Cluster UKP07283
- INTEGRAL TRANSMEMBRANE PROTEIN 2
Standard knownness: 4.0; Custom knownness: None; Num. species: 29; Orthology database: Panther19.0; Protein members: 73
Collated Gene Ontology terms
Molecular function: negative regulation of amyloid precursor protein biosynthetic process2012, 2017, 2024 plasma cell differentiation2016, 2024 neuron differentiation2019, 2024 negative regulation of neuron projection development2010, 2024 positive regulation of extrinsic apoptotic signaling pathway2013, 2024 sexual reproduction2011 nervous system development2003
Cellular component:
plasma membrane2012, 2017, 2024
Golgi apparatus2010, 2017, 2023, 2024
membrane2014, 2024
lysosome2010, 2019, 2024
endosome membrane2024
endosome2024
Golgi membrane2024
lysosomal membrane2024
extracellular space2011, 2012, 2024
organelle membrane2012, 2024
Golgi-associated vesicle membrane2012, 2024
intracellular membrane-bounded organelle2023, 2024
extracellular region2013, 2024
perinuclear region of cytoplasm2010, 2024
extracellular exosome2013, 2014, 2024
Phylogenetic distribution
| Chordates: | 21/21 |  |
| Echinoderms: | 0/0 | |
| Hemichordates: | 1/1 | |
| Annelids: | 1/1 | |
| Molluscs: | 0/0 | |
| Bryozoans: | 0/0 | |
| Platyhelminthes: | 0/0 | |
| Rotifers: | 0/0 | |
| Nematodes: | 2/3 | |
| Arthropods: | 4/5 | |
| Tardigrades: | 0/0 | |
| Placozoa: | 0/1 | |
| Cnidaria: | 0/1 | |
| Porifera: | 0/0 | |
| Choanoflagellates+: | 0/1 | |
| Dikarya: | 0/14 | |
| Fungi (other): | 0/1 | |
| Protozoa: | 0/3 | |
| Excavates: | 0/4 | |
| Harosa: | 0/4 | |
| Hacrobia: | 0/0 | |
| Plants: | 0/39 | |
| Archea: | 0/8 | |
| Bacteria: | 0/35 |
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Proteins
| UniProt ID Organism DB» |
Standard knownness | clustom knownness | Gene name | Description | Species [Key only] | GO terms | Seq. links | Protein domain links | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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G1KAY7_ANOCA Ensembl» |
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Integral membrane protein 2 |
Anolis carolinensis TI:28377 None |
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G1KQA4_ANOCA Ensembl» |
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Integral membrane protein 2 |
Anolis carolinensis TI:28377 None |
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H9G4H2_ANOCA Ensembl» |
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ITM2A | Integral membrane protein 2 |
Anolis carolinensis TI:28377 None |
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Q7PVX7_ANOGA EnsemblMetazoa» |
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1280111 | Integral membrane protein 2 |
Anopheles gambiae TI:7165 None |
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F1N026_BOVIN Ensembl» |
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ITM2B | Integral membrane protein 2 |
Bos taurus TI:9913 None |
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ITM2B_BOVIN CTD» |
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ITM2B | Integral membrane protein 2B (Immature BRI2) (imBRI2) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)] |
Bos taurus TI:9913 None |
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ITM2C_BOVIN Ensembl» |
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ITM2C | Integral membrane protein 2C [Cleaved into: CT-BRI3] |
Bos taurus TI:9913 None |
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A0A9J7L9H1_BRAFL CTD» |
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LOC118416861 | Integral membrane protein 2 |
Branchiostoma floridae TI:7739 None |
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A0A9J7N7M7_BRAFL CTD» |
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LOC118427257 | Integral membrane protein 2 |
Branchiostoma floridae TI:7739 None |
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C3ZHK0_BRAFL CTD» |
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LOC118423765 | Integral membrane protein 2 |
Branchiostoma floridae TI:7739 None |
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A8XKG2_CAEBR WormBase» |
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CBG14684 CBG_14684 | Integral membrane protein 2 |
Caenorhabditis briggsae TI:6238 None |
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H2KZ11_CAEEL WormBase» |
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itm-2 | Integral membrane protein 2 |
Caenorhabditis elegans TI:6239 None |
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A0A8I3N078_CANLF Ensembl» |
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ITM2B | Integral membrane protein 2 |
Canis lupus TI:9612 None |
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A0A8I3PI18_CANLF Ensembl» |
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ITM2C | Integral membrane protein 2 |
Canis lupus TI:9612 None |
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A0A8M9QGD2_DANRE CTD» |
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itm2cb | Integral membrane protein 2 |
Danio rerio TI:7955 None |
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Q6DGT2_DANRE ZFIN» |
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fj52a04 | Integral membrane protein 2 |
Danio rerio TI:7955 None |
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Q7T328_DANRE ZFIN» |
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fb94b03 | Integral membrane protein 2 |
Danio rerio TI:7955 None |
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Q803H7_DANRE ZFIN» |
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itm2b | Integral membrane protein 2 |
Danio rerio TI:7955 None |
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Q9VPT9_DROME FlyBase» |
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Dmel\CG3662 | Integral membrane protein 2 |
Drosophila melanogaster TI:7227 None |
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F6WLL4_HORSE Ensembl» |
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ITM2C | Integral membrane protein 2 |
Equus caballus TI:9796 None |
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F7AEH6_HORSE Ensembl» |
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ITM2A | Integral membrane protein 2 |
Equus caballus TI:9796 None |
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A0A2I2UVC1_FELCA Ensembl» |
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ITM2B | Integral membrane protein 2 |
Felis catus TI:9685 None |
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A0A5F5XX48_FELCA Ensembl» |
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ITM2A | Integral membrane protein 2 |
Felis catus TI:9685 None |
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M3WCN0_FELCA Ensembl» |
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ITM2C | Integral membrane protein 2C |
Felis catus TI:9685 None |
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A0A8V0XF42_CHICK Ensembl» |
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ITM2B | Integral membrane protein 2 |
Gallus gallus TI:9031 None |
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A0A8V0ZVX0_CHICK Ensembl» |
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ITM2C | Integral membrane protein 2 |
Gallus gallus TI:9031 None |
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F1P4X6_CHICK Ensembl» |
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ITM2A | Integral membrane protein 2 |
Gallus gallus TI:9031 None |
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ITM2B_CHICK VEuPathDB» |
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ITM2B | Integral membrane protein 2B (Transmembrane protein E3-16) |
Gallus gallus TI:9031 None |
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G3QII8_GORGO Ensembl» |
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ITM2C | Integral membrane protein 2 |
Gorilla gorilla TI:9593 None |
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G3QV34_GORGO Ensembl» |
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ITM2B | Integral membrane protein 2 |
Gorilla gorilla TI:9593 None |
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G3RPS3_GORGO Ensembl» |
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ITM2A | Integral membrane protein 2 |
Gorilla gorilla TI:9593 None |
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T1FQ93_HELRO EnsemblMetazoa» |
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20210990 | Integral membrane protein 2 |
Helobdella robusta TI:6412 None |
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ITM2A_HUMAN Ensembl» |
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ITM2A | Integral membrane protein 2A (Protein E25) |
Homo sapiens TI:9606 None |
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ITM2B_HUMAN Ensembl» |
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ITM2B | Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)] |
Homo sapiens TI:9606 None |
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ITM2C_HUMAN Ensembl» |
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ITM2C | Integral membrane protein 2C (Cerebral protein 14) (Transmembrane protein BRI3) [Cleaved into: CT-BRI3] |
Homo sapiens TI:9606 None |
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B7P6E1_IXOSC EnsemblMetazoa» |
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IscW_ISCW016522 | Integral membrane protein 2 |
Ixodes scapularis TI:6945 None |
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W5MAI6_LEPOC Ensembl» |
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Integral membrane protein 2 |
Lepisosteus oculatus TI:7918 None |
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W5MWJ3_LEPOC Ensembl» |
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Integral membrane protein 2 |
Lepisosteus oculatus TI:7918 None |
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W5NCU4_LEPOC Ensembl» |
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ITM2A | Integral membrane protein 2 |
Lepisosteus oculatus TI:7918 None |
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A0A5F7Z9Q1_MACMU Ensembl» |
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ITM2A | Integral membrane protein 2 |
Macaca mulatta TI:9544 None |
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F7B0D0_MACMU Ensembl» |
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ITM2B | Integral membrane protein 2 |
Macaca mulatta TI:9544 None |
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H9G095_MACMU Ensembl» |
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ITM2C | Integral membrane protein 2 |
Macaca mulatta TI:9544 None |
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A0A5F8GUP3_MONDO Ensembl» |
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Integral membrane protein 2 |
Monodelphis domestica TI:13616 None |
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F6UBN5_MONDO Ensembl» |
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ITM2A | Integral membrane protein 2 |
Monodelphis domestica TI:13616 None |
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F6ZAG8_MONDO Ensembl» |
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ITM2B | Integral membrane protein 2 |
Monodelphis domestica TI:13616 None |
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F7G818_MONDO Ensembl» |
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BRICHOS domain-containing protein |
Monodelphis domestica TI:13616 None |
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ITM2A_MOUSE Ensembl» |
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Itm2a | Integral membrane protein 2A (Protein E25) |
Mus musculus TI:10090 None |
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ITM2B_MOUSE Ensembl» |
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Itm2b | Integral membrane protein 2B (Immature BRI2) (imBRI2) (Protein E25B) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)] |
Mus musculus TI:10090 None |
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ITM2C_MOUSE Ensembl» |
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Itm2c | Integral membrane protein 2C (Transmembrane protein BRI3) [Cleaved into: CT-BRI3] |
Mus musculus TI:10090 None |
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A0A6I8PB82_ORNAN Ensembl» |
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ITM2C | Integral membrane protein 2 |
Ornithorhynchus anatinus TI:9258 None |
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F7E819_ORNAN Ensembl» |
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ITM2B | Integral membrane protein 2 |
Ornithorhynchus anatinus TI:9258 None |
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F7EQ38_ORNAN Ensembl» |
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ITM2A | Integral membrane protein 2 |
Ornithorhynchus anatinus TI:9258 None |
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A0A3B3H886_ORYLA Ensembl» |
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LOC101161582 | Integral membrane protein 2 |
Oryzias latipes TI:8090 None |
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H2LW72_ORYLA Ensembl» |
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itm2b | Integral membrane protein 2 |
Oryzias latipes TI:8090 None |
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H2LWZ8_ORYLA Ensembl» |
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ITM2C | Integral membrane protein 2 |
Oryzias latipes TI:8090 None |
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H2M3I4_ORYLA Ensembl» |
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ITM2A | Integral membrane protein 2 |
Oryzias latipes TI:8090 None |
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H2QJK7_PANTR Ensembl» |
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ITM2C | Integral membrane protein 2 |
Pan troglodytes TI:9598 None |
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H2QYU4_PANTR Ensembl» |
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ITM2A | Integral membrane protein 2 |
Pan troglodytes TI:9598 None |
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ITM2B_PANTR Ensembl» |
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ITM2B | Integral membrane protein 2B (Immature BRI2) (imBRI2) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)] |
Pan troglodytes TI:9598 None |
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A6IV68_RAT RGD» |
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Itm2a | Integral membrane protein 2 |
Rattus norvegicus TI:10116 None |
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ITM2B_RAT RGD» |
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Itm2b | Integral membrane protein 2B (Immature BRI2) (imBRI2) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)] |
Rattus norvegicus TI:10116 None |
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ITM2C_RAT RGD» |
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Itm2c | Integral membrane protein 2C [Cleaved into: CT-BRI3] |
Rattus norvegicus TI:10116 None |
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A0A7M7NJS3_STRPU EnsemblMetazoa» |
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Integral membrane protein 2 |
Strongylocentrotus purpuratus TI:7668 None |
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F1RK12_PIG Ensembl» |
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ITM2B | Integral membrane protein 2 |
Sus scrofa TI:9823 None |
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ITM2B_PIG CTD» |
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ITM2B | Integral membrane protein 2B (Immature BRI2) (imBRI2) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)] |
Sus scrofa TI:9823 None |
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ITM2C_PIG Ensembl» |
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ITM2C | Integral membrane protein 2C [Cleaved into: CT-BRI3] |
Sus scrofa TI:9823 None |
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K7GMP3_PIG Ensembl» |
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ITM2A | Integral membrane protein 2 |
Sus scrofa TI:9823 None |
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D6WJ30_TRICA EnsemblMetazoa» |
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AUGUSTUS-3.0.2_13805 | Integral membrane protein 2 |
Tribolium castaneum TI:7070 None |
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Q6GL76_XENTR Xenbase» |
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itm2a | Integral membrane protein 2 |
Xenopus tropicalis TI:8364 None |
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Q6IP70_XENLA Xenbase» |
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itm2a.L | Integral membrane protein 2 |
Xenopus laevis TI:8355 None |
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Q6P3P6_XENTR Xenbase» |
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itm2b | Integral membrane protein 2 |
Xenopus tropicalis TI:8364 None |
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Q7ZXQ1_XENLA Xenbase» |
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itm2a.S | Integral membrane protein 2 |
Xenopus laevis TI:8355 None |
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Q8AVF1_XENLA Xenbase» |
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itm2b.L | Integral membrane protein 2 |
Xenopus laevis TI:8355 None |
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