Unknome v3

Cluster UKP07311
CDC42 GTPASE-ACTIVATING PROTEIN
Standard knownness: 5.4; Custom knownness: None; Num. species: 33; Orthology database: Panther19.0; Protein members: 114

Collated Gene Ontology terms

Biological process: GTPase activator activity^{(2003, 2005, 2011, 2013, 2020, 2024, 2025)} phosphatidylinositol binding⁽²⁰²⁵⁾ phosphatidylinositol phosphate binding⁽²⁰²⁵⁾ SH3 domain binding^{(2004, 2025)} protein kinase binding^{(2017, 2025)}

Molecular function: signal transduction²⁰²⁵ small GTPase-mediated signal transduction^{2003, 2017, 2025} regulation of postsynapse assembly^{2024, 2025} regulation of dendritic spine morphogenesis^{2018, 2025} negative regulation of Rho protein signal transduction^{2024, 2025} protein transport²⁰²⁵ regulation of small GTPase mediated signal transduction²⁰²⁵ positive regulation of neuron migration^{2022, 2025} positive regulation of axon extension^{2022, 2025} positive regulation of GTPase activity²⁰¹¹
retinal ganglion cell axon guidance²⁰⁰⁸ response to toxic substance²⁰¹⁸ cerebellum development²⁰²² Rho protein signal transduction²⁰⁰⁵

Cellular component: postsynaptic density^{2018, 2024, 2025} glutamatergic synapse^{2024, 2025} cytoplasm^{2011, 2025} lamellipodium^{2003, 2018, 2025} cell cortex^{2003, 2025} Golgi apparatus^{2024, 2025} endomembrane system²⁰²⁵ actin cytoskeleton^{2003, 2025} cytosol^{2013, 2025} plasma membrane^{2011, 2025}
protein-containing complex^{2017, 2025} nucleoplasm²⁰²⁵ fibrillar center²⁰²⁵ dendritic spine^{2018, 2025} membrane²⁰²⁵ focal adhesion²⁰²⁵ endosome membrane²⁰²⁵ endoplasmic reticulum membrane²⁰²⁵ cytoplasmic vesicle²⁰²⁵ Golgi membrane²⁰²⁵

Phylogenetic distribution

Chordates:	22/21
Echinoderms:	0/0
Hemichordates:	1/1
Annelids:	1/1
Molluscs:	0/0
Bryozoans:	0/0
Platyhelminthes:	0/0
Rotifers:	0/0
Nematodes:	3/3
Arthropods:	5/5
Tardigrades:	0/0
Placozoa:	0/1
Cnidaria:	1/1
Porifera:	0/0
Choanoflagellates+:	0/1
Dikarya:	0/14
Fungi (other):	0/1
Protozoa:	0/3
Excavates:	0/4
Harosa:	0/4
Hacrobia:	0/0
Plants:	0/39
Archea:	0/8
Bacteria:	0/35

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Protein sequences (FASTA format)

Knownness history

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Proteins

UniProt ID
Organism DB»

Species [Show all]

RHG33_MOUSE
Ensembl»

5.4

Arhgap33

Rho GTPase-activating protein 33 (Rho-type GTPase-activating
protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein)

Mus musculus
TI:10090 None

RHG30_HUMAN
Ensembl»

4.4

ARHGAP30

Rho GTPase-activating protein 30
(Rho-type GTPase-activating protein 30)

Homo sapiens
TI:9606 None

RHG32_MOUSE
Ensembl»

4.0

Arhgap32

Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (Rho-type GTPase-activating protein
32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)

Mus musculus
TI:10090 None

RHG32_HUMAN
Ensembl»

3.8

ARHGAP32

Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA)
(Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)

Homo sapiens
TI:9606 None

RHG31_MOUSE
Ensembl»

3.4

Arhgap31

Rho GTPase-activating protein
31 (Cdc42 GTPase-activating protein)

Mus musculus
TI:10090 None

A0A8I6AJS5_RAT
RGD»

3.1

Arhgap33

Rho GTPase-activating protein 33 (Rho-type GTPase-activating
protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein)

Rattus norvegicus
TI:10116 None

RHG31_HUMAN
Ensembl»

2.8

ARHGAP31

Rho GTPase-activating protein
31 (Cdc42 GTPase-activating protein)

Homo sapiens
TI:9606 None

RHG33_HUMAN
Ensembl»

2.8

ARHGAP33

Rho GTPase-activating protein 33 (Rho-type GTPase-activating
protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein)

Homo sapiens
TI:9606 None

D4A987_RAT
RGD»

2.5

Arhgap31

Rho GTPase activating protein 31

Rattus norvegicus
TI:10116 None

A0ABK0LN08_RAT
RGD»

2.4

Arhgap32

Rho GTPase activating protein 32

Rattus norvegicus
TI:10116 None

CDGAP_DROME
FlyBase»

2.3

CdGAPr

GTPase-activating protein CdGAPr (d-CdGAPr)

Drosophila melanogaster
TI:7227 None

A0A8M2B5A9_DANRE
ZFIN»

2.0

arhgap33

Uncharacterized protein arhgap33 isoform X1

Danio rerio
TI:7955 None

A0A8M3ALJ2_DANRE
ZFIN»

2.0

arhgap32b

Rho GTPase-activating protein 32 (Rho-type GTPase-activating
protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS)

Danio rerio
TI:7955 None

A0A8V0ZMZ0_CHICK
Ensembl»

2.0

ARHGAP33

Rho GTPase-activating protein 32 (Rho-type GTPase-activating
protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS)

Gallus gallus
TI:9031 None

D3ZCI3_RAT
RGD»

2.0

Arhgap30

Rho GTPase activating protein 30

Rattus norvegicus
TI:10116 None

F1RDK4_DANRE
ZFIN»

2.0

arhgap32a

Rho GTPase-activating protein 32 (Rho-type GTPase-activating
protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS)

Danio rerio
TI:7955 None

RHG30_MOUSE
AG»

2.0

Arhgap30

Rho GTPase-activating protein 30
(Rho-type GTPase-activating protein 30)

Mus musculus
TI:10090 None

RRC1_CAEEL
WormBase»

1.6

rrc-1

GTPase-activating protein rrc-1 (RhoGAP
for Rac-1 and Cdc-42)

Caenorhabditis elegans
TI:6239 None

A0A8M9PP74_DANRE
ZFIN»

1.0

si:dkeyp-68b7.12

Uncharacterized protein
si:dkeyp-68b7.12 isoform X1

Danio rerio
TI:7955 None

A0A8V1A8E2_CHICK
Ensembl»

1.0

ARHGAP31

Rho GTPase activating protein 31

Gallus gallus
TI:9031 None

A0A8V1AGK1_CHICK
Ensembl»

1.0

LOC101749378

Rho GTPase activating protein 30

Gallus gallus
TI:9031 None

E9QGF9_DANRE
ZFIN»

1.0

arhgap31

Rho GTPase-activating protein 31

Danio rerio
TI:7955 None

A0A8V0X2W8_CHICK
Ensembl»

0.0

ARHGAP33L1