Collated Gene Ontology terms

Biological process: metal ion binding(2025) cytochrome-c oxidase activity(2003, 2005, 2006, 2008, 2013, 2023, 2025) oxidoreductase activity(2025) electron transfer activity(2006)

Molecular function: mitochondrial electron transport, cytochrome c to oxygen2010, 2021, 2024, 2025 oxidative phosphorylation2024 proton transmembrane transport2025 cellular respiration2025 spinal cord motor neuron differentiation2008 embryonic organ development2008 positive regulation of cell cycle2008

Cellular component: respiratory chain complex IV2013, 2019, 2021, 2023, 2024, 2025 mitochondrial inner membrane2005, 2006, 2013, 2017, 2024, 2025 mitochondrion2006, 2009, 2013, 2014, 2018, 2021, 2024, 2025 mitochondrial membrane2025 plasma membrane2014 myelin sheath2014 mitochondrial intermembrane space2024

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
H9GNZ0_ANOCA
Ensembl»
0.0
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Anolis carolinensis
TI:28377 None
   
Q7PSR9_ANOGA
EnsemblMetazoa»
0.0
AgaP_AGAP011159 Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Anopheles gambiae
TI:7165 None
 
Q4WEE8_ASPFU
TubercuList»
0.0
AFUA_5G02750 Cytochrome c oxidase subunit 6,
mitochondrial (Cytochrome c oxidase polypeptide VI)		 Aspergillus fumigatus
TI:746128 None
 
F4NSR1_BATDJ
euHCVdb»
0.0
BATDEDRAFT_22167 Cytochrome c oxidase subunit 6,
mitochondrial (Cytochrome c oxidase polypeptide VI)		 Batrachochytrium dendrobatidis
TI:109871 None
 
A0A3Q1M132_BOVIN
Ensembl»
0.0
Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Bos taurus
TI:9913 None
   
COX5A_BOVIN
Ensembl»
0.0
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Bos taurus
TI:9913 None
 
A0A9J7HWW9_BRAFL
euHCVdb»
0.0
LOC118409363 Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Branchiostoma floridae
TI:7739 None
   
A8XMR1_CAEBR
WormBase»
0.0
cox-5a Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Caenorhabditis briggsae
TI:6238 None
 
COX5A_CAEEL
WormBase»
1.3
cox-5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Caenorhabditis elegans
TI:6239 None
 
A0A1D8PH08_CANAL
CGD»
0.0
COX6 Cytochrome c oxidase subunit 6,
mitochondrial (Cytochrome c oxidase polypeptide VI)		 Candida albicans
TI:5476 None
 
A0A8I3P4I3_CANLF
Ensembl»
0.0
Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Canis lupus
TI:9612 None
   
A0A8I3PI57_CANLF
Ensembl»
0.0
Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Canis lupus
TI:9612 None
   
A0A8I3S3K8_CANLF
Ensembl»
0.0
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Canis lupus
TI:9612 None
   
F7ANT6_CIOIN
Ensembl»
0.0
LOC100181337 Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Ciona intestinalis
TI:7719 None
 
Q5KLZ6_CRYD1
TubercuList»
0.0
CNB03500 Cytochrome c oxidase subunit 6,
mitochondrial (Cytochrome c oxidase polypeptide VI)		 Cryptococcus deneoformans
TI:40410 None
 
A0A0R4IVC8_DANRE
ZFIN»
2.9
cox5ab Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Danio rerio
TI:7955 None
 
Q4VBU7_DANRE
ZFIN»
2.9
cox5aa Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Danio rerio
TI:7955 None
 
E9GXW8_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_55751 Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Daphnia pulex
TI:6669 None
 
COX5A_DROME
FlyBase»
3.4
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Drosophila melanogaster
TI:7227 None
 
Q5AUB2_EMENI
TubercuList»
0.0
ANIA_08118 Cytochrome c oxidase subunit 6,
mitochondrial (Cytochrome c oxidase polypeptide VI)		 Emericella nidulans
TI:162425 None
 
A0A5F5Q0G4_HORSE
Ensembl»
0.0
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Equus caballus
TI:9796 None
   
Q75CM9_EREGS
euHCVdb»
0.0
AGOS_ACL110W Cytochrome c oxidase subunit 6,
mitochondrial (Cytochrome c oxidase polypeptide VI)		 Eremothecium gossypii
TI:33169 None
 
A0ABI7WVW6_FELCA
Ensembl»
0.0
Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Felis catus
TI:9685 None
   
A0ABI7Y3A7_FELCA
Ensembl»
0.0
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Felis catus
TI:9685 None
   
A0ABI7ZZQ5_FELCA
Ensembl»
0.0
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Felis catus
TI:9685 None
   
A0A8V0ZU95_CHICK
Ensembl»
0.5
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Gallus gallus
TI:9031 None
   
A0A2I2Y3T0_GORGO
Ensembl»
0.0
Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Gorilla gorilla
TI:9593 None
 
A0A2I2YFB7_GORGO
Ensembl»
0.0
Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Gorilla gorilla
TI:9593 None
 
COX5A_GORGO
CTD»
0.0
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Gorilla gorilla
TI:9593 None
 
G3S175_GORGO
Ensembl»
0.0
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Gorilla gorilla
TI:9593 None
 
T1G042_HELRO
EnsemblMetazoa»
0.0
20214440 Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Helobdella robusta
TI:6412 None
 
COX5A_HUMAN
Ensembl»
3.5
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Homo sapiens
TI:9606 None
 
B7Q1Q0_IXOSC
EnsemblMetazoa»
0.0
8034582 Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Ixodes scapularis
TI:6945 None
 
W5NDD2_LEPOC
Ensembl»
0.0
Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Lepisosteus oculatus
TI:7918 None
 
COX5A_MACMU
Ensembl»
0.0
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Macaca mulatta
TI:9544 None
 
A0A5F8GTN4_MONDO
Ensembl»
0.0
Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Monodelphis domestica
TI:13616 None
   
A0A5F8HHT3_MONDO
Ensembl»
0.0
Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Monodelphis domestica
TI:13616 None
   
A9V3P0_MONBE
euHCVdb»
0.0
MONBRDRAFT_9557 Cytochrome c oxidase polypeptide Va Monosiga brevicollis
TI:81824 None
 
COX5A_MOUSE
Ensembl»
1.0
Cox5a Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Mus musculus
TI:10090 None
 
A7SX99_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g175253 Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Nematostella vectensis
TI:45351 None
 
COX6_NEUCR
EnsemblFungi»
0.0
cox-6 Cytochrome c oxidase subunit 6, mitochondrial (Cytochrome c
oxidase polypeptide VI) (Cytochrome c oxidase subunit Cox6)		 Neurospora crassa
TI:5141 None
 
F6YAR7_ORNAN
Ensembl»
0.0
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A3B3HR30_ORYLA
Ensembl»
0.0
LOC101170179 Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Oryzias latipes
TI:8090 None
   
H2MIK9_ORYLA
Ensembl»
0.0
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Oryzias latipes
TI:8090 None
   
A0A2I3RFC0_PANTR
Ensembl»
0.0
Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Pan troglodytes
TI:9598 None
 
A0A2I3TIX8_PANTR
Ensembl»
0.0
Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Pan troglodytes
TI:9598 None
 
COX5A_PANTR
Ensembl»
0.0
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Pan troglodytes
TI:9598 None
 
A0A7U2I7I9_PHANO
TubercuList»
0.0
JI435_109380 Cytochrome c oxidase subunit 6,
mitochondrial (Cytochrome c oxidase polypeptide VI)		 Phaeosphaeria nodorum
TI:13684 None
 
A0A454Y0G9_PRIPA
EnsemblMetazoa»
0.0
WBGene00109480 Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Pristionchus pacificus
TI:54126 None
   
E3L8N2_PUCGT
TubercuList»
0.0
PGTG_19036 Cytochrome c oxidase subunit 6,
mitochondrial (Cytochrome c oxidase polypeptide VI)		 Puccinia graminis
TI:5297 None
 
COX5A_RAT
RGD»
2.2
Cox5a Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Rattus norvegicus
TI:10116 None
 
COX6_YEAST
SGD»
2.9
COX6 Cytochrome c oxidase subunit 6,
mitochondrial (Cytochrome c oxidase polypeptide VI)		 Saccharomyces cerevisiae
TI:4932 None
 
B6K0G2_SCHJY
TubercuList»
0.0
cox6 Cytochrome c oxidase subunit 6,
mitochondrial (Cytochrome c oxidase polypeptide VI)		 Schizosaccharomyces japonicus
TI:4897 None
 
COX6_SCHPO
PomBase»
2.5
cox6 Cytochrome c oxidase subunit 6,
mitochondrial (Cytochrome c oxidase polypeptide VI)		 Schizosaccharomyces pombe
TI:4896 None
 
A7E7W8_SCLS1
euHCVdb»
0.0
SS1G_01396 Cytochrome c oxidase subunit 6,
mitochondrial (Cytochrome c oxidase polypeptide VI)		 Sclerotinia sclerotiorum
TI:5180 None
 
A0A7M7REI8_STRPU
EnsemblMetazoa»
0.0
Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Strongylocentrotus purpuratus
TI:7668 None
   
F1SJ34_PIG
Ensembl»
0.0
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Sus scrofa
TI:9823 None
 
D6WSE8_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_09255 Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Tribolium castaneum
TI:7070 None
 
D7EJQ8_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_01862 Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Tribolium castaneum
TI:7070 None
 
B3RT21_TRIAD
CTD»
0.0
TRIADDRAFT_22356 Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Trichoplax adhaerens
TI:10228 None
 
A0A1L8GTA1_XENLA
Xenbase»
0.0
cox5a.L Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Xenopus laevis
TI:8355 None
   
A4IHP3_XENTR
Xenbase»
0.0
cox5a Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Xenopus tropicalis
TI:8364 None
 
Q6IP26_XENLA
Xenbase»
0.0
cox5a.S Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Xenopus laevis
TI:8355 None
 
Q6C6E6_YARLI
TubercuList»
0.0
YALI0_E10144g Cytochrome c oxidase subunit 6,
mitochondrial (Cytochrome c oxidase polypeptide VI)		 Yarrowia lipolytica
TI:4952 None