Collated Gene Ontology terms

Biological process: hydro-lyase activity(2024) (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity(2010, 2017, 2022, 2024) lyase activity(2024) fatty acid synthase activity(2014, 2022, 2024) oxidoreductase activity(2014) 3-hydroxyacyl-CoA dehydratase activity(2024)

Molecular function: fatty acid biosynthetic process2014, 2017, 2022, 2024 thylakoid membrane organization2017, 2024 photorespiration2017, 2024 fatty acid metabolic process2024 tRNA processing2024 tRNA 5'-leader removal2024 long-chain fatty acid biosynthetic process2010 fatty-acyl-CoA biosynthetic process2024 fatty acid elongation2010

Cellular component: mitochondrion2014, 2017, 2022, 2023, 2024 nucleolus2023, 2024 plasma membrane2010 nuclear lumen2017 membrane2024 cytoplasm2017 ciliary plasm2017 fatty acid synthase complex2024 ribonucleoprotein complex2024 ribonuclease P complex2024
peptidoglycan-based cell wall2012 mitochondrial matrix2017 endoribonuclease complex2024

Phylogenetic distribution

Chordates: 17/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 0/3 
Arthropods: 2/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 1/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 35/39 
Archea: 0/8 
Bacteria: 8/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
MTHD_ARATH
TAIR»
4.0
MTHD 3-hydroxyacyl-[acyl-carrier-protein] dehydratase, mitochondrial
(mtHD) (EC 4.2.1.59)		 Arabidopsis thaliana
TI:3702 None
 
HTD2_HUMAN
Ensembl»
2.8
HTD2 Hydroxyacyl-thioester dehydratase type 2, mitochondrial
(HsHTD2) (EC 4.2.1.59) (3-hydroxyacyl-[acyl-carrier-protein] dehydratase)		 Homo sapiens
TI:9606 None
 
Q54T75_DICDI
dictyBase»
1.0
DDB_G0281965 MaoC-like domain-containing protein Dictyostelium discoideum
TI:44689 None
 
Q9VEV6_DROME
FlyBase»
1.0
Dmel\CG14881 Uncharacterized protein, isoform A Drosophila melanogaster
TI:7227 None
 
A0A022RB45_ERYGU
EnsemblFungi»
0.0
MIMGU_mgv1a014865mg MaoC-like domain-containing protein Erythranthe guttata
TI:4155 None
 
A0A061GVA5_THECC
EnsemblPlants»
0.0
TCM_041087 Thioesterase superfamily protein,
putative isoform 2		 Theobroma cacao
TI:3641 None
 
A0A067G0J2_CITSI
Ensembl»
0.0
CISIN_1g031503mg MaoC-like domain-containing protein Citrus sinensis
TI:2711 None
 
A0A0A0KCN3_CUCSA
EnsemblPlants»
0.0
Csa_6G290840 MaoC-like domain-containing protein Cucumis sativus
TI:3659 None
 
A0A0K9PK73_ZOSMR
EnsemblPlants»
0.0
ZOSMA_235G00220 MaoC-like domain-containing protein Zostera marina
TI:29655 None
 
A0A0Q3GNE1_BRADI
EnsemblPlants»
0.0
BRADI_1g00740v3 MaoC-like domain-containing protein Brachypodium distachyon
TI:15368 None
 
A0A1S3XUU0_TOBAC
EnsemblFungi»
0.0
LOC107769053 (R)-specific enoyl-CoA hydratase-like Nicotiana tabacum
TI:4097 None
   
A0A1S3Y2P7_TOBAC
EnsemblFungi»
0.0
LOC107771533 (R)-specific enoyl-CoA hydratase-like Nicotiana tabacum
TI:4097 None
   
A0A1S4C7W8_TOBAC
EnsemblFungi»
0.0
LOC107816070 (R)-specific enoyl-CoA hydratase-like Nicotiana tabacum
TI:4097 None
   
A0A1U7ZFM2_NELNU
EnsemblBacteria»
0.0
LOC104589636 Uncharacterized protein LOC104589636 isoform X1 Nelumbo nucifera
TI:4432 None
   
A0A1U8H3B4_CAPAN
EnsemblPlants»
0.0
T459_18134 MaoC-like domain-containing protein Capsicum annuum
TI:4072 None
 
A0A1U8P149_GOSHI
Ensembl»
0.0
LOC107953207 (R)-specific enoyl-CoA hydratase-like Gossypium hirsutum
TI:3635 None
   
A0A1U8P4T7_GOSHI
Ensembl»
0.0
LOC107954242 (R)-specific enoyl-CoA hydratase-like Gossypium hirsutum
TI:3635 None
   
A0A1Y1IFX2_KLENI
EnsemblPlants»
0.0
KFL_005330080 MaoC-like domain-containing protein Klebsormidium nitens
TI:105231 None
 
A0A251VQU7_HELAN
EnsemblPlants»
0.0
HannXRQ_Chr01g0019131 HanXRQr2_Chr01g0030841 Enoyl-CoA hydratase 2 (EC
4.2.1.119) (Putative thioesterase superfamily protein)		 Helianthus annuus
TI:4232 None
 
A0A2C9V2E2_MANES
EnsemblPlants»
0.0
MANES_11G141200 MaoC-like domain-containing protein Manihot esculenta
TI:3983 None
 
A0A2I2YP22_GORGO
Ensembl»
0.0
HTD2 Hydroxyacyl-thioester dehydratase type 2 Gorilla gorilla
TI:9593 None
 
A0A2I4EHE7_JUGRE
EnsemblPlants»
0.0
LOC108989606 (R)-specific enoyl-CoA hydratase Juglans regia
TI:51240 None
 
A0A2K1XCM0_POPTR
EnsemblPlants»
0.0
POPTR_016G083000 Thioesterase domain-containing protein Populus trichocarpa
TI:3694 None
 
A0A2K3D5I8_CHLRE
EnsemblPlants»
0.0
CHLRE_12g560100v5 MaoC-like domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A2K3DW09_CHLRE
EnsemblPlants»
0.0
CHLRE_03g156000v5 Guanylate cyclase domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
   
A0A2R6XIB2_MARPO
EnsemblPlants»
0.0
MARPO_0013s0067 MaoC-like domain-containing protein Marchantia polymorpha
TI:3197 None
 
A0A337SPN4_FELCA
Ensembl»
0.0
HTD2 Hydroxyacyl-thioester dehydratase type 2 Felis catus
TI:9685 None
 
A0A3B5Y4I8_WHEAT
EnsemblPlants»
0.0
MaoC-like domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B5Y5B3_WHEAT
EnsemblPlants»
0.0
MaoC-like domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B5Z2D9_WHEAT
EnsemblPlants»
0.0
CFC21_008331 MaoC-like domain-containing protein Triticum aestivum
TI:4565 None
 
A0A3B5Z405_WHEAT
EnsemblPlants»
0.0
MaoC-like domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6A0G5_WHEAT
EnsemblPlants»
0.0
MaoC-like domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6A0Q2_WHEAT
EnsemblPlants»
0.0
CFC21_013228 MaoC-like domain-containing protein Triticum aestivum
TI:4565 None
 
A0A3N7F9M1_POPTR
EnsemblPlants»
0.0
POPTR_006G133800 MaoC-like domain-containing protein Populus trichocarpa
TI:3694 None
 
A0A4X1VKF6_PIG
Ensembl»
0.0
HTD2 Hydroxyacyl-thioester dehydratase type 2
(Hydroxyacyl-thioester dehydratase type 2, mitochondrial)		 Sus scrofa
TI:9823 None
 
A0A5F8HJA8_MONDO
Ensembl»
0.0
HTD2 Hydroxyacyl-thioester dehydratase type 2 Monodelphis domestica
TI:13616 None
   
A0A6I8NLW5_ORNAN
Ensembl»
0.0
HTD2 Hydroxyacyl-thioester dehydratase type 2 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7FZQ6_STRPU
EnsemblMetazoa»
0.0
MaoC-like domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A803SPJ6_ANOCA
Ensembl»
0.0
HTD2 Hydroxyacyl-thioester dehydratase type 2 Anolis carolinensis
TI:28377 None
   
A0A804IL54_MUSAM
EnsemblPlants»
0.0
103980634 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A804MIL7_MAIZE
EnsemblPlants»
0.0
MaoC-like domain-containing protein Zea mays
TI:4577 None
   
A0A8I3P7F3_CANLF
Ensembl»
0.0
HTD2 Hydroxyacyl-thioester dehydratase type 2 Canis lupus
TI:9612 None
   
A0A8I6WXH5_HORVV
EnsemblPlants»
0.0
MaoC-like domain-containing protein Hordeum vulgare
TI:4513 None
   
A0A8I7B1H2_HORVV
EnsemblPlants»
0.0
MaoC-like domain-containing protein Hordeum vulgare
TI:4513 None
   
A0A8J0U7T6_XENLA
Xenbase»
0.0
LOC108704592 Hydroxyacyl-thioester dehydratase
type 2, mitochondrial		 Xenopus laevis
TI:8355 None
   
A0A8V0ZFV6_CHICK
Ensembl»
0.0
RPP14 Hydroxyacyl-thioester dehydratase type 2 Gallus gallus
TI:9031 None
   
A0A9J7LWG7_BRAFL
CTD»
0.0
LOC118425584 Hydroxyacyl-thioester dehydratase
type 2, mitochondrial-like		 Branchiostoma floridae
TI:7739 None
   
A0CIH5_PARTE
EnsemblProtists»
0.0
GSPATT00007727001 Chromosome undetermined scaffold_19,
whole genome shotgun sequence		 Paramecium tetraurelia
TI:5888 None
 
A9S7I9_PHYPA
EnsemblPlants»
0.0
PHYPA_030762 MaoC-like domain-containing protein Physcomitrium patens
TI:3218 None
 
A9UWL2_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_36649 MaoC-like domain-containing protein Monosiga brevicollis
TI:81824 None
 
A9WAM4_CHLAA
EnsemblBacteria»
0.0
Caur_3631 MaoC domain protein dehydratase Chloroflexus aurantiacus
TI:1108 None
 
A9WAM6_CHLAA
EnsemblBacteria»
0.0
Caur_3633 MaoC-like dehydratase Chloroflexus aurantiacus
TI:1108 None
 
B3RKL4_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_52813 MaoC-like domain-containing protein Trichoplax adhaerens
TI:10228 None
 
B7Q588_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW011050 MaoC-like domain-containing protein Ixodes scapularis
TI:6945 None
 
B8C6Y3_THAPS
EnsemblProtists»
0.0
THAPSDRAFT_36013 MaoC-like domain-containing protein Thalassiosira pseudonana
TI:35128 None
 
B9SK30_RICCO
EnsemblBacteria»
0.0
RCOM_1399350 Oxidoreductase, putative Ricinus communis
TI:3988 None
 
B9TLA3_RICCO
EnsemblBacteria»
0.0
RCOM_2017100 MaoC-like domain-containing protein Ricinus communis
TI:3988 None
 
C0P3F6_MAIZE
EnsemblPlants»
0.0
100381995 Thioesterase superfamily protein Zea mays
TI:4577 None
 
C5YC76_SORBI
EnsemblPlants»
0.0
SORBI_3006G016500 MaoC-like domain-containing protein Sorghum bicolor
TI:4558 None
 
D8R0P0_SELML
EnsemblPlants»
0.0
SELMODRAFT_270463 MaoC-like domain-containing protein Selaginella moellendorffii
TI:88036 None
 
D8T1K4_SELML
EnsemblPlants»
0.0
SELMODRAFT_269526 MaoC-like domain-containing protein Selaginella moellendorffii
TI:88036 None
 
F1A2F8_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_11264 MaoC-like domain-containing protein Dictyostelium purpureum
TI:5786 None
 
F6GTY3_VITVI
EnsemblPlants»
0.0
VIT_06s0004g03290 MaoC-like domain-containing protein Vitis vinifera
TI:29760 None
 
F7H2H7_MACMU
Ensembl»
0.0
HTD2 Hydroxyacyl-thioester dehydratase type 2 Macaca mulatta
TI:9544 None
   
FERN_SOLLC
EnsemblPlants»
0.0
FERN 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FERN, mitochondrial (3-hydroxyl-ACP dehydratase
FERN) (EC 4.2.1.59) (Protein FERN-LIKE) (SlFERN)		 Solanum lycopersicum
TI:4081 None
   
G3XD52_PSEAE
EnsemblBacteria»
0.0
PA3302 MaoC-like domain-containing protein Pseudomonas aeruginosa
TI:287 None
 
G7K300_MEDTR
EnsemblPlants»
0.0
11429674 (R)-specific enoyl-CoA hydratase (Putative
enoyl-CoA hydratase 2 (EC 4.2.1.119))		 Medicago truncatula
TI:3880 None
 
H2MDH5_ORYLA
Ensembl»
0.0
HTD2 Hydroxyacyl-thioester dehydratase
type 2, mitochondrial-like		 Oryzias latipes
TI:8090 None
   
H2RGP9_PANTR
Ensembl»
0.0
HTD2 Hydroxyacyl-thioester dehydratase type 2 Pan troglodytes
TI:9598 None
 
H2XTC8_CIOIN
Ensembl»
0.0
MaoC-like domain-containing protein Ciona intestinalis
TI:7719 None
 
I1M7A1_SOYBN
EnsemblPlants»
0.0
102666018 MaoC-like domain-containing protein Glycine max
TI:3847 None
 
I6Y340_MYCTU
TubercuList»
0.0
Rv0216 Double hotdog hydratase Mycobacterium tuberculosis
TI:1773 None
 
K3YAC9_SETIT
EnsemblPlants»
0.0
101776543 MaoC-like domain-containing protein Setaria italica
TI:4555 None
 
K7KB44_SOYBN
EnsemblPlants»
0.0
100811584 MaoC-like domain-containing protein Glycine max
TI:3847 None
 
K9K405_HORSE
Ensembl»
0.0
LOC111768318 Hydroxyacyl-thioester dehydratase type 2 Equus caballus
TI:9796 None
 
M1AVI0_SOLTU
EnsemblPlants»
0.0
102588137 Oxidoreductase Solanum tuberosum
TI:4113 None
   
M4CE57_BRACM
EnsemblPlants»
0.0
MaoC-like domain-containing protein Brassica campestris
TI:3711 None
   
M4CR26_BRACM
EnsemblPlants»
0.0
MaoC-like domain-containing protein Brassica campestris
TI:3711 None
   
M5W3G3_PRUPE
EnsemblPlants»
0.0
PRUPE_6G094800 MaoC-like domain-containing protein Prunus persica
TI:3760 None
 
Q4QIP9_LEIMA
EnsemblProtists»
0.0
HTD2-1 Putative 3-hydroxyacyl-ACP
dehydratase (EC 4.2.1.-)		 Leishmania major
TI:5664 None
 
Q4QIQ0_LEIMA
EnsemblProtists»
0.0
HTD2-2 Putative 3-hydroxyacyl-ACP
dehydratase (EC 4.2.1.-)		 Leishmania major
TI:5664 None
 
Q580H9_TRYB2
VEuPathDB»
0.0
Tb08.29O9.70 MaoC-like dehydratase, putative Trypanosoma brucei
TI:5691 None
 
Q7UGS9_RHOBA
EnsemblBacteria»
0.0
maoC Similar to monoamine oxidase regulatory protein Rhodopirellula baltica
TI:265606 None
 
Q81G96_BACCR
EnsemblBacteria»
0.0
BC_1312 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) Bacillus cereus
TI:1396 None
 
Q89Q24_BRADU
EnsemblBacteria»
0.0
blr3306 Blr3306 protein Bradyrhizobium diazoefficiens
TI:1355477 None
 
Q89Q25_BRADU
EnsemblBacteria»
0.0
blr3305 Blr3305 protein Bradyrhizobium diazoefficiens
TI:1355477 None
 
Q8RFA0_FUSNN
EnsemblBacteria»
0.0
FN0816 Dehydrogenase with MaoC-like domain Fusobacterium nucleatum
TI:851 None
 
T1F997_HELRO
EnsemblMetazoa»
0.0
20205396 MaoC-like domain-containing protein Helobdella robusta
TI:6412 None
 
W1NI24_AMBTC
EnsemblPlants»
0.0
AMTR_s00009p00063240 MaoC-like domain-containing protein Amborella trichopoda
TI:13333 None
 
W5N6K4_LEPOC
Ensembl»
0.0
HTD2 Hydroxyacyl-thioester dehydratase type 2 Lepisosteus oculatus
TI:7918 None
 
Y4636_STRCO
EnsemblBacteria»
0.0
SCO4636 UPF0336 protein SCO4636 Streptomyces coelicolor
TI:1902 None
 
Y504_MYCTU
TubercuList»
0.0
Rv0504c UPF0336 protein Rv0504c Mycobacterium tuberculosis
TI:1773 None
 
Y635_MYCTU
TubercuList»
0.0
Rv0635 UPF0336 protein Rv0635 Mycobacterium tuberculosis
TI:1773 None
 
Y637_MYCTU
TubercuList»
0.0
Rv0637 UPF0336 protein Rv0637 Mycobacterium tuberculosis
TI:1773 None