Unknome v3

Cluster UKP07311
CDC42 GTPASE-ACTIVATING PROTEIN
Standard knownness: 4.1; Custom knownness: None; Num. species: 33; Orthology database: Panther19.0; Protein members: 110

Collated Gene Ontology terms

Biological process: GTPase activator activity^{(2003, 2005, 2011, 2013, 2017, 2020, 2024)} phosphatidylinositol binding⁽²⁰²⁴⁾ phosphatidylinositol phosphate binding⁽²⁰²⁴⁾ SH3 domain binding^{(2004, 2024)} protein kinase binding^{(2017, 2024)}

Molecular function: signal transduction²⁰²⁴ small GTPase mediated signal transduction^{2003, 2017, 2024} regulation of postsynapse assembly²⁰²⁴ response to toxic substance^{2018, 2024} regulation of small GTPase mediated signal transduction²⁰²⁴ regulation of dendritic spine morphogenesis^{2018, 2024} positive regulation of GTPase activity^{2011, 2024} protein transport²⁰²⁴ positive regulation of neuron migration^{2022, 2024} positive regulation of axon extension^{2022, 2024}
cerebellum development^{2022, 2024} retinal ganglion cell axon guidance²⁰⁰⁸ Rho protein signal transduction²⁰⁰⁵

Cellular component: cell cortex^{2003, 2018, 2024} Golgi apparatus^{2018, 2023, 2024} nucleoplasm^{2018, 2023, 2024} fibrillar center^{2018, 2023, 2024} actin cytoskeleton^{2003, 2018, 2024} lamellipodium^{2003, 2018, 2024} postsynaptic density^{2018, 2024} plasma membrane^{2011, 2017, 2024} glutamatergic synapse²⁰²⁴ cytoplasm^{2011, 2024}
protein-containing complex^{2017, 2024} intracellular membrane-bounded organelle^{2023, 2024} dendritic spine^{2018, 2024} membrane²⁰²⁴ cytosol²⁰¹³ cell projection²⁰²⁴ synapse²⁰²⁴ focal adhesion²⁰²⁴ endosome membrane²⁰²⁴ endosome²⁰²⁴ endoplasmic reticulum membrane²⁰²⁴ endoplasmic reticulum²⁰²⁴ cytoplasmic vesicle²⁰²⁴ anchoring junction²⁰²⁴ Golgi membrane²⁰²⁴

Phylogenetic distribution

Chordates:	22/21
Echinoderms:	0/0
Hemichordates:	1/1
Annelids:	1/1
Molluscs:	0/0
Bryozoans:	0/0
Platyhelminthes:	0/0
Rotifers:	0/0
Nematodes:	3/3
Arthropods:	5/5
Tardigrades:	0/0
Placozoa:	0/1
Cnidaria:	1/1
Porifera:	0/0
Choanoflagellates+:	0/1
Dikarya:	0/14
Fungi (other):	0/1
Protozoa:	0/3
Excavates:	0/4
Harosa:	0/4
Hacrobia:	0/0
Plants:	0/39
Archea:	0/8
Bacteria:	0/35

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Protein sequences (FASTA format)

Knownness history

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Proteins

UniProt ID
Organism DB»

Standard knownness

clustom knownness

Species [Show all]

Protein domain links

A0A8M2B5A9_DANRE
CTD»

0.0

arhgap33

Rho GTPase-activating protein 33 isoform X1

Danio rerio
TI:7955 None

A0A8M3ALJ2_DANRE
CTD»

1.0

arhgap32b

Rho GTPase-activating protein 32 isoform X1

Danio rerio
TI:7955 None

A0A8M9PP74_DANRE
CTD»

0.0

si:ch73-203a8.1

Rho GTPase-activating protein 30 isoform X1

Danio rerio
TI:7955 None

A0A8V0X2W8_CHICK
Ensembl»

0.0

ARHGAP33L1

Rho-GAP domain-containing protein

Gallus gallus
TI:9031 None

A0A8V0X3G3_CHICK
Ensembl»

0.0

LOC107049808

Rho-GAP domain-containing protein

Gallus gallus
TI:9031 None

A0A8V0X3I4_CHICK
Ensembl»

0.0

ARHGAP33L4

Rho-GAP domain-containing protein

Gallus gallus
TI:9031 None

A0A8V0X3J8_CHICK
Ensembl»

0.0

Rho-GAP domain-containing protein

Gallus gallus
TI:9031 None

A0A8V0X6T7_CHICK
Ensembl»

0.0

ARHGAP33L6

Rho-GAP domain-containing protein

Gallus gallus
TI:9031 None

A0A8V0XC09_CHICK
Ensembl»

0.0

LOC107050418

Rho-GAP domain-containing protein

Gallus gallus
TI:9031 None

A0A8V0XGZ7_CHICK
Ensembl»

0.0

LOC112531211

Rho-GAP domain-containing protein

Gallus gallus
TI:9031 None

A0A8V0ZMZ0_CHICK
Ensembl»

0.0

ARHGAP33

Rho GTPase activating protein 32

Gallus gallus
TI:9031 None

A0A8V1A8E2_CHICK
Ensembl»

0.0

ARHGAP31

Rho GTPase activating protein 31

Gallus gallus
TI:9031 None

A0A8V1AGK1_CHICK
Ensembl»

0.0

LOC101749378

Rho GTPase activating protein 30

Gallus gallus
TI:9031 None

CDGAP_DROME
FlyBase»

2.3

CdGAPr

GTPase-activating protein CdGAPr (d-CdGAPr)

Drosophila melanogaster
TI:7227 None

D3ZCI3_RAT
RGD»

1.0

Arhgap30

Rho GTPase activating protein 30

Rattus norvegicus
TI:10116 None

D4A987_RAT
RGD»

2.5

Arhgap31

Rho GTPase activating protein 31

Rattus norvegicus
TI:10116 None

D4A9G6_RAT
RGD»

4.1

Arhgap33

Rho GTPase activating protein 33

Rattus norvegicus
TI:10116 None

E9QGF9_DANRE
ZFIN»

1.0

arhgap31

Rho GTPase-activating protein 31 (Rho
GTPase-activating protein 31 isoform X1)

Danio rerio
TI:7955 None

F1MAK3_RAT
RGD»

3.4

Arhgap32

Rho GTPase activating protein 32

Rattus norvegicus
TI:10116 None

F1RDK4_DANRE
ZFIN»

1.0

arhgap32a

Rho GTPase-activating protein 32 isoform
X1 (Rho GTPase-activating protein 32a)

Danio rerio
TI:7955 None

RHG30_HUMAN
Ensembl»

2.8

ARHGAP30

Rho GTPase-activating protein 30
(Rho-type GTPase-activating protein 30)

Homo sapiens
TI:9606 None

RHG30_MOUSE
AG»

0.0

Arhgap30

Rho GTPase-activating protein 30
(Rho-type GTPase-activating protein 30)

Mus musculus
TI:10090 None

RHG31_HUMAN
Ensembl»

2.8

ARHGAP31

Rho GTPase-activating protein
31 (Cdc42 GTPase-activating protein)

Homo sapiens
TI:9606 None

RHG31_MOUSE
Ensembl»

2.4

Arhgap31

Rho GTPase-activating protein
31 (Cdc42 GTPase-activating protein)

Mus musculus
TI:10090 None

RHG32_HUMAN
Ensembl»

2.8

ARHGAP32

Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA)
(Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)

Homo sapiens
TI:9606 None

RHG32_MOUSE
Ensembl»

1.0

Arhgap32

Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (Rho-type GTPase-activating protein
32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)

Mus musculus
TI:10090 None

RHG33_HUMAN
Ensembl»

1.8

ARHGAP33

Rho GTPase-activating protein 33 (Rho-type GTPase-activating
protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein)

Homo sapiens
TI:9606 None

RHG33_MOUSE
Ensembl»

2.4

Arhgap33

Rho GTPase-activating protein 33 (Rho-type GTPase-activating
protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein)

Mus musculus
TI:10090 None

RRC1_CAEEL
WormBase»

1.6

rrc-1

GTPase-activating protein rrc-1 (RhoGAP
for Rac-1 and Cdc-42)

Caenorhabditis elegans
TI:6239 None