Collated Gene Ontology terms

Biological process: oxidoreductase activity(2025) NAD(P)H oxidase H2O2-forming activity(2025) molecular sensor activity(2025) flavin adenine dinucleotide binding(2011, 2014, 2017, 2025) thiosulfate-cyanide sulfurtransferase activity(2024) NADPH dehydrogenase activity(2025) NADH dehydrogenase activity(2025) NADP binding(2025) protein disulfide isomerase activity(2025) electron-transferring-flavoprotein dehydrogenase activity(2017)
CoA-disulfide reductase (NADPH) activity2025 rubredoxin-NAD+ reductase activity2014, 2025 oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor2014, 2025 rubredoxin-NADP+ reductase activity2011 nitrite reductase activity2025 metal ion binding2025 iron-sulfur cluster binding2025 heme binding2025 NADPH:sulfur oxidoreductase activity2025 L-amino-acid oxidase activity2025 2 iron, 2 sulfur cluster binding2025

Molecular function: cellular response to oxidative stress2017, 2025 tRNA exon ligation2025 tRNA processing2025 sulfur utilization2024 respiratory electron transport chain2025 nitric oxide catabolic process2014 nitrate assimilation2025 cellular response to nitric oxide2014 alkane catabolic process2024

Cellular component: cytoplasm2018, 2022, 2024, 2025 nucleus2017, 2018, 2024, 2025 sarcomere2017, 2025 cytosol2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 1/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 1/39 
Archea: 7/8 
Bacteria: 23/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
NORW_ECOLI
EnsemblBacteria»
4.5
norW Nitric oxide reductase FlRd-NAD(+) reductase (EC
1.18.1.-) (Flavorubredoxin reductase) (FlRd-reductase) (FlavoRb reductase)		 Escherichia coli
TI:562 None
 
PYRD1_HUMAN
Ensembl»
3.2
PYROXD1 tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1 (EC
1.6.99.1) (Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1)		 Homo sapiens
TI:9606 None
 
PYRD1_MOUSE
Ensembl»
2.5
Pyroxd1 tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1 (EC
1.6.99.1) (Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1)		 Mus musculus
TI:10090 None
 
PYRD1_RAT
RGD»
2.5
Pyroxd1 tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1 (EC
1.6.99.1) (Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1)		 Rattus norvegicus
TI:10116 None
 
PYRD1_DROME
FlyBase»
0.5
Pyroxd1 tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1 (EC
1.6.99.1) (Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1)		 Drosophila melanogaster
TI:7227 None
 
A0A1L8GVW1_XENLA
Xenbase»
0.0
pyroxd1.L Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Xenopus laevis
TI:8355 None
   
A0A1S4LHU2_IXOSC
EnsemblMetazoa»
0.0
Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein, putative		 Ixodes scapularis
TI:6945 None
 
A0A2I2Z7N4_GORGO
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Gorilla gorilla
TI:9593 None
 
A0A2K3DNE4_CHLRE
neXtProt»
0.0
CHLRE_06g271200v5 Rhodanese domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A2K3DXV8_CHLRE
neXtProt»
0.0
CHLRE_03g182550v5 FAD/NAD(P)-binding domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A3B3HFM0_ORYLA
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Oryzias latipes
TI:8090 None
   
A0A5P8YI30_YERPE
euHCVdb»
0.0
YPO3001 Pyridine nucleotide-disulphide oxidoreductase Yersinia pestis
TI:632 None
 
A0A644EYY1_GIAIC
TubercuList»
0.0
GL50803_0033769 NADH oxidase Giardia intestinalis
TI:5741 None
 
A0A7M7PHF1_STRPU
EnsemblMetazoa»
0.0
Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A8I3P0R6_CANLF
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Canis lupus
TI:9612 None
   
A0A8V0YNN2_CHICK
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Gallus gallus
TI:9031 None
   
A0A9J7NCT1_BRAFL
neXtProt»
0.0
LOC118431408 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Branchiostoma floridae
TI:7739 None
   
A0ABI7YIT5_FELCA
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Felis catus
TI:9685 None
   
A0ABN5J397_FUSNN
euHCVdb»
0.0
C7Y58_08465 CoA-disulfide reductase Fusobacterium nucleatum
TI:851 None
 
A5HY76_CLOBH
neXtProt»
0.0
CBO0183 Pyridine nucleotide-disulphide oxidoreductase Clostridium botulinum
TI:1491 None
 
A5I1G8_CLOBH
euHCVdb»
0.0
CBO1333 Oxidoreductase, NAD/FAD binding subunit Clostridium botulinum
TI:1491 None
 
A5I254_CLOBH
neXtProt»
0.0
CBO1580 Oxidoreductase Clostridium botulinum
TI:1491 None
 
A7RHE0_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g81327 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Nematostella vectensis
TI:45351 None
 
A7T583_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g222496 FAD/NAD(P)-binding domain-containing protein Nematostella vectensis
TI:45351 None
 
A8WNA0_CAEBR
CTD»
0.0
CBG00695 CBG_00695 Protein CBG00695 Caenorhabditis briggsae
TI:6238 None 		 
 
A8WNA2_CAEBR
WormBase»
0.0
CBG00693 CBG_00693 Protein CBG00693 Caenorhabditis briggsae
TI:6238 None
 
A9WAH8_CHLAA
EnsemblBacteria»
0.0
Caur_3584 FAD-dependent pyridine
nucleotide-disulphide oxidoreductase		 Chloroflexus aurantiacus
TI:1108 None
 
B1L687_KORCO
EnsemblBacteria»
0.0
Kcr_1220 NADH oxidase Korarchaeum cryptofilum
TI:498846 None
 
B1WAU8_XENTR
Xenbase»
0.0
pyroxd1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Xenopus tropicalis
TI:8364 None
 
B3RS58_TRIAD
CTD»
0.0
TRIADDRAFT_22271 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Trichoplax adhaerens
TI:10228 None
 
B8C7A2_THAPS
neXtProt»
0.0
THAPSDRAFT_7704 Rhodanese domain-containing protein Thalassiosira pseudonana
TI:35128 None
 
B8DYU4_DICTD
EnsemblBacteria»
0.0
Dtur_0145 FAD-dependent pyridine
nucleotide-disulphide oxidoreductase		 Dictyoglomus turgidum
TI:513050 None
 
B8E1J3_DICTD
EnsemblBacteria»
0.0
Dtur_0189 FAD-dependent pyridine
nucleotide-disulphide oxidoreductase		 Dictyoglomus turgidum
TI:513050 None
 
C4LS93_ENTH1
TubercuList»
0.0
EHI_153000 Pyridine nucleotide-disulfide
oxidoreductase family protein		 Entamoeba histolytica
TI:5759 None
 
CDR_STAA8
euHCVdb»
0.0
cdr Coenzyme A disulfide reductase
(CoA-disulfide reductase) (CoADR) (EC 1.8.1.14)		 Staphylococcus aureus
TI:1280 None
 
D6WL78_TRICA
CTD»
0.0
AUGUSTUS-3.0.2_14309 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Tribolium castaneum
TI:7070 None
 
E9G1T4_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_44178 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Daphnia pulex
TI:6669 None
 
F0ZNL1_DICPU
TubercuList»
0.0
DICPUDRAFT_88309 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Dictyostelium purpureum
TI:5786 None
 
F1SQZ8_PIG
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Sus scrofa
TI:9823 None
   
F6WM02_HORSE
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Equus caballus
TI:9796 None
   
F6ZXZ9_MONDO
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Monodelphis domestica
TI:13616 None
   
F7G3D3_MACMU
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Macaca mulatta
TI:9544 None
   
G1KR18_ANOCA
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase domain-containing
protein 1 (EC 1.4.3.2)		 Anolis carolinensis
TI:28377 None
   
H2Q5K8_PANTR
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Pan troglodytes
TI:9598 None
 
H2XK75_CIOIN
Ensembl»
0.0
Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Ciona intestinalis
TI:7719 None
 
K7EEF4_ORNAN
Ensembl»
0.0
PYROXD1 Pyridine nucleotide-disulphide
oxidoreductase domain 1		 Ornithorhynchus anatinus
TI:9258 None
   
NAOX_METJA
EnsemblBacteria»
0.0
MJ0649 NADH oxidase (NOXase) (EC 1.6.3.4) Methanocaldococcus jannaschii
TI:2190 None
 
NAOX_MYCGE
euHCVdb»
0.0
nox NADH oxidase (NOXase) (EC 1.6.3.4) Mycoplasma genitalium
TI:2097 None
 
NAOX_STRR6
euHCVdb»
0.0
nox NADH oxidase (NOXase) (EC 1.6.3.4) Streptococcus pneumoniae
TI:1313 None
 
NASB_BACSU
EnsemblBacteria»
0.0
nasB Assimilatory nitrate reductase
electron transfer subunit		 Bacillus subtilis
TI:1423 None
 
NORW_SALTY
euHCVdb»
0.0
norW Nitric oxide reductase FlRd-NAD(+) reductase (EC
1.18.1.-) (Flavorubredoxin reductase) (FlRd-reductase) (FlavoRb reductase)		 Salmonella typhimurium
TI:28901 None
 
NSR_THEKO
EnsemblBacteria»
0.0
TK1299 NAD(P)H sulfur oxidoreductase (CoA-dependent) (NSR) (EC
1.8.1.18) (NAD(P)H oxidase (H2O-forming)) (NOX) (EC 1.6.3.2)		 Thermococcus kodakarensis
TI:311400 None
 
O67007_AQUAE
EnsemblBacteria»
0.0
nox NADH oxidase Aquifex aeolicus
TI:63363 None
 
O69869_STRCO
neXtProt»
0.0
SCO6039 Flavoprotein oxidoreductase Streptomyces coelicolor
TI:1902 None
 
PYRD1_BOVIN
Ensembl»
0.0
PYROXD1 tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1 (EC
1.6.99.1) (Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1)		 Bos taurus
TI:9913 None
 
PYRD1_DANRE
ZFIN»
0.0
pyroxd1 tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1 (EC
1.6.99.1) (Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1)		 Danio rerio
TI:7955 None
 
PYRD1_DICDI
dictyBase»
0.0
pyroxd1 tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1 (EC
1.6.99.1) (Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1)		 Dictyostelium discoideum
TI:44689 None
 
Q18213_CAEEL
WormBase»
0.0
C26D10.3 CELE_C26D10.3 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Caenorhabditis elegans
TI:6239 None
 
Q4WF39_ASPFU
TubercuList»
0.0
AFUA_3G03560 Pyridine nucleotide-disulfide
oxidoreductase, putative		 Aspergillus fumigatus
TI:746128 None
 
Q5JFZ8_THEKO
EnsemblBacteria»
0.0
TK0304 NADH oxidase Thermococcus kodakarensis
TI:311400 None
 
Q5JHY2_THEKO
EnsemblBacteria»
0.0
TK0828 NAD(P)H:rubredoxin oxidoreductase Thermococcus kodakarensis
TI:311400 None
 
Q5JJB9_THEKO
EnsemblBacteria»
0.0
TK1481 NADH:polysulfide oxidoreductase Thermococcus kodakarensis
TI:311400 None
 
Q74BE6_GEOSL
EnsemblBacteria»
0.0
GSU2095 FAD-dependent pyridine nucleotide-disulfide
oxidoreductase family protein		 Geobacter sulfurreducens
TI:35554 None
 
Q74DS8_GEOSL
EnsemblBacteria»
0.0
GSU1237 FAD-dependent pyridine nucleotide-disulfide
oxidoreductase family protein		 Geobacter sulfurreducens
TI:35554 None
 
Q74EQ3_GEOSL
EnsemblBacteria»
0.0
GSU0909 FAD-dependent pyridine nucleotide-disulfide
oxidoreductase family protein		 Geobacter sulfurreducens
TI:35554 None
 
Q74EW6_GEOSL
EnsemblBacteria»
0.0
GSU0843 Rubredoxin reductase Geobacter sulfurreducens
TI:35554 None
 
Q74F15_GEOSL
EnsemblBacteria»
0.0
GSU0794 FAD-dependent pyridine nucleotide-disulfide oxidoreductase
family protein, rhodanese homology domain-containing		 Geobacter sulfurreducens
TI:35554 None
 
Q7Q3T9_ANOGA
EnsemblMetazoa»
0.0
1277910 AGAP008042-PA Anopheles gambiae
TI:7165 None
 
Q7UMA9_RHOBA
EnsemblBacteria»
0.0
noxA Probable NADH oxidase (EC 1.6.99.3) Rhodopirellula baltica
TI:265606 None
 
Q81GF7_BACCR
neXtProt»
0.0
BC_1246 NADH dehydrogenase (EC 1.6.99.3) Bacillus cereus
TI:1396 None
 
Q81HL3_BACCR
euHCVdb»
0.0
BC_0791 NADH dehydrogenase (EC 1.6.99.3) Bacillus cereus
TI:1396 None
 
Q83EN9_COXBU
EnsemblBacteria»
0.0
CBU_0276 Rubredoxin-NAD(+) reductase (EC 1.18.1.1) Coxiella burnetii
TI:777 None
 
Q89RG4_BRADU
EnsemblBacteria»
0.0
blr2808 Blr2808 protein Bradyrhizobium diazoefficiens
TI:1355477 None
 
Q8A513_BACTN
EnsemblBacteria»
0.0
BT_2434 Pyridine nucleotide-disulphide oxidoreductase Bacteroides thetaiotaomicron
TI:818 None
 
Q8RHU1_FUSNN
EnsemblBacteria»
0.0
FN1903 CoA-disulfide reductase (Coenzyme A disulfide
reductase/ disulfide bond regulator domain)		 Fusobacterium nucleatum
TI:851 None
 
Q8TH86_METAC
EnsemblBacteria»
0.0
ndh NADH dehydrogenase Methanosarcina acetivorans
TI:2214 None
 
Q8ZVB1_PYRAE
EnsemblBacteria»
0.0
PAE2371 NADH oxidase (Nox) Pyrobaculum aerophilum
TI:13773 None
 
Q97WE3_SACS2
EnsemblBacteria»
0.0
SSO2283 NADH oxidase Saccharolobus solfataricus
TI:2287 None
 
Q9HP48_HALSA
neXtProt»
0.0
noxA Flavin-dependent pyridine
nucleotideoxidoreductase (NADH oxidase)		 Halobacterium salinarum
TI:2242 None
 
Q9KLU7_VIBCH
EnsemblBacteria»
0.0
VC_A0644 NADH oxidase, putative Vibrio cholerae
TI:666 None
 
Q9L2D3_STRCO
neXtProt»
0.0
nirB Nitrite reductase NirB Streptomyces coelicolor
TI:1902 None
 
Q9RVN5_DEIRA
EnsemblBacteria»
0.0
DR_0992 NADH oxidase Deinococcus radiodurans
TI:1299 None
 
Q9WYL1_THEMA
EnsemblBacteria»
0.0
TM_0379 NADH oxidase Thermotoga maritima
TI:2336 None
 
Q9WYM6_THEMA
EnsemblBacteria»
0.0
TM_0395 NADH oxidase, putative Thermotoga maritima
TI:2336 None
 
Q9WZL3_THEMA
EnsemblBacteria»
0.0
TM_0754 Oxidoreductase Thermotoga maritima
TI:2336 None
 
RURE_PSEAE
PharmGKB»
0.0
alkT Rubredoxin-NAD(+) reductase (RdxR) (EC 1.18.1.1) Pseudomonas aeruginosa
TI:287 None
 
T1FX41_HELRO
EnsemblMetazoa»
0.0
20213389 Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Helobdella robusta
TI:6412 None
 
W5NE84_LEPOC
Ensembl»
0.0
Pyridine nucleotide-disulfide oxidoreductase
domain-containing protein 1		 Lepisosteus oculatus
TI:7918 None