Collated Gene Ontology terms

Biological process: growth factor activity(2024) sulfatide binding(2018, 2024) lipid binding(2024) transferase activity(2024) calcium ion binding(2024) RNA binding(2014)

Molecular function: neuron projection development2009, 2017, 2024 dopaminergic neuron differentiation2012, 2017, 2024 signal transduction2024 regulation of response to endoplasmic reticulum stress2018, 2024 vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure2012, 2024 response to unfolded protein2024 regulation of dopaminergic neuron differentiation2023, 2024 developmental growth2018, 2024 synaptic transmission, dopaminergic2010 neuron cellular homeostasis2009
dopamine metabolic process2013

Cellular component: extracellular region2013, 2016, 2024 endoplasmic reticulum2013, 2017, 2024 extracellular space2007, 2017, 2024 endoplasmic reticulum lumen2018, 2024 sarcoplasmic reticulum lumen2024 sarcoplasmic reticulum2024 synapse2024 perinuclear region of cytoplasm2010 nucleus2014 membrane2024
endomembrane system2014 cytosol2016

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
G1KGX2_ANOCA
Ensembl»
0.0
MANF Mesencephalic astrocyte
derived neurotrophic factor		 Anolis carolinensis
TI:28377 None
   
R4GCU1_ANOCA
Ensembl»
0.0
CDNF Cerebral dopamine neurotrophic factor Anolis carolinensis
TI:28377 None
   
Q7QD98_ANOGA
EnsemblMetazoa»
0.0
1272937 Mesencephalic astrocyte-derived neurotrophic
factor homolog (MANF/CDNF-like protein)		 Anopheles gambiae
TI:7165 None
 
F1N4N8_BOVIN
Ensembl»
0.0
CDNF Cerebral dopamine neurotrophic factor Bos taurus
TI:9913 None
   
MANF_BOVIN
Ensembl»
0.0
MANF Mesencephalic astrocyte-derived neurotrophic factor
(Arginine-rich protein) (Protein ARMET)		 Bos taurus
TI:9913 None
 
C3ZQA0_BRAFL
CTD»
0.0
LOC118416907 Mesencephalic astrocyte-derived
neurotrophic factor homolog		 Branchiostoma floridae
TI:7739 None
 
A8XI39_CAEBR
WormBase»
0.0
manf-1 Mesencephalic astrocyte-derived neurotrophic
factor homolog (MANF/CDNF-like protein)		 Caenorhabditis briggsae
TI:6238 None
 
MANF_CAEEL
WormBase»
3.4
manf-1 Mesencephalic astrocyte-derived neurotrophic factor
homolog (ARMET-like protein) (MANF/CDNF-like protein)		 Caenorhabditis elegans
TI:6239 None
 
A0A8I3P4A7_CANLF
Ensembl»
0.0
CDNF Cerebral dopamine neurotrophic factor Canis lupus
TI:9612 None
   
A0A8I3P5H2_CANLF
Ensembl»
0.0
MANF Mesencephalic astrocyte
derived neurotrophic factor		 Canis lupus
TI:9612 None
   
H2XP91_CIOIN
Ensembl»
0.0
LOC100178512 Mesencephalic astrocyte-derived
neurotrophic factor homolog		 Ciona intestinalis
TI:7719 None
 
A4QNW4_DANRE
ZFIN»
1.8
cdnf Cerebral dopamine neurotrophic factor (Cerebral
dopamine neurotrophic factor precursor) (Zgc:162209 protein)		 Danio rerio
TI:7955 None
 
Q08CA7_DANRE
ZFIN»
1.8
zgc:153327 Mesencephalic astrocyte-derived neurotrophic factor
precursor (Zgc:153327) (Zgc:153327 protein)		 Danio rerio
TI:7955 None
 
E9GGG6_DAPPU
EnsemblMetazoa»
0.0
EOG090X0F26 Mesencephalic astrocyte-derived neurotrophic
factor homolog (MANF/CDNF-like protein)		 Daphnia pulex
TI:6669 None
 
ARMET_DROME
FlyBase»
4.2
Manf Mesencephalic astrocyte-derived neurotrophic factor
homolog (DmMANF) (MANF/CDNF-like protein)		 Drosophila melanogaster
TI:7227 None
 
F6U999_HORSE
Ensembl»
0.0
MANF Mesencephalic astrocyte
derived neurotrophic factor		 Equus caballus
TI:9796 None
   
A0A2I2ULZ5_FELCA
Ensembl»
0.0
MANF Mesencephalic astrocyte
derived neurotrophic factor		 Felis catus
TI:9685 None
 
M3WAW6_FELCA
Ensembl»
0.0
CDNF Cerebral dopamine neurotrophic factor Felis catus
TI:9685 None
 
A0A8V1A7N4_CHICK
Ensembl»
0.0
MANF Mesencephalic astrocyte
derived neurotrophic factor		 Gallus gallus
TI:9031 None
   
G3QEZ2_GORGO
Ensembl»
0.0
CDNF Cerebral dopamine neurotrophic factor Gorilla gorilla
TI:9593 None
 
G3QFF0_GORGO
Ensembl»
0.0
MANF Mesencephalic astrocyte
derived neurotrophic factor		 Gorilla gorilla
TI:9593 None
 
T1FAB3_HELRO
EnsemblMetazoa»
0.0
20205762 Mesencephalic astrocyte-derived
neurotrophic factor homolog		 Helobdella robusta
TI:6412 None
 
CDNF_HUMAN
Ensembl»
1.0
CDNF Cerebral dopamine neurotrophic factor (ARMET-like
protein 1) (Conserved dopamine neurotrophic factor)		 Homo sapiens
TI:9606 None
 
MANF_HUMAN
Ensembl»
3.1
MANF Mesencephalic astrocyte-derived neurotrophic factor
(Arginine-rich protein) (Protein ARMET)		 Homo sapiens
TI:9606 None
 
B7PPP3_IXOSC
EnsemblMetazoa»
0.0
8052086 Mesencephalic astrocyte-derived neurotrophic
factor homolog (MANF/CDNF-like protein)		 Ixodes scapularis
TI:6945 None
 
W5N7C8_LEPOC
Ensembl»
0.0
Mesencephalic astrocyte
derived neurotrophic factor		 Lepisosteus oculatus
TI:7918 None
 
W5NJ57_LEPOC
Ensembl»
0.0
Cerebral dopamine neurotrophic factor Lepisosteus oculatus
TI:7918 None
 
A0A5F7ZJW9_MACMU
Ensembl»
0.0
MANF Mesencephalic astrocyte
derived neurotrophic factor		 Macaca mulatta
TI:9544 None
   
F7GYX4_MACMU
Ensembl»
0.0
CDNF Cerebral dopamine neurotrophic factor Macaca mulatta
TI:9544 None
   
A0A5F8G1U9_MONDO
Ensembl»
0.0
MANF Mesencephalic astrocyte
derived neurotrophic factor		 Monodelphis domestica
TI:13616 None
   
A0A5F8GGW7_MONDO
Ensembl»
0.0
CDNF Cerebral dopamine neurotrophic factor Monodelphis domestica
TI:13616 None
   
F7DBF4_MONDO
Ensembl»
0.0
Mesencephalic astrocyte
derived neurotrophic factor		 Monodelphis domestica
TI:13616 None
   
A9UY42_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_20855 Mesencephalic astrocyte-derived
neurotrophic factor homolog		 Monosiga brevicollis
TI:81824 None
 
CDNF_MOUSE
Ensembl»
0.0
Cdnf Cerebral dopamine neurotrophic factor (ARMET-like
protein 1) (Conserved dopamine neurotrophic factor)		 Mus musculus
TI:10090 None
 
MANF_MOUSE
Ensembl»
0.8
Manf Mesencephalic astrocyte-derived neurotrophic factor
(Arginine-rich protein) (Protein ARMET)		 Mus musculus
TI:10090 None
 
A7RKA3_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g84327 ARMET C-terminal domain-containing protein Nematostella vectensis
TI:45351 None 		 
 
F7A6B3_ORNAN
Ensembl»
0.0
MANF Mesencephalic astrocyte
derived neurotrophic factor		 Ornithorhynchus anatinus
TI:9258 None
   
A0A3B3HA36_ORYLA
Ensembl»
0.0
manf Mesencephalic astrocyte
derived neurotrophic factor		 Oryzias latipes
TI:8090 None
   
H2Q1N1_PANTR
Ensembl»
0.0
CDNF Cerebral dopamine neurotrophic factor Pan troglodytes
TI:9598 None
 
H2QMP7_PANTR
Ensembl»
0.0
MANF Mesencephalic astrocyte
derived neurotrophic factor		 Pan troglodytes
TI:9598 None
 
H3GE79_PHYRM
EnsemblProtists»
0.0
Saposin B-type domain-containing protein Phytophthora ramorum
TI:164328 None
 
A0A2A6BYP7_PRIPA
EnsemblMetazoa»
0.0
WBGene00109284 Mesencephalic astrocyte-derived neurotrophic
factor homolog (MANF/CDNF-like protein)		 Pristionchus pacificus
TI:54126 None
 
CDNF_RAT
RGD»
1.0
Cdnf Cerebral dopamine neurotrophic factor (ARMET-like protein 1) (Arginine-rich protein
mutated in early stage tumors-like 1) (Conserved dopamine neurotrophic factor)		 Rattus norvegicus
TI:10116 None
 
MANF_RAT
RGD»
2.5
Manf Mesencephalic astrocyte-derived neurotrophic factor
(Arginine-rich protein) (Protein ARMET)		 Rattus norvegicus
TI:10116 None
 
A0A7M7PWK8_STRPU
EnsemblMetazoa»
0.0
Saposin B-type domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A8D1PE04_PIG
Ensembl»
0.0
MANF Mesencephalic astrocyte
derived neurotrophic factor		 Sus scrofa
TI:9823 None
   
B8BWT8_THAPS
EnsemblProtists»
0.0
THAPSDRAFT_21600 Uncharacterized protein Thalassiosira pseudonana
TI:35128 None
 
D2A3Y7_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_15785 Mesencephalic astrocyte-derived neurotrophic
factor homolog (MANF/CDNF-like protein)		 Tribolium castaneum
TI:7070 None
 
B3RIB4_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_37028 EF-hand domain-containing protein Trichoplax adhaerens
TI:10228 None
 
A0A1L8GPG1_XENLA
Xenbase»
0.0
manf.L Mesencephalic astrocyte-derived
neurotrophic factor		 Xenopus laevis
TI:8355 None
   
A0A1L8GZJ7_XENLA
Xenbase»
0.0
cdnf.L Cerebral dopamine neurotrophic factor isoform X1 Xenopus laevis
TI:8355 None
   
A0A6I8SUZ0_XENTR
Xenbase»
0.0
cdnf Cerebral dopamine neurotrophic factor Xenopus tropicalis
TI:8364 None
   
B7ZTI5_XENTR
Xenbase»
0.0
manf Arginine-rich, mutated in early stage tumors (Mesencephalic
astrocyte-derived neurotrophic factor) (Mesencephalic astrocyte-derived neurotrophic factor precursor)		 Xenopus tropicalis
TI:8364 None
 
Q63ZM4_XENLA
Xenbase»
0.0
manf.S Armet protein (Mesencephalic
astrocyte-derived neurotrophic factor)		 Xenopus laevis
TI:8355 None