Collated Gene Ontology terms

Biological process: oxidoreductase activity(2025) cytochrome-c oxidase activity(2003, 2004, 2013, 2014, 2023, 2025) nitrite reductase (NO-forming) activity(2013)

Molecular function: mitochondrial electron transport, cytochrome c to oxygen2010, 2020, 2021, 2024, 2025 oxidative phosphorylation2024 proton transmembrane transport2025 cellular respiration2002, 2025 response to nutrient2008, 2025 generation of precursor metabolites and energy2002, 2003 response to hypoxia2005 development of symbiont in host2014 cellular response to hypoxia2016 aerobic respiration2014

Cellular component: respiratory chain complex IV2004, 2013, 2019, 2020, 2021, 2023, 2024, 2025 mitochondrial inner membrane2005, 2011, 2013, 2019, 2024, 2025 mitochondrial membrane2014, 2025 mitochondrion2009, 2014, 2017, 2018, 2021, 2024, 2025 mitochondrial intermembrane space2011, 2024, 2025 cytosol2019, 2025 plasma membrane2014 nucleoplasm2025 mitochondrial crista2021 membrane2014

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
COX41_HUMAN
Ensembl»
3.5
COX4I1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase
polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)		 Homo sapiens
TI:9606 None
 
COX41_MOUSE
Ensembl»
0.5
Cox4i1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase
polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)		 Mus musculus
TI:10090 None
 
Q9VIQ8_DROME
FlyBase»
2.6
COX4 Cytochrome c oxidase subunit 4 Drosophila melanogaster
TI:7227 None
 
COX41_RAT
RGD»
1.3
Cox4i1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase
polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)		 Rattus norvegicus
TI:10116 None
 
COX5A_YEAST
SGD»
2.9
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Saccharomyces cerevisiae
TI:4932 None
 
COX42_HUMAN
Ensembl»
2.5
COX4I2 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
(Cytochrome c oxidase subunit IV isoform 2) (COX IV-2)		 Homo sapiens
TI:9606 None
 
COX5B_YEAST
SGD»
3.7
COX5B Cytochrome c oxidase subunit 5B,
mitochondrial (Cytochrome c oxidase polypeptide Vb)		 Saccharomyces cerevisiae
TI:4932 None
 
COX5_SCHPO
PomBase»
2.5
cox5 Cytochrome c oxidase polypeptide 5,
mitochondrial (Cytochrome c oxidase polypeptide V)		 Schizosaccharomyces pombe
TI:4896 None
 
COX42_MOUSE
Ensembl»
1.5
Cox4i2 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
(Cytochrome c oxidase subunit IV isoform 2) (COX IV-2)		 Mus musculus
TI:10090 None
 
Q8T4H8_DROME
FlyBase»
1.6
COX4L Cytochrome c oxidase subunit 4 Drosophila melanogaster
TI:7227 None
 
COX42_RAT
RGD»
1.8
Cox4i2 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
(Cytochrome c oxidase subunit IV isoform 2) (COX IV-2)		 Rattus norvegicus
TI:10116 None
 
A0A8V0XW68_CHICK
Ensembl»
0.5
COX4I1 Cytochrome c oxidase subunit 4 Gallus gallus
TI:9031 None
   
Q9U329_CAEEL
WormBase»
1.3
cox-4 Cytochrome c oxidase subunit 4 Caenorhabditis elegans
TI:6239 None
 
Q6TNV0_DANRE
ZFIN»
1.3
cox4i1 Cytochrome c oxidase subunit 4 Danio rerio
TI:7955 None
 
F1R6I1_DANRE
ZFIN»
0.5
cox4i1l Cytochrome c oxidase subunit 4 Danio rerio
TI:7955 None
 
Q6PBL1_DANRE
ZFIN»
0.5
cox4i2 Cytochrome c oxidase subunit 4 Danio rerio
TI:7955 None