Collated Gene Ontology terms

Biological process: amyloid-beta binding(2009, 2017, 2024) ATP binding(2011, 2024)

Molecular function: negative regulation of amyloid precursor protein biosynthetic process2012, 2017, 2024 plasma cell differentiation2016, 2024 neuron differentiation2019, 2024 negative regulation of neuron projection development2010, 2024 positive regulation of extrinsic apoptotic signaling pathway2013, 2024 sexual reproduction2011 nervous system development2003

Cellular component: plasma membrane2012, 2017, 2024 Golgi apparatus2010, 2017, 2023, 2024 membrane2014, 2024 lysosome2010, 2019, 2024 endosome membrane2024 endosome2024 Golgi membrane2024 lysosomal membrane2024 extracellular space2011, 2012, 2024 organelle membrane2012, 2024
Golgi-associated vesicle membrane2012, 2024 intracellular membrane-bounded organelle2023, 2024 extracellular region2013, 2024 perinuclear region of cytoplasm2010, 2024 extracellular exosome2013, 2014, 2024

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 4/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
ITM2C_RAT
RGD»
4.0
Itm2c Integral membrane protein
2C [Cleaved into: CT-BRI3]		 Rattus norvegicus
TI:10116 None
 
ITM2B_HUMAN
Ensembl»
3.5
ITM2B Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form
(Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]		 Homo sapiens
TI:9606 None
 
ITM2B_PANTR
Ensembl»
0.0
ITM2B Integral membrane protein 2B (Immature BRI2) (imBRI2) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature
BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]		 Pan troglodytes
TI:9598 None
 
ITM2B_RAT
RGD»
3.0
Itm2b Integral membrane protein 2B (Immature BRI2) (imBRI2) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature
BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]		 Rattus norvegicus
TI:10116 None
 
ITM2B_MOUSE
Ensembl»
1.3
Itm2b Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form
(Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]		 Mus musculus
TI:10090 None
 
ITM2C_HUMAN
Ensembl»
3.4
ITM2C Integral membrane protein 2C (Cerebral protein
14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3]		 Homo sapiens
TI:9606 None
 
A0A2I2UVC1_FELCA
Ensembl»
0.0
ITM2B Integral membrane protein 2 Felis catus
TI:9685 None
 
F1N026_BOVIN
Ensembl»
0.0
ITM2B Integral membrane protein 2 Bos taurus
TI:9913 None
   
F1RK12_PIG
Ensembl»
0.0
ITM2B Integral membrane protein 2 Sus scrofa
TI:9823 None
 
F7B0D0_MACMU
Ensembl»
0.0
ITM2B Integral membrane protein 2 Macaca mulatta
TI:9544 None
 
F7E819_ORNAN
Ensembl»
0.0
ITM2B Integral membrane protein 2 Ornithorhynchus anatinus
TI:9258 None
   
G3QV34_GORGO
Ensembl»
0.0
ITM2B Integral membrane protein 2 Gorilla gorilla
TI:9593 None
 
ITM2B_BOVIN
CTD»
0.0
ITM2B Integral membrane protein 2B (Immature BRI2) (imBRI2) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature
BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]		 Bos taurus
TI:9913 None
 
ITM2B_PIG
CTD»
0.0
ITM2B Integral membrane protein 2B (Immature BRI2) (imBRI2) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature
BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]		 Sus scrofa
TI:9823 None
 
A0A8I3N078_CANLF
Ensembl»
0.0
ITM2B Integral membrane protein 2 Canis lupus
TI:9612 None
   
G3QII8_GORGO
Ensembl»
0.0
ITM2C Integral membrane protein 2 Gorilla gorilla
TI:9593 None
 
H2QJK7_PANTR
Ensembl»
0.0
ITM2C Integral membrane protein 2 Pan troglodytes
TI:9598 None
 
ITM2C_MOUSE
Ensembl»
1.6
Itm2c Integral membrane protein 2C (Transmembrane
protein BRI3) [Cleaved into: CT-BRI3]		 Mus musculus
TI:10090 None
 
ITM2C_BOVIN
Ensembl»
0.0
ITM2C Integral membrane protein
2C [Cleaved into: CT-BRI3]		 Bos taurus
TI:9913 None
 
ITM2C_PIG
Ensembl»
0.0
ITM2C Integral membrane protein
2C [Cleaved into: CT-BRI3]		 Sus scrofa
TI:9823 None
 
A0A5F8GUP3_MONDO
Ensembl»
0.0
Integral membrane protein 2 Monodelphis domestica
TI:13616 None
   
F6ZAG8_MONDO
Ensembl»
0.0
ITM2B Integral membrane protein 2 Monodelphis domestica
TI:13616 None
   
G1KQA4_ANOCA
Ensembl»
0.0
Integral membrane protein 2 Anolis carolinensis
TI:28377 None
   
H2LW72_ORYLA
Ensembl»
0.0
itm2b Integral membrane protein 2 Oryzias latipes
TI:8090 None
   
ITM2B_CHICK
VEuPathDB»
1.0
ITM2B Integral membrane protein
2B (Transmembrane protein E3-16)		 Gallus gallus
TI:9031 None
 
Q7T328_DANRE
ZFIN»
1.0
fb94b03 Integral membrane protein 2 Danio rerio
TI:7955 None
 
Q803H7_DANRE
ZFIN»
1.0
itm2b Integral membrane protein 2 Danio rerio
TI:7955 None
 
W5MWJ3_LEPOC
Ensembl»
0.0
Integral membrane protein 2 Lepisosteus oculatus
TI:7918 None
 
Q8AVF1_XENLA
Xenbase»
0.0
itm2b.L Integral membrane protein 2 Xenopus laevis
TI:8355 None
 
Q9VPT9_DROME
FlyBase»
1.5
Dmel\CG3662 Integral membrane protein 2 Drosophila melanogaster
TI:7227 None
 
A0A3B3H886_ORYLA
Ensembl»
0.0
LOC101161582 Integral membrane protein 2 Oryzias latipes
TI:8090 None
   
A0A5F5XX48_FELCA
Ensembl»
0.0
ITM2A Integral membrane protein 2 Felis catus
TI:9685 None
 
A0A5F7Z9Q1_MACMU
Ensembl»
0.0
ITM2A Integral membrane protein 2 Macaca mulatta
TI:9544 None
   
A0A6I8PB82_ORNAN
Ensembl»
0.0
ITM2C Integral membrane protein 2 Ornithorhynchus anatinus
TI:9258 None
   
A0A8M9QGD2_DANRE
CTD»
1.0
itm2cb Integral membrane protein 2 Danio rerio
TI:7955 None
   
A6IV68_RAT
RGD»
1.5
Itm2a Integral membrane protein 2 Rattus norvegicus
TI:10116 None
 
F1P4X6_CHICK
Ensembl»
1.0
ITM2A Integral membrane protein 2 Gallus gallus
TI:9031 None
   
F7EQ38_ORNAN
Ensembl»
0.0
ITM2A Integral membrane protein 2 Ornithorhynchus anatinus
TI:9258 None
   
F7G818_MONDO
Ensembl»
0.0
BRICHOS domain-containing protein Monodelphis domestica
TI:13616 None
   
G1KAY7_ANOCA
Ensembl»
0.0
Integral membrane protein 2 Anolis carolinensis
TI:28377 None
   
G3RPS3_GORGO
Ensembl»
0.0
ITM2A Integral membrane protein 2 Gorilla gorilla
TI:9593 None
 
H2LWZ8_ORYLA
Ensembl»
0.0
ITM2C Integral membrane protein 2 Oryzias latipes
TI:8090 None
   
H2QYU4_PANTR
Ensembl»
0.0
ITM2A Integral membrane protein 2 Pan troglodytes
TI:9598 None
 
H9G4H2_ANOCA
Ensembl»
0.0
ITM2A Integral membrane protein 2 Anolis carolinensis
TI:28377 None
   
K7GMP3_PIG
Ensembl»
0.0
ITM2A Integral membrane protein 2 Sus scrofa
TI:9823 None
 
M3WCN0_FELCA
Ensembl»
0.0
ITM2C Integral membrane protein 2C Felis catus
TI:9685 None
 
Q6DGT2_DANRE
ZFIN»
1.0
fj52a04 Integral membrane protein 2 Danio rerio
TI:7955 None
 
W5MAI6_LEPOC
Ensembl»
0.0
Integral membrane protein 2 Lepisosteus oculatus
TI:7918 None
 
A0A7M7NJS3_STRPU
EnsemblMetazoa»
0.0
Integral membrane protein 2 Strongylocentrotus purpuratus
TI:7668 None
   
A8XKG2_CAEBR
WormBase»
0.0
CBG14684 CBG_14684 Integral membrane protein 2 Caenorhabditis briggsae
TI:6238 None
 
C3ZHK0_BRAFL
CTD»
0.0
LOC118423765 Integral membrane protein 2 Branchiostoma floridae
TI:7739 None
 
D6WJ30_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_13805 Integral membrane protein 2 Tribolium castaneum
TI:7070 None
 
F6UBN5_MONDO
Ensembl»
0.0
ITM2A Integral membrane protein 2 Monodelphis domestica
TI:13616 None
   
H2KZ11_CAEEL
WormBase»
1.0
itm-2 Integral membrane protein 2 Caenorhabditis elegans
TI:6239 None
 
H2M3I4_ORYLA
Ensembl»
0.0
ITM2A Integral membrane protein 2 Oryzias latipes
TI:8090 None
   
ITM2A_HUMAN
Ensembl»
1.0
ITM2A Integral membrane protein 2A (Protein E25) Homo sapiens
TI:9606 None
 
Q6IP70_XENLA
Xenbase»
0.0
itm2a.L Integral membrane protein 2 Xenopus laevis
TI:8355 None
 
Q7PVX7_ANOGA
EnsemblMetazoa»
0.0
1280111 Integral membrane protein 2 Anopheles gambiae
TI:7165 None
 
Q7ZXQ1_XENLA
Xenbase»
0.0
itm2a.S Integral membrane protein 2 Xenopus laevis
TI:8355 None
 
T1FQ93_HELRO
EnsemblMetazoa»
0.0
20210990 Integral membrane protein 2 Helobdella robusta
TI:6412 None
 
W5NCU4_LEPOC
Ensembl»
0.0
ITM2A Integral membrane protein 2 Lepisosteus oculatus
TI:7918 None
 
A0A8V0XF42_CHICK
Ensembl»
0.0
ITM2B Integral membrane protein 2 Gallus gallus
TI:9031 None
   
Q6P3P6_XENTR
Xenbase»
0.0
itm2b Integral membrane protein 2 Xenopus tropicalis
TI:8364 None
 
A0A8I3PI18_CANLF
Ensembl»
0.0
ITM2C Integral membrane protein 2 Canis lupus
TI:9612 None
   
A0A8V0ZVX0_CHICK
Ensembl»
0.0
ITM2C Integral membrane protein 2 Gallus gallus
TI:9031 None
   
F6WLL4_HORSE
Ensembl»
0.0
ITM2C Integral membrane protein 2 Equus caballus
TI:9796 None
   
H9G095_MACMU
Ensembl»
0.0
ITM2C Integral membrane protein 2 Macaca mulatta
TI:9544 None
 
A0A9J7L9H1_BRAFL
CTD»
0.0
LOC118416861 Integral membrane protein 2 Branchiostoma floridae
TI:7739 None
   
A0A9J7N7M7_BRAFL
CTD»
0.0
LOC118427257 Integral membrane protein 2 Branchiostoma floridae
TI:7739 None
   
B7P6E1_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW016522 Integral membrane protein 2 Ixodes scapularis
TI:6945 None
 
F7AEH6_HORSE
Ensembl»
0.0
ITM2A Integral membrane protein 2 Equus caballus
TI:9796 None
   
ITM2A_MOUSE
Ensembl»
0.8
Itm2a Integral membrane protein 2A (Protein E25) Mus musculus
TI:10090 None
 
Q6GL76_XENTR
Xenbase»
0.0
itm2a Integral membrane protein 2 Xenopus tropicalis
TI:8364 None