Unknome v3

Cluster UKP07311
CDC42 GTPASE-ACTIVATING PROTEIN
Standard knownness: 3.6; Custom knownness: None; Num. species: 32; Orthology database: Panther18.0; Protein members: 104

Collated Gene Ontology terms

Biological process: GTPase activator activity^{(2003, 2005, 2011, 2013, 2017, 2020, 2023)} phosphatidylinositol binding⁽²⁰²³⁾ phosphatidylinositol phosphate binding⁽²⁰²³⁾ protein kinase binding^{(2017, 2023)} SH3 domain binding^{(2004, 2023)}

Molecular function: signal transduction²⁰²³ small GTPase mediated signal transduction^{2003, 2017, 2023} system development²⁰²³ cell development²⁰²³ regulation of dendritic spine morphogenesis^{2018, 2023} response to toxic substance^{2018, 2023} regulation of small GTPase mediated signal transduction²⁰²³ positive regulation of neuron migration^{2022, 2023} positive regulation of axon extension^{2022, 2023} protein transport²⁰²³
positive regulation of GTPase activity²⁰¹¹ cerebellum development^{2022, 2023} retinal ganglion cell axon guidance²⁰⁰⁸ Rho protein signal transduction²⁰⁰⁵

Cellular component: cell cortex^{2003, 2018, 2023} Golgi apparatus^{2018, 2023} nucleoplasm^{2018, 2023} fibrillar center^{2018, 2023} actin cytoskeleton^{2003, 2018, 2023} lamellipodium^{2003, 2018, 2023} plasma membrane^{2011, 2017, 2023} postsynaptic density^{2018, 2023} cytoplasm^{2011, 2023} protein-containing complex^{2017, 2023}
intracellular membrane-bounded organelle²⁰²³ dendritic spine^{2018, 2023} membrane²⁰²³ cytosol²⁰¹³ cell projection²⁰²³ synapse²⁰²³ focal adhesion²⁰²³ endosome membrane²⁰²³ endosome²⁰²³ endoplasmic reticulum membrane²⁰²³ endoplasmic reticulum²⁰²³ cytoplasmic vesicle²⁰²³ anchoring junction²⁰²³ Golgi membrane²⁰²³

Phylogenetic distribution

Chordates:	21/21
Echinoderms:	0/0
Hemichordates:	1/1
Annelids:	1/1
Molluscs:	0/0
Bryozoans:	0/0
Platyhelminthes:	0/0
Rotifers:	0/0
Nematodes:	3/3
Arthropods:	5/5
Tardigrades:	0/0
Placozoa:	0/1
Cnidaria:	1/1
Porifera:	0/0
Choanoflagellates+:	0/1
Dikarya:	0/14
Fungi (other):	0/1
Protozoa:	0/3
Excavates:	0/4
Harosa:	0/4
Hacrobia:	0/0
Plants:	0/39
Archea:	0/8
Bacteria:	0/35

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Protein sequences (FASTA format)

Knownness history

Proteins

UniProt ID
Organism DB»

Species [Show all]

RHG31_MOUSE
Ensembl»

3.4

Arhgap31

Rho GTPase-activating protein
31 (Cdc42 GTPase-activating protein)

Mus musculus
TI:10090 None

RHG32_HUMAN
Ensembl»

2.8

ARHGAP32

Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA)
(Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)

Homo sapiens
TI:9606 None

RHG33_HUMAN
Ensembl»

1.8

ARHGAP33

Rho GTPase-activating protein 33 (Rho-type GTPase-activating
protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein)

Homo sapiens
TI:9606 None

RHG30_HUMAN
Ensembl»

2.8

ARHGAP30

Rho GTPase-activating protein 30
(Rho-type GTPase-activating protein 30)

Homo sapiens
TI:9606 None

RHG32_MOUSE
Ensembl»

3.0

Arhgap32

Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (Rho-type GTPase-activating protein
32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)

Mus musculus
TI:10090 None

RHG33_MOUSE
Ensembl»

2.8

Arhgap33

Rho GTPase-activating protein 33 (Rho-type GTPase-activating
protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein)

Mus musculus
TI:10090 None

CDGAP_DROME
FlyBase»

2.3

CdGAPr

GTPase-activating protein CdGAPr (d-CdGAPr)

Drosophila melanogaster
TI:7227 None

RHG31_HUMAN
Ensembl»

2.8

ARHGAP31

Rho GTPase-activating protein
31 (Cdc42 GTPase-activating protein)

Homo sapiens
TI:9606 None

RHG30_MOUSE
AG»

1.0

Arhgap30

Rho GTPase-activating protein 30
(Rho-type GTPase-activating protein 30)

Mus musculus
TI:10090 None

E9QGF9_DANRE
ZFIN»

1.0

arhgap31

Rho GTPase-activating protein 31 (Rho
GTPase-activating protein 31 isoform X1)

Danio rerio
TI:7955 None

F1RDK4_DANRE
ZFIN»

1.0

arhgap32a

Rho GTPase-activating protein 32 isoform
X1 (Rho GTPase-activating protein 32a)

Danio rerio
TI:7955 None

RRC1_CAEEL
WormBase»

1.6

rrc-1

GTPase-activating protein rrc-1 (RhoGAP
for Rac-1 and Cdc-42)

Caenorhabditis elegans
TI:6239 None

A0A8M2B5A9_DANRE
CTD»

0.0

arhgap33

Rho GTPase-activating protein 33 isoform X1

Danio rerio
TI:7955 None

A0A8M3ALJ2_DANRE
CTD»

0.0

arhgap32b

Rho GTPase-activating protein 32 isoform X1

Danio rerio
TI:7955 None

A0A8M9PP74_DANRE
CTD»

0.0

si:ch73-203a8.1

Rho GTPase-activating protein 30 isoform X1

Danio rerio
TI:7955 None

A0A8V0X2W8_CHICK
Ensembl»

0.0

ARHGAP33L1