Collated Gene Ontology terms

Biological process: RNA binding(2006, 2013, 2014, 2025) zinc ion binding(2022, 2025) metal ion binding(2025) nucleic acid binding(2014, 2025) sequence-specific double-stranded DNA binding(2020, 2025) enzyme binding(2025) proton-transporting ATPase activity, rotational mechanism(2021) nuclease activity(2025) hydrolase activity(2025) endonuclease activity(2025)
RNA endonuclease activity2006 DNA binding2025

Molecular function: mRNA processing2023, 2025 mRNA 3'-end processing2025 termination of RNA polymerase II transcription, poly(A)-coupled2025 polycistronic mRNA processing2014 embryonic body morphogenesis2018 RNA processing2018, 2022 response to xenobiotic stimulus2014 regulation of gene expression2025 regulation of RNA metabolic process2025 proton transmembrane transport2025
eye photoreceptor cell development2008 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway2023

Cellular component: nucleus2009, 2013, 2017, 2025 mRNA cleavage and polyadenylation specificity factor complex2004, 2006, 2010, 2013, 2016, 2017, 2018, 2019, 2022, 2025 nucleoplasm2018, 2022, 2024, 2025 cytosol2009, 2017, 2025 cytoplasm2025 PcG protein complex2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 4/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 6/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A078IT19_BRANA
neXtProt»
0.0
BnaAnng11340D BnaAnng11340D protein Brassica napus
TI:3708 None
 
A0A2C9VN56_MANES
euHCVdb»
0.0
MANES_06G055600v8 C3H1-type domain-containing protein Manihot esculenta
TI:3983 None
 
A0A2K3CN33_CHLRE
neXtProt»
0.0
CHLRE_24g755647v5 C3H1-type domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A3B6NMZ2_WHEAT
EnsemblPlants»
0.0
C3H1-type domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6PHL7_WHEAT
EnsemblPlants»
0.0
C3H1-type domain-containing protein Triticum aestivum
TI:4565 None
   
A0D6V7_PARTE
euHCVdb»
0.0
GSPATT00001815001 C3H1-type domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0DK00_PARTE
euHCVdb»
0.0
GSPATT00017711001 C3H1-type domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A2DBS7_TRIV3
TubercuList»
0.0
TVAG_094550 C3H1-type domain-containing protein Trichomonas vaginalis
TI:5722 None
 
A2EAT1_TRIV3
TubercuList»
0.0
TVAG_047060 C3H1-type domain-containing protein Trichomonas vaginalis
TI:5722 None
 
B8C4J7_THAPS
euHCVdb»
0.0
THAPSDRAFT_19126 C3H1-type domain-containing protein Thalassiosira pseudonana
TI:35128 None
 
Q55CA3_DICDI
dictyBase»
0.5
cpsf4 CCCH-type zinc finger-containing protein Dictyostelium discoideum
TI:44689 None
 
A0A7M7NSC2_STRPU
EnsemblMetazoa»
0.0
Cleavage and polyadenylation
specificity factor subunit 4		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A8R1Y6P1_PRIPA
EnsemblMetazoa»
0.0
WBGene00092888 Cleavage and polyadenylation
specificity factor subunit 4		 Pristionchus pacificus
TI:54126 None
   
A0A9J7NB40_BRAFL
neXtProt»
0.0
LOC118429553 Cleavage and polyadenylation
specificity factor subunit 4		 Branchiostoma floridae
TI:7739 None
   
A7S8B4_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g35001 Cleavage and polyadenylation
specificity factor subunit 4		 Nematostella vectensis
TI:45351 None
 
A8X0L5_CAEBR
WormBase»
0.0
mig-32 Cleavage and polyadenylation
specificity factor subunit 4		 Caenorhabditis briggsae
TI:6238 None
 
B3RPS1_TRIAD
CTD»
0.0
TRIADDRAFT_53642 Cleavage and polyadenylation
specificity factor subunit 4		 Trichoplax adhaerens
TI:10228 None
 
B7Q714_IXOSC
EnsemblMetazoa»
0.0
8036848 Cleavage and polyadenylation
specificity factor subunit 4		 Ixodes scapularis
TI:6945 None
 
CPSF4_XENLA
Xenbase»
0.0
cpsf4 Cleavage and polyadenylation
specificity factor subunit 4		 Xenopus laevis
TI:8355 None
 
CPSF4_XENTR
Xenbase»
0.0
cpsf4 Cleavage and polyadenylation
specificity factor subunit 4		 Xenopus tropicalis
TI:8364 None
 
D6WBZ0_TRICA
euHCVdb»
0.0
GLEAN_05002 Cleavage and polyadenylation
specificity factor subunit 4		 Tribolium castaneum
TI:7070 None
 
D6WGD0_TRICA
neXtProt»
0.0
AUGUSTUS-3.0.2_10339 Cleavage and polyadenylation
specificity factor subunit 4		 Tribolium castaneum
TI:7070 None
 
E9GIQ6_DAPPU
euHCVdb»
0.0
DAPPUDRAFT_51128 Cleavage and polyadenylation
specificity factor subunit 4		 Daphnia pulex
TI:6669 None
 
F5HKN3_ANOGA
EnsemblMetazoa»
0.0
11175715 Cleavage and polyadenylation
specificity factor subunit 4		 Anopheles gambiae
TI:7165 None
 
H2XUQ0_CIOIN
Ensembl»
0.0
Cleavage and polyadenylation
specificity factor subunit 4		 Ciona intestinalis
TI:7719 None
 
H3GWX4_PHYRM
EnsemblProtists»
0.0
Cleavage and polyadenylation
specificity factor subunit 4		 Phytophthora ramorum
TI:164328 None
 
Q7YTG9_CAEEL
WormBase»
0.0
cpsf-4 Cleavage and polyadenylation
specificity factor subunit 4		 Caenorhabditis elegans
TI:6239 None
 
Q382Q6_TRYB2
TubercuList»
0.0
Tb11.01.4600 Cleavage and polyadenylation specificity
factor 30 kDa subunit		 Trypanosoma brucei
TI:5691 None
 
A0A1L8EM14_XENLA
Xenbase»
0.0
cpsf4l.S Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Xenopus laevis
TI:8355 None
   
A0A1L8EXA7_XENLA
Xenbase»
0.0
cpsf4.L Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Xenopus laevis
TI:8355 None
   
A0A287BMQ8_PIG
Ensembl»
0.0
Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Sus scrofa
TI:9823 None
   
A0A2I2YK73_GORGO
Ensembl»
0.0
CPSF4L Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Gorilla gorilla
TI:9593 None
 
A0A2I3RK59_PANTR
Ensembl»
0.0
CPSF4L Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Pan troglodytes
TI:9598 None
 
A0A3Q2H6W1_HORSE
Ensembl»
0.0
CPSF4 Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Equus caballus
TI:9796 None
   
A0A480Y2Q2_PIG
Ensembl»
0.0
CPSF4 Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Sus scrofa
TI:9823 None
 
A0A5F8GQU9_MONDO
Ensembl»
0.0
Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Monodelphis domestica
TI:13616 None
   
A0A6I8NJD6_ORNAN
Ensembl»
0.0
CPSF4L Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A6I8NTJ0_ORNAN
Ensembl»
0.0
CPSF4 Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Ornithorhynchus anatinus
TI:9258 None
   
A0A803SMN3_ANOCA
Ensembl»
0.0
CPSF4 Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Anolis carolinensis
TI:28377 None
   
A0A8I3N5M4_CANLF
Ensembl»
0.0
CPSF4 Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Canis lupus
TI:9612 None
   
A0A8I3S188_CANLF
Ensembl»
0.0
Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Canis lupus
TI:9612 None
   
A0A8I6AUI5_RAT
RGD»
0.0
Cpsf4-ps1 Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Rattus norvegicus
TI:10116 None
   
A0A8V0ZJP7_CHICK
Ensembl»
0.0
CPSF4 Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Gallus gallus
TI:9031 None
   
A0A8V1AMD1_CHICK
Ensembl»
0.0
Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Gallus gallus
TI:9031 None
   
A0A9L0TQV3_HORSE
Ensembl»
0.0
CPSF4L Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Equus caballus
TI:9796 None
   
A0ABI7WCF3_FELCA
Ensembl»
0.0
CPSF4 Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Felis catus
TI:9685 None
   
A0ABI8AHN1_FELCA
Ensembl»
0.0
Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Felis catus
TI:9685 None
   
A0ABK0LZV4_RAT
RGD»
0.0
Cpsf4l Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Rattus norvegicus
TI:10116 None
   
F6QYI7_MACMU
Ensembl»
0.0
CPSF4 Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Macaca mulatta
TI:9544 None
   
F6U107_MONDO
Ensembl»
0.0
Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Monodelphis domestica
TI:13616 None
   
F7CXF4_MACMU
Ensembl»
0.0
CPSF4L Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Macaca mulatta
TI:9544 None
   
F7FVV8_MONDO
Ensembl»
0.0
CPSF4 Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Monodelphis domestica
TI:13616 None
   
G3RGL8_GORGO
Ensembl»
0.0
CPSF4 Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Gorilla gorilla
TI:9593 None
 
G3UWW6_MOUSE
Ensembl»
0.0
Cpsf4l Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Mus musculus
TI:10090 None
   
H2MF66_ORYLA
Ensembl»
0.0
CPSF4 Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Oryzias latipes
TI:8090 None
   
H2QV04_PANTR
Ensembl»
0.0
CPSF4 Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Pan troglodytes
TI:9598 None
 
Q28DB2_XENTR
Xenbase»
0.0
cpsf4l Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Xenopus tropicalis
TI:8364 None
 
Q28FZ4_XENTR
Xenbase»
0.0
cpsf4 Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Xenopus tropicalis
TI:8364 None
 
Q98881_DANRE
ZFIN»
0.8
cpsf4 Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Danio rerio
TI:7955 None
 
W5MBM3_LEPOC
Ensembl»
0.0
Cleavage and polyadenylation specificity factor subunit 4 (CPSF 30
kDa subunit) (Cleavage and polyadenylation specificity factor 30 kDa subunit)		 Lepisosteus oculatus
TI:7918 None
 
CPSF4_BOVIN
CTD»
0.0
CPSF4 Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and
polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit)		 Bos taurus
TI:9913 None
 
CPSF4_RAT
RGD»
1.0
Cpsf4 Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and
polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit)		 Rattus norvegicus
TI:10116 None
 
CPSF4_MOUSE
Ensembl»
1.0
Cpsf4 Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity
factor 30 kDa subunit) (CPSF 30 kDa subunit) (Clipper homolog) (Clipper/CPSF 30K)		 Mus musculus
TI:10090 None
 
CPSF4_HUMAN
Ensembl»
2.1
CPSF4 Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa
subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog)		 Homo sapiens
TI:9606 None
 
CPSF4_DROME
FlyBase»
1.3
Clp Cleavage and polyadenylation specificity factor subunit 4 (EC 3.1.-.-)
(Cleavage and polyadenylation specificity factor 30 kDa subunit) (Protein clipper)		 Drosophila melanogaster
TI:7227 None
 
M1BW73_SOLTU
EnsemblPlants»
0.0
Isoform 2 of Cleavage
and polyadenylation specificity factor CPSF30		 Solanum tuberosum
TI:4113 None
   
F2EIS5_HORVV
EnsemblPlants»
0.0
Predicted protein Hordeum vulgare
TI:4513 None
 
CPS4L_HUMAN
Ensembl»
0.0
CPSF4L Putative cleavage and polyadenylation
specificity factor subunit 4-like protein		 Homo sapiens
TI:9606 None
 
Q4QHV2_LEIMA
TubercuList»
0.0
LMJF_09_0720 Putative cleavage and polyadenylation
specificity factor 30 kDa subunit		 Leishmania major
TI:5664 None
 
A0A2A6C547_PRIPA
EnsemblMetazoa»
0.0
WBGene00096627 Uncharacterized protein Pristionchus pacificus
TI:54126 None
   
A8BFA9_GIAIC
TubercuList»
0.0
GL50803_0013225 YTH1 family protein Giardia intestinalis
TI:5741 None
 
C4M9G4_ENTH1
TubercuList»
0.0
EHI_067580 Zinc finger protein, putative Entamoeba histolytica
TI:5759 None
 
A0A7U2F4S2_PHANO
TubercuList»
0.0
JI435_047210 mRNA 3'-end-processing protein Phaeosphaeria nodorum
TI:13684 None
 
A7EKP8_SCLS1
euHCVdb»
0.0
SS1G_05895 mRNA 3'-end-processing protein Sclerotinia sclerotiorum
TI:5180 None
 
B6JVW0_SCHJY
TubercuList»
0.0
yth1 mRNA 3'-end-processing protein Schizosaccharomyces japonicus
TI:4897 None
 
E3KBS3_PUCGT
TubercuList»
0.0
PGTG_07785 mRNA 3'-end-processing protein Puccinia graminis
TI:5297 None
 
F4P3G1_BATDJ
euHCVdb»
0.0
BATDEDRAFT_5960 mRNA 3'-end-processing protein Batrachochytrium dendrobatidis
TI:109871 None
 
YTH1_CANAL
EnsemblFungi»
0.0
YTH1 mRNA 3'-end-processing protein YTH1 Candida albicans
TI:5476 None
 
YTH1_CRYD1
EnsemblFungi»
0.0
YTH1 mRNA 3'-end-processing protein YTH1 Cryptococcus deneoformans
TI:40410 None
 
YTH1_EREGS
EnsemblFungi»
0.0
YTH1 mRNA 3'-end-processing protein YTH1 Eremothecium gossypii
TI:33169 None
 
YTH1_YARLI
EnsemblFungi»
0.0
YTH1 mRNA 3'-end-processing protein YTH1 Yarrowia lipolytica
TI:4952 None
 
YTH1_YEAST
SGD»
3.6
YTH1 mRNA 3'-end-processing protein YTH1
(Yeast 30 kDa homolog 1)		 Saccharomyces cerevisiae
TI:4932 None
 
YTH1_NEUCR
EnsemblFungi»
0.0
yth-1 mRNA 3'-end-processing protein yth-1 Neurospora crassa
TI:5141 None
 
YTH1_ASPFU
EnsemblFungi»
0.0
yth1 mRNA 3'-end-processing protein yth1 Aspergillus fumigatus
TI:746128 None
 
YTH1_EMENI
EnsemblFungi»
0.0
yth1 mRNA 3'-end-processing protein yth1 Emericella nidulans
TI:162425 None
 
YTH1_SCHPO
PomBase»
1.6
yth1 mRNA 3'-end-processing protein yth1 Schizosaccharomyces pombe
TI:4896 None