Collated Gene Ontology terms

Biological process: amyloid-beta binding(2009, 2017, 2025) ATP binding(2011, 2025)

Molecular function: negative regulation of amyloid precursor protein biosynthetic process2012, 2017, 2025 neuron differentiation2019, 2025 negative regulation of neuron projection development2010, 2025 positive regulation of extrinsic apoptotic signaling pathway2013, 2025 extrinsic apoptotic signaling pathway in absence of ligand2013 plasma cell differentiation2016 nervous system development2003 insemination2025

Cellular component: plasma membrane2012, 2017, 2025 Golgi apparatus2010, 2017, 2024, 2025 membrane2014, 2025 endosome membrane2025 Golgi membrane2025 lysosomal membrane2025 extracellular space2011, 2012, 2025 organelle membrane2012, 2025 Golgi-associated vesicle membrane2012, 2025 lysosome2010, 2019, 2025
perinuclear region of cytoplasm2010, 2025 extracellular region2013, 2025 extracellular exosome2013, 2014, 2025

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
ITM2B_MOUSE
Ensembl»
4.9
Itm2b Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form
(Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]		 Mus musculus
TI:10090 None
 
ITM2C_HUMAN
Ensembl»
3.4
ITM2C Integral membrane protein 2C (Cerebral protein
14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3]		 Homo sapiens
TI:9606 None
 
ITM2B_HUMAN
Ensembl»
3.5
ITM2B Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form
(Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]		 Homo sapiens
TI:9606 None
 
ITM2A_HUMAN
Ensembl»
1.0
ITM2A Integral membrane protein 2A (Protein E25) Homo sapiens
TI:9606 None
 
ITM2A_MOUSE
Ensembl»
1.8
Itm2a Integral membrane protein 2A (Protein E25) Mus musculus
TI:10090 None
 
ITM2C_MOUSE
Ensembl»
4.1
Itm2c Integral membrane protein 2C (Transmembrane
protein BRI3) [Cleaved into: CT-BRI3]		 Mus musculus
TI:10090 None
 
Q803H7_DANRE
ZFIN»
1.0
itm2ba Integral membrane protein 2 Danio rerio
TI:7955 None
 
Q9VPT9_DROME
FlyBase»
1.5
Dmel\CG3662 Integral membrane protein 2 Drosophila melanogaster
TI:7227 None
 
Q7T328_DANRE
ZFIN»
1.0
itm2bb Integral membrane protein 2 Danio rerio
TI:7955 None
 
H2KZ11_CAEEL
WormBase»
1.0
itm-2 Integral membrane protein 2 Caenorhabditis elegans
TI:6239 None
 
ITM2B_CHICK
TubercuList»
1.0
ITM2B Integral membrane protein
2B (Transmembrane protein E3-16)		 Gallus gallus
TI:9031 None
 
ITM2B_RAT
RGD»
3.5
Itm2b Integral membrane protein 2B (Immature BRI2) (imBRI2) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature
BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]		 Rattus norvegicus
TI:10116 None
 
ITM2C_RAT
RGD»
4.0
Itm2c Integral membrane protein
2C [Cleaved into: CT-BRI3]		 Rattus norvegicus
TI:10116 None
 
Q6DGT2_DANRE
ZFIN»
1.0
itm2ca Integral membrane protein 2 Danio rerio
TI:7955 None
 
A0A8V0XF42_CHICK
Ensembl»
1.0
ITM2B Integral membrane protein 2 Gallus gallus
TI:9031 None
   
A0A8V0ZVX0_CHICK
Ensembl»
1.0
ITM2C Integral membrane protein 2 Gallus gallus
TI:9031 None
   
A0ABZ3NND9_RAT
RGD»
0.5
Itm2a Integral membrane protein 2 Rattus norvegicus
TI:10116 None
   
F1P4X6_CHICK
Ensembl»
1.0
ITM2A Integral membrane protein 2 Gallus gallus
TI:9031 None