_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_96983 Uncharacterized protein Dictyostelium purpureum
TI:5786 None
 
F0ZCY5_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_76217 Uncharacterized protein Dictyostelium purpureum
TI:5786 None
 
F0ZD51_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_53490 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZKZ2_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_152291 Uncharacterized protein Dictyostelium purpureum
TI:5786 None
 
F0ZKZ3_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_152292 Uncharacterized protein Dictyostelium purpureum
TI:5786 None
 
F0ZKZ5_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_78913 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZLL6_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_33826 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZLM2_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_79120 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZLM3_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_55328 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZMF7_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_48018 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZPE3_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_80058 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZPE4_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_80059 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZPE5_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_80060 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZPE6_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_80061 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZR23_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_154330 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZRF7_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_154480 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZWM4_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_92742 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZXB7_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_82703 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F0ZXB8_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_156745 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None 		 
 
F1A074_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_83657 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F1A2I7_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_5486 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F1A4C8_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_43581 AMP-dependent synthetase/ligase
domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F4NSI8_BATDJ
EnsemblBacteria»
0.0
BATDEDRAFT_84559 Propionyl-CoA synthetase Batrachochytrium dendrobatidis
TI:109871 None
 
F6QXX6_ORNAN
Ensembl»
0.0
ACSS3 propionate--CoA ligase (EC
6.2.1.17) (Propionate--CoA ligase)		 Ornithorhynchus anatinus
TI:9258 None
   
F6T734_MACMU
Ensembl»
0.0
ACSS3 propionate--CoA ligase (EC
6.2.1.17) (Propionate--CoA ligase)		 Macaca mulatta
TI:9544 None
   
F7FIW5_MONDO
Ensembl»
0.0
ACSS3 propionate--CoA ligase (EC
6.2.1.17) (Propionate--CoA ligase)		 Monodelphis domestica
TI:13616 None
   
G1KPY7_ANOCA
Ensembl»
0.0
ACSS3 propionate--CoA ligase (EC
6.2.1.17) (Propionate--CoA ligase)		 Anolis carolinensis
TI:28377 None
   
G3R3N2_GORGO
Ensembl»
0.0
ACSS3 propionate--CoA ligase (EC
6.2.1.17) (Propionate--CoA ligase)		 Gorilla gorilla
TI:9593 None
 
H2Q6J5_PANTR
Ensembl»
0.0
ACSS3 propionate--CoA ligase (EC
6.2.1.17) (Propionate--CoA ligase)		 Pan troglodytes
TI:9598 None
 
H2XYB0_CIOIN
Ensembl»
0.0
propionate--CoA ligase (EC
6.2.1.17) (Propionate--CoA ligase)		 Ciona intestinalis
TI:7719 None
 
H3G9T1_PHYRM
EnsemblProtists»
0.0
Propionate--CoA ligase Phytophthora ramorum
TI:164328 None
 
K4PTY7_SHEON
EnsemblPlants»
0.0
prpE Propionyl-CoA synthetase PrpE (EC 6.2.1.17) Shewanella oneidensis
TI:70863 None
 
M3WI05_FELCA
Ensembl»
0.0
ACSS3 propionate--CoA ligase (EC
6.2.1.17) (Propionate--CoA ligase)		 Felis catus
TI:9685 None
 
PRPE_SALTY
EnsemblBacteria»
0.0
prpE Propionate--CoA ligase (EC
6.2.1.17) (Propionyl-CoA synthetase)		 Salmonella typhimurium
TI:28901 None
 
Q4WAZ5_ASPFU
EnsemblFungi»
0.0
AFUA_8G00500 Acetate-CoA ligase, putative (EC 6.2.1.1) Aspergillus fumigatus
TI:746128 None
 
Q4X240_ASPFU
EnsemblFungi»
0.0
AFUA_2G07780 Acyl-CoA synthetase, putative (EC 6.2.1.-) Aspergillus fumigatus
TI:746128 None
 
Q5B0U7_EMENI
EnsemblFungi»
0.0
ANIA_05833 Propionate-CoA ligase (Eurofung) Emericella nidulans
TI:162425 None
 
Q7PXM0_ANOGA
EnsemblMetazoa»
0.0
1281701 AGAP001473-PA Anopheles gambiae
TI:7165 None
 
Q7S7A6_NEUCR
EnsemblFungi»
0.0
NCU01417 Propionate-CoA ligase Neurospora crassa
TI:5141 None
 
Q89UV0_BRADU
EnsemblBacteria»
0.0
acs Acetyl-coenzyme A synthetase Bradyrhizobium diazoefficiens
TI:1355477 None
 
Q9KSB8_VIBCH
EnsemblBacteria»
0.0
VC_1340 PrpE protein Vibrio cholerae
TI:666 None
 
Q9X1Q9_THEMA
EnsemblBacteria»
0.0
TM_1573 Uncharacterized protein Thermotoga maritima
TI:2336 None 		 
 
W5NHL9_LEPOC
Ensembl»
0.0
propionate--CoA ligase (EC
6.2.1.17) (Propionate--CoA ligase)		 Lepisosteus oculatus
TI:7918 None
 
Y3568_PSEAE
EnsemblBacteria»
0.0
PA3568 Uncharacterized protein PA3568 Pseudomonas aeruginosa
TI:287 None