Collated Gene Ontology terms

Biological process: cytochrome-c oxidase activity(2002, 2003, 2004, 2013, 2014, 2023, 2024) oxidoreductase activity(2024) nitrite reductase (NO-forming) activity(2013)

Molecular function: mitochondrial electron transport, cytochrome c to oxygen2010, 2013, 2020, 2021, 2023, 2024 oxidative phosphorylation2024 proton transmembrane transport2024 response to hypoxia2005, 2024 generation of precursor metabolites and energy2002, 2003 cellular respiration2002, 2020 response to nutrient2008 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2021 development of symbiont in host2014
cellular response to hypoxia2016 aerobic respiration2014

Cellular component: respiratory chain complex IV2004, 2013, 2019, 2020, 2021, 2023, 2024 mitochondrion2009, 2014, 2018, 2021, 2023, 2024 mitochondrial inner membrane2003, 2005, 2011, 2013, 2019, 2024 mitochondrial membrane2008, 2014, 2020, 2024 membrane2014, 2024 cytosol2019, 2024 nucleoplasm2023, 2024 mitochondrial intermembrane space2011, 2024 plasma membrane2014 mitochondrial crista2021

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 13/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A803SNK1_ANOCA
Ensembl»
0.0
Uncharacterized protein Anolis carolinensis
TI:28377 None
   
H9GA90_ANOCA
Ensembl»
0.0
COX4I1 Cytochrome c oxidase subunit 4 Anolis carolinensis
TI:28377 None
   
H9GHL4_ANOCA
Ensembl»
0.0
COX4I2 Cytochrome c oxidase subunit 4 Anolis carolinensis
TI:28377 None
   
A0A1S4GZ26_ANOGA
EnsemblMetazoa»
0.0
Cytochrome c oxidase subunit 4 Anopheles gambiae
TI:7165 None
 
Q753T6_ASHGO
EnsemblFungi»
0.0
AGOS_AFR240C AFR240Cp Ashbya gossypii
TI:33169 None
 
Q75B20_ASHGO
EnsemblFungi»
0.0
AGOS_ADL243W ADL243Wp Ashbya gossypii
TI:33169 None
 
Q4WV26_ASPFU
EnsemblFungi»
0.0
AFUA_5G10560 Cytochrome c oxidase subunit V Aspergillus fumigatus
TI:746128 None
 
F4P9J2_BATDJ
EnsemblBacteria»
0.0
BATDEDRAFT_90822 Cytochrome c oxidase subunit IV Batrachochytrium dendrobatidis
TI:109871 None
 
A0A3Q1M380_BOVIN
Ensembl»
0.0
Cytochrome c oxidase subunit 4 Bos taurus
TI:9913 None
   
COX41_BOVIN
Ensembl»
0.0
COX4I1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase
polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)		 Bos taurus
TI:9913 None
 
E1B8K7_BOVIN
Ensembl»
0.0
COX4I2 Cytochrome c oxidase subunit 4I2 Bos taurus
TI:9913 None
   
A0A9J7LEN4_BRAFL
CTD»
0.0
LOC118418543 Cytochrome c oxidase subunit 4 Branchiostoma floridae
TI:7739 None
   
A8XWC8_CAEBR
WormBase»
0.0
cox-4 Cytochrome c oxidase subunit 4 Caenorhabditis briggsae
TI:6238 None
 
Q9U329_CAEEL
WormBase»
1.3
cox-4 Cytochrome c oxidase subunit 4 Caenorhabditis elegans
TI:6239 None
 
A0A1D8PRH4_CANAL
EnsemblFungi»
0.0
CAALFM_C703880CA orf19.7194 Genetic interactor of
prohibitin 7, mitochondrial		 Candida albicans
TI:5476 None
 
Q5APK5_CANAL
EnsemblFungi»
0.0
COX5 Cytochrome c oxidase subunit Va Candida albicans
TI:5476 None
 
A0A8I3MW16_CANLF
Ensembl»
0.0
COX4I1 Cytochrome c oxidase subunit 4 Canis lupus
TI:9612 None
   
A0A8I3P185_CANLF
Ensembl»
0.0
COX4I2 Cytochrome c oxidase subunit 4 Canis lupus
TI:9612 None
   
H2Y0B5_CIOIN
Ensembl»
0.0
LOC113474267 Cytochrome c oxidase subunit
4 isoform 1, mitochondrial-like		 Ciona intestinalis
TI:7719 None
 
Q5K946_CRYNJ
EnsemblFungi»
0.0
CNK03240 Cytochrome c oxidase subunit V, putative Cryptococcus neoformans
TI:5207 None
 
F1R6I1_DANRE
ZFIN»
0.5
cox4i1l Cytochrome c oxidase subunit 4 Danio rerio
TI:7955 None
 
Q6PBL1_DANRE
ZFIN»
0.5
zgc:73355 Cytochrome c oxidase subunit 4 Danio rerio
TI:7955 None
 
Q6TNV0_DANRE
ZFIN»
1.3
COX4I1 Cytochrome c oxidase subunit 4 Danio rerio
TI:7955 None
 
E9GI31_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_230889 Cytochrome c oxidase subunit 4 Daphnia pulex
TI:6669 None
 
Q8T4H8_DROME
FlyBase»
1.0
COX4L Cytochrome c oxidase subunit 4 Drosophila melanogaster
TI:7227 None
 
Q9VIQ8_DROME
FlyBase»
1.0
COX4 Cytochrome c oxidase subunit 4 Drosophila melanogaster
TI:7227 None
 
Q5BAW4_EMENI
EnsemblFungi»
0.0
ANIA_02316 Cytochrome c oxidase
polypeptide 5, mitochondrial		 Emericella nidulans
TI:162425 None
 
F6ZKC8_HORSE
Ensembl»
0.0
COX4I1 Cytochrome c oxidase subunit 4 Equus caballus
TI:9796 None
   
F7DTN7_HORSE
Ensembl»
0.0
COX4I2 Cytochrome c oxidase subunit 4 Equus caballus
TI:9796 None
   
A0A5F5XFI7_FELCA
Ensembl»
0.0
COX4I1 Cytochrome c oxidase subunit 4 Felis catus
TI:9685 None
 
M3WL40_FELCA
Ensembl»
0.0
COX4I2 Cytochrome c oxidase subunit 4 Felis catus
TI:9685 None
 
A0A8V0XW68_CHICK
Ensembl»
0.0
COX4I1 Cytochrome c oxidase subunit 4 Gallus gallus
TI:9031 None
   
COX41_GORGO
Ensembl»
0.0
COX4I1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase
polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)		 Gorilla gorilla
TI:9593 None
 
G3R102_GORGO
Ensembl»
0.0
COX4I2 Cytochrome c oxidase subunit 4 Gorilla gorilla
TI:9593 None
 
G3R3H9_GORGO
Ensembl»
0.0
COX4I1 Cytochrome c oxidase subunit 4 Gorilla gorilla
TI:9593 None
 
T1G001_HELRO
EnsemblMetazoa»
0.0
20214399 Cytochrome c oxidase subunit 4 Helobdella robusta
TI:6412 None
 
COX41_HUMAN
Ensembl»
3.5
COX4I1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase
polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)		 Homo sapiens
TI:9606 None
 
COX42_HUMAN
Ensembl»
3.3
COX4I2 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
(Cytochrome c oxidase subunit IV isoform 2) (COX IV-2)		 Homo sapiens
TI:9606 None
 
W5LY67_LEPOC
Ensembl»
0.0
Cytochrome c oxidase subunit 4 Lepisosteus oculatus
TI:7918 None
 
W5MG49_LEPOC
Ensembl»
0.0
Cytochrome c oxidase subunit 4 Lepisosteus oculatus
TI:7918 None
 
W5N4F5_LEPOC
Ensembl»
0.0
Cytochrome c oxidase subunit 4 Lepisosteus oculatus
TI:7918 None
 
F7E0N8_MACMU
Ensembl»
0.0
COX4I2 Cytochrome c oxidase subunit 4 Macaca mulatta
TI:9544 None
 
F7HCZ5_MACMU
Ensembl»
0.0
COX4I1 Cytochrome c oxidase subunit 4 Macaca mulatta
TI:9544 None
   
A0A5F8HE95_MONDO
Ensembl»
0.0
Cytochrome c oxidase subunit 4 Monodelphis domestica
TI:13616 None
   
F6QIS8_MONDO
Ensembl»
0.0
COX4I1 Cytochrome c oxidase subunit 4 Monodelphis domestica
TI:13616 None
   
COX41_MOUSE
Ensembl»
0.0
Cox4i1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase
polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)		 Mus musculus
TI:10090 None
 
COX42_MOUSE
Ensembl»
0.5
Cox4i2 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
(Cytochrome c oxidase subunit IV isoform 2) (COX IV-2)		 Mus musculus
TI:10090 None
 
A7RRF4_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g240152 Cytochrome c oxidase subunit 4 Nematostella vectensis
TI:45351 None
 
COX5_NEUCR
EnsemblFungi»
0.0
cya-4 Cytochrome c oxidase subunit 5, mitochondrial (Cytochrome a-4 protein)
(Cytochrome c oxidase polypeptide V) (Cytochrome c oxidase subunit Cox5a)		 Neurospora crassa
TI:5141 None
 
F7CU15_ORNAN
Ensembl»
0.0
COX4I1 Cytochrome c oxidase subunit 4 Ornithorhynchus anatinus
TI:9258 None
   
A0A3B3HVW4_ORYLA
Ensembl»
0.0
Uncharacterized protein Oryzias latipes
TI:8090 None
   
A0A3B3IJI3_ORYLA
Ensembl»
0.0
LOC101171816 Cytochrome c oxidase subunit 4 Oryzias latipes
TI:8090 None
   
H2L8S5_ORYLA
Ensembl»
0.0
LOC101172078 Cytochrome c oxidase subunit 4 Oryzias latipes
TI:8090 None
   
COX41_PANTR
CTD»
0.0
COX4I1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase
polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)		 Pan troglodytes
TI:9598 None
 
H2QBN5_PANTR
Ensembl»
0.0
COX4I1 Cytochrome c oxidase subunit 4 Pan troglodytes
TI:9598 None
 
H2QK52_PANTR
Ensembl»
0.0
COX4I2 Cytochrome c oxidase subunit 4 Pan troglodytes
TI:9598 None
 
A0A2A6BMN4_PRIPA
EnsemblMetazoa»
0.0
WBGene00274081 Cytochrome c oxidase subunit 4 Pristionchus pacificus
TI:54126 None
 
A0A2A6BMQ8_PRIPA
EnsemblMetazoa»
0.0
WBGene00272012 Cytochrome c oxidase subunit 4 Pristionchus pacificus
TI:54126 None
 
E3K8U1_PUCGT
EnsemblFungi»
0.0
PGTG_06603 Cytochrome c oxidase subunit IV Puccinia graminis
TI:5297 None
 
COX41_RAT
RGD»
1.3
Cox4i1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase
polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)		 Rattus norvegicus
TI:10116 None
 
COX42_RAT
RGD»
2.3
Cox4i2 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial
(Cytochrome c oxidase subunit IV isoform 2) (COX IV-2)		 Rattus norvegicus
TI:10116 None
 
COX5A_YEAST
SGD»
2.1
COX5A Cytochrome c oxidase subunit 5A,
mitochondrial (Cytochrome c oxidase polypeptide Va)		 Saccharomyces cerevisiae
TI:4932 None
 
COX5B_YEAST
SGD»
2.9
COX5B Cytochrome c oxidase subunit 5B,
mitochondrial (Cytochrome c oxidase polypeptide Vb)		 Saccharomyces cerevisiae
TI:4932 None
 
B6JXE9_SCHJY
EnsemblFungi»
0.0
SJAG_01077 Cytochrome c oxidase subunit V Schizosaccharomyces japonicus
TI:4897 None
 
COX5_SCHPO
PomBase»
1.3
cox5 Cytochrome c oxidase polypeptide 5,
mitochondrial (Cytochrome c oxidase polypeptide V)		 Schizosaccharomyces pombe
TI:4896 None
 
A7ER43_SCLS1
VEuPathDB»
0.0
SS1G_07796 Uncharacterized protein Sclerotinia sclerotiorum
TI:5180 None
 
A0A7M7LVV0_STRPU
EnsemblMetazoa»
0.0
Cytochrome c oxidase subunit 4 Strongylocentrotus purpuratus
TI:7668 None
   
A0A287A440_PIG
Ensembl»
0.0
COX4I2 Cytochrome c oxidase subunit 4 Sus scrofa
TI:9823 None
   
COX41_PIG
CTD»
0.0
COX4I1 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (Cytochrome c oxidase
polypeptide IV) (Cytochrome c oxidase subunit IV isoform 1) (COX IV-1)		 Sus scrofa
TI:9823 None
 
I3LER5_PIG
Ensembl»
0.0
COX4I1 Cytochrome c oxidase subunit 4 Sus scrofa
TI:9823 None
   
D6WRY0_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_09512 Cytochrome c oxidase subunit 4 Tribolium castaneum
TI:7070 None
 
B3S7F0_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_60142 Cytochrome c oxidase subunit 4 Trichoplax adhaerens
TI:10228 None
 
A0A1L8ELW9_XENLA
Xenbase»
0.0
cox4i2.S Cytochrome c oxidase subunit 4 Xenopus laevis
TI:8355 None
   
A0A1L8FS97_XENLA
Xenbase»
0.0
LOC108720086 Cytochrome c oxidase subunit 4 Xenopus laevis
TI:8355 None
   
A0A1L8FXP6_XENLA
Xenbase»
0.0
LOC108719104 Cytochrome c oxidase subunit 4 Xenopus laevis
TI:8355 None
   
A0A8J0SUS1_XENTR
Xenbase»
0.0
LOC100127750 Cytochrome c oxidase subunit 4 Xenopus tropicalis
TI:8364 None
   
Q28FR5_XENTR
Xenbase»
0.0
cox4i2 Cytochrome c oxidase subunit 4 Xenopus tropicalis
TI:8364 None
 
Q28HG6_XENTR
Xenbase»
0.0
cox4i1 Cytochrome c oxidase subunit 4 Xenopus tropicalis
TI:8364 None
 
Q66L34_XENLA
Xenbase»
0.0
MGC85216 Cytochrome c oxidase subunit 4 Xenopus laevis
TI:8355 None
 
Q6GN62_XENLA
Xenbase»
0.0
cox4i1.S Cytochrome c oxidase subunit 4 Xenopus laevis
TI:8355 None
 
Q6PH92_XENLA
Xenbase»
0.0
cox4i2.L Cytochrome c oxidase subunit 4 Xenopus laevis
TI:8355 None
 
Q6C309_YARLI
EnsemblFungi»
0.0
YALI0_F03567g YALI0F03567p Yarrowia lipolytica
TI:4952 None