Collated Gene Ontology terms

Biological process: RNA binding(2014, 2024) nucleic acid binding(2024) ligase activity(2024) transferase activity(2024) ATP binding(2024) 5-formyltetrahydrofolate cyclo-ligase activity(2012)

Molecular function: anterior/posterior pattern specification2011 pole plasm oskar mRNA localization2011 pole plasm mRNA localization2011 pole cell development2011 mRNA splicing, via spliceosome2010

Cellular component: cytoplasm2011, 2020, 2024 chloroplast2012, 2021, 2024 ribonucleoprotein complex2011 precatalytic spliceosome2010 mitochondrion2019 cytosol2015 catalytic step 2 spliceosome2010

Phylogenetic distribution

Chordates: 19/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 3/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 0/3 
Excavates: 0/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 35/39 
Archea: 4/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
5FCLL_ARATH
TAIR»
0.8
COG0212 5-formyltetrahydrofolate cyclo-ligase-like protein COG0212 (Protein
CLUSTERS OF ORTHOLOGOUS GROUP 212)		 Arabidopsis thaliana
TI:3702 None
 
A0A022PRQ4_ERYGU
EnsemblFungi»
0.0
MIMGU_mgv1a006923mg 5-formyltetrahydrofolate cyclo-ligase Erythranthe guttata
TI:4155 None
 
A0A061FJD7_THECC
EnsemblPlants»
0.0
TCM_035650 Catalytic, putative isoform 1 Theobroma cacao
TI:3641 None
 
A0A067H7V4_CITSI
Ensembl»
0.0
CISIN_1g018338mg 5-formyltetrahydrofolate cyclo-ligase Citrus sinensis
TI:2711 None
 
A0A072U8D4_MEDTR
EnsemblPlants»
0.0
25496158 5-formyltetrahydrofolate cyclo-ligase Medicago truncatula
TI:3880 None 		 
 
A0A0A0K8Q5_CUCSA
EnsemblPlants»
0.0
Csa_6G055950 Uncharacterized protein Cucumis sativus
TI:3659 None 		 
 
A0A0A0KBB0_CUCSA
EnsemblPlants»
0.0
Csa_6G056470 5-formyltetrahydrofolate cyclo-ligase Cucumis sativus
TI:3659 None 		 
 
A0A0A0KCL2_CUCSA
EnsemblPlants»
0.0
Csa_6G055965 Uncharacterized protein Cucumis sativus
TI:3659 None 		 
 
A0A0A0KED0_CUCSA
EnsemblPlants»
0.0
Csa_6G055960 5-formyltetrahydrofolate cyclo-ligase Cucumis sativus
TI:3659 None
 
A0A0P0Y793_ORYSJ
EnsemblPlants»
0.0
Os12g0168000 Os12g0168000 protein Oryza sativa
TI:4530 None 		 
 
A0A1D6ITY9_MAIZE
EnsemblPlants»
0.0
100192785 5-formyltetrahydrofolate cyclo-ligase1 Zea mays
TI:4577 None
 
A0A1S3ZLV8_TOBAC
EnsemblFungi»
0.0
LOC107788183 5-formyltetrahydrofolate cyclo-ligase-like protein
COG0212 isoform X1		 Nicotiana tabacum
TI:4097 None
   
A0A1S4C0U1_TOBAC
EnsemblFungi»
0.0
LOC107813891 5-formyltetrahydrofolate cyclo-ligase-like
protein COG0212		 Nicotiana tabacum
TI:4097 None 		     
A0A1S4G9G6_ANOGA
EnsemblMetazoa»
0.0
Uncharacterized protein Anopheles gambiae
TI:7165 None
 
A0A1U8AF64_NELNU
EnsemblBacteria»
0.0
LOC104599940 5-formyltetrahydrofolate cyclo-ligase-like
protein COG0212		 Nelumbo nucifera
TI:4432 None
   
A0A1U8L097_GOSHI
Ensembl»
0.0
LOC107922504 5-formyltetrahydrofolate cyclo-ligase-like
protein COG0212		 Gossypium hirsutum
TI:3635 None
   
A0A1Y1HMF3_KLENI
EnsemblPlants»
0.0
KFL_000380180 5-formyltetrahydrofolate cyclo-ligase Klebsormidium nitens
TI:105231 None
 
A0A1Z5R5G0_SORBI
EnsemblPlants»
0.0
SORBI_3008G050400 5-formyltetrahydrofolate cyclo-ligase Sorghum bicolor
TI:4558 None
 
A0A251MSI3_PRUPE
EnsemblPlants»
0.0
PRUPE_8G036900 5-formyltetrahydrofolate cyclo-ligase Prunus persica
TI:3760 None
 
A0A251UZN9_HELAN
EnsemblPlants»
0.0
HannXRQ_Chr04g0115661 HanXRQr2_Chr04g0158321 5-formyltetrahydrofolate cyclo-ligase, nagB/RpiA transferase
(Putative nagB/RpiA/CoA transferase-like superfamily protein)		 Helianthus annuus
TI:4232 None
 
A0A287APY9_PIG
Ensembl»
0.0
MTHFSD Methenyltetrahydrofolate synthase
domain-containing protein		 Sus scrofa
TI:9823 None
 
A0A2C9U3H7_MANES
EnsemblPlants»
0.0
MANES_18G093500 5-formyltetrahydrofolate cyclo-ligase Manihot esculenta
TI:3983 None
 
A0A2G2ZPU8_CAPAN
EnsemblPlants»
0.0
T459_12446 Methenyltetrahydrofolate synthase
domain-containing protein		 Capsicum annuum
TI:4072 None
 
A0A2I3SDF9_PANTR
Ensembl»
0.0
MTHFSD Methenyltetrahydrofolate synthase
domain-containing protein		 Pan troglodytes
TI:9598 None
 
A0A2I4DMA6_JUGRE
EnsemblPlants»
0.0
LOC108981528 5-formyltetrahydrofolate cyclo-ligase-like
protein COG0212		 Juglans regia
TI:51240 None
 
A0A2K1J1F5_PHYPA
EnsemblPlants»
0.0
PHYPA_023257 Methenyltetrahydrofolate synthase
domain-containing protein		 Physcomitrium patens
TI:3218 None
 
A0A2K3D0U3_CHLRE
EnsemblPlants»
0.0
CHLRE_13g587450v5 5-formyltetrahydrofolate cyclo-ligase Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6XP51_MARPO
EnsemblPlants»
0.0
MARPO_0007s0250 5-formyltetrahydrofolate cyclo-ligase Marchantia polymorpha
TI:3197 None
 
A0A3B3HKA9_ORYLA
Ensembl»
0.0
mthfsd Methenyltetrahydrofolate synthase
domain-containing protein		 Oryzias latipes
TI:8090 None
   
A0A3B6KDH3_WHEAT
EnsemblPlants»
0.0
CFC21_064903 5-formyltetrahydrofolate cyclo-ligase Triticum aestivum
TI:4565 None
 
A0A3B6LH33_WHEAT
EnsemblPlants»
0.0
CFC21_070697 5-formyltetrahydrofolate cyclo-ligase Triticum aestivum
TI:4565 None
 
A0A3B6MNM3_WHEAT
EnsemblPlants»
0.0
CFC21_076748 5-formyltetrahydrofolate cyclo-ligase Triticum aestivum
TI:4565 None 		 
 
A0A3Q7G6I7_SOLLC
EnsemblPlants»
0.0
101249350 5-formyltetrahydrofolate cyclo-ligase Solanum lycopersicum
TI:4081 None
   
A0A7M7PF59_STRPU
EnsemblMetazoa»
0.0
Methenyltetrahydrofolate synthase
domain-containing protein		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7T3H3_STRPU
EnsemblMetazoa»
0.0
Methenyltetrahydrofolate synthase
domain-containing protein		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A803T359_ANOCA
Ensembl»
0.0
Methenyltetrahydrofolate synthase
domain-containing protein		 Anolis carolinensis
TI:28377 None
   
A0A804JI01_MUSAM
EnsemblPlants»
0.0
103988101 5-formyltetrahydrofolate cyclo-ligase Musa acuminata
TI:4641 None 		     
A0A8I3MRL8_CANLF
Ensembl»
0.0
MTHFSD Methenyltetrahydrofolate synthase
domain-containing protein		 Canis lupus
TI:9612 None
   
A0A8I3RRX1_CANLF
Ensembl»
0.0
Uncharacterized protein Canis lupus
TI:9612 None 		     
A0A8I5ZVM1_RAT
RGD»
0.0
Mthfsd Methenyltetrahydrofolate synthase
domain-containing protein		 Rattus norvegicus
TI:10116 None
   
A0A8I6XKN2_HORVV
EnsemblPlants»
0.0
5-formyltetrahydrofolate cyclo-ligase Hordeum vulgare
TI:4513 None 		     
A0A8J0UZ79_XENLA
CTD»
0.0
mthfsd.L Methenyltetrahydrofolate synthase
domain-containing protein		 Xenopus laevis
TI:8355 None
   
A0A8V0XX30_CHICK
Ensembl»
0.0
MTHFSD Methenyltetrahydrofolate synthase
domain-containing protein		 Gallus gallus
TI:9031 None
   
A7ERE4_SCLS1
VEuPathDB»
0.0
SS1G_07898 Uncharacterized protein Sclerotinia sclerotiorum
TI:5180 None 		 
 
B1L771_KORCO
EnsemblBacteria»
0.0
Kcr_1554 5-formyltetrahydrofolate cyclo-ligase Korarchaeum cryptofilum
TI:498846 None
 
B5YLV2_THAPS
EnsemblProtists»
0.0
THAPS_15961 5-formyltetrahydrofolate cyclo-ligase Thalassiosira pseudonana
TI:35128 None
 
B9H7U6_POPTR
EnsemblPlants»
0.0
POPTR_005G194800 5-formyltetrahydrofolate cyclo-ligase
family protein		 Populus trichocarpa
TI:3694 None
 
B9SE88_RICCO
EnsemblBacteria»
0.0
RCOM_0959760 Catalytic, putative Ricinus communis
TI:3988 None
 
D6X243_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_12407 Methenyltetrahydrofolate synthase
domain-containing protein-like Protein		 Tribolium castaneum
TI:7070 None
 
D8R9A9_SELML
EnsemblPlants»
0.0
SELMODRAFT_88014 5-formyltetrahydrofolate cyclo-ligase Selaginella moellendorffii
TI:88036 None
 
D8RLR8_SELML
EnsemblPlants»
0.0
SELMODRAFT_56118 5-formyltetrahydrofolate cyclo-ligase Selaginella moellendorffii
TI:88036 None
 
D8RNA0_SELML
EnsemblPlants»
0.0
SELMODRAFT_56116 5-formyltetrahydrofolate cyclo-ligase Selaginella moellendorffii
TI:88036 None
 
D8TAE3_SELML
EnsemblPlants»
0.0
SELMODRAFT_430751 5-formyltetrahydrofolate cyclo-ligase Selaginella moellendorffii
TI:88036 None
 
D8TAL7_SELML
EnsemblPlants»
0.0
SELMODRAFT_186907 5-formyltetrahydrofolate cyclo-ligase Selaginella moellendorffii
TI:88036 None
 
D8TGN9_SELML
EnsemblPlants»
0.0
SELMODRAFT_432656 Uncharacterized protein Selaginella moellendorffii
TI:88036 None
 
F6GY50_VITVI
EnsemblPlants»
0.0
VIT_18s0072g00300 5-formyltetrahydrofolate cyclo-ligase-like
protein COG0212		 Vitis vinifera
TI:29760 None
 
F6Q2V4_MACMU
Ensembl»
0.0
MTHFSD Methenyltetrahydrofolate synthase
domain-containing protein		 Macaca mulatta
TI:9544 None
   
F6U963_MONDO
Ensembl»
0.0
MTHFSD Methenyltetrahydrofolate synthase
domain-containing protein		 Monodelphis domestica
TI:13616 None
   
F7B691_XENTR
Xenbase»
0.0
mthfsd Methenyltetrahydrofolate synthase
domain-containing protein		 Xenopus tropicalis
TI:8364 None
   
F7D3U7_ORNAN
Ensembl»
0.0
MTHFSD Methenyltetrahydrofolate synthase
domain-containing protein		 Ornithorhynchus anatinus
TI:9258 None
   
G3RF41_GORGO
Ensembl»
0.0
MTHFSD Methenyltetrahydrofolate synthase
domain-containing protein		 Gorilla gorilla
TI:9593 None
 
I1IU26_BRADI
EnsemblPlants»
0.0
100831995 5-formyltetrahydrofolate cyclo-ligase Brachypodium distachyon
TI:15368 None
 
I3T039_MEDTR
EnsemblPlants»
0.0
25496155 5-formyltetrahydrofolate cyclo-ligase Medicago truncatula
TI:3880 None
 
K3Y8D4_SETIT
EnsemblPlants»
0.0
101768067 5-formyltetrahydrofolate cyclo-ligase Setaria italica
TI:4555 None
 
K3YF41_SETIT
EnsemblPlants»
0.0
5-formyltetrahydrofolate cyclo-ligase Setaria italica
TI:4555 None 		 
 
K7K717_SOYBN
EnsemblPlants»
0.0
GLYMA_02G080400 5-formyltetrahydrofolate cyclo-ligase Glycine max
TI:3847 None
 
K7MHQ6_SOYBN
EnsemblPlants»
0.0
GLYMA_16G164900 5-formyltetrahydrofolate cyclo-ligase Glycine max
TI:3847 None
 
M1A7G1_SOLTU
EnsemblPlants»
0.0
102583821 5-formyltetrahydrofolate cyclo-ligase
family protein		 Solanum tuberosum
TI:4113 None
   
M3X8M0_FELCA
Ensembl»
0.0
MTHFSD Methenyltetrahydrofolate synthase
domain-containing protein		 Felis catus
TI:9685 None
 
M4CHM7_BRACM
EnsemblPlants»
0.0
5-formyltetrahydrofolate cyclo-ligase Brassica campestris
TI:3711 None
   
MTHSD_BOVIN
Ensembl»
0.0
MTHFSD Methenyltetrahydrofolate synthase
domain-containing protein		 Bos taurus
TI:9913 None
 
MTHSD_DANRE
ZFIN»
0.0
mthfsd Methenyltetrahydrofolate synthase
domain-containing protein		 Danio rerio
TI:7955 None
 
MTHSD_HUMAN
Ensembl»
0.5
MTHFSD Methenyltetrahydrofolate synthase
domain-containing protein		 Homo sapiens
TI:9606 None
 
MTHSD_MOUSE
Ensembl»
0.0
Mthfsd Methenyltetrahydrofolate synthase
domain-containing protein		 Mus musculus
TI:10090 None
 
MTHSD_XENLA
Xenbase»
0.0
mthfsd Methenyltetrahydrofolate synthase
domain-containing protein		 Xenopus laevis
TI:8355 None
 
Q8ZUZ3_PYRAE
EnsemblBacteria»
0.0
PAE2536 5-formyltetrahydrofolate cyclo-ligase Pyrobaculum aerophilum
TI:13773 None
 
Q97ZW6_SACS2
EnsemblBacteria»
0.0
SSO0456 5-formyltetrahydrofolate cyclo-ligase Saccharolobus solfataricus
TI:2287 None
 
Q9HP36_HALSA
EnsemblBacteria»
0.0
VNG_1823C Probable COG0212-type thiamine metabolismprotein Halobacterium salinarum
TI:2242 None
 
Q9VN21_DROME
FlyBase»
5.0
lost LD30155p (Lost) Drosophila melanogaster
TI:7227 None
 
T1FRL0_HELRO
EnsemblMetazoa»
0.0
20211457 Methenyltetrahydrofolate synthase
domain-containing protein		 Helobdella robusta
TI:6412 None
 
T1FWP9_HELRO
EnsemblMetazoa»
0.0
20213244 Methenyltetrahydrofolate synthase
domain-containing protein		 Helobdella robusta
TI:6412 None
 
T1G909_HELRO
EnsemblMetazoa»
0.0
20217556 Methenyltetrahydrofolate synthase
domain-containing protein		 Helobdella robusta
TI:6412 None
 
W1PFG5_AMBTC
EnsemblPlants»
0.0
AMTR_s00017p00235750 5-formyltetrahydrofolate cyclo-ligase Amborella trichopoda
TI:13333 None
 
W5LYJ4_LEPOC
Ensembl»
0.0
Methenyltetrahydrofolate synthase
domain-containing protein		 Lepisosteus oculatus
TI:7918 None