Collated Gene Ontology terms

Biological process: protein-containing complex binding(2014, 2016, 2021, 2025) protein phosphatase inhibitor activity(2025) phospholipid binding(2016, 2025) GTPase activator activity(2022, 2025) GTPase activating protein binding(2009, 2025) phosphatidylinositol-3,4,5-trisphosphate binding(2021, 2025) myosin I binding(2020, 2025) ribonuclease inhibitor activity(2025) protein-macromolecule adaptor activity(2025)

Molecular function: cell migration2011, 2024, 2025 regulation of Arp2/3 complex-mediated actin nucleation2020, 2021, 2025 positive regulation of cell migration2014, 2016, 2025 positive regulation of lamellipodium organization2014, 2016, 2025 actin filament network formation2016, 2025 negative regulation of barbed-end actin filament capping2016, 2019, 2025 positive regulation of substrate adhesion-dependent cell spreading2014, 2025 positive regulation of stress fiber assembly2014, 2025 urate metabolic process2011, 2014, 2025 ruffle organization2011, 2025
macropinocytosis2016, 2025 lamellipodium assembly2011, 2025 regulation of postsynapse assembly2024, 2025 positive regulation of actin filament polymerization2014, 2025 barbed-end actin filament uncapping2014, 2025 establishment or maintenance of cell polarity2016, 2025 wound healing, spreading of cells2016, 2025 positive regulation of ruffle assembly2016, 2025 positive regulation of lamellipodium assembly2016, 2025 positive regulation of extracellular matrix disassembly2016, 2025 establishment or maintenance of monopolar cell polarity2016, 2025 regulation of cell migration2009, 2022, 2025 regulation of actin cytoskeleton organization2023, 2025 regulation of axon extension involved in axon guidance2009, 2025 negative regulation of Rac protein signal transduction2009, 2025 locomotion2009, 2025 axon guidance2009, 2025 thymus development2014 signal transduction2025 regulation of phagocytosis2022, 2025 regulation of macropinocytosis2023, 2025 regulation of filopodium assembly2023, 2025 regulation of aggregation involved in sorocarp development2022, 2025 positive regulation of type II interferon production2014 positive regulation of regulatory T cell differentiation2014 positive regulation of interleukin-2 production2020 positive regulation of T cell proliferation2014 homeostasis of number of cells2014 establishment of protein localization2014 T cell receptor signaling pathway2014 regulation of angiogenesis2021 primary miRNA processing2020 negative regulation of immune response2015 negative regulation of canonical NF-kappaB signal transduction2023 cilium assembly2008 actin filament organization2011

Cellular component: plasma membrane2012, 2016, 2022, 2025 lamellipodium2011, 2014, 2016, 2021, 2025 cytoplasm2014, 2016, 2021, 2025 cell leading edge2016, 2020, 2021, 2022, 2025 macropinosome2016, 2025 ruffle2016, 2025 cytosol2013, 2025 actin cytoskeleton2016, 2020, 2025 postsynapse2024, 2025 glutamatergic synapse2024, 2025
filamentous actin2014, 2025 intermediate filament cytoskeleton2016, 2025 cytoskeleton2025 phagocytic cup2021, 2022, 2025 macropinocytic cup2020, 2021, 2025 phagocytic vesicle2020, 2025 leading edge of lamellipodium2020, 2025 immunological synapse2014 cell-cell junction2014 F-actin capping protein complex2014 pseudopodium2025 nucleoplasm2021 nuclear speck2025 nuclear body2020 muscle tendon junction2014 membrane2014 extrinsic component of cytoplasmic side of plasma membrane2016 extracellular exosome2013 angiogenin-PRI complex2021

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 3/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 5 10 15 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
CARL1_MOUSE
Ensembl»
16.9
Carmil1 F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3
and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (CARML1) (Leucine-rich repeat-containing protein 16A)		 Mus musculus
TI:10090 None
 
CARL2_MOUSE
AG»
19.4
Carmil2 Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker
2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein)		 Mus musculus
TI:10090 None
 
CARL1_HUMAN
Ensembl»
12.7
CARMIL1 F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3
and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A)		 Homo sapiens
TI:9606 None
 
D3ZC15_RAT
RGD»
10.0
Carmil2 Capping protein regulator and myosin 1 linker 2 Rattus norvegicus
TI:10116 None
   
CARL2_HUMAN
Ensembl»
10.6
CARMIL2 Capping protein, Arp2/3 and myosin-I linker protein 2 (Capping protein regulator and myosin 1 linker
2) (F-actin-uncapping protein RLTPR) (Leucine-rich repeat-containing protein 16C) (RGD, leucine-rich repeat, tropomodulin and proline-rich-containing protein)		 Homo sapiens
TI:9606 None
 
A0A1D5PTP4_CHICK
Ensembl»
1.0
CARMIL1 Capping protein regulator and myosin 1 linker 1 Gallus gallus
TI:9031 None
   
A0A8V0ZPC8_CHICK
Ensembl»
1.0
RLTPR Capping protein regulator and myosin 1 linker 2 Gallus gallus
TI:9031 None
   
A0A8I6A2B1_RAT
RGD»
0.0
Carmil1 Capping protein regulator and myosin 1 linker 1 Rattus norvegicus
TI:10116 None
   
CARL3_MOUSE
Ensembl»
2.6
Carmil3 Capping protein, Arp2/3 and myosin-I linker protein 3 (Capping protein
regulator and myosin 1 linker protein 3) (Leucine-rich repeat-containing protein 16B)		 Mus musculus
TI:10090 None
 
GACW_DICDI
dictyBase»
5.0
gacW Rho GTPase-activating protein gacW (GTPase
activating factor for raC protein W)		 Dictyostelium discoideum
TI:44689 None
 
CARL3_RAT
RGD»
1.5
Carmil3 Capping protein, Arp2/3 and myosin-I linker protein 3 (Capping protein
regulator and myosin 1 linker protein 3) (Leucine-rich repeat-containing protein 16B)		 Rattus norvegicus
TI:10116 None
 
CARML_DICDI
dictyBase»
2.6
carmil Protein CARMIL (dDcarmil) (Capping protein, arp2/3 and
myosin I linker) (Leucine-rich repeat-containing protein p116) (p116)		 Dictyostelium discoideum
TI:44689 None
 
Q54B43_DICDI
dictyBase»
5.0
DDB_G0293920 Leucine-rich repeat-containing protein Dictyostelium discoideum
TI:44689 None
 
CARL3_HUMAN
Ensembl»
1.0
CARMIL3 Capping protein, Arp2/3 and myosin-I linker protein 3 (Capping protein
regulator and myosin 1 linker protein 3) (Leucine-rich repeat-containing protein 16B)		 Homo sapiens
TI:9606 None
 
Q21301_CAEEL
WormBase»
5.8
crml-1 CARMIL pleckstrin
homology domain-containing protein		 Caenorhabditis elegans
TI:6239 None
 
A0A0B4KEE7_DROME
FlyBase»
3.1
LRR Leucine-rich repeat, isoform F Drosophila melanogaster
TI:7227 None
 
A0A1B0GSW2_MOUSE
Ensembl»
2.0
Lrrc78 Leucine rich repeat containing
78 (Predicted gene 28729)		 Mus musculus
TI:10090 None
   
Q54LE3_DICDI
dictyBase»
1.0
DDB_G0286681 Leucine-rich repeat-containing protein Dictyostelium discoideum
TI:44689 None
 
Q54MF0_DICDI
dictyBase»
1.0
DDB_G0286003 Leucine-rich repeat-containing protein Dictyostelium discoideum
TI:44689 None
 
Q54NS2_DICDI
dictyBase»
1.0
DDB_G0285081 Leucine-rich repeat-containing protein Dictyostelium discoideum
TI:44689 None
 
Q54SR9_DICDI
dictyBase»
1.0
DDB_G0282263 Leucine-rich repeat-containing protein Dictyostelium discoideum
TI:44689 None
 
Q54YK2_DICDI
dictyBase»
1.0
DDB_G0278629 Leucine-rich repeat-containing protein Dictyostelium discoideum
TI:44689 None
 
Q7KWW4_DICDI
dictyBase»
1.0
DDB_G0276791 Leucine-rich repeat-containing protein Dictyostelium discoideum
TI:44689 None
 
Q869U6_DICDI
dictyBase»
1.0
DG1112 RasGTPase-activating protein Dictyostelium discoideum
TI:44689 None
 
A0A8V0Y3X1_CHICK
Ensembl»
0.0
Protein phosphatase 1 regulatory subunit
37 (Leucine-rich repeat-containing protein 68)		 Gallus gallus
TI:9031 None
   
PPR37_DANRE
ZFIN»
0.0
ppp1r37 Protein phosphatase 1 regulatory subunit
37 (Leucine-rich repeat-containing protein 68)		 Danio rerio
TI:7955 None
 
PPR37_HUMAN
Ensembl»
0.0
PPP1R37 Protein phosphatase 1 regulatory subunit
37 (Leucine-rich repeat-containing protein 68)		 Homo sapiens
TI:9606 None
 
PPR37_MOUSE
Ensembl»
0.0
Ppp1r37 Protein phosphatase 1 regulatory subunit
37 (Leucine-rich repeat-containing protein 68)		 Mus musculus
TI:10090 None
 
PPR37_RAT
RGD»
0.0
Ppp1r37 Protein phosphatase 1 regulatory subunit
37 (Leucine-rich repeat-containing protein 68)		 Rattus norvegicus
TI:10116 None
 
A0A8V0XH41_CHICK
Ensembl»
0.0
Leucine rich repeat containing 45 Gallus gallus
TI:9031 None 		     
M9PCB8_DROME
FlyBase»
0.0
Dmel\CG31635 Uncharacterized protein, isoform C Drosophila melanogaster
TI:7227 None 		 
 
PPR37_CAEEL
WormBase»
0.0
F28C1.3 Protein phosphatase 1
regulatory subunit 37 homolog		 Caenorhabditis elegans
TI:6239 None