Collated Gene Ontology terms

Biological process: cysteine-type endopeptidase inhibitor activity involved in apoptotic process(2007, 2017, 2023) identical protein binding(2023) phosphatidylinositol transfer activity(2015, 2020, 2023) phosphatidylinositol binding(2015, 2023) small molecule binding(2022) molecular sequestering activity(2022)

Molecular function: regulation of apoptotic process2023 negative regulation of inflammatory response2012, 2017, 2023 negative regulation of T cell activation2012, 2017, 2023 negative regulation of TOR signaling2014, 2017, 2023 positive regulation of apoptotic process2017, 2023 T cell activation2012, 2023 innate immune response2023 immune system process2023 positive regulation of ERK1 and ERK2 cascade2015, 2023 phospholipid transport2015, 2023
intermembrane lipid transfer2023 apoptotic process2023 lipid transport2023 defense response to Gram-positive bacterium2013 salivary gland morphogenesis2015 regulation of microtubule cytoskeleton organization2015 regulation of autophagy2015 positive regulation of JNK cascade2015 phospholipid metabolic process2023 negative regulation of apoptotic process2003

Cellular component: cytoplasm2007, 2012, 2014, 2015, 2017, 2023 nucleoplasm2023 cytosol2016, 2023 plasma membrane2015, 2023 nucleus2023 lysosome2023 membrane2023 cytoskeleton2023 cell projection2015

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 1/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 0 2 4 6 8 10 Knownness

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A0G2K2P3_RAT
RGD»
3.0
Tnfaip8 TNF alpha induced protein 8 Rattus norvegicus
TI:10116 None
   
A0A2A6BUQ3_PRIPA
EnsemblMetazoa»
0.0
WBGene00115702 Uncharacterized protein Pristionchus pacificus
TI:54126 None
 
A0A2I2UTF9_FELCA
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Felis catus
TI:9685 None
 
A0A2I2UZA0_FELCA
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Felis catus
TI:9685 None
 
A0A2I2ZF89_GORGO
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Gorilla gorilla
TI:9593 None
 
A0A3B3HWN8_ORYLA
Ensembl»
0.0
tnfaip8l3 TNF alpha induced protein 8 like 3 Oryzias latipes
TI:8090 None
   
A0A3B3HXL8_ORYLA
Ensembl»
0.0
LOC101164796 Tumor necrosis factor alpha-induced
protein 8-like protein 1		 Oryzias latipes
TI:8090 None
   
A0A3B3IB86_ORYLA
Ensembl»
0.0
LOC101166904 Tumor necrosis factor, alpha-induced
protein 8-like protein 2 B		 Oryzias latipes
TI:8090 None
   
A0A3Q3AZP2_CHICK
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Gallus gallus
TI:9031 None
   
A0A4X1SYB6_PIG
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Sus scrofa
TI:9823 None
   
A0A4X1VRK3_PIG
Ensembl»
0.0
TNFAIP8L1 TNF alpha induced protein 8 like 1 Sus scrofa
TI:9823 None
   
A0A5F8GJM7_MONDO
Ensembl»
0.0
Tumor necrosis factor alpha-induced protein 8 Monodelphis domestica
TI:13616 None
   
A0A5F8GYV3_MONDO
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Monodelphis domestica
TI:13616 None
   
A0A6I8PHY1_ORNAN
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8R443_XENTR
Xenbase»
0.0
tnfaip8l3 TNF alpha induced protein 8 like 3
(Tumor necrosis factor alpha-induced protein 8-like protein 3)		 Xenopus tropicalis
TI:8364 None
   
A0A7M7GNH7_STRPU
EnsemblMetazoa»
0.0
Tumor necrosis factor
alpha-induced protein 8-like protein		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A8D1D4H1_PIG
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Sus scrofa
TI:9823 None
   
A0A8I3MV62_CANLF
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Canis lupus
TI:9612 None
   
A0A8I3P2D3_CANLF
Ensembl»
0.0
TNFAIP8L1 TNF alpha induced protein 8 like 1 Canis lupus
TI:9612 None
   
A0A8I3PPH9_CANLF
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2 Canis lupus
TI:9612 None
   
A0A8I3S4Z4_CANLF
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Canis lupus
TI:9612 None
   
A0A8I5ZY03_RAT
RGD»
1.5
Tnfaip8l1 TNF alpha induced protein 8 like 1 Rattus norvegicus
TI:10116 None
   
A0A9J7MHL8_BRAFL
CTD»
0.0
LOC118409992 Tumor necrosis factor alpha-induced
protein 8-like protein isoform X1		 Branchiostoma floridae
TI:7739 None
   
A7SGA8_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g189527 Tumor necrosis factor
alpha-induced protein 8-like protein		 Nematostella vectensis
TI:45351 None
 
A9UVZ6_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_31877 Tumor necrosis factor
alpha-induced protein 8-like protein		 Monosiga brevicollis
TI:81824 None
 
B3S862_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_30950 Tumor necrosis factor
alpha-induced protein 8-like protein		 Trichoplax adhaerens
TI:10228 None
 
B7Q629_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW011774 Tumor necrosis factor induced protein, putative Ixodes scapularis
TI:6945 None
 
D6WCZ3_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_04961 Tumor necrosis factor
alpha-induced protein 8-like protein		 Tribolium castaneum
TI:7070 None
 
E9G2H5_DAPPU
EnsemblMetazoa»
0.0
EOG090X0GLS EOG090X0GLS Daphnia pulex
TI:6669 None
 
F1LX20_RAT
RGD»
2.0
Tnfaip8l3 TNF alpha induced protein 8 like 3 Rattus norvegicus
TI:10116 None
   
F1N6N6_BOVIN
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Bos taurus
TI:9913 None
   
F1NZ26_CHICK
Ensembl»
0.5
TNFAIP8L1 TNF alpha induced protein 8 like 1 Gallus gallus
TI:9031 None
   
F1SSY0_PIG
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2
(Tumor necrosis factor alpha-induced protein 8-like 2)		 Sus scrofa
TI:9823 None
 
F5HKB6_ANOGA
EnsemblMetazoa»
0.0
1272961 AGAP002997-PC Anopheles gambiae
TI:7165 None
 
F6QWM5_HORSE
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Equus caballus
TI:9796 None
   
F6U4Y1_HORSE
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Equus caballus
TI:9796 None
   
F6UGS6_MONDO
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Monodelphis domestica
TI:13616 None
   
F6UIW8_ORNAN
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Ornithorhynchus anatinus
TI:9258 None
   
F6YPI6_XENTR
Xenbase»
0.0
tnfaip8 Tumor necrosis factor alpha-induced protein 8 (Tumor
necrosis factor alpha-induced protein 8 isoform X1)		 Xenopus tropicalis
TI:8364 None
   
F6ZF96_MONDO
Ensembl»
0.0
TNFAIP8L1 TNF alpha induced protein 8 like 1 Monodelphis domestica
TI:13616 None
   
F7AZH6_MACMU
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2
(Tumor necrosis factor alpha-induced protein 8-like protein 2)		 Macaca mulatta
TI:9544 None
 
F7CMS2_MONDO
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2 Monodelphis domestica
TI:13616 None
   
F7D0A7_MACMU
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Macaca mulatta
TI:9544 None
   
F7EY21_ORNAN
Ensembl»
0.0
TNFAIP8L1 TNF alpha induced protein 8 like 1 Ornithorhynchus anatinus
TI:9258 None
   
F7G2C3_ORNAN
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2 Ornithorhynchus anatinus
TI:9258 None
   
F7GS55_MACMU
Ensembl»
0.0
TNFAIP8L1 TNF alpha induced protein 8 like 1 Macaca mulatta
TI:9544 None
   
G3RDT4_GORGO
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2 Gorilla gorilla
TI:9593 None
 
G3RSV4_GORGO
Ensembl»
0.0
TNF alpha induced protein 8 like 3 Gorilla gorilla
TI:9593 None
 
H2PZX9_PANTR
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2 Pan troglodytes
TI:9598 None
 
H2Q9F4_PANTR
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Pan troglodytes
TI:9598 None
 
H2QRD4_PANTR
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8
(Tumor necrosis factor, alpha-induced protein 8)		 Pan troglodytes
TI:9598 None
 
H2R6G8_PANTR
Ensembl»
0.0
TNFAIP8L1 TNF alpha induced protein 8 like 1
(Tumor necrosis factor, alpha-induced protein 8-like 1)		 Pan troglodytes
TI:9598 None
 
H9G4S8_ANOCA
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Anolis carolinensis
TI:28377 None
   
H9G8B7_ANOCA
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Anolis carolinensis
TI:28377 None
   
H9GLD4_ANOCA
Ensembl»
0.0
TNF alpha induced protein 8 like 2 Anolis carolinensis
TI:28377 None
   
M3W497_FELCA
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2 Felis catus
TI:9685 None
 
M3WM33_FELCA
Ensembl»
0.0
TNFAIP8L1 TNF alpha induced protein 8 like 1 Felis catus
TI:9685 None
 
T1END6_HELRO
EnsemblMetazoa»
0.0
20198086 Tumor necrosis factor
alpha-induced protein 8-like protein		 Helobdella robusta
TI:6412 None
 
TFIP8_BOVIN
Ensembl»
0.0
TNFAIP8 Tumor necrosis factor alpha-induced protein
8 (TNF alpha-induced protein 8)		 Bos taurus
TI:9913 None
 
TFIP8_CHICK
Ensembl»
1.5
TNFAIP8 Tumor necrosis factor alpha-induced protein
8 (TNF alpha-induced protein 8)		 Gallus gallus
TI:9031 None
 
TFIP8_HUMAN
Ensembl»
3.0
TNFAIP8 Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) (Head and neck
tumor and metastasis-related protein) (MDC-3.13) (NF-kappa-B-inducible DED-containing protein) (NDED) (SCC-S2) (TNF-induced protein GG2-1)		 Homo sapiens
TI:9606 None
 
TFIP8_MOUSE
Ensembl»
4.9
Tnfaip8 Tumor necrosis factor alpha-induced protein
8 (TNF alpha-induced protein 8)		 Mus musculus
TI:10090 None
 
TFIP8_XENTR
Xenbase»
0.0
tnfaip8 Tumor necrosis factor alpha-induced protein
8 (TNF alpha-induced protein 8)		 Xenopus tropicalis
TI:8364 None
 
TFP8L_DROME
FlyBase»
4.2
sigmar Protein salivary glands marred (Tumor necrosis factor alpha-induced
protein 8-like protein) (TNF alpha-induced protein 8-like protein)		 Drosophila melanogaster
TI:7227 None
 
TP8L1_BOVIN
Ensembl»
0.0
TNFAIP8L1 Tumor necrosis factor alpha-induced protein 8-like protein 1 (TIPE1)
(TNF alpha-induced protein 8-like protein 1) (TNFAIP8-like protein 1)		 Bos taurus
TI:9913 None
 
TP8L1_CHICK
CTD»
1.0
TNFAIP8L1 Tumor necrosis factor alpha-induced protein 8-like protein 1 (TIPE1)
(TNF alpha-induced protein 8-like protein 1) (TNFAIP8-like protein 1)		 Gallus gallus
TI:9031 None
 
TP8L1_DANRE
ZFIN»
0.5
tnfaip8l1 Tumor necrosis factor alpha-induced protein 8-like protein 1 (TIPE1)
(TNF alpha-induced protein 8-like protein 1) (TNFAIP8-like protein 1)		 Danio rerio
TI:7955 None
 
TP8L1_HUMAN
Ensembl»
1.8
TNFAIP8L1 Tumor necrosis factor alpha-induced protein 8-like protein 1 (TIPE1) (TNF alpha-induced
protein 8-like protein 1) (TNFAIP8-like protein 1) (Oxidative stress-regulated gene-beta) (Oxy-beta)		 Homo sapiens
TI:9606 None
 
TP8L1_MOUSE
Ensembl»
1.8
Tnfaip8l1 Tumor necrosis factor alpha-induced protein 8-like protein 1 (TIPE1) (TNF alpha-induced
protein 8-like protein 1) (TNFAIP8-like protein 1) (Oxidative stress regulated gene-beta) (Oxy-beta)		 Mus musculus
TI:10090 None
 
TP8L2_BOVIN
Ensembl»
0.0
TNFAIP8L2 Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2)
(TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2)		 Bos taurus
TI:9913 None
 
TP8L2_HUMAN
Ensembl»
1.0
TNFAIP8L2 Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2) (TNF alpha-induced
protein 8-like protein 2) (TNFAIP8-like protein 2) (Inflammation factor protein 20)		 Homo sapiens
TI:9606 None
 
TP8L2_MOUSE
Ensembl»
3.4
Tnfaip8l2 Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2)
(TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2)		 Mus musculus
TI:10090 None
 
TP8L2_RAT
RGD»
2.5
Tnfaip8l2 Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2)
(TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2)		 Rattus norvegicus
TI:10116 None
 
TP8L2_XENTR
Xenbase»
0.0
tnfaip8l2 Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2)
(TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2)		 Xenopus tropicalis
TI:8364 None
 
TP8L3_DANRE
ZFIN»
0.0
tnfaip8l3 Tumor necrosis factor alpha-induced protein 8-like protein 3
(TNF alpha-induced protein 8-like protein 3) (TNFAIP8-like protein 3)		 Danio rerio
TI:7955 None
 
TP8L3_HUMAN
Ensembl»
3.8
TNFAIP8L3 Tumor necrosis factor alpha-induced protein 8-like protein 3
(TNF alpha-induced protein 8-like protein 3) (TNFAIP8-like protein 3)		 Homo sapiens
TI:9606 None
 
TP8L3_MOUSE
Ensembl»
3.2
Tnfaip8l3 Tumor necrosis factor alpha-induced protein 8-like protein 3
(TNF alpha-induced protein 8-like protein 3) (TNFAIP8-like protein 3)		 Mus musculus
TI:10090 None
 
TPL2A_DANRE
ZFIN»
0.0
tnfaip8l2a Tumor necrosis factor, alpha-induced protein 8-like protein 2 A (TIPE2 A)
(TNF alpha-induced protein 8-like protein 2 A) (TNFAIP8-like protein 2 A)		 Danio rerio
TI:7955 None
 
TPL2B_DANRE
ZFIN»
0.0
tnfaip8l2b Tumor necrosis factor, alpha-induced protein 8-like protein 2 B (TIPE2 B)
(TNF alpha-induced protein 8-like protein 2 B) (TNFAIP8-like protein 2 B)		 Danio rerio
TI:7955 None
 
W5M8T8_LEPOC
Ensembl»
0.0
Tumor necrosis factor,
alpha-induced protein 8-like 1		 Lepisosteus oculatus
TI:7918 None
 
W5MM33_LEPOC
Ensembl»
0.0
Tumor necrosis factor,
alpha-induced protein 8-like 2b		 Lepisosteus oculatus
TI:7918 None
 
W5MQU8_LEPOC
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Lepisosteus oculatus
TI:7918 None
 
W5N6Z8_LEPOC
Ensembl»
0.0
TNF alpha induced protein 8 like 3 Lepisosteus oculatus
TI:7918 None