Collated Gene Ontology terms

Biological process: cytochrome-c oxidase activity(2001, 2013, 2024, 2025) oxidoreductase activity(2025)

Molecular function: oxidative phosphorylation2024 mitochondrial electron transport, cytochrome c to oxygen2025 proton transmembrane transport2025 cellular respiration2025 mitochondrial respiratory chain complex IV assembly2013, 2025 substantia nigra development2014 stem cell division2025 respiratory chain complex IV assembly2025 placenta development2025 oxygen metabolic process2025
cell differentiation2025 ATP biosynthetic process2025

Cellular component: mitochondrion2008, 2009, 2018, 2021, 2024, 2025 respiratory chain complex IV2013, 2016, 2019, 2024, 2025 membrane2025 mitochondrial inner membrane2005, 2008, 2013, 2016, 2024, 2025 mitochondrial crista2004, 2018, 2025 mitochondrial membrane2025 mitochondrial intermembrane space2013, 2025 sperm principal piece2025

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 3/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 7/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A1D8PQD5_CANAL
CGD»
0.0
CAALFM_C604250WA orf19.1082.1 Cytochrome c oxidase subunit Candida albicans
TI:5476 None
 
A0A2A6BAV4_PRIPA
EnsemblMetazoa»
0.0
WBGene00109573 C-CAP/cofactor C-like domain-containing protein Pristionchus pacificus
TI:54126 None
   
A0A2J8IWV0_PANTR
Ensembl»
0.0
COX6B2 Cytochrome c oxidase subunit 6B2 (Cytochrome c oxidase subunit
VIb isoform 2) (Cytochrome c oxidase subunit VIb, testis-specific isoform)		 Pan troglodytes
TI:9598 None
 
A0A3B3HDQ9_ORYLA
Ensembl»
0.0
LOC101168982 Cytochrome c oxidase subunit Oryzias latipes
TI:8090 None
   
A0A4X1TG97_PIG
Ensembl»
0.0
COX6B Cytochrome c oxidase subunit Sus scrofa
TI:9823 None
   
A0A4X1UF65_PIG
Ensembl»
0.0
COX6B2 Cytochrome c oxidase subunit Sus scrofa
TI:9823 None
   
A0A5F8AAS8_MACMU
Ensembl»
0.0
COX6B2 Cytochrome c oxidase subunit 6B1 (Cytochrome
c oxidase subunit VIb isoform 1)		 Macaca mulatta
TI:9544 None
   
A0A5F8GLB6_MONDO
Ensembl»
0.0
Cytochrome c oxidase subunit Monodelphis domestica
TI:13616 None
   
A0A5F8GMF7_MONDO
Ensembl»
0.0
Cytochrome c oxidase subunit 6B1 (Cytochrome
c oxidase subunit VIb isoform 1)		 Monodelphis domestica
TI:13616 None
   
A0A5F8GQP4_MONDO
Ensembl»
0.0
Cytochrome c oxidase subunit Monodelphis domestica
TI:13616 None
   
A0A5F8GV09_MONDO
Ensembl»
0.0
Cytochrome c oxidase subunit 6B2-like Monodelphis domestica
TI:13616 None
   
A0A5G2QL31_PIG
Ensembl»
0.0
LOC100519366 Cytochrome c oxidase subunit 6B1 (Cytochrome
c oxidase subunit VIb isoform 1)		 Sus scrofa
TI:9823 None
   
A0A6I8P2B1_ORNAN
Ensembl»
0.0
COX6B1 Cytochrome c oxidase subunit 6B1 (Cytochrome
c oxidase subunit VIb isoform 1)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8P4J0_ORNAN
Ensembl»
0.0
Cytochrome c oxidase subunit 6B2 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7RE48_STRPU
EnsemblMetazoa»
0.0
Cytochrome c oxidase subunit Strongylocentrotus purpuratus
TI:7668 None
   
A0A803TDJ6_ANOCA
Ensembl»
0.0
Cytochrome c oxidase subunit 6B1 (Cytochrome
c oxidase subunit VIb isoform 1)		 Anolis carolinensis
TI:28377 None
   
A0A803TZ89_ANOCA
Ensembl»
0.0
LOC100552884 Cytochrome c oxidase subunit Anolis carolinensis
TI:28377 None
   
A0A8I3MNC4_CANLF
Ensembl»
0.0
COX6B2 Cytochrome c oxidase subunit Canis lupus
TI:9612 None
   
A0A8I3MRB3_CANLF
Ensembl»
0.0
LOC612644 Cytochrome c oxidase subunit Canis lupus
TI:9612 None
   
A0A8I3PKI6_CANLF
Ensembl»
0.0
Uncharacterized protein Canis lupus
TI:9612 None
   
A0A8I3PYW0_CANLF
Ensembl»
0.0
LOC102156642 Cytochrome c oxidase subunit 6B1 (Cytochrome
c oxidase subunit VIb isoform 1)		 Canis lupus
TI:9612 None
   
A0A8I3RTA5_CANLF
Ensembl»
0.0
Cytochrome c oxidase subunit 6B1 (Cytochrome
c oxidase subunit VIb isoform 1)		 Canis lupus
TI:9612 None
   
A0A8I3S990_CANLF
Ensembl»
0.0
LOC119866325 Cytochrome c oxidase subunit Canis lupus
TI:9612 None
   
A0A8V0X6I3_CHICK
Ensembl»
0.0
LOC121108888 Cytochrome c oxidase subunit 6B1 (Cytochrome
c oxidase subunit VIb isoform 1)		 Gallus gallus
TI:9031 None
   
A0A8W4FAU4_PIG
Ensembl»
0.0
Uncharacterized protein Sus scrofa
TI:9823 None
   
A0A9J7M763_BRAFL
euHCVdb»
0.0
LOC118429385 Cytochrome c oxidase subunit Branchiostoma floridae
TI:7739 None
   
A0A9L0RZX4_HORSE
Ensembl»
0.0
Cytochrome c oxidase subunit 6B1 Equus caballus
TI:9796 None
   
A0ABI7WUE7_FELCA
Ensembl»
0.0
Cytochrome c oxidase subunit Felis catus
TI:9685 None
   
A2RVB6_XENLA
Xenbase»
0.0
cox6b1.S Cytochrome c oxidase subunit Xenopus laevis
TI:8355 None
 
A7EYS4_SCLS1
euHCVdb»
0.0
SS1G_10490 Cytochrome c oxidase subunit Sclerotinia sclerotiorum
TI:5180 None
 
A7RJL7_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g236414 Cytochrome c oxidase subunit Nematostella vectensis
TI:45351 None
 
A7T9B2_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g49232 Uncharacterized protein Nematostella vectensis
TI:45351 None
 
A8X9Q4_CAEBR
WormBase»
0.0
cox-6b Protein CBG09819 Caenorhabditis briggsae
TI:6238 None
 
A9UWQ3_MONBE
euHCVdb»
0.0
MONBRDRAFT_16380 Cytochrome c oxidase subunit Monosiga brevicollis
TI:81824 None
 
B3RMH5_TRIAD
CTD»
0.0
TRIADDRAFT_21297 Cytochrome c oxidase subunit Trichoplax adhaerens
TI:10228 None
 
COX12_YEAST
SGD»
3.7
COX12 Cytochrome c oxidase subunit 12,
mitochondrial (Cytochrome c oxidase polypeptide VIb)		 Saccharomyces cerevisiae
TI:4932 None
 
COX6B_DICDI
dictyBase»
0.0
DDB_G0284693 Probable cytochrome c oxidase subunit 6B Dictyostelium discoideum
TI:44689 None
 
CX6B1_BOVIN
Ensembl»
0.0
COX6B1 Cytochrome c oxidase subunit 6B1 (Cytochrome c oxidase polypeptide VII) (Cytochrome c
oxidase subunit AED) (Cytochrome c oxidase subunit VIb isoform 1) (COX VIb-1)		 Bos taurus
TI:9913 None
 
CX6B1_HUMAN
Ensembl»
2.3
COX6B1 Cytochrome c oxidase subunit 6B1 (Cytochrome c
oxidase subunit VIb isoform 1) (COX VIb-1)		 Homo sapiens
TI:9606 None
 
CX6B1_MACMU
Ensembl»
0.0
COX6B1 Cytochrome c oxidase subunit 6B1 (Cytochrome c
oxidase subunit VIb isoform 1) (COX VIb-1)		 Macaca mulatta
TI:9544 None
 
CX6B1_MOUSE
Ensembl»
0.0
Cox6b1 Cytochrome c oxidase subunit 6B1 (Cytochrome c
oxidase subunit VIb isoform 1) (COX VIb-1)		 Mus musculus
TI:10090 None
 
CX6B2_BOVIN
Ensembl»
0.0
COX6B2 Cytochrome c oxidase subunit 6B2 (Cytochrome c oxidase subunit VIb
isoform 2) (COX VIb-2) (Cytochrome c oxidase subunit VIb, testis-specific isoform)		 Bos taurus
TI:9913 None
 
CX6B2_HUMAN
Ensembl»
0.0
COX6B2 Cytochrome c oxidase subunit 6B2 (Cancer/testis antigen 59) (CT59) (Cytochrome c oxidase
subunit VIb isoform 2) (COX VIb-2) (Cytochrome c oxidase subunit VIb, testis-specific isoform)		 Homo sapiens
TI:9606 None
 
CX6B2_MOUSE
Ensembl»
4.8
Cox6b2 Cytochrome c oxidase subunit 6B2 (Cytochrome c oxidase subunit VIb
isoform 2) (COX VIb-2) (Cytochrome c oxidase subunit VIb, testis-specific isoform)		 Mus musculus
TI:10090 None
 
CX6B2_RAT
RGD»
0.0
Cox6b2 Cytochrome c oxidase subunit 6B2 (Cytochrome c oxidase subunit VIb
isoform 2) (COX VIb-2) (Cytochrome c oxidase subunit VIb, testis-specific isoform)		 Rattus norvegicus
TI:10116 None
 
E1BAV7_BOVIN
Ensembl»
0.0
Cytochrome c oxidase subunit Bos taurus
TI:9913 None
   
E9G6X0_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_230594 Cytochrome c oxidase subunit Daphnia pulex
TI:6669 None
 
F0Z8L6_DICPU
TubercuList»
0.0
DICPUDRAFT_147409 Cytochrome c oxidase subunit Dictyostelium purpureum
TI:5786 None
 
F4NSE4_BATDJ
euHCVdb»
0.0
BATDEDRAFT_8182 Cytochrome c oxidase subunit Batrachochytrium dendrobatidis
TI:109871 None
 
F5HLX5_ANOGA
EnsemblMetazoa»
0.0
11176134 Cytochrome c oxidase subunit Anopheles gambiae
TI:7165 None
 
F6RS65_MONDO
Ensembl»
0.0
COX6B1 Cytochrome c oxidase subunit Monodelphis domestica
TI:13616 None
   
F7BFL6_MONDO
Ensembl»
0.0
Cytochrome c oxidase subunit 6B2 (Cytochrome c oxidase subunit
VIb isoform 2) (Cytochrome c oxidase subunit VIb, testis-specific isoform)		 Monodelphis domestica
TI:13616 None
   
F7BQU1_MONDO
Ensembl»
0.0
Cytochrome c oxidase subunit Monodelphis domestica
TI:13616 None
   
G3QG87_GORGO
Ensembl»
0.0
LOC101140152 Cytochrome c oxidase subunit Gorilla gorilla
TI:9593 None
 
G3QQ13_GORGO
Ensembl»
0.0
LOC101139203 Cytochrome c oxidase subunit Gorilla gorilla
TI:9593 None
 
H2LNK4_ORYLA
Ensembl»
0.0
LOC101163911 Cytochrome c oxidase subunit Oryzias latipes
TI:8090 None
   
H2LVT0_ORYLA
Ensembl»
0.0
LOC101169072 Cytochrome c oxidase subunit Oryzias latipes
TI:8090 None
   
H2MPA9_ORYLA
Ensembl»
0.0
Cytochrome c oxidase subunit Oryzias latipes
TI:8090 None
   
H2QG35_PANTR
Ensembl»
0.0
COX6B1 Cytochrome c oxidase subunit Pan troglodytes
TI:9598 None
 
H9H9I1_MONDO
Ensembl»
0.0
Cytochrome c oxidase subunit 6B2 (Cytochrome c oxidase subunit
VIb isoform 2) (Cytochrome c oxidase subunit VIb, testis-specific isoform)		 Monodelphis domestica
TI:13616 None
   
Q6C5M8_YARLI
TubercuList»
0.0
YALI0_E16709g Cytochrome c oxidase subunit Yarrowia lipolytica
TI:4952 None
 
Q6DEQ9_XENTR
Xenbase»
0.0
cox6b1 Cytochrome c oxidase subunit Xenopus tropicalis
TI:8364 None
 
Q6DH63_DANRE
ZFIN»
0.0
cox6b1 Cytochrome c oxidase subunit Danio rerio
TI:7955 None
 
Q6NTR9_XENLA
CTD»
0.0
MGC82428 Cytochrome c oxidase subunit Xenopus laevis
TI:8355 None
 
Q759N5_EREGS
euHCVdb»
0.0
AGOS_ADR240C Cytochrome c oxidase subunit Eremothecium gossypii
TI:33169 None
 
Q7SXM1_DANRE
ZFIN»
0.0
cox6b2 Cytochrome c oxidase subunit Danio rerio
TI:7955 None
 
Q9BL34_CAEEL
WormBase»
0.0
cox-6b Cytochrome oxidase c subunit VIb Caenorhabditis elegans
TI:6239 None
 
Q9VWD1_DROME
FlyBase»
1.6
COX6B Cytochrome c oxidase subunit Drosophila melanogaster
TI:7227 None
 
T1G288_HELRO
EnsemblMetazoa»
0.0
20215186 Cytochrome c oxidase subunit Helobdella robusta
TI:6412 None
 
W5MMP2_LEPOC
Ensembl»
0.0
Cytochrome c oxidase subunit Lepisosteus oculatus
TI:7918 None