Collated Gene Ontology terms

Biological process: phospholipase A2 activity(2004, 2019, 2024) calcium ion binding(2024) hydrolase activity(2024) metal ion binding(2024) serine-type peptidase activity(2024) serine-type endopeptidase activity(2024) cysteine-type peptidase activity(2024) cysteine-type endopeptidase activity(2024) calcium-dependent phospholipase A2 activity(2003, 2021) identical protein binding(2024)
cysteine-type endopeptidase activity involved in execution phase of apoptosis2024 cysteine-type endopeptidase activity involved in apoptotic process2024

Molecular function: lipid catabolic process2004, 2024 phospholipid metabolic process2024 arachidonic acid secretion2024 triglyceride homeostasis2013, 2019, 2024 cholesterol homeostasis2013, 2019, 2024 proteolysis2024 low-density lipoprotein particle remodeling2020 regulation of programmed cell death2024 pyroptosis2024 protein autoprocessing2024
positive regulation of necroptotic process2024 positive regulation of apoptotic process2024 intrinsic apoptotic signaling pathway by p53 class mediator2024 hepatocyte apoptotic process2024 execution phase of apoptosis2024 epithelial cell differentiation2024 complement activation2024 cellular response to staurosporine2024 apoptotic process2024 activation of innate immune response2024

Cellular component: extracellular region2003, 2011, 2024 membrane2024 cytoplasm2024 nucleus2024 nucleoplasm2024 endoplasmic reticulum2011 cytosol2024 Golgi apparatus2011

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A803SS01_ANOCA
Ensembl»
0.0
PLA2G12B Phospholipase A2 group XIIB Anolis carolinensis
TI:28377 None
   
A0A803TGE4_ANOCA
Ensembl»
0.0
pla2g12a Phospholipase A2 group XIIA Anolis carolinensis
TI:28377 None
   
Q7QHA9_ANOGA
EnsemblMetazoa»
0.0
1270816 AGAP011108-PA Anopheles gambiae
TI:7165 None
 
E1BFK0_BOVIN
Ensembl»
0.0
PLA2G12B Phospholipase A2 group XIIB Bos taurus
TI:9913 None
   
A0A9J7KWD4_BRAFL
CTD»
0.0
LOC118412599 Group XIIA secretory phospholipase A2-like Branchiostoma floridae
TI:7739 None
   
B6IM84_CAEBR
WormBase»
0.0
CBG26099 CBG_26099 Protein CBG26099 Caenorhabditis briggsae
TI:6238 None
 
Q18339_CAEEL
WormBase»
0.0
C31H1.5 CELE_C31H1.5 Phospholipase A(2) Caenorhabditis elegans
TI:6239 None
 
Q8MQ50_CAEEL
WormBase»
0.0
CELE_F44B9.10 F44B9.10 Secretory peptide Caenorhabditis elegans
TI:6239 None
 
A0A8I3Q2H7_CANLF
Ensembl»
0.0
PLA2G12A Phospholipase A2 group XIIA Canis lupus
TI:9612 None
   
A0A8I3RSZ9_CANLF
Ensembl»
0.0
PLA2G12B Phospholipase A2 group XIIB Canis lupus
TI:9612 None
   
A3KNJ5_DANRE
ZFIN»
0.5
zgc:162119 Group XIIA secretory phospholipase A2 precursor (EC
3.1.1.4) (Phospholipase A2, group XIIA) (Zgc:162119 protein)		 Danio rerio
TI:7955 None
 
F1R147_DANRE
ZFIN»
1.0
wu:fb26d02 Group XIIB secretory phospholipase A2-like protein
isoform X1 (Phospholipase A2, group XIIB)		 Danio rerio
TI:7955 None
 
E9G470_DAPPU
EnsemblMetazoa»
0.0
PLA2G12B Phospholipase-like protein A2,
group (EC 3.1.1.4)		 Daphnia pulex
TI:6669 None
 
E9G471_DAPPU
EnsemblMetazoa»
0.0
PLA2G12A Phospholipase-like protein A2,
group (EC 3.1.1.4)		 Daphnia pulex
TI:6669 None
 
E9GMY7_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_225232 Phospholipase A(2) Daphnia pulex
TI:6669 None
 
Q9VUV6_DROME
FlyBase»
0.6
GXIVsPLA2 GXIVsPLA2, isoform A (GXIVsPLA2, isoform D
(EC 3.1.1.4)) (Group XIV secreted phospholipase A2)		 Drosophila melanogaster
TI:7227 None
 
F6UYG8_HORSE
Ensembl»
0.0
CASP6 Caspase 6 Equus caballus
TI:9796 None
   
A0A2I2U5B3_FELCA
Ensembl»
0.0
PLA2G12B Phospholipase A2 group XIIB Felis catus
TI:9685 None
 
A0A5F5XI58_FELCA
Ensembl»
0.0
CASP6 Caspase 6 Felis catus
TI:9685 None
 
A0A8V0XHP6_CHICK
Ensembl»
0.0
PLA2G12A Phospholipase A2 group XIIA Gallus gallus
TI:9031 None
   
A0A8V0ZJ65_CHICK
Ensembl»
0.0
PLA2G12B Phospholipase A2 group XIIB Gallus gallus
TI:9031 None
   
A0A2I2ZUU7_GORGO
Ensembl»
0.0
PLA2G12A Phospholipase A2 group XIIA Gorilla gorilla
TI:9593 None
 
G3RAI5_GORGO
Ensembl»
0.0
PLA2G12B Phospholipase A2 group XIIB Gorilla gorilla
TI:9593 None
 
A0A2R8Y3M9_HUMAN
Ensembl»
0.0
Complement factor I Homo sapiens
TI:9606 None
 
PG12A_HUMAN
Ensembl»
1.1
PLA2G12A Group XIIA secretory phospholipase A2 (GXII
sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A)		 Homo sapiens
TI:9606 None
 
PG12B_HUMAN
Ensembl»
1.0
PLA2G12B Group XIIB secretory phospholipase A2-like protein (Group XIII
secretory phospholipase A2-like protein) (GXIII sPLA2-like) (sPLA2-GXIIB) (GXIIB)		 Homo sapiens
TI:9606 None
 
B7P1D1_IXOSC
EnsemblMetazoa»
0.0
8053294 Secreted salivary gland
peptide, putative (EC 3.1.1.4)		 Ixodes scapularis
TI:6945 None
 
B7P603_IXOSC
EnsemblMetazoa»
0.0
8025135 Salivary phospholipase A2, putative
(Salivary phospholipase A2, putative (Fragment))		 Ixodes scapularis
TI:6945 None
 
W5MPV7_LEPOC
Ensembl»
0.0
PLA2G12B Phospholipase A2 group XIIB Lepisosteus oculatus
TI:7918 None
 
W5N370_LEPOC
Ensembl»
0.0
Phospholipase A2 group XIIA Lepisosteus oculatus
TI:7918 None
 
F6U7T4_MACMU
Ensembl»
0.0
PLA2G12B Phospholipase A2 group XIIB Macaca mulatta
TI:9544 None
   
F7HTT9_MACMU
Ensembl»
0.0
CFI Complement factor I Macaca mulatta
TI:9544 None
   
F6WX38_MONDO
Ensembl»
0.0
PLA2G12A Phospholipase A2 group XIIA Monodelphis domestica
TI:13616 None
   
F6YC85_MONDO
Ensembl»
0.0
PLA2G12B Phospholipase A2 group XIIB Monodelphis domestica
TI:13616 None
   
PG12A_MOUSE
Ensembl»
1.8
Pla2g12a Group XIIA secretory phospholipase A2 (GXII
sPLA2) (sPLA2-XII) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 12A)		 Mus musculus
TI:10090 None
 
PG12B_MOUSE
AG»
2.4
Pla2g12b Group XIIB secretory phospholipase A2-like protein (Group XIII
secretory phospholipase A2-like protein) (GXIII sPLA2-like) (sPLA2-GXIIB) (GXIIB)		 Mus musculus
TI:10090 None
 
A7STQ9_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g131395 Group XIIA secretory phospholipase A2 Nematostella vectensis
TI:45351 None
 
A0A6I8P722_ORNAN
Ensembl»
0.0
PLA2G12A Phospholipase A2 group XIIA Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8P744_ORNAN
Ensembl»
0.0
PLA2G12B Phospholipase A2 group XIIB Ornithorhynchus anatinus
TI:9258 None
   
A0A3B3H3R7_ORYLA
Ensembl»
0.0
LOC101162393 Group XIIB secretory
phospholipase A2-like protein		 Oryzias latipes
TI:8090 None
   
A0A3B3I4C5_ORYLA
Ensembl»
0.0
PLA2G12B Group XIIB secretory
phospholipase A2-like protein		 Oryzias latipes
TI:8090 None
   
H2Q229_PANTR
Ensembl»
0.0
PLA2G12B Phospholipase A2 group XIIB Pan troglodytes
TI:9598 None
 
K7BN83_PANTR
Ensembl»
0.0
PLA2G12A Phospholipase A2 group XIIA
(Phospholipase A2, group XIIA)		 Pan troglodytes
TI:9598 None
 
H3GN10_PHYRM
EnsemblProtists»
0.0
Phospholipase A2 Phytophthora ramorum
TI:164328 None
 
B0K018_RAT
RGD»
1.0
Pla2g12a Phospholipase A2, group XIIA (Pla2g12a protein) Rattus norvegicus
TI:10116 None
 
M0RCI5_RAT
RGD»
2.5
Pla2g12b Phospholipase A2, group XIIB Rattus norvegicus
TI:10116 None
   
A0A7M7LLI4_STRPU
EnsemblMetazoa»
0.0
Uncharacterized protein Strongylocentrotus purpuratus
TI:7668 None
   
F1S132_PIG
Ensembl»
0.0
PLA2G12A Phospholipase A2 group XIIA Sus scrofa
TI:9823 None
   
F1SU77_PIG
Ensembl»
0.0
PLA2G12B Phospholipase A2 group XIIB Sus scrofa
TI:9823 None
   
B8BX83_THAPS
EnsemblProtists»
0.0
THAPSDRAFT_3244 Phospholipase A2 Thalassiosira pseudonana
TI:35128 None
 
D6WWD0_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_06362 Group XIIA secretory
phospholipase A2-like Protein		 Tribolium castaneum
TI:7070 None
 
B3RKT8_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_51761 Phospholipase A2 domain-containing protein Trichoplax adhaerens
TI:10228 None
 
A0A1L8FF19_XENLA
Xenbase»
0.0
pla2g12b.S Group XIIB secretory phospholipase
A2-like protein isoform X1		 Xenopus laevis
TI:8355 None
   
A0A1L8FJV5_XENLA
Xenbase»
0.0
pla2g12b.L Group XIIB secretory phospholipase
A2-like protein isoform X1		 Xenopus laevis
TI:8355 None
   
A0A8J0STL3_XENTR
Xenbase»
0.0
pla2g12b Group XIIB secretory phospholipase
A2-like protein isoform X1		 Xenopus tropicalis
TI:8364 None
   
Q28GM9_XENTR
Xenbase»
0.0
pla2g12a Group XIIA secretory phospholipase A2 precursor
(EC 3.1.1.4) (Phospholipase A2, group XIIA)		 Xenopus tropicalis
TI:8364 None
 
Q6GQC0_XENLA
Xenbase»
0.0
pla2g12a.S MGC80173 protein (Phospholipase A2 group
XIIA S homeolog (EC 3.1.1.4))		 Xenopus laevis
TI:8355 None