Collated Gene Ontology terms

Biological process: ubiquitin protein ligase activity(2017, 2019, 2020, 2025) zinc ion binding(2017, 2025) metal ion binding(2025) transferase activity(2025) ubiquitin conjugating enzyme binding(2017, 2025) p53 binding(2017, 2025) ubiquitin-protein transferase activity(2024, 2025) calcium ion binding(2025)

Molecular function: ubiquitin-dependent protein catabolic process2017, 2019, 2025 protein polyubiquitination2017, 2019, 2025 protein ubiquitination2024 spermatogenesis2025 cell differentiation2025 negative regulation of type I interferon production2017, 2025 negative regulation of RIG-I signaling pathway2017, 2025 immune system process2025 adaptive immune response2025 innate immune response2025
autophagy2025 cellular response to leukemia inhibitory factor2017

Cellular component: cytoplasm2017, 2024, 2025 VCP-NPL4-UFD1 AAA ATPase complex2017, 2019, 2025 nucleus2025 cytosol2013, 2016, 2024, 2025 Golgi membrane2016, 2025 Golgi apparatus2024, 2025 nuclear lumen2017 intracellular membrane-bounded organelle2016 ciliary plasm2017 plasma membrane2025

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 2/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 1/3 
Excavates: 1/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 1/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
A0A8M3B3Y0_DANRE
ZFIN»
0.0
rnf125 E3 ubiquitin-protein ligase RNF166 (RING finger
protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Danio rerio
TI:7955 None
   
E7FEA4_DANRE
ZFIN»
1.5
rnf166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Danio rerio
TI:7955 None
 
Q6J0N1_DANRE
ZFIN»
1.5
rnf114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein
114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)		 Danio rerio
TI:7955 None
 
Q54EA4_DICDI
TubercuList»
1.5
DDB_G0291698 RING-type domain-containing protein Dictyostelium discoideum
TI:44689 None
 
Q54IP3_DICDI
dictyBase»
0.0
DDB_G0288619 RING-type domain-containing protein Dictyostelium discoideum
TI:44689 None
 
A0A8V0YHL7_CHICK
Ensembl»
1.5
RNF114 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Gallus gallus
TI:9031 None
   
RN166_CHICK
Ensembl»
1.5
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Gallus gallus
TI:9031 None
 
RN114_HUMAN
Ensembl»
1.5
RNF114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type
E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)		 Homo sapiens
TI:9606 None
 
RN125_HUMAN
Ensembl»
7.9
RNF125 E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger
protein 125) (T-cell RING activation protein 1) (TRAC-1)		 Homo sapiens
TI:9606 None
 
RN166_HUMAN
Ensembl»
1.5
RNF166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Homo sapiens
TI:9606 None
 
RN114_MOUSE
Ensembl»
1.5
Rnf114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type
E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)		 Mus musculus
TI:10090 None
 
RN125_MOUSE
Ensembl»
9.1
Rnf125 E3 ubiquitin-protein ligase RNF125 (EC
2.3.2.27) (RING finger protein 125)		 Mus musculus
TI:10090 None
 
RN166_MOUSE
Ensembl»
1.5
Rnf166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Mus musculus
TI:10090 None
 
A0A8I5ZUW9_RAT
RGD»
5.0
Rnf125 RING-type E3 ubiquitin transferase (EC 2.3.2.27) Rattus norvegicus
TI:10116 None
   
RN114_RAT
RGD»
1.5
Rnf114 E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein
114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 313)		 Rattus norvegicus
TI:10116 None
 
RN166_RAT
RGD»
1.5
Rnf166 E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING
finger protein 166) (RING-type E3 ubiquitin transferase RNF166)		 Rattus norvegicus
TI:10116 None