Standard knownness: 4.7; Custom knownness: None; Num. species: 34; Orthology database: Panther19.0; Protein members: 69
Molecular function: protein insertion into ER membrane2016, 2021, 2024 SRP-dependent cotranslational protein targeting to membrane, translocation2015, 2024 protein transport2024 response to unfolded protein2021, 2024 cotranslational protein targeting to membrane2003, 2021, 2024 collagen biosynthetic process2009, 2024 determination of heart left/right asymmetry2020, 2024 sphingolipid metabolic process2024 ceramide biosynthetic process2024
Cellular component: membrane2003, 2024 endoplasmic reticulum membrane2010, 2018, 2021, 2024 endoplasmic reticulum2003, 2015, 2024 rough endoplasmic reticulum2013 periciliary membrane compartment2014 dendrite terminus2015
| Chordates: | 22/21 | ![]()  | 
                   
                 
| Echinoderms: | 0/0 | |
| Hemichordates: | 1/1 | |
| Annelids: | 1/1 | |
| Molluscs: | 0/0 | |
| Bryozoans: | 0/0 | |
| Platyhelminthes: | 0/0 | |
| Rotifers: | 0/0 | |
| Nematodes: | 3/3 | |
| Arthropods: | 5/5 | |
| Tardigrades: | 0/0 | |
| Placozoa: | 1/1 | |
| Cnidaria: | 1/1 | |
| Porifera: | 0/0 | |
| Choanoflagellates+: | 0/1 | |
| Dikarya: | 0/14 | |
| Fungi (other): | 0/1 | |
| Protozoa: | 0/3 | |
| Excavates: | 0/4 | |
| Harosa: | 0/4 | |
| Hacrobia: | 0/0 | |
| Plants: | 0/39 | |
| Archea: | 0/8 | |
| Bacteria: | 0/35 | 
Click here to switch to the previous version of the database.
| UniProt ID Organism DB»  | 
	    
        
          
            Standard knownness | clustom knownness | Gene name | Description | Species [Key only] | GO terms | Seq. links | Protein domain links | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 
        Q7QDS0_ANOGA EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        1272659 | AGAP010386-PA | 
        Anopheles gambiae TI:7165 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        A0A5F5Q0X1_HORSE Ensembl»  | 
        
          
  | 
        
          
  | 
        LACTB2 | Lactamase beta 2 | 
        Equus caballus TI:9796 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A6I8N2E0_ORNAN Ensembl»  | 
        
          
  | 
        
          
  | 
        TLC domain-containing protein | 
        Ornithorhynchus anatinus TI:9258 None  | 
        
          
           | 
        
          
           | 
        |||||||
| 
        A0A7M7N2H9_STRPU EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        TLC domain-containing protein | 
        Strongylocentrotus purpuratus TI:7668 None  | 
        
          
           | 
        
          
           | 
        |||||||
| 
        A0A8R1Z766_PRIPA EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        WBGene00304377 | TLC domain-containing protein | 
        Pristionchus pacificus TI:54126 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A7S839_NEMVE EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        NEMVEDRAFT_v1g108310 | TLC domain-containing protein | 
        Nematostella vectensis TI:45351 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        A7T828_NEMVE EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        NEMVEDRAFT_v1g223617 | TLC domain-containing protein | 
        Nematostella vectensis TI:45351 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        B3S439_TRIAD EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        TRIADDRAFT_58943 | TLC domain-containing protein | 
        Trichoplax adhaerens TI:10228 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        F7EXV8_MONDO Ensembl»  | 
        
          
  | 
        
          
  | 
        TLC domain-containing protein | 
        Monodelphis domestica TI:13616 None  | 
        
          
           | 
        
          
           | 
        |||||||
| 
        TRAM2_HUMAN Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM2 | Translocating chain-associated membrane protein 2  | 
        
        Homo sapiens TI:9606 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        TRAM2_MOUSE Ensembl»  | 
        
          
  | 
        
          
  | 
        Tram2 | Translocating chain-associated membrane protein 2  | 
        
        Mus musculus TI:10090 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        A0A9J7HIK3_BRAFL CTD»  | 
        
          
  | 
        
          
  | 
        LOC118404847 | Translocating chain-associated membrane protein 1-like isoform X1  | 
        
        Branchiostoma floridae TI:7739 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        D6WFR2_TRICA EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        AUGUSTUS-3.0.2_01570 | Translocating chain-associated membrane protein 1-like Protein  | 
        
        Tribolium castaneum TI:7070 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        TR1L1_HUMAN Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM1L1 | Translocating chain-associated membrane protein 1-like 1  | 
        
        Homo sapiens TI:9606 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        TR1L1_MOUSE Ensembl»  | 
        
          
  | 
        
          
  | 
        Tram1l1 | Translocating chain-associated membrane protein 1-like 1  | 
        
        Mus musculus TI:10090 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        TR1L1_XENLA Xenbase»  | 
        
          
  | 
        
          
  | 
        tram1l1 | Translocating chain-associated membrane protein 1-like 1  | 
        
        Xenopus laevis TI:8355 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        TRAM1_BOVIN Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM1 | Translocating chain-associated membrane protein 1 (Protein TRAM1)  | 
        
        Bos taurus TI:9913 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        TRAM1_CANLF Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM1 | Translocating chain-associated membrane protein 1 (Protein TRAM1)  | 
        
        Canis lupus TI:9612 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        TRAM1_HUMAN Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM1 | Translocating chain-associated membrane protein 1 (Protein TRAM1)  | 
        
        Homo sapiens TI:9606 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        TRAM1_MOUSE Ensembl»  | 
        
          
  | 
        
          
  | 
        Tram1 | Translocating chain-associated membrane protein 1 (Protein TRAM1)  | 
        
        Mus musculus TI:10090 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        TRAM1_RAT RGD»  | 
        
          
  | 
        
          
  | 
        Tram1 | Translocating chain-associated membrane protein 1 (Protein TRAM1)  | 
        
        Rattus norvegicus TI:10116 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        A0A1L8G5V6_XENLA Xenbase»  | 
        
          
  | 
        
          
  | 
        tram2.S | Translocating chain-associated membrane protein | 
        Xenopus laevis TI:8355 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A5F7ZK86_MACMU Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM2 | Translocating chain-associated membrane protein | 
        Macaca mulatta TI:9544 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A6I8NRY7_ORNAN Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM2 | Translocating chain-associated membrane protein | 
        Ornithorhynchus anatinus TI:9258 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A803U1L2_ANOCA Ensembl»  | 
        
          
  | 
        
          
  | 
        LOC100563926 | Translocating chain-associated membrane protein | 
        Anolis carolinensis TI:28377 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A8W4FI69_PIG Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM1L1 | Translocating chain-associated membrane protein | 
        Sus scrofa TI:9823 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A7S840_NEMVE EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        NEMVEDRAFT_v1g186830 | Translocating chain-associated membrane protein | 
        Nematostella vectensis TI:45351 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        A8WUY1_CAEBR WormBase»  | 
        
          
  | 
        
          
  | 
        tram-1 | Translocating chain-associated membrane protein | 
        Caenorhabditis briggsae TI:6238 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        B4F6I6_XENTR Xenbase»  | 
        
          
  | 
        
          
  | 
        tram2 | Translocating chain-associated membrane protein | 
        Xenopus tropicalis TI:8364 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        E1BCM2_BOVIN Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM2 | Translocating chain-associated membrane protein | 
        Bos taurus TI:9913 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        E9H3M1_DAPPU EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        DAPPUDRAFT_325070 | Translocating chain-associated membrane protein | 
        Daphnia pulex TI:6669 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        F1LUA2_RAT RGD»  | 
        
          
  | 
        
          
  | 
        Tram2 | Translocating chain-associated membrane protein | 
        Rattus norvegicus TI:10116 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        F7GCV4_MACMU Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM1 | Translocating chain-associated membrane protein | 
        Macaca mulatta TI:9544 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        F7HQE5_MACMU Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM1L1 | Translocating chain-associated membrane protein | 
        Macaca mulatta TI:9544 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        G1KDK7_ANOCA Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM2 | Translocating chain-associated membrane protein | 
        Anolis carolinensis TI:28377 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        G1KQI6_ANOCA Ensembl»  | 
        
          
  | 
        
          
  | 
        tram1 | Translocating chain-associated membrane protein | 
        Anolis carolinensis TI:28377 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        G3QD22_GORGO Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM1L1 | Translocating chain-associated membrane protein | 
        Gorilla gorilla TI:9593 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        G3R8C8_GORGO Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM2 | Translocating chain-associated membrane protein | 
        Gorilla gorilla TI:9593 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        H2LVK8_ORYLA Ensembl»  | 
        
          
  | 
        
          
  | 
        tram1 | Translocating chain-associated membrane protein | 
        Oryzias latipes TI:8090 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        H2M9D4_ORYLA Ensembl»  | 
        
          
  | 
        
          
  | 
        LOC101155768 | Translocating chain-associated membrane protein | 
        Oryzias latipes TI:8090 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        H2MCG9_ORYLA Ensembl»  | 
        
          
  | 
        
          
  | 
        LOC101161454 | Translocating chain-associated membrane protein | 
        Oryzias latipes TI:8090 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        H2QWA3_PANTR Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM1 | Translocating chain-associated membrane protein | 
        Pan troglodytes TI:9598 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        H2RFU8_PANTR Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM2 | Translocating chain-associated membrane protein | 
        Pan troglodytes TI:9598 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        M3VZI1_FELCA Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM2 | Translocating chain-associated membrane protein | 
        Felis catus TI:9685 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        M3X7C1_FELCA Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM1 | Translocating chain-associated membrane protein | 
        Felis catus TI:9685 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        Q58EH7_DANRE ZFIN»  | 
        
          
  | 
        
          
  | 
        zgc:113278 | Translocating chain-associated membrane protein | 
        Danio rerio TI:7955 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        Q5HZN0_XENLA Xenbase»  | 
        
          
  | 
        
          
  | 
        tram2.L | Translocating chain-associated membrane protein | 
        Xenopus laevis TI:8355 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        Q68A32_CIOIN Ensembl»  | 
        
          
  | 
        
          
  | 
        Ci-Tram1/2 | Translocating chain-associated membrane protein | 
        Ciona intestinalis TI:7719 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        Q6NVP0_XENTR Xenbase»  | 
        
          
  | 
        
          
  | 
        tram1 | Translocating chain-associated membrane protein | 
        Xenopus tropicalis TI:8364 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        Q6P4U7_DANRE ZFIN»  | 
        
          
  | 
        
          
  | 
        tram | Translocating chain-associated membrane protein | 
        Danio rerio TI:7955 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        Q802X7_DANRE ZFIN»  | 
        
          
  | 
        
          
  | 
        wu:fb20c11 | Translocating chain-associated membrane protein | 
        Danio rerio TI:7955 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        Q8AXQ0_CHICK Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM | Translocating chain-associated membrane protein | 
        Gallus gallus TI:9031 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        Q90ZM0_XENLA Xenbase»  | 
        
          
  | 
        
          
  | 
        tram1.S | Translocating chain-associated membrane protein | 
        Xenopus laevis TI:8355 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        Q9W5C2_DROME FlyBase»  | 
        
          
  | 
        
          
  | 
        TRAM | Translocating chain-associated membrane protein | 
        Drosophila melanogaster TI:7227 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        Q9XXK7_CAEEL WormBase»  | 
        
          
  | 
        
          
  | 
        tram-1 | Translocating chain-associated membrane protein | 
        Caenorhabditis elegans TI:6239 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        T1G3D9_HELRO EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        20215587 | Translocating chain-associated membrane protein | 
        Helobdella robusta TI:6412 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        W5LXW4_LEPOC Ensembl»  | 
        
          
  | 
        
          
  | 
        Translocating chain-associated membrane protein | 
        Lepisosteus oculatus TI:7918 None  | 
        
          
           | 
        
          
           | 
        |||||||
| 
        W5M8N2_LEPOC Ensembl»  | 
        
          
  | 
        
          
  | 
        Translocating chain-associated membrane protein | 
        Lepisosteus oculatus TI:7918 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        ||||||
| 
        W5M8Z7_LEPOC Ensembl»  | 
        
          
  | 
        
          
  | 
        Translocating chain-associated membrane protein | 
        Lepisosteus oculatus TI:7918 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A3Q2HBF4_HORSE Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM1L1 | Translocation associated membrane protein 1 like 1  | 
        
        Equus caballus TI:9796 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A8I3S761_CANLF Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM1L1 | Translocation associated membrane protein 1 like 1  | 
        
        Canis lupus TI:9612 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A287AY88_PIG Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM1 | Translocation associated membrane protein 1 | 
        Sus scrofa TI:9823 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        G3QJX0_GORGO Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM1 | Translocation associated membrane protein 1 | 
        Gorilla gorilla TI:9593 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        A0A287A9W0_PIG Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM2 | Translocation associated membrane protein 2 | 
        Sus scrofa TI:9823 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A3Q2GV83_HORSE Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM2 | Translocation associated membrane protein 2 | 
        Equus caballus TI:9796 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        A0A8I3N8J0_CANLF Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM2 | Translocation associated membrane protein 2 | 
        Canis lupus TI:9612 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        F6YZB4_MONDO Ensembl»  | 
        
          
  | 
        
          
  | 
        TRAM2 | Translocation associated membrane protein 2 | 
        Monodelphis domestica TI:13616 None  | 
        
          
           | 
        
          
           | 
        ||||||
| 
        B7P616_IXOSC EnsemblMetazoa»  | 
        
          
  | 
        
          
  | 
        IscW_ISCW000550 | Translocation associated membrane protein, putative (Translocation associated membrane protein, putative (Fragment))  | 
        
        Ixodes scapularis TI:6945 None  | 
        
          
           | 
        
          
           | 
        
          
           | 
        |||||
| 
        A0A5F8GF20_MONDO Ensembl»  | 
        
          
  | 
        
          
  | 
        Uncharacterized protein | 
        Monodelphis domestica TI:13616 None  | 
        
          
           | 
        
          
           | 
        |||||||