Collated Gene Ontology terms

Biological process: ubiquitin protein ligase activity(2017, 2019, 2020, 2025) zinc ion binding(2017, 2025) metal ion binding(2025) transferase activity(2025) ubiquitin conjugating enzyme binding(2017, 2025) p53 binding(2017, 2025) ubiquitin-protein transferase activity(2024, 2025) calcium ion binding(2025)

Molecular function: ubiquitin-dependent protein catabolic process2017, 2019, 2025 protein polyubiquitination2017, 2019, 2025 protein ubiquitination2024 spermatogenesis2025 cell differentiation2025 negative regulation of type I interferon production2017, 2025 negative regulation of RIG-I signaling pathway2017, 2025 immune system process2025 adaptive immune response2025 innate immune response2025
autophagy2025 cellular response to leukemia inhibitory factor2017

Cellular component: cytoplasm2017, 2024, 2025 VCP-NPL4-UFD1 AAA ATPase complex2017, 2019, 2025 nucleus2025 cytosol2013, 2016, 2024, 2025 Golgi membrane2016, 2025 Golgi apparatus2024, 2025 nuclear lumen2017 intracellular membrane-bounded organelle2016 ciliary plasm2017 plasma membrane2025

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 2/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 1/3 
Excavates: 1/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 1/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A803T852_ANOCA
Ensembl»
0.0
RNF125 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Anolis carolinensis
TI:28377 None
   
G1KRD0_ANOCA
Ensembl»
0.0
RNF114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein
114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)		 Anolis carolinensis
TI:28377 None
   
H9GBV4_ANOCA
Ensembl»
0.0
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Anolis carolinensis
TI:28377 None
   
F5HK12_ANOGA
EnsemblMetazoa»
0.0
11175958 AGAP013215-PA Anopheles gambiae
TI:7165 None
 
A0AAA9T3E1_BOVIN
Ensembl»
0.0
RNF125 E3 ubiquitin-protein ligase RNF125 (EC
2.3.2.27) (RING finger protein 125)		 Bos taurus
TI:9913 None
   
F6RFN8_BOVIN
Ensembl»
0.0
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Bos taurus
TI:9913 None
   
RN114_BOVIN
Ensembl»
0.0
RNF114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein
114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)		 Bos taurus
TI:9913 None
 
C3XU51_BRAFL
neXtProt»
0.0
LOC118417704 E3 ubiquitin-protein ligase RNF166-like Branchiostoma floridae
TI:7739 None
 
A0A8I3N5G2_CANLF
Ensembl»
0.0
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Canis lupus
TI:9612 None
   
A0A8I3N8R2_CANLF
Ensembl»
0.0
RNF125 E3 ubiquitin-protein ligase RNF125 (EC
2.3.2.27) (RING finger protein 125)		 Canis lupus
TI:9612 None
   
A0A8I3PS94_CANLF
Ensembl»
0.0
RNF114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein
114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)		 Canis lupus
TI:9612 None
   
A0A2K3DX71_CHLRE
euHCVdb»
0.0
CHLRE_03g172600v5 RING-type domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A8M3B3Y0_DANRE
ZFIN»
0.0
rnf125 E3 ubiquitin-protein ligase RNF166 (RING finger
protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Danio rerio
TI:7955 None
   
E7FEA4_DANRE
ZFIN»
1.5
rnf166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Danio rerio
TI:7955 None
 
Q6J0N1_DANRE
ZFIN»
1.5
rnf114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein
114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)		 Danio rerio
TI:7955 None
 
Q54EA4_DICDI
TubercuList»
1.5
DDB_G0291698 RING-type domain-containing protein Dictyostelium discoideum
TI:44689 None
 
Q54IP3_DICDI
dictyBase»
0.0
DDB_G0288619 RING-type domain-containing protein Dictyostelium discoideum
TI:44689 None
 
A0A9L0RHM0_HORSE
Ensembl»
0.0
RNF125 E3 ubiquitin-protein ligase RNF125 (EC
2.3.2.27) (RING finger protein 125)		 Equus caballus
TI:9796 None
   
A0A9L0SFX6_HORSE
Ensembl»
0.0
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Equus caballus
TI:9796 None
   
F7DIZ6_HORSE
Ensembl»
0.0
RNF114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein
114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)		 Equus caballus
TI:9796 None
   
A0ABI7WDG7_FELCA
Ensembl»
0.0
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Felis catus
TI:9685 None
   
A0ABI7XUQ2_FELCA
Ensembl»
0.0
RNF125 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Felis catus
TI:9685 None
   
A0ABI7ZDF9_FELCA
Ensembl»
0.0
RNF114 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Felis catus
TI:9685 None
   
A0A8V0YHL7_CHICK
Ensembl»
1.5
RNF114 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Gallus gallus
TI:9031 None
   
RN166_CHICK
Ensembl»
1.5
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Gallus gallus
TI:9031 None
 
A0A2I2YRG8_GORGO
Ensembl»
0.0
Uncharacterized protein Gorilla gorilla
TI:9593 None 		 
 
G3RA09_GORGO
Ensembl»
0.0
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Gorilla gorilla
TI:9593 None
 
G3SE69_GORGO
Ensembl»
0.0
RNF114 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Gorilla gorilla
TI:9593 None
 
T1EKY6_HELRO
EnsemblMetazoa»
0.0
20197236 RING-type domain-containing protein Helobdella robusta
TI:6412 None
 
T1ETM5_HELRO
EnsemblMetazoa»
0.0
20199925 RING-type domain-containing protein Helobdella robusta
TI:6412 None
 
T1FNA4_HELRO
EnsemblMetazoa»
0.0
20210301 Zinc finger protein 313 Helobdella robusta
TI:6412 None
 
T1FR36_HELRO
EnsemblMetazoa»
0.0
20211283 RING-type domain-containing protein Helobdella robusta
TI:6412 None
 
RN114_HUMAN
Ensembl»
1.5
RNF114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type
E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)		 Homo sapiens
TI:9606 None
 
RN125_HUMAN
Ensembl»
7.9
RNF125 E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger
protein 125) (T-cell RING activation protein 1) (TRAC-1)		 Homo sapiens
TI:9606 None
 
RN166_HUMAN
Ensembl»
1.5
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Homo sapiens
TI:9606 None
 
B7PTS3_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW019978 Zinc finger protein, putative Ixodes scapularis
TI:6945 None
 
Q4QAJ2_LEIMA
TubercuList»
0.0
LMJF_24_1390 Uncharacterized protein Leishmania major
TI:5664 None
 
Q4QAJ3_LEIMA
TubercuList»
0.0
LMJF_24_1380 Uncharacterized protein Leishmania major
TI:5664 None
 
W5MB55_LEPOC
Ensembl»
0.0
E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein
114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)		 Lepisosteus oculatus
TI:7918 None
 
W5MBU5_LEPOC
Ensembl»
0.0
E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Lepisosteus oculatus
TI:7918 None
 
W5N2W9_LEPOC
Ensembl»
0.0
RNF125 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Lepisosteus oculatus
TI:7918 None
   
W5NGH5_LEPOC
Ensembl»
0.0
Cadherin-like beta-sandwich-like
domain-containing protein		 Lepisosteus oculatus
TI:7918 None 		 
 
A0A1D5RH24_MACMU
Ensembl»
0.0
RNF114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein
114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)		 Macaca mulatta
TI:9544 None
   
G7NKK2_MACMU
Ensembl»
0.0
RNF125 E3 ubiquitin-protein ligase RNF125 (EC
2.3.2.27) (RING finger protein 125)		 Macaca mulatta
TI:9544 None
 
H9YWX4_MACMU
Ensembl»
0.0
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Macaca mulatta
TI:9544 None
 
F6R9W7_MONDO
Ensembl»
0.0
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Monodelphis domestica
TI:13616 None
   
F7A674_MONDO
Ensembl»
0.0
RNF114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein
114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)		 Monodelphis domestica
TI:13616 None
   
F7FW88_MONDO
Ensembl»
0.0
RNF125 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Monodelphis domestica
TI:13616 None
   
RN114_MOUSE
Ensembl»
1.5
Rnf114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type
E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)		 Mus musculus
TI:10090 None
 
RN125_MOUSE
Ensembl»
9.1
Rnf125 E3 ubiquitin-protein ligase RNF125 (EC
2.3.2.27) (RING finger protein 125)		 Mus musculus
TI:10090 None
 
RN166_MOUSE
Ensembl»
1.5
Rnf166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Mus musculus
TI:10090 None
 
A7RIP0_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g197692 RING-type domain-containing protein Nematostella vectensis
TI:45351 None
 
A0A6I8NT96_ORNAN
Ensembl»
0.0
RNF114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein
114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8PIQ9_ORNAN
Ensembl»
0.0
RING-type E3 ubiquitin transferase (EC 2.3.2.27) Ornithorhynchus anatinus
TI:9258 None
   
F7FE34_ORNAN
Ensembl»
0.0
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Ornithorhynchus anatinus
TI:9258 None
   
H2M0J4_ORYLA
Ensembl»
0.0
RNF114 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Oryzias latipes
TI:8090 None
   
H2MYD4_ORYLA
Ensembl»
0.0
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Oryzias latipes
TI:8090 None
   
A0A2I3TFY9_PANTR
Ensembl»
0.0
RNF125 E3 ubiquitin-protein ligase RNF125 (EC
2.3.2.27) (RING finger protein 125)		 Pan troglodytes
TI:9598 None
 
H2QBQ3_PANTR
Ensembl»
0.0
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Pan troglodytes
TI:9598 None
 
H2QKK0_PANTR
Ensembl»
0.0
RNF114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein
114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)		 Pan troglodytes
TI:9598 None
 
RN114_PANTR
CTD»
0.0
RNF114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein
114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)		 Pan troglodytes
TI:9598 None
 
A0BPP8_PARTE
neXtProt»
0.0
GSPATT00005265001 RING-type domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0C1A9_PARTE
neXtProt»
0.0
GSPATT00034052001 RING-type domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0CCF7_PARTE
euHCVdb»
0.0
GSPATT00037259001 RING-type domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0CPP5_PARTE
euHCVdb»
0.0
GSPATT00009154001 RING-type domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0CQD0_PARTE
neXtProt»
0.0
GSPATT00009345001 SIAH-type domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0D5N3_PARTE
neXtProt»
0.0
GSPATT00013780001 RING-type domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0DRC8_PARTE
neXtProt»
0.0
GSPATT00019312001 RING-type domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0A8I5ZUW9_RAT
RGD»
5.0
Rnf125 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Rattus norvegicus
TI:10116 None
   
RN114_RAT
RGD»
1.5
Rnf114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein
114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)		 Rattus norvegicus
TI:10116 None
 
RN166_RAT
RGD»
1.5
Rnf166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Rattus norvegicus
TI:10116 None
 
A0A7M7N4C6_STRPU
EnsemblMetazoa»
0.0
RING-type domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7N6J5_STRPU
EnsemblMetazoa»
0.0
RING-type E3 ubiquitin transferase Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7PPW8_STRPU
EnsemblMetazoa»
0.0
Cadherin-like beta-sandwich-like
domain-containing protein		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A5G2QEN7_PIG
Ensembl»
0.0
RNF125 E3 ubiquitin-protein ligase RNF125 (EC
2.3.2.27) (RING finger protein 125)		 Sus scrofa
TI:9823 None
   
A0A5G2RDT7_PIG
Ensembl»
0.0
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Sus scrofa
TI:9823 None
 
RN114_PIG
Ensembl»
0.0
RNF114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein
114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)		 Sus scrofa
TI:9823 None
 
A0A1L8ELG3_XENLA
Xenbase»
0.0
rnf114.S RING-type E3 ubiquitin transferase (EC 2.3.2.27) Xenopus laevis
TI:8355 None
   
A0A1L8FT09_XENLA
Xenbase»
0.0
rnf125.S RING-type E3 ubiquitin transferase (EC 2.3.2.27) Xenopus laevis
TI:8355 None
   
A0A1L8FYV8_XENLA
Xenbase»
0.0
rnf125.L RING-type E3 ubiquitin transferase (EC 2.3.2.27) Xenopus laevis
TI:8355 None
   
A0A1L8G7A1_XENLA
CTD»
0.0
LOC108716581 Uncharacterized protein LOC108716581 isoform X1 Xenopus laevis
TI:8355 None
   
A0A6I8PTI5_XENTR
Xenbase»
0.0
rnf125 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Xenopus tropicalis
TI:8364 None
   
A0A8J0QIM7_XENTR
Xenbase»
0.0
LOC100488029 Uncharacterized protein LOC100488029 Xenopus tropicalis
TI:8364 None 		     
A0A8J1KIB3_XENLA
CTD»
0.0
rnf166.S E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Xenopus laevis
TI:8355 None
   
Q0VFJ0_XENTR
Xenbase»
0.0
rnf166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Xenopus tropicalis
TI:8364 None
 
Q5M9A8_XENLA
Xenbase»
0.0
rnf114.L RING-type E3 ubiquitin transferase (EC 2.3.2.27) Xenopus laevis
TI:8355 None
 
Q6IZ49_XENTR
Xenbase»
0.0
rnf114 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Xenopus tropicalis
TI:8364 None
 
RN166_XENLA
Xenbase»
0.0
rnf166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Xenopus laevis
TI:8355 None