Collated Gene Ontology terms

Biological process: cysteine-type endopeptidase inhibitor activity involved in apoptotic process(2007, 2017, 2024) identical protein binding(2024) phosphatidylinositol transfer activity(2015, 2020, 2024) phosphatidylinositol binding(2015, 2024) small molecule binding(2022) molecular sequestering activity(2022)

Molecular function: regulation of apoptotic process2024 negative regulation of inflammatory response2012, 2017, 2024 negative regulation of T cell activation2012, 2017, 2024 negative regulation of TOR signaling2014, 2017, 2024 innate immune response2024 apoptotic process2024 positive regulation of apoptotic process2017, 2024 T cell activation2012, 2024 positive regulation of ERK1 and ERK2 cascade2015, 2024 phospholipid transport2015, 2024
intermembrane lipid transfer2024 lipid transport2024 defense response to Gram-positive bacterium2013 salivary gland morphogenesis2015 regulation of microtubule cytoskeleton organization2015 regulation of autophagy2015 positive regulation of JNK cascade2015 phospholipid metabolic process2024 negative regulation of apoptotic process2003

Cellular component: cytoplasm2007, 2012, 2014, 2015, 2017, 2024 nucleoplasm2023, 2024 cytosol2016, 2023, 2024 plasma membrane2015, 2024 nucleus2024 lysosome2024 cytoskeleton2024 cell projection2015

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 1/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A0G2K2P3_RAT
RGD»
3.0
Tnfaip8 TNF alpha induced protein 8 Rattus norvegicus
TI:10116 None
   
A0A1L8F4R6_XENLA
Xenbase»
0.0
tnfaip8l2.S Tumor necrosis factor alpha-induced protein
8-like protein 2 isoform X1		 Xenopus laevis
TI:8355 None
   
A0A2A6BUQ3_PRIPA
EnsemblMetazoa»
0.0
WBGene00115702 Uncharacterized protein Pristionchus pacificus
TI:54126 None
 
A0A2I2UTF9_FELCA
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Felis catus
TI:9685 None
 
A0A2I2UZA0_FELCA
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Felis catus
TI:9685 None
 
A0A2I3TBB9_PANTR
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Pan troglodytes
TI:9598 None
 
A0A3B3HWN8_ORYLA
Ensembl»
0.0
tnfaip8l3 TNF alpha induced protein 8 like 3 Oryzias latipes
TI:8090 None
   
A0A3B3HXL8_ORYLA
Ensembl»
0.0
LOC101164796 Tumor necrosis factor alpha-induced
protein 8-like protein 1		 Oryzias latipes
TI:8090 None
   
A0A3B3IB86_ORYLA
Ensembl»
0.0
LOC101166904 Tumor necrosis factor, alpha-induced
protein 8-like protein 2 B		 Oryzias latipes
TI:8090 None
   
A0A3Q2HS48_HORSE
Ensembl»
0.0
TNFAIP8L1 TNF alpha induced protein 8 like 1 Equus caballus
TI:9796 None
   
A0A3Q3AZP2_CHICK
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Gallus gallus
TI:9031 None
   
A0A4X1SYB6_PIG
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Sus scrofa
TI:9823 None
   
A0A4X1VRK3_PIG
Ensembl»
0.0
TNFAIP8L1 TNF alpha induced protein 8 like 1 Sus scrofa
TI:9823 None
   
A0A5F8GJM7_MONDO
Ensembl»
0.0
Tumor necrosis factor alpha-induced protein 8 Monodelphis domestica
TI:13616 None
   
A0A5F8GYV3_MONDO
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Monodelphis domestica
TI:13616 None
   
A0A6I8R443_XENTR
Xenbase»
0.0
tnfaip8l3 TNF alpha induced protein 8 like 3
(Tumor necrosis factor alpha-induced protein 8-like protein 3)		 Xenopus tropicalis
TI:8364 None
   
A0A7M7GNH7_STRPU
EnsemblMetazoa»
0.0
Tumor necrosis factor
alpha-induced protein 8-like protein		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A8D1D4H1_PIG
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Sus scrofa
TI:9823 None
   
A0A8I3MV62_CANLF
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Canis lupus
TI:9612 None
   
A0A8I3P2D3_CANLF
Ensembl»
0.0
TNFAIP8L1 TNF alpha induced protein 8 like 1 Canis lupus
TI:9612 None
   
A0A8I3PPH9_CANLF
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2 Canis lupus
TI:9612 None
   
A0A8I3S4Z4_CANLF
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Canis lupus
TI:9612 None
   
A0A8I5ZY03_RAT
RGD»
1.5
Tnfaip8l1 TNF alpha induced protein 8 like 1 Rattus norvegicus
TI:10116 None
   
A0A8J0TY13_XENLA
Xenbase»
0.0
tnfaip8.S Tumor necrosis factor alpha-induced protein 8 Xenopus laevis
TI:8355 None
   
A0A8J0USB9_XENLA
Xenbase»
0.0
tnfaip8l3.L Tumor necrosis factor alpha-induced
protein 8-like protein 3		 Xenopus laevis
TI:8355 None
   
A0A8J0VDD2_XENLA
Xenbase»
0.0
tnfaip8.L Tumor necrosis factor alpha-induced protein 8 Xenopus laevis
TI:8355 None
   
A0A8J1MR46_XENLA
Xenbase»
0.0
tnfaip8l3.S Tumor necrosis factor alpha-induced protein
8-like protein 3 isoform X1		 Xenopus laevis
TI:8355 None
   
A0A9J7MHL8_BRAFL
CTD»
0.0
LOC118409992 Tumor necrosis factor alpha-induced
protein 8-like protein isoform X1		 Branchiostoma floridae
TI:7739 None
   
A7SGA8_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g189527 Tumor necrosis factor
alpha-induced protein 8-like protein		 Nematostella vectensis
TI:45351 None
 
A9UVZ6_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_31877 Tumor necrosis factor
alpha-induced protein 8-like protein		 Monosiga brevicollis
TI:81824 None
 
B3S862_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_30950 Tumor necrosis factor
alpha-induced protein 8-like protein		 Trichoplax adhaerens
TI:10228 None
 
B7Q629_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW011774 Tumor necrosis factor induced protein, putative Ixodes scapularis
TI:6945 None
 
D6WCZ3_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_04961 Tumor necrosis factor
alpha-induced protein 8-like protein		 Tribolium castaneum
TI:7070 None
 
E9G2H5_DAPPU
EnsemblMetazoa»
0.0
EOG090X0GLS EOG090X0GLS Daphnia pulex
TI:6669 None
 
F1LX20_RAT
RGD»
2.0
Tnfaip8l3 TNF alpha induced protein 8 like 3 Rattus norvegicus
TI:10116 None
   
F1NZ26_CHICK
Ensembl»
0.5
TNFAIP8L1 TNF alpha induced protein 8 like 1 Gallus gallus
TI:9031 None
   
F1SSY0_PIG
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2
(Tumor necrosis factor alpha-induced protein 8-like 2)		 Sus scrofa
TI:9823 None
 
F5HKB6_ANOGA
EnsemblMetazoa»
0.0
1272961 AGAP002997-PC Anopheles gambiae
TI:7165 None
 
F6QWM5_HORSE
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Equus caballus
TI:9796 None
   
F6U4Y1_HORSE
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Equus caballus
TI:9796 None
   
F6UGS6_MONDO
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Monodelphis domestica
TI:13616 None
   
F6UIW8_ORNAN
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Ornithorhynchus anatinus
TI:9258 None
   
F6ZF96_MONDO
Ensembl»
0.0
TNFAIP8L1 TNF alpha induced protein 8 like 1 Monodelphis domestica
TI:13616 None
   
F7AZH6_MACMU
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2
(Tumor necrosis factor alpha-induced protein 8-like protein 2)		 Macaca mulatta
TI:9544 None
 
F7BRR0_ORNAN
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Ornithorhynchus anatinus
TI:9258 None
   
F7CMS2_MONDO
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2 Monodelphis domestica
TI:13616 None
   
F7D0A7_MACMU
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Macaca mulatta
TI:9544 None
   
F7EY21_ORNAN
Ensembl»
0.0
TNFAIP8L1 TNF alpha induced protein 8 like 1 Ornithorhynchus anatinus
TI:9258 None
   
F7G2C3_ORNAN
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2 Ornithorhynchus anatinus
TI:9258 None
   
F7GS55_MACMU
Ensembl»
0.0
TNFAIP8L1 TNF alpha induced protein 8 like 1 Macaca mulatta
TI:9544 None
   
G3QKF7_GORGO
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Gorilla gorilla
TI:9593 None
 
G3RDT4_GORGO
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2 Gorilla gorilla
TI:9593 None
 
G3RSV4_GORGO
Ensembl»
0.0
TNF alpha induced protein 8 like 3 Gorilla gorilla
TI:9593 None
 
H2PZX9_PANTR
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2 Pan troglodytes
TI:9598 None
 
H2Q9F4_PANTR
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Pan troglodytes
TI:9598 None
 
H2R6G8_PANTR
Ensembl»
0.0
TNFAIP8L1 TNF alpha induced protein 8 like 1
(Tumor necrosis factor, alpha-induced protein 8-like 1)		 Pan troglodytes
TI:9598 None
 
H9G4S8_ANOCA
Ensembl»
0.0
TNFAIP8L3 TNF alpha induced protein 8 like 3 Anolis carolinensis
TI:28377 None
   
H9G8B7_ANOCA
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Anolis carolinensis
TI:28377 None
   
H9GLD4_ANOCA
Ensembl»
0.0
TNF alpha induced protein 8 like 2 Anolis carolinensis
TI:28377 None
   
M3W497_FELCA
Ensembl»
0.0
TNFAIP8L2 TNF alpha induced protein 8 like 2 Felis catus
TI:9685 None
 
M3WM33_FELCA
Ensembl»
0.0
TNFAIP8L1 TNF alpha induced protein 8 like 1 Felis catus
TI:9685 None
 
T1END6_HELRO
EnsemblMetazoa»
0.0
20198086 Tumor necrosis factor
alpha-induced protein 8-like protein		 Helobdella robusta
TI:6412 None
 
TFIP8_BOVIN
Ensembl»
0.0
TNFAIP8 Tumor necrosis factor alpha-induced protein
8 (TNF alpha-induced protein 8)		 Bos taurus
TI:9913 None
 
TFIP8_CHICK
Ensembl»
1.5
TNFAIP8 Tumor necrosis factor alpha-induced protein
8 (TNF alpha-induced protein 8)		 Gallus gallus
TI:9031 None
 
TFIP8_HUMAN
Ensembl»
3.0
TNFAIP8 Tumor necrosis factor alpha-induced protein 8 (TNF alpha-induced protein 8) (Head and neck
tumor and metastasis-related protein) (MDC-3.13) (NF-kappa-B-inducible DED-containing protein) (NDED) (SCC-S2) (TNF-induced protein GG2-1)		 Homo sapiens
TI:9606 None
 
TFIP8_MOUSE
Ensembl»
3.4
Tnfaip8 Tumor necrosis factor alpha-induced protein
8 (TNF alpha-induced protein 8)		 Mus musculus
TI:10090 None
 
TFIP8_XENLA
Xenbase»
0.0
tnfaip8 Tumor necrosis factor alpha-induced protein
8 (TNF alpha-induced protein 8)		 Xenopus laevis
TI:8355 None
 
TFIP8_XENTR
Xenbase»
0.0
tnfaip8 Tumor necrosis factor alpha-induced protein
8 (TNF alpha-induced protein 8)		 Xenopus tropicalis
TI:8364 None
 
TFP8L_DROME
FlyBase»
4.2
sigmar Protein salivary glands marred (Tumor necrosis factor alpha-induced
protein 8-like protein) (TNF alpha-induced protein 8-like protein)		 Drosophila melanogaster
TI:7227 None
 
TP8L1_BOVIN
Ensembl»
0.0
TNFAIP8L1 Tumor necrosis factor alpha-induced protein 8-like protein 1 (TIPE1)
(TNF alpha-induced protein 8-like protein 1) (TNFAIP8-like protein 1)		 Bos taurus
TI:9913 None
 
TP8L1_CHICK
CTD»
1.0
TNFAIP8L1 Tumor necrosis factor alpha-induced protein 8-like protein 1 (TIPE1)
(TNF alpha-induced protein 8-like protein 1) (TNFAIP8-like protein 1)		 Gallus gallus
TI:9031 None
 
TP8L1_DANRE
ZFIN»
0.5
tnfaip8l1 Tumor necrosis factor alpha-induced protein 8-like protein 1 (TIPE1)
(TNF alpha-induced protein 8-like protein 1) (TNFAIP8-like protein 1)		 Danio rerio
TI:7955 None
 
TP8L1_HUMAN
Ensembl»
1.8
TNFAIP8L1 Tumor necrosis factor alpha-induced protein 8-like protein 1 (TIPE1) (TNF alpha-induced
protein 8-like protein 1) (TNFAIP8-like protein 1) (Oxidative stress-regulated gene-beta) (Oxy-beta)		 Homo sapiens
TI:9606 None
 
TP8L1_MOUSE
Ensembl»
0.8
Tnfaip8l1 Tumor necrosis factor alpha-induced protein 8-like protein 1 (TIPE1) (TNF alpha-induced
protein 8-like protein 1) (TNFAIP8-like protein 1) (Oxidative stress regulated gene-beta) (Oxy-beta)		 Mus musculus
TI:10090 None
 
TP8L2_BOVIN
Ensembl»
0.0
TNFAIP8L2 Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2)
(TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2)		 Bos taurus
TI:9913 None
 
TP8L2_HUMAN
Ensembl»
1.0
TNFAIP8L2 Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2) (TNF alpha-induced
protein 8-like protein 2) (TNFAIP8-like protein 2) (Inflammation factor protein 20)		 Homo sapiens
TI:9606 None
 
TP8L2_MOUSE
Ensembl»
2.4
Tnfaip8l2 Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2)
(TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2)		 Mus musculus
TI:10090 None
 
TP8L2_RAT
RGD»
2.5
Tnfaip8l2 Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2)
(TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2)		 Rattus norvegicus
TI:10116 None
 
TP8L2_XENLA
Xenbase»
0.0
tnfaip8l2 Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2)
(TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2)		 Xenopus laevis
TI:8355 None
 
TP8L2_XENTR
Xenbase»
0.0
tnfaip8l2 Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2)
(TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2)		 Xenopus tropicalis
TI:8364 None
 
TP8L3_DANRE
ZFIN»
0.0
tnfaip8l3 Tumor necrosis factor alpha-induced protein 8-like protein 3
(TNF alpha-induced protein 8-like protein 3) (TNFAIP8-like protein 3)		 Danio rerio
TI:7955 None
 
TP8L3_HUMAN
Ensembl»
3.8
TNFAIP8L3 Tumor necrosis factor alpha-induced protein 8-like protein 3
(TNF alpha-induced protein 8-like protein 3) (TNFAIP8-like protein 3)		 Homo sapiens
TI:9606 None
 
TP8L3_MOUSE
Ensembl»
3.2
Tnfaip8l3 Tumor necrosis factor alpha-induced protein 8-like protein 3
(TNF alpha-induced protein 8-like protein 3) (TNFAIP8-like protein 3)		 Mus musculus
TI:10090 None
 
TP8L3_XENLA
Xenbase»
0.0
tnfaip8l3 Tumor necrosis factor alpha-induced protein 8-like protein 3
(TNF alpha-induced protein 8-like protein 3) (TNFAIP8-like protein 3)		 Xenopus laevis
TI:8355 None
 
TPL2A_DANRE
ZFIN»
0.0
tnfaip8l2a Tumor necrosis factor, alpha-induced protein 8-like protein 2 A (TIPE2 A)
(TNF alpha-induced protein 8-like protein 2 A) (TNFAIP8-like protein 2 A)		 Danio rerio
TI:7955 None
 
TPL2B_DANRE
ZFIN»
0.0
tnfaip8l2b Tumor necrosis factor, alpha-induced protein 8-like protein 2 B (TIPE2 B)
(TNF alpha-induced protein 8-like protein 2 B) (TNFAIP8-like protein 2 B)		 Danio rerio
TI:7955 None
 
W5M8T8_LEPOC
Ensembl»
0.0
Tumor necrosis factor,
alpha-induced protein 8-like 1		 Lepisosteus oculatus
TI:7918 None
 
W5MM33_LEPOC
Ensembl»
0.0
Tumor necrosis factor,
alpha-induced protein 8-like 2b		 Lepisosteus oculatus
TI:7918 None
 
W5MQU8_LEPOC
Ensembl»
0.0
TNFAIP8 TNF alpha induced protein 8 Lepisosteus oculatus
TI:7918 None
 
W5N6Z8_LEPOC
Ensembl»
0.0
TNF alpha induced protein 8 like 3 Lepisosteus oculatus
TI:7918 None