Cluster UKP07745
- CYTOCHROME C OXIDASE SUBUNIT IV
Standard knownness: 3.7; Custom knownness: None; Num. species: 47; Orthology database: Panther19.0; Protein members: 81
Collated Gene Ontology terms
Biological process:
oxidoreductase activity(2025)
cytochrome-c oxidase activity(2003, 2004, 2013, 2014, 2023, 2025)
nitrite reductase (NO-forming) activity(2013)
Molecular function: mitochondrial electron transport, cytochrome c to oxygen2010, 2020, 2021, 2024, 2025 oxidative phosphorylation2024 proton transmembrane transport2025 cellular respiration2002, 2025 response to nutrient2008, 2025 generation of precursor metabolites and energy2002, 2003 response to hypoxia2005 development of symbiont in host2014 cellular response to hypoxia2016 aerobic respiration2014
Cellular component: respiratory chain complex IV2004, 2013, 2019, 2020, 2021, 2023, 2024, 2025 mitochondrial inner membrane2005, 2011, 2013, 2019, 2024, 2025 mitochondrial membrane2014, 2025 mitochondrion2009, 2014, 2017, 2018, 2021, 2024, 2025 mitochondrial intermembrane space2011, 2024, 2025 cytosol2019, 2025 plasma membrane2014 nucleoplasm2025 mitochondrial crista2021 membrane2014
Phylogenetic distribution
| Chordates: | 22/21 |  |
| Echinoderms: | 0/0 | |
| Hemichordates: | 1/1 | |
| Annelids: | 1/1 | |
| Molluscs: | 0/0 | |
| Bryozoans: | 0/0 | |
| Platyhelminthes: | 0/0 | |
| Rotifers: | 0/0 | |
| Nematodes: | 3/3 | |
| Arthropods: | 4/5 | |
| Tardigrades: | 0/0 | |
| Placozoa: | 1/1 | |
| Cnidaria: | 1/1 | |
| Porifera: | 0/0 | |
| Choanoflagellates+: | 14/1 | |
| Dikarya: | 0/14 | |
| Fungi (other): | 0/1 | |
| Protozoa: | 0/3 | |
| Excavates: | 0/4 | |
| Harosa: | 0/4 | |
| Hacrobia: | 0/0 | |
| Plants: | 0/39 | |
| Archea: | 0/8 | |
| Bacteria: | 0/35 |
Click here to switch to the previous version of the database.
Proteins
| UniProt ID Organism DB» |
Standard knownness | clustom knownness | Gene name | Description | Species [Key only] | GO terms | Seq. links | Protein domain links | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
A0A1D8PRH4_CANAL CGD» |
|
|
CAALFM_C703880CA orf19.7194 | Genetic interactor of prohibitin 7, mitochondrial |
Candida albicans TI:5476 None |
|
|
|
|||||
|
A0A1L8ELW9_XENLA Xenbase» |
|
|
cox4i2.S | Cytochrome c oxidase subunit 4 |
Xenopus laevis TI:8355 None |
|
|
||||||
|
A0A1L8FS97_XENLA euHCVdb» |
|
|
LOC108720086 | Cytochrome c oxidase subunit 4 |
Xenopus laevis TI:8355 None |
|
|
||||||
|
A0A1L8FXP6_XENLA CTD» |
|
|
LOC108719104 | Cytochrome c oxidase subunit 4 |
Xenopus laevis TI:8355 None |
|
|
||||||
|
A0A1S4GZ26_ANOGA EnsemblMetazoa» |
|
|
Cytochrome c oxidase subunit 4 |
Anopheles gambiae TI:7165 None |
|
|
|
||||||
|
A0A287A440_PIG Ensembl» |
|
|
COX4I2 | Cytochrome c oxidase subunit 4 |
Sus scrofa TI:9823 None |
|
|
||||||
|
A0A2A6BMN4_PRIPA EnsemblMetazoa» |
|
|
WBGene00274081 | Cytochrome c oxidase subunit 4 |
Pristionchus pacificus TI:54126 None |
|
|
||||||
|
A0A2A6BMQ8_PRIPA EnsemblMetazoa» |
|
|
WBGene00272012 | Uncharacterized protein |
Pristionchus pacificus TI:54126 None |
|
|
||||||
|
A0A3B3HVW4_ORYLA Ensembl» |
|
|
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase subunit IV isoform 1) |
Oryzias latipes TI:8090 None |
|
|
|||||||
|
A0A3B3IJI3_ORYLA Ensembl» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 |
Oryzias latipes TI:8090 None |
|
|
||||||
|
A0A5F8HE95_MONDO Ensembl» |
|
|
Cytochrome c oxidase subunit 4 |
Monodelphis domestica TI:13616 None |
|
|
|||||||
|
A0A7M7LVV0_STRPU EnsemblMetazoa» |
|
|
Cytochrome c oxidase subunit 4 |
Strongylocentrotus purpuratus TI:7668 None |
|
|
|||||||
|
A0A7U2F2C5_PHANO TubercuList» |
|
|
JI435_012770 | Cytochrome c oxidase polypeptide V |
Phaeosphaeria nodorum TI:13684 None |
|
|
|
|||||
|
A0A803SNK1_ANOCA Ensembl» |
|
|
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase subunit IV isoform 1) |
Anolis carolinensis TI:28377 None |
|
|
|||||||
|
A0A8I3MW16_CANLF Ensembl» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 |
Canis lupus TI:9612 None |
|
|
||||||
|
A0A8I3P185_CANLF Ensembl» |
|
|
COX4I2 | Cytochrome c oxidase subunit 4 |
Canis lupus TI:9612 None |
|
|
||||||
|
A0A8J0SUS1_XENTR Xenbase» |
|
|
LOC100127750 | Cytochrome c oxidase subunit 4 |
Xenopus tropicalis TI:8364 None |
|
|
||||||
|
A0A8V0XW68_CHICK Ensembl» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 |
Gallus gallus TI:9031 None |
|
|
||||||
|
A0A9J7LEN4_BRAFL euHCVdb» |
|
|
LOC118418543 | Cytochrome c oxidase subunit 4 |
Branchiostoma floridae TI:7739 None |
|
|
||||||
|
A0ABI7WGZ5_FELCA Ensembl» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 |
Felis catus TI:9685 None |
|
|
||||||
|
A0ABI7XUW1_FELCA Ensembl» |
|
|
COX4I2 | Cytochrome c oxidase subunit 4 |
Felis catus TI:9685 None |
|
|
||||||
|
A7ER43_SCLS1 TubercuList» |
|
|
SS1G_07796 | Cytochrome c oxidase polypeptide V |
Sclerotinia sclerotiorum TI:5180 None |
|
|
|
|||||
|
A7RRF4_NEMVE euHCVdb» |
|
|
NEMVEDRAFT_v1g240152 | Cytochrome c oxidase subunit 4 |
Nematostella vectensis TI:45351 None |
|
|
|
|||||
|
A8XWC8_CAEBR WormBase» |
|
|
cox-4 | Cytochrome c oxidase subunit 4 |
Caenorhabditis briggsae TI:6238 None |
|
|
|
|||||
|
B3S7F0_TRIAD CTD» |
|
|
TRIADDRAFT_60142 | Cytochrome c oxidase subunit 4 |
Trichoplax adhaerens TI:10228 None |
|
|
|
|||||
|
B6JXE9_SCHJY TubercuList» |
|
|
cox5 | Cytochrome c oxidase subunit V |
Schizosaccharomyces japonicus TI:4897 None |
|
|
|
|||||
|
COX41_BOVIN Ensembl» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) |
Bos taurus TI:9913 None |
|
|
|
|||||
|
COX41_GORGO euHCVdb» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) |
Gorilla gorilla TI:9593 None |
|
|
|
|||||
|
COX41_HUMAN Ensembl» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) |
Homo sapiens TI:9606 None |
|
|
|
|||||
|
COX41_MOUSE Ensembl» |
|
|
Cox4i1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) |
Mus musculus TI:10090 None |
|
|
|
|||||
|
COX41_PANTR euHCVdb» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) |
Pan troglodytes TI:9598 None |
|
|
|
|||||
|
COX41_PIG euHCVdb» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) |
Sus scrofa TI:9823 None |
|
|
|
|||||
|
COX41_RAT RGD» |
|
|
Cox4i1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1) |
Rattus norvegicus TI:10116 None |
|
|
|
|||||
|
COX42_HUMAN Ensembl» |
|
|
COX4I2 | Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (Cytochrome c oxidase subunit IV isoform 2) (COX IV-2) |
Homo sapiens TI:9606 None |
|
|
|
|||||
|
COX42_MOUSE Ensembl» |
|
|
Cox4i2 | Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (Cytochrome c oxidase subunit IV isoform 2) (COX IV-2) |
Mus musculus TI:10090 None |
|
|
|
|||||
|
COX42_RAT RGD» |
|
|
Cox4i2 | Cytochrome c oxidase subunit 4 isoform 2, mitochondrial (Cytochrome c oxidase subunit IV isoform 2) (COX IV-2) |
Rattus norvegicus TI:10116 None |
|
|
|
|||||
|
COX5A_YEAST SGD» |
|
|
COX5A | Cytochrome c oxidase subunit 5A, mitochondrial (Cytochrome c oxidase polypeptide Va) |
Saccharomyces cerevisiae TI:4932 None |
|
|
|
|||||
|
COX5B_YEAST SGD» |
|
|
COX5B | Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb) |
Saccharomyces cerevisiae TI:4932 None |
|
|
|
|||||
|
COX5_NEUCR EnsemblFungi» |
|
|
cya-4 | Cytochrome c oxidase subunit 5, mitochondrial (Cytochrome a-4 protein) (Cytochrome c oxidase polypeptide V) (Cytochrome c oxidase subunit Cox5a) |
Neurospora crassa TI:5141 None |
|
|
|
|||||
|
COX5_SCHPO PomBase» |
|
|
cox5 | Cytochrome c oxidase polypeptide 5, mitochondrial (Cytochrome c oxidase polypeptide V) |
Schizosaccharomyces pombe TI:4896 None |
|
|
|
|||||
|
D6WRY0_TRICA euHCVdb» |
|
|
AUGUSTUS-3.0.2_09512 | Cytochrome c oxidase subunit 4 |
Tribolium castaneum TI:7070 None |
|
|
|
|||||
|
E1B8K7_BOVIN Ensembl» |
|
|
COX4I2 | Cytochrome c oxidase subunit 4 |
Bos taurus TI:9913 None |
|
|
||||||
|
E3K8U1_PUCGT TubercuList» |
|
|
PGTG_06603 | Cytochrome c oxidase subunit IV |
Puccinia graminis TI:5297 None |
|
|
|
|||||
|
E9GI31_DAPPU euHCVdb» |
|
|
DAPPUDRAFT_230889 | Cytochrome c oxidase subunit 4 |
Daphnia pulex TI:6669 None |
|
|
|
|||||
|
F1R6I1_DANRE ZFIN» |
|
|
cox4i1l | Cytochrome c oxidase subunit 4 |
Danio rerio TI:7955 None |
|
|
|
|||||
|
F4P9J2_BATDJ neXtProt» |
|
|
BATDEDRAFT_90822 | Cytochrome c oxidase subunit IV |
Batrachochytrium dendrobatidis TI:109871 None |
|
|
|
|||||
|
F6QIS8_MONDO Ensembl» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 |
Monodelphis domestica TI:13616 None |
|
|
||||||
|
F6ZKC8_HORSE Ensembl» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) |
Equus caballus TI:9796 None |
|
|
||||||
|
F7CU15_ORNAN Ensembl» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 |
Ornithorhynchus anatinus TI:9258 None |
|
|
||||||
|
F7DTN7_HORSE Ensembl» |
|
|
COX4I2 | Cytochrome c oxidase subunit 4 |
Equus caballus TI:9796 None |
|
|
||||||
|
F7E0N8_MACMU Ensembl» |
|
|
COX4I2 | Cytochrome c oxidase subunit 4 |
Macaca mulatta TI:9544 None |
|
|
|
|||||
|
F7HCZ5_MACMU Ensembl» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 |
Macaca mulatta TI:9544 None |
|
|
||||||
|
G3R102_GORGO Ensembl» |
|
|
LOC101141650 | Cytochrome c oxidase subunit 4 |
Gorilla gorilla TI:9593 None |
|
|
|
|||||
|
G3R3H9_GORGO Ensembl» |
|
|
LOC101151536 | Cytochrome c oxidase subunit 4 |
Gorilla gorilla TI:9593 None |
|
|
|
|||||
|
H2L8S5_ORYLA Ensembl» |
|
|
COX4I2 | Cytochrome c oxidase subunit 4 |
Oryzias latipes TI:8090 None |
|
|
||||||
|
H2QBN5_PANTR Ensembl» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 |
Pan troglodytes TI:9598 None |
|
|
|
|||||
|
H2QK52_PANTR Ensembl» |
|
|
COX4I2 | Cytochrome c oxidase subunit 4 |
Pan troglodytes TI:9598 None |
|
|
|
|||||
|
H2Y0B5_CIOIN Ensembl» |
|
|
LOC113474267 | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like |
Ciona intestinalis TI:7719 None |
|
|
|
|||||
|
H9GA90_ANOCA Ensembl» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 |
Anolis carolinensis TI:28377 None |
|
|
||||||
|
H9GHL4_ANOCA Ensembl» |
|
|
COX4I2 | Cytochrome c oxidase subunit 4 |
Anolis carolinensis TI:28377 None |
|
|
||||||
|
I3LER5_PIG Ensembl» |
|
|
COX4I1 | Cytochrome c oxidase subunit 4 |
Sus scrofa TI:9823 None |
|
|
||||||
|
Q28FR5_XENTR Xenbase» |
|
|
cox4i2 | Cytochrome c oxidase subunit 4 |
Xenopus tropicalis TI:8364 None |
|
|
|
|||||
|
Q28HG6_XENTR Xenbase» |
|
|
cox4i1 | Cytochrome c oxidase subunit 4 |
Xenopus tropicalis TI:8364 None |
|
|
|
|||||
|
Q4WV26_ASPFU TubercuList» |
|
|
AFUA_5G10560 | Cytochrome c oxidase polypeptide V |
Aspergillus fumigatus TI:746128 None |
|
|
|
|||||
|
Q5APK5_CANAL CGD» |
|
|
COX5 | Cytochrome c oxidase subunit Va |
Candida albicans TI:5476 None |
|
|
|
|||||
|
Q5BAW4_EMENI TubercuList» |
|
|
ANIA_02316 | Cytochrome c oxidase polypeptide V |
Emericella nidulans TI:162425 None |
|
|
|
|||||
|
Q5K946_CRYD1 TubercuList» |
|
|
CNK03240 | Cytochrome c oxidase subunit V, putative |
Cryptococcus deneoformans TI:40410 None |
|
|
|
|||||
|
Q66L34_XENLA euHCVdb» |
|
|
MGC85216 | Cytochrome c oxidase subunit 4 |
Xenopus laevis TI:8355 None |
|
|
|
|||||
|
Q6C309_YARLI TubercuList» |
|
|
YALI0_F03567g | YALI0F03567p |
Yarrowia lipolytica TI:4952 None |
|
|
|
|||||
|
Q6GN62_XENLA Xenbase» |
|
|
cox4i1.S | Cytochrome c oxidase subunit 4 |
Xenopus laevis TI:8355 None |
|
|
|
|||||
|
Q6PBL1_DANRE ZFIN» |
|
|
cox4i2 | Cytochrome c oxidase subunit 4 |
Danio rerio TI:7955 None |
|
|
|
|||||
|
Q6PH92_XENLA Xenbase» |
|
|
cox4i2.L | Cytochrome c oxidase subunit 4 |
Xenopus laevis TI:8355 None |
|
|
|
|||||
|
Q6TNV0_DANRE ZFIN» |
|
|
cox4i1 | Cytochrome c oxidase subunit 4 |
Danio rerio TI:7955 None |
|
|
|
|||||
|
Q75B20_EREGS neXtProt» |
|
|
AGOS_ADL243W | ADL243Wp |
Eremothecium gossypii TI:33169 None |
|
|
|
|||||
|
Q8T4H8_DROME FlyBase» |
|
|
COX4L | Cytochrome c oxidase subunit 4 |
Drosophila melanogaster TI:7227 None |
|
|
|
|||||
|
Q9U329_CAEEL WormBase» |
|
|
cox-4 | Cytochrome c oxidase subunit 4 |
Caenorhabditis elegans TI:6239 None |
|
|
|
|||||
|
Q9VIQ8_DROME FlyBase» |
|
|
COX4 | Cytochrome c oxidase subunit 4 |
Drosophila melanogaster TI:7227 None |
|
|
|
|||||
|
T1G001_HELRO EnsemblMetazoa» |
|
|
20214399 | Cytochrome c oxidase subunit 4 |
Helobdella robusta TI:6412 None |
|
|
|
|||||
|
W5LY67_LEPOC Ensembl» |
|
|
Cytochrome c oxidase subunit 4 |
Lepisosteus oculatus TI:7918 None |
|
|
|
||||||
|
W5MG49_LEPOC Ensembl» |
|
|
Cytochrome c oxidase subunit 4 |
Lepisosteus oculatus TI:7918 None |
|
|
|
||||||
|
W5N4F5_LEPOC Ensembl» |
|
|
Cytochrome c oxidase subunit 4 |
Lepisosteus oculatus TI:7918 None |
|
|
|
||||||
