Collated Gene Ontology terms

Biological process: protein kinase activity(2025) nucleotide binding(2025) molecular adaptor activity(2024) ATP binding(2025)

Molecular function: retrograde transport, endosome to Golgi2013, 2024, 2025 endocytosis2009, 2017, 2025 intracellular protein localization2013, 2017, 2025 protein transport2025 apical protein localization2015, 2025 intracellular protein transport2006 clathrin-coated vesicle cargo loading, AP-1-mediated2020 axis elongation2018

Cellular component: Golgi apparatus2009, 2024, 2025 endocytic vesicle2009, 2017, 2025 cytosol2009, 2025 cytoplasmic vesicle2025 clathrin-coated vesicle2024, 2025 nucleus2009, 2025 membrane2014, 2025 perinuclear region of cytoplasm2025 nucleoplasm2025 cytoplasm2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
LAA1_YEAST
SGD»
4.7
LAA1 AP-1 accessory protein LAA1
(Large AP-1 accessory protein 1)		 Saccharomyces cerevisiae
TI:4932 None
 
SIP1_SCHPO
PomBase»
3.3
sip1 Pof6 interactor protein 1 Schizosaccharomyces pombe
TI:4896 None
 
A0A0B4KGF6_DROME
FlyBase»
3.1
Heatr5 HEAT repeat-containing protein 5A Drosophila melanogaster
TI:7227 None
 
O01485_CAEEL
WormBase»
2.3
soap-1 HEAT repeat-containing protein 5B Caenorhabditis elegans
TI:6239 None
 
A0A0R4ISV1_DANRE
ZFIN»
1.5
heatr5b HEAT repeat-containing protein 5B Danio rerio
TI:7955 None
 
A0A8V0XMK3_CHICK
Ensembl»
1.5
HEATR5A HEAT repeat-containing protein 5A Gallus gallus
TI:9031 None
   
E1C8J1_CHICK
Ensembl»
1.5
HEATR5B HEAT repeat-containing protein 5B Gallus gallus
TI:9031 None
   
HTR5A_DANRE
CTD»
1.5
heatr5a HEAT repeat-containing protein 5A Danio rerio
TI:7955 None
 
HTR5A_HUMAN
Ensembl»
1.5
HEATR5A HEAT repeat-containing protein 5A Homo sapiens
TI:9606 None
 
HTR5A_MOUSE
Ensembl»
1.5
Heatr5a HEAT repeat-containing protein 5A Mus musculus
TI:10090 None
 
HTR5B_HUMAN
Ensembl»
1.5
HEATR5B HEAT repeat-containing protein 5B Homo sapiens
TI:9606 None
 
HTR5B_MOUSE
Ensembl»
1.5
Heatr5b HEAT repeat-containing protein 5B Mus musculus
TI:10090 None
 
Q54U23_DICDI
dictyBase»
1.5
DDB_G0281353 LAA1-like C-terminal TPR
repeats domain-containing protein		 Dictyostelium discoideum
TI:44689 None
 
A0A139WP21_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_04631 HEAT repeat-containing protein 5A Tribolium castaneum
TI:7070 None
 
A0A1D5REU2_MACMU
Ensembl»
0.0
HEATR5B HEAT repeat-containing protein 5B Macaca mulatta
TI:9544 None
   
A0A287BPP2_PIG
Ensembl»
0.0
HEATR5B HEAT repeat-containing protein 5B Sus scrofa
TI:9823 None
   
A0A2A6CRY3_PRIPA
EnsemblMetazoa»
0.0
WBGene00102000 HEAT repeat-containing protein 5A Pristionchus pacificus
TI:54126 None
   
A0A5F5PXX2_HORSE
Ensembl»
0.0
HEATR5B HEAT repeat-containing protein 5B Equus caballus
TI:9796 None
   
A0A5F8ARR6_MACMU
Ensembl»
0.0
HEATR5A HEAT repeat-containing protein 5A Macaca mulatta
TI:9544 None
   
A0A5F8H7P6_MONDO
Ensembl»
0.0
HEATR5B HEAT repeat-containing protein 5B Monodelphis domestica
TI:13616 None
   
A0A6I8QC90_XENTR
Xenbase»
0.0
heatr5a HEAT repeat-containing protein 5A Xenopus tropicalis
TI:8364 None 		     
A0A7M7PWN0_STRPU
EnsemblMetazoa»
0.0
HEAT repeat-containing protein 5A Strongylocentrotus purpuratus
TI:7668 None
   
A0A7U2F1U4_PHANO
TubercuList»
0.0
JI435_016800 LAA1-like C-terminal TPR
repeats domain-containing protein		 Phaeosphaeria nodorum
TI:13684 None 		 
 
A0A803TPX7_ANOCA
Ensembl»
0.0
HEATR5A HEAT repeat-containing protein 5A Anolis carolinensis
TI:28377 None
   
A0A8I3NLT1_CANLF
Ensembl»
0.0
HEATR5A HEAT repeat-containing protein 5A Canis lupus
TI:9612 None
   
A0A8I3PDP6_CANLF
Ensembl»
0.0
HEATR5B HEAT repeat-containing protein 5B Canis lupus
TI:9612 None
   
A0A8J0TMY3_XENLA
Xenbase»
0.0
heatr5a.L HEAT repeat-containing protein 5A Xenopus laevis
TI:8355 None
   
A0A8M3AJX9_DANRE
ZFIN»
0.0
heatr5a HEAT repeat-containing protein 5A Danio rerio
TI:7955 None 		     
A0A8W4FMJ8_PIG
Ensembl»
0.0
HEAT repeat containing 5A Sus scrofa
TI:9823 None 		     
A0A9J7M2G1_BRAFL
euHCVdb»
0.0
LOC118427331 HEAT repeat-containing protein 5A Branchiostoma floridae
TI:7739 None
   
A0A9L0R4I9_HORSE
Ensembl»
0.0
HEATR5A HEAT repeat-containing protein 5A Equus caballus
TI:9796 None
   
A0ABI7XKW5_FELCA
Ensembl»
0.0
HEATR5B HEAT repeat containing 5B Felis catus
TI:9685 None 		     
A0ABI7ZBA1_FELCA
Ensembl»
0.0
HEATR5A HEAT repeat containing 5A Felis catus
TI:9685 None 		     
A0ABK0LG41_RAT
RGD»
0.0
Heatr5a HEAT repeat containing 5A Rattus norvegicus
TI:10116 None 		     
A0ABK0LGW6_RAT
RGD»
0.0
Heatr5b HEAT repeat containing 5B Rattus norvegicus
TI:10116 None
   
A7EUF0_SCLS1
TubercuList»
0.0
SS1G_08957 HEAT repeat-containing protein 5B Sclerotinia sclerotiorum
TI:5180 None 		 
 
A7EUF1_SCLS1
TubercuList»
0.0
SS1G_08958 LAA1-like C-terminal TPR
repeats domain-containing protein		 Sclerotinia sclerotiorum
TI:5180 None 		 
 
A7T979_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g151016 HEAT repeat-containing protein 1 Nematostella vectensis
TI:45351 None 		 
 
A8XUT0_CAEBR
WormBase»
0.0
soap-1 Protein CBG19103 Caenorhabditis briggsae
TI:6238 None
 
A9VBE0_MONBE
euHCVdb»
0.0
MONBRDRAFT_34393 Protein kinase domain-containing protein Monosiga brevicollis
TI:81824 None
 
B3RZ01_TRIAD
CTD»
0.0
TRIADDRAFT_26322 LAA1-like C-terminal TPR
repeats domain-containing protein		 Trichoplax adhaerens
TI:10228 None
 
B5YN77_THAPS
neXtProt»
0.0
THAPS_23497 Uncharacterized protein Thalassiosira pseudonana
TI:35128 None 		 
 
B6K4E8_SCHJY
TubercuList»
0.0
sip1 Pof6 interacting protein Sip1 Schizosaccharomyces japonicus
TI:4897 None
 
B7PYM8_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW020278 HEAT repeat-containing protein 5A Ixodes scapularis
TI:6945 None
 
E1BB26_BOVIN
Ensembl»
0.0
HEATR5B HEAT repeat-containing protein 5B Bos taurus
TI:9913 None
   
E1BGU0_BOVIN
Ensembl»
0.0
HEATR5A HEAT repeat-containing protein 5A Bos taurus
TI:9913 None 		     
E3KZY1_PUCGT
TubercuList»
0.0
PGTG_15818 LAA1-like C-terminal TPR
repeats domain-containing protein		 Puccinia graminis
TI:5297 None
 
E9HBA8_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_112212 HEAT repeat-containing protein 5B Daphnia pulex
TI:6669 None
 
F0ZNM1_DICPU
TubercuList»
0.0
DICPUDRAFT_34947 LAA1-like C-terminal TPR
repeats domain-containing protein		 Dictyostelium purpureum
TI:5786 None
 
F1SHF7_PIG
Ensembl»
0.0
HEATR5A HEAT repeat containing 5A Sus scrofa
TI:9823 None 		     
F4NZM3_BATDJ
euHCVdb»
0.0
BATDEDRAFT_34806 LAA1-like C-terminal TPR
repeats domain-containing protein		 Batrachochytrium dendrobatidis
TI:109871 None
 
F6Q9A6_ORNAN
Ensembl»
0.0
HEATR5A HEAT repeat containing 5A Ornithorhynchus anatinus
TI:9258 None
   
F6Y2G6_MONDO
Ensembl»
0.0
HEATR5A HEAT repeat-containing protein 5A Monodelphis domestica
TI:13616 None
   
F7G406_ORNAN
Ensembl»
0.0
HEATR5B HEAT repeat-containing protein 5B Ornithorhynchus anatinus
TI:9258 None
   
G1KHM8_ANOCA
Ensembl»
0.0
HEATR5B HEAT repeat-containing protein 5B Anolis carolinensis
TI:28377 None
   
G3QEF3_GORGO
Ensembl»
0.0
HEATR5A HEAT repeat-containing protein 5A Gorilla gorilla
TI:9593 None
 
G3QQP3_GORGO
Ensembl»
0.0
HEAT repeat-containing protein 5B Gorilla gorilla
TI:9593 None
 
H2MAH0_ORYLA
Ensembl»
0.0
HEATR5B HEAT repeat-containing protein 5B Oryzias latipes
TI:8090 None
   
H2QHR2_PANTR
Ensembl»
0.0
HEATR5B HEAT repeat-containing protein 5B Pan troglodytes
TI:9598 None
 
H2Y0W9_CIOIN
Ensembl»
0.0
HEAT repeat-containing protein 5B Ciona intestinalis
TI:7719 None
 
H3GHD1_PHYRM
EnsemblProtists»
0.0
Uncharacterized protein Phytophthora ramorum
TI:164328 None 		 
 
HTR5A_XENTR
Xenbase»
0.0
heatr5a HEAT repeat-containing protein 5A Xenopus tropicalis
TI:8364 None
 
HTR5B_XENTR
Xenbase»
0.0
heatr5b HEAT repeat-containing protein 5B Xenopus tropicalis
TI:8364 None
 
K7CEL0_PANTR
Ensembl»
0.0
HEATR5A HEAT repeat-containing protein 5A Pan troglodytes
TI:9598 None
 
Q4V7I5_XENLA
Xenbase»
0.0
heatr5b.L MGC115675 protein
(Uncharacterized protein LOC734613)		 Xenopus laevis
TI:8355 None
 
Q4WDA7_ASPFU
TubercuList»
0.0
AFUA_6G04080 LAA1-like C-terminal TPR
repeats domain-containing protein		 Aspergillus fumigatus
TI:746128 None
 
Q5A881_CANAL
CGD»
0.0
CAALFM_CR01080WA orf19.10757 LAA1-like C-terminal TPR
repeats domain-containing protein		 Candida albicans
TI:5476 None
 
Q5AYN2_EMENI
TubercuList»
0.0
ANIA_06598 LAA1-like C-terminal TPR
repeats domain-containing protein		 Emericella nidulans
TI:162425 None
 
Q5KER6_CRYD1
TubercuList»
0.0
CNF04530 Clathrin-coated vesicle protein, putative Cryptococcus deneoformans
TI:40410 None
 
Q6CA83_YARLI
TubercuList»
0.0
YALI0_D05049g YALI0D05049p Yarrowia lipolytica
TI:4952 None
 
Q7PEZ3_ANOGA
EnsemblMetazoa»
0.0
AgaP_AGAP002215 HEAT repeat-containing protein 5A Anopheles gambiae
TI:7165 None
 
Q7S2X7_NEUCR
TubercuList»
0.0
NCU08993 HEAT repeat containing protein Neurospora crassa
TI:5141 None
 
T1ELN1_HELRO
EnsemblMetazoa»
0.0
20197481 HEAT repeat-containing protein 5A Helobdella robusta
TI:6412 None
 
W5MTI8_LEPOC
Ensembl»
0.0
HEAT repeat-containing protein 5A Lepisosteus oculatus
TI:7918 None 		 
 
W5MTJ7_LEPOC
Ensembl»
0.0
HEAT repeat containing 5A Lepisosteus oculatus
TI:7918 None
 
W5NG46_LEPOC
Ensembl»
0.0
HEAT repeat-containing protein 5B Lepisosteus oculatus
TI:7918 None