Collated Gene Ontology terms

Biological process: non-membrane spanning protein tyrosine kinase activity(2003, 2011, 2017, 2020, 2022, 2024, 2025) protein tyrosine kinase activity(2003, 2005, 2011, 2014, 2016, 2019, 2022, 2024, 2025) protein kinase activity(2003, 2025) transferase activity(2025) nucleotide binding(2025) kinase activity(2025) ATP binding(2025) lipid binding(2025) phosphatidylinositol-4,5-bisphosphate binding(2009, 2017, 2025) integrin binding(2010, 2016, 2019, 2025)
signaling receptor activator activity2025 protein-containing complex binding2007, 2010, 2025 neurotransmitter receptor regulator activity2024, 2025 molecular function activator activity2022, 2025 ionotropic glutamate receptor binding2025 calcium/calmodulin-dependent protein kinase activity2014, 2025 protein tyrosine phosphatase activity2022, 2025 protein phosphatase binding2018, 2025 protein kinase binding2011, 2025 identical protein binding2025 actin binding2013, 2025 SH2 domain binding2005, 2025 JUN kinase binding2011, 2025 ubiquitin protein ligase binding2017, 2025 phosphatidylinositol 3-kinase binding2010, 2025 phosphatase binding2017, 2025 glutamate receptor binding2024, 2025 enzyme binding2016, 2025 3-phosphoinositide-dependent protein kinase binding2006, 2025 signaling receptor binding2022 protein-membrane adaptor activity2020 protease binding2016 calcium-dependent cysteine-type endopeptidase activity2016

Molecular function: positive regulation of cell population proliferation2003, 2007, 2011, 2016, 2025 signal complex assembly2025 positive regulation of cell migration2007, 2008, 2011, 2012, 2023, 2025 regulation of cell adhesion2011, 2020, 2025 negative regulation of apoptotic process2008, 2011, 2025 integrin-mediated signaling pathway2002, 2011, 2014, 2025 epidermal growth factor receptor signaling pathway2007, 2017, 2025 regulation of cell shape2011, 2025 vascular endothelial growth factor receptor signaling pathway2011, 2025 regulation of multicellular organismal process2025
cell differentiation2007, 2025 angiogenesis2007, 2011, 2025 signal transduction2003, 2018, 2025 positive regulation of ubiquitin-dependent protein catabolic process2011, 2025 regulation of G protein-coupled receptor signaling pathway2017, 2025 establishment of protein localization to membrane2017, 2025 positive regulation of signal transduction2025 positive regulation of endothelial cell migration2011, 2012, 2025 positive regulation of cell-matrix adhesion2011, 2025 positive regulation of actin filament polymerization2011, 2025 positive regulation of JNK cascade2011, 2025 positive regulation of ERK1 and ERK2 cascade2011, 2025 negative regulation of cell population proliferation2011, 2025 immune system process2025 endothelin receptor signaling pathway2019, 2025 cell surface receptor signaling pathway2011, 2025 adaptive immune response2025 sprouting angiogenesis2011, 2025 regulation of release of sequestered calcium ion into cytosol2011, 2025 regulation of macrophage chemotaxis2011, 2025 regulation of actin cytoskeleton organization2023, 2025 positive regulation of B cell chemotaxis2011, 2025 negative regulation of bone mineralization2011, 2025 cortical cytoskeleton organization2023, 2025 chemokine-mediated signaling pathway2011, 2025 bone resorption2011, 2025 tumor necrosis factor-mediated signaling pathway2011, 2025 regulation of ubiquitin-dependent protein catabolic process2011, 2025 regulation of postsynaptic density assembly2024, 2025 positive regulation of protein metabolic process2015, 2025 positive regulation of neuron projection development2011, 2025 negative regulation of potassium ion transport2011, 2025 negative regulation of myeloid cell differentiation2011, 2025 marginal zone B cell differentiation2011, 2025 cellular response to retinoic acid2011, 2025 positive regulation of angiogenesis2011, 2025 establishment of protein localization2025 cell surface receptor protein tyrosine kinase signaling pathway2025 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction2011, 2022, 2023, 2025 regulation of cell differentiation2025 animal organ morphogenesis2025 peptidyl-tyrosine phosphorylation2006, 2011, 2017, 2025 positive regulation of cell growth2007, 2008, 2025 neuron migration2003, 2004, 2024 neuron differentiation2025 regulation of osteoblast differentiation2011, 2025 regulation of cell population proliferation2011, 2025 positive regulation of protein kinase activity2011, 2025 peptidyl-tyrosine autophosphorylation2014, 2017, 2025 negative regulation of cell adhesion mediated by integrin2025 ephrin receptor signaling pathway2011, 2025 activation of GTPase activity2007, 2024, 2025 regulation of focal adhesion assembly2011, 2015, 2025 protein autophosphorylation2007, 2011, 2016 positive regulation of synaptic transmission, glutamatergic2014, 2025 positive regulation of excitatory postsynaptic potential2014, 2025 negative regulation of ossification2007, 2025 negative regulation of neuron apoptotic process2021, 2025 negative regulation of anoikis2012, 2016, 2025 long-term synaptic potentiation2014, 2025 ionotropic glutamate receptor signaling pathway2021, 2025 cellular defense response2021, 2025 cell migration2002, 2022, 2025 activation of Janus kinase activity2007, 2011, 2025 MAPK cascade2007, 2008, 2025 transforming growth factor beta receptor signaling pathway2014, 2025 regulation of substrate adhesion-dependent cell spreading2015, 2025 regulation of modification of postsynaptic actin cytoskeleton2024 regulation of epithelial cell migration2015, 2025 postsynaptic modulation of chemical synaptic transmission2024, 2025 positive regulation of wound healing2019, 2025 positive regulation of synapse structural plasticity2009, 2025 positive regulation of macrophage proliferation2020, 2025 positive regulation of macrophage chemotaxis2020, 2025 positive regulation of fibroblast migration2019, 2025 positive regulation of epithelial to mesenchymal transition2022, 2025 positive regulation of epithelial cell migration2022, 2025 positive regulation of cell-cell adhesion mediated by integrin2025 negative regulation of cell-cell adhesion2012, 2025 negative regulation of autophagy2017 growth hormone receptor signaling pathway2011, 2025 actin filament organization2007, 2016, 2025 vasodilation2008, 2025 vasculogenesis2007 system development2025 stress fiber assembly2007, 2025 response to xenobiotic stimulus2007, 2008 response to mechanical stimulus2007, 2008 response to light intensity2024 response to ischemia2021, 2025 response to hydrogen peroxide2007, 2025 response to glucose2007, 2008 response to cation stress2021, 2025 regulation of protein localization2021 regulation of neurogenesis2025 regulation of cell-matrix adhesion2025 protein transport2024 protein phosphorylation2003 positive regulation of translation2007, 2025 positive regulation of synaptic transmission2008, 2025 positive regulation of smooth muscle cell proliferation2008, 2025 positive regulation of smooth muscle cell migration2008, 2025 positive regulation of reactive oxygen species metabolic process2007, 2025 positive regulation of phagocytosis2008, 2025 positive regulation of nitric-oxide synthase activity2015, 2025 positive regulation of nitric oxide biosynthetic process2015, 2025 positive regulation of glial cell proliferation2008, 2025 positive regulation of cytosolic calcium ion concentration2007, 2025 positive regulation of cell adhesion2008, 2025 positive regulation of cardiac muscle hypertrophy2017 positive regulation of JUN kinase activity2007, 2025 positive regulation of DNA biosynthetic process2015, 2025 oocyte maturation2007, 2025 nuclear migration2017 neuron projection development2007, 2025 negative regulation of synapse assembly2010 negative regulation of organ growth2006 negative regulation of muscle cell apoptotic process2007, 2025 negative regulation of cell migration2008, 2025 negative regulation of axonogenesis2007 microtubule cytoskeleton organization2003 long-term synaptic depression2015, 2025 light adaption2024 intracellular chloride ion homeostasis2008, 2025 focal adhesion assembly2006, 2025 extracellular matrix organization2005 endothelial cell migration2007 cytoskeleton organization2024 central nervous system neuron axonogenesis2007 cellular response to transforming growth factor beta stimulus2014 cellular response to fluid shear stress2015 cell adhesion2007, 2025 blood vessel endothelial cell migration2007, 2025 blood vessel development2007 JNK cascade2008, 2025 Golgi organization2024 wound healing, spreading of cells2016 vascular endothelial cell response to oscillatory fluid shear stress2025 response to reactive oxygen species2007 response to pH2016 response to muscle stretch2016 response to immobilization stress2007 response to hypoxia2007 response to hormone2007 response to ethanol2007 response to estradiol2008 response to cocaine2007 response to calcium ion2007 response to cAMP2007 response to arsenic-containing substance2008 regulation of synaptic plasticity2017 regulation of growth2025 regulation of endothelial cell migration2011 regulation of cytoskeleton organization2011 regulation of cell adhesion mediated by integrin2025 radial glia-guided pyramidal neuron migration2021 protein-containing complex assembly2003 protein localization to plasma membrane2020 postsynaptic actin cytoskeleton organization2025 positive regulation of substrate-dependent cell migration, cell attachment to substrate2016 positive regulation of protein tyrosine kinase activity2016 positive regulation of protein binding2016 positive regulation of focal adhesion assembly2016 placenta development2011 netrin-activated signaling pathway2011 negative regulation of synaptic assembly at neuromuscular junction2013 negative regulation of receptor recycling2018 negative regulation of protein autophosphorylation2016 negative regulation of cell-substrate adhesion2016 heart morphogenesis2011 glial cell proliferation2007 fat cell differentiation2008 establishment of cell polarity2011 detection of muscle stretch2020 cellular response to morphine2024 cell motility2011 axon guidance2011 apoptotic process2003 angiogenesis involved in wound healing2016 Fc-gamma receptor signaling pathway involved in phagocytosis2025

Cellular component: plasma membrane2016, 2017, 2018, 2024, 2025 focal adhesion2005, 2007, 2008, 2011, 2014, 2016, 2017, 2025 cell cortex2007, 2017, 2018, 2025 cell junction2025 dendritic spine2009, 2017, 2025 cytosol2011, 2013, 2018, 2024, 2025 glutamatergic synapse2024, 2025 cytoplasm2003, 2016, 2025 nucleus2011, 2015, 2025 perinuclear region of cytoplasm2007, 2011, 2015, 2025
lamellipodium2005, 2011, 2025 postsynapse2024, 2025 cell projection2018, 2025 protein-containing complex2017, 2025 postsynaptic density, intracellular component2024, 2025 presynapse2024, 2025 cell periphery2025 postsynaptic density2014, 2017, 2024, 2025 ciliary basal body2020, 2025 apical plasma membrane2006, 2008, 2025 cytoskeleton2003, 2025 neuronal cell body2014, 2025 growth cone2021, 2025 dendrite2014, 2025 centrosome2025 cell body2014, 2018, 2025 apical dendrite2014, 2025 NMDA selective glutamate receptor complex2014, 2025 stress fiber2014, 2025 sarcolemma2008, 2016, 2025 Schaffer collateral - CA1 synapse2024, 2025 nuclear body2008, 2025 intercalated disc2008, 2025 basolateral plasma membrane2008, 2025 axon2007, 2025 type Is terminal bouton2012 type Ib terminal bouton2012 tertiary granule membrane2016 secretory granule membrane2016 cilium2025 ciliary tip2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 0/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 0/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 20.0 40.0 60.0 80.0 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
FAK2_MOUSE
Ensembl»
70.5
Ptk2b Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta)
(CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)		 Mus musculus
TI:10090 None
 
FAK2_RAT
RGD»
88.1
Ptk2b Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell
adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2)		 Rattus norvegicus
TI:10116 None
 
FAK1_MOUSE
Ensembl»
58.1
Ptk2 Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal
adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)		 Mus musculus
TI:10090 None
 
FAK1_RAT
RGD»
56.7
Ptk2 Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal
adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)		 Rattus norvegicus
TI:10116 None
 
FAK2_HUMAN
Ensembl»
41.8
PTK2B Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta)
(CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)		 Homo sapiens
TI:9606 None
 
FAK1_HUMAN
Ensembl»
46.7
PTK2 Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase)
(FRNK) (Protein phosphatase 1 regulatory subunit 71) (PPP1R71) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)		 Homo sapiens
TI:9606 None
 
A0A8V0XZ82_CHICK
Ensembl»
2.0
PTK2B Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (Calcium-regulated non-receptor proline-rich tyrosine
kinase) (Cell adhesion kinase beta) (Focal adhesion kinase 2) (Proline-rich tyrosine kinase 2)		 Gallus gallus
TI:9031 None
   
FAK1_CHICK
TubercuList»
20.1
PTK2 Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal
adhesion kinase-related nonkinase) (FRNK) (p41/p43FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)		 Gallus gallus
TI:9031 None
 
Q7T2P8_DANRE
ZFIN»
2.0
ptk2bb non-specific protein-tyrosine
kinase (EC 2.7.10.2)		 Danio rerio
TI:7955 None
 
B7YZL9_DROME
FlyBase»
2.4
Fak Focal adhesion kinase, isoform D (EC 2.7.10.2) Drosophila melanogaster
TI:7227 None
 
A0A8M2B5G2_DANRE
ZFIN»
2.0
ptk2ba non-specific protein-tyrosine
kinase (EC 2.7.10.2)		 Danio rerio
TI:7955 None
 
FRPD1_MOUSE
Ensembl»
3.4
Frmpd1 FERM and PDZ domain-containing protein 1 Mus musculus
TI:10090 None
 
FRPD4_MOUSE
Ensembl»
2.5
Frmpd4 FERM and PDZ domain-containing protein 4 (PDZ domain-containing
protein 10) (PSD-95-interacting regulator of spine morphogenesis) (Preso)		 Mus musculus
TI:10090 None
 
D3ZW88_RAT
RGD»
2.5
Frmpd1 FERM and PDZ domain containing 1 Rattus norvegicus
TI:10116 None
   
Q7T2V4_DANRE
ZFIN»
1.6
ptk2aa Focal adhesion kinase 1 (EC
2.7.10.2) (Protein-tyrosine kinase 2) (pp125FAK)		 Danio rerio
TI:7955 None
 
A0A8V0Y9A0_CHICK
Ensembl»
0.0
PTK2 Focal adhesion kinase 1 (EC
2.7.10.2) (Protein-tyrosine kinase 2) (pp125FAK)		 Gallus gallus
TI:9031 None
   
FRPD1_HUMAN
Ensembl»
1.6
FRMPD1 FERM and PDZ domain-containing protein
1 (FERM domain-containing protein 2)		 Homo sapiens
TI:9606 None
 
FRPD4_HUMAN
Ensembl»
2.1
FRMPD4 FERM and PDZ domain-containing protein 4 (PDZ domain-containing
protein 10) (PSD-95-interacting regulator of spine morphogenesis) (Preso)		 Homo sapiens
TI:9606 None
 
A0A8V0X9L2_CHICK
Ensembl»
0.0
FRMPD1 FERM and PDZ domain containing 1 Gallus gallus
TI:9031 None
   
A0A8V0X7S1_CHICK
Ensembl»
0.5
FRMPD4 FERM and PDZ domain-containing protein 4 (PDZ
domain-containing protein 10) (PSD-95-interacting regulator of spine morphogenesis)		 Gallus gallus
TI:9031 None
   
Q9VFD3_DROME
FlyBase»
0.5
Dmel\CG42788 Uncharacterized protein, isoform B Drosophila melanogaster
TI:7227 None
 
FRPD3_HUMAN
Ensembl»
0.0
FRMPD3 FERM and PDZ domain-containing protein 3 Homo sapiens
TI:9606 None
 
A0A140LIW3_MOUSE
Ensembl»
0.0
Frmpd3 FERM and PDZ domain containing 3 Mus musculus
TI:10090 None
   
A0ABK0LHQ8_RAT
RGD»
0.0
Frmpd3 FERM and PDZ domain containing 3 Rattus norvegicus
TI:10116 None
   
A0A8I6GKT4_RAT
RGD»
0.0
Frmpd4 FERM and PDZ domain containing 4 Rattus norvegicus
TI:10116 None
   
A0A8M2BIA2_DANRE
ZFIN»
0.0
frmpd1a FERM and PDZ domain-containing protein 1 Danio rerio
TI:7955 None 		     
A0A8V0YVV3_CHICK
Ensembl»
0.0
FRMPD3 FERM and PDZ domain containing 3 Gallus gallus
TI:9031 None 		     
A0ACD6B5V7_DANRE
ZFIN»
0.0
frmpd1b Uncharacterized protein frmpd1b Danio rerio
TI:7955 None 		     
F1QKJ4_DANRE
ZFIN»
0.0
frmpd3 FERM and PDZ domain-containing 3 (FERM
and PDZ domain-containing protein 3 isoform X1)		 Danio rerio
TI:7955 None 		 
 
Q8MXF0_CAEEL
WormBase»
0.0
frm-8 FERM and PDZ domain-containing protein 4 Caenorhabditis elegans
TI:6239 None