Collated Gene Ontology terms

Biological process: guanyl-nucleotide exchange factor activity(2012, 2021, 2025) nucleotide binding(2025) ATP hydrolysis activity(2025) ATP binding(2025)

Molecular function: positive regulation of cell-cell adhesion mediated by cadherin2012, 2025

Cellular component: recycling endosome2012, 2017, 2025 cytoplasm2012, 2017, 2025 cytosol2016 chloroplast2018

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 6/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 3/4 
Harosa: 2/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
A0A2I2ZLY1_GORGO
Ensembl»
0.0
DENN domain containing 6B Gorilla gorilla
TI:9593 None
 
A0A3Q7FUQ6_SOLLC
EnsemblPlants»
0.0
UDENN domain-containing protein Solanum lycopersicum
TI:4081 None
   
A0A7M7MXZ2_STRPU
EnsemblMetazoa»
0.0
UDENN domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A804MEA1_MAIZE
EnsemblPlants»
0.0
Uncharacterized protein Zea mays
TI:4577 None
   
A0A804PGT3_MAIZE
EnsemblPlants»
0.0
Splicing factor cactin
central domain-containing protein		 Zea mays
TI:4577 None
   
H3HDW6_PHYRM
EnsemblProtists»
0.0
UDENN domain-containing protein Phytophthora ramorum
TI:164328 None
 
H9GCM9_ANOCA
Ensembl»
0.0
UDENN domain-containing protein Anolis carolinensis
TI:28377 None
   
M4CV70_BRACM
EnsemblPlants»
0.0
UDENN domain-containing protein Brassica campestris
TI:3711 None
   
W5N6T8_LEPOC
Ensembl»
0.0
DENN/MADD domain containing 6Aa Lepisosteus oculatus
TI:7918 None
 
W5NJE1_LEPOC
Ensembl»
0.0
DENN/MADD domain containing 6B Lepisosteus oculatus
TI:7918 None
 
T1G6N9_HELRO
EnsemblMetazoa»
0.0
20216736 UDENN domain-containing protein Helobdella robusta
TI:6412 None
 
A0NBI8_ANOGA
EnsemblMetazoa»
0.0
4576741 AGAP007682-PA Anopheles gambiae
TI:7165 None
 
W1NKT9_AMBTC
neXtProt»
0.0
AMTR_s00060p00051530 UDENN domain-containing protein Amborella trichopoda
TI:13333 None
 
D6W6S7_TRICA
CTD»
0.0
AUGUSTUS-3.0.2_16056 Protein DENND6B-like Protein Tribolium castaneum
TI:7070 None
 
Q9C9B4_ARATH
TAIR»
0.5
At1g73930 AT1G73930 protein (Polarity
axis stabilization protein)		 Arabidopsis thaliana
TI:3702 None
 
F4PB82_BATDJ
euHCVdb»
0.0
BATDEDRAFT_91628 UDENN domain-containing protein Batrachochytrium dendrobatidis
TI:109871 None
 
Q9W4D1_DROME
FlyBase»
0.5
BEST:LD39762 LD41638p (Uncharacterized protein, isoform A) Drosophila melanogaster
TI:7227 None
 
A0A078I9Y5_BRANA
euHCVdb»
0.0
BnaA02g16600D BnaA02g16600D protein Brassica napus
TI:3708 None
 
A0A078I9P2_BRANA
neXtProt»
0.0
BnaC02g22520D BnaC02g22520D protein Brassica napus
TI:3708 None
 
A8XJ03_CAEBR
WormBase»
0.0
CBG13932 CBG_13932 Protein CBG13932 Caenorhabditis briggsae
TI:6238 None
 
O45074_CAEEL
WormBase»
0.5
CELE_F53H1.3 F53H1.3 UDENN domain-containing protein Caenorhabditis elegans
TI:6239 None
 
A0A2K3CYX7_CHLRE
euHCVdb»
0.0
CHLRE_14g633500v5 UDENN domain-containing protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A067FM42_CITSI
neXtProt»
0.0
CISIN_1g006037mg UDENN domain-containing protein Citrus sinensis
TI:2711 None
 
Q5KB37_CRYD1
TubercuList»
0.0
CNI03900 UDENN domain-containing protein Cryptococcus deneoformans
TI:40410 None
 
A0A0A0LUU3_CUCSA
euHCVdb»
0.0
Csa_1G021910 UDENN domain-containing protein Cucumis sativus
TI:3659 None
 
E9FTW7_DAPPU
neXtProt»
0.0
DAPPUDRAFT_303223 UDENN domain-containing protein Daphnia pulex
TI:6669 None
 
F116_DICDI
dictyBase»
0.5
DDB_G0280481 Protein DENND6 homolog Dictyostelium discoideum
TI:44689 None
 
A0A1D5NY14_CHICK
Ensembl»
1.0
DENND6A DENN domain containing 6A Gallus gallus
TI:9031 None
   
A0A1D5R1E5_MACMU
Ensembl»
0.0
DENND6A DENN domain containing 6A Macaca mulatta
TI:9544 None
   
A0A3Q2GSA1_HORSE
Ensembl»
0.0
DENND6A DENN domain containing 6A Equus caballus
TI:9796 None
   
A0A6I8NGS2_ORNAN
Ensembl»
0.0
DENND6A DENN domain containing 6A Ornithorhynchus anatinus
TI:9258 None
   
A0A8I3PLX7_CANLF
Ensembl»
0.0
DENND6A DENN domain containing 6A Canis lupus
TI:9612 None
   
A0ABI7ZTQ1_FELCA
Ensembl»
0.0
DENND6A UDENN domain-containing protein Felis catus
TI:9685 None
   
DEN6A_CHICK
CTD»
1.0
DENND6A Protein DENND6A (DENN
domain-containing protein 6A)		 Gallus gallus
TI:9031 None
 
DEN6A_HUMAN
Ensembl»
3.5
DENND6A Protein DENND6A (DENN
domain-containing protein 6A)		 Homo sapiens
TI:9606 None
 
F1MBQ4_BOVIN
Ensembl»
0.0
DENND6A DENN domain containing 6A Bos taurus
TI:9913 None
   
F1SGK8_PIG
Ensembl»
0.0
DENND6A DENN domain containing 6A Sus scrofa
TI:9823 None
   
F6TF37_MONDO
Ensembl»
0.0
DENND6A DENN domain containing 6A Monodelphis domestica
TI:13616 None
   
G1KBG0_ANOCA
Ensembl»
0.0
DENND6A DENN domain containing 6A Anolis carolinensis
TI:28377 None
   
G3SKS6_GORGO
Ensembl»
0.0
DENND6A DENN domain containing 6A Gorilla gorilla
TI:9593 None
 
H2MSI1_ORYLA
Ensembl»
0.0
DENND6A DENN/MADD domain containing 6Aa Oryzias latipes
TI:8090 None
   
H2QMU5_PANTR
Ensembl»
0.0
DENND6A DENN domain containing 6A (Family
with sequence similarity 116, member A)		 Pan troglodytes
TI:9598 None
 
A0A1D5Q6D4_MACMU
Ensembl»
0.0
DENND6B DENN domain containing 6B Macaca mulatta
TI:9544 None
   
A0A287AUV2_PIG
Ensembl»
0.0
DENND6B DENN domain containing 6B (Protein DENND6B) Sus scrofa
TI:9823 None
 
A0A6I8MX58_ORNAN
Ensembl»
0.0
DENND6B DENN domain containing 6B Ornithorhynchus anatinus
TI:9258 None
   
A0A8I3MTS3_CANLF
Ensembl»
0.0
DENND6B DENN domain containing 6B Canis lupus
TI:9612 None
   
A0A8V0XV55_CHICK
Ensembl»
0.5
DENND6B DENN domain containing 6B Gallus gallus
TI:9031 None
   
A0ABI7ZMN0_FELCA
Ensembl»
0.0
DENND6B UDENN domain-containing protein Felis catus
TI:9685 None
   
DEN6B_HUMAN
Ensembl»
2.2
DENND6B Protein DENND6B (DENN
domain-containing protein 6B)		 Homo sapiens
TI:9606 None
 
F6QE84_MONDO
Ensembl»
0.0
DENND6B DENN domain containing 6B Monodelphis domestica
TI:13616 None
   
F6ZYA1_HORSE
Ensembl»
0.0
DENND6B DENN domain containing 6B Equus caballus
TI:9796 None
   
G3X7L3_BOVIN
Ensembl»
0.0
DENND6B DENN domain containing 6B Bos taurus
TI:9913 None
   
H2N218_ORYLA
Ensembl»
0.0
DENND6B DENN/MADD domain containing 6B Oryzias latipes
TI:8090 None
   
K7A9X2_PANTR
Ensembl»
0.0
DENND6B DENN domain containing 6B (Family
with sequence similarity 116, member B)		 Pan troglodytes
TI:9598 None
 
F0ZU35_DICPU
TubercuList»
0.0
DICPUDRAFT_155470 UDENN domain-containing protein Dictyostelium purpureum
TI:5786 None
 
D4A544_RAT
RGD»
2.0
Dennd6a DENN domain containing 6A Rattus norvegicus
TI:10116 None
   
DEN6A_MOUSE
Ensembl»
3.0
Dennd6a Protein DENND6A (DENN
domain-containing protein 6A)		 Mus musculus
TI:10090 None
 
D3ZAE3_RAT
RGD»
1.0
Dennd6b DENN domain containing 6B Rattus norvegicus
TI:10116 None
   
DEN6B_MOUSE
Ensembl»
1.5
Dennd6b Protein DENND6B (DENN
domain-containing protein 6B)		 Mus musculus
TI:10090 None
 
C4LWI6_ENTH1
TubercuList»
0.0
EHI_096760 UDENN domain-containing protein Entamoeba histolytica
TI:5759 None
 
A0A0R0JPJ2_SOYBN
EnsemblPlants»
0.0
GLYMA_05G013100 UDENN domain-containing protein Glycine max
TI:3847 None
 
A0A804JEC6_MUSAM
EnsemblPlants»
0.0
GSMUA_155380.1 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0CI45_PARTE
euHCVdb»
0.0
GSPATT00038566001 UDENN domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0CI46_PARTE
euHCVdb»
0.0
GSPATT00038567001 UDENN domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0A251TYR8_HELAN
euHCVdb»
0.0
HannXRQ_Chr09g0269781 HanXRQr2_Chr09g0407651 Tripartite DENN domain-containing protein Helianthus annuus
TI:4232 None
 
B7PH08_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW005050 UDENN domain-containing protein Ixodes scapularis
TI:6945 None
 
A0A7U2F2M7_PHANO
TubercuList»
0.0
JI435_030420 UDENN domain-containing protein Phaeosphaeria nodorum
TI:13684 None
 
A0A1Y1IRN5_KLENI
euHCVdb»
0.0
KFL_008800030 UDENN domain-containing protein Klebsormidium nitens
TI:105231 None
 
Q4Q1L3_LEIMA
TubercuList»
0.0
LMJF_36_2090 UDENN domain-containing protein Leishmania major
TI:5664 None
 
H2XTT5_CIOIN
Ensembl»
0.0
LOC100181589 Protein DENND6A Ciona intestinalis
TI:7719 None
 
K7KWD0_SOYBN
EnsemblPlants»
0.0
LOC100780852 UDENN domain-containing protein Glycine max
TI:3847 None
 
K7KK42_SOYBN
EnsemblPlants»
0.0
LOC100782429 UDENN domain-containing protein Glycine max
TI:3847 None
 
I1MUG0_SOYBN
EnsemblPlants»
0.0
LOC100790861 UDENN domain-containing protein Glycine max
TI:3847 None
 
K4A715_SETIT
EnsemblPlants»
0.0
LOC101775134 UDENN domain-containing protein Setaria italica
TI:4555 None
 
M1A418_SOLTU
EnsemblPlants»
0.0
LOC102604805 UDENN domain-containing protein Solanum tuberosum
TI:4113 None
   
A0A804LHF5_MAIZE
EnsemblPlants»
0.0
LOC103633980 UDENN domain-containing protein Zea mays
TI:4577 None
   
I1H795_BRADI
EnsemblPlants»
0.0
LOC104581817 UDENN domain-containing protein Brachypodium distachyon
TI:15368 None
 
A0A1U8ABT2_NELNU
euHCVdb»
0.0
LOC104601240 Protein DENND6A isoform X1 Nelumbo nucifera
TI:4432 None
   
A0A1S4D058_TOBAC
euHCVdb»
0.0
LOC107824525 Protein DENND6A isoform X1
(Uncharacterized protein LOC107824525 isoform X1)		 Nicotiana tabacum
TI:4097 None
   
A0A1U8J8A4_GOSHI
euHCVdb»
0.0
LOC107904645 Protein DENND6A Gossypium hirsutum
TI:3635 None
   
A0A1U8L696_GOSHI
euHCVdb»
0.0
LOC107924277 Protein DENND6A Gossypium hirsutum
TI:3635 None
   
A0A6P9EFR2_JUGRE
euHCVdb»
0.0
LOC109005610 Protein DENND6B isoform X2 Juglans regia
TI:51240 None
   
A0A9R0IIJ3_SPIOL
neXtProt»
0.0
LOC110789493 UDENN domain-containing protein Spinacia oleracea
TI:3562 None
   
A9TGV2_PHYPA
EnsemblPlants»
0.0
LOC112281058 UDENN domain-containing protein Physcomitrium patens
TI:3218 None
 
A0A2K1JR93_PHYPA
EnsemblPlants»
0.0
LOC112289758 UDENN domain-containing protein Physcomitrium patens
TI:3218 None
 
A0A9J7L7H1_BRAFL
neXtProt»
0.0
LOC118416041 Protein DENND6A-like isoform X1 Branchiostoma floridae
TI:7739 None
   
A0A3B6HT19_WHEAT
EnsemblPlants»
0.0
LOC123085343 UDENN domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6IV57_WHEAT
EnsemblPlants»
0.0
LOC123092702 UDENN domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6JLZ1_WHEAT
EnsemblPlants»
0.0
LOC123097999 UDENN domain-containing protein Triticum aestivum
TI:4565 None
   
F2DAQ8_HORVV
EnsemblPlants»
0.0
LOC123449105 Predicted protein Hordeum vulgare
TI:4513 None
 
Q10NT2_ORYSJ
neXtProt»
0.0
LOC_Os03g15390 Os03g0259700 Expressed protein (Os03g0259700 protein) (cDNA,
clone: J100029H23, full insert sequence)		 Oryza sativa
TI:4530 None
 
A0A9R1W3G1_LACSA
euHCVdb»
0.0
LSAT_V11C300105610 UDENN domain-containing protein Lactuca sativa
TI:4236 None
 
A0A2C9VXI2_MANES
euHCVdb»
0.0
MANES_05G139300v8 UDENN domain-containing protein Manihot esculenta
TI:3983 None
 
A0A2R6XG78_MARPO
euHCVdb»
0.0
MARPO_0016s0160 UDENN domain-containing protein Marchantia polymorpha
TI:3197 None
 
A0A022PXT6_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a002158mg UDENN domain-containing protein Erythranthe guttata
TI:4155 None
 
A9URA1_MONBE
euHCVdb»
0.0
MONBRDRAFT_1970 UDENN domain-containing protein Monosiga brevicollis
TI:81824 None
 
A7RNP1_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g180238 UDENN domain-containing protein Nematostella vectensis
TI:45351 None
 
E3NXF7_PUCGT
TubercuList»
0.0
PGTG_20185 UDENN domain-containing protein Puccinia graminis
TI:5297 None
 
A0A2K1Y9L1_POPTR
euHCVdb»
0.0
POPTR_012G060200 UDENN domain-containing protein Populus trichocarpa
TI:3694 None
 
U5FLB5_POPTR
euHCVdb»
0.0
POPTR_015G049900 UDENN domain-containing protein Populus trichocarpa
TI:3694 None
 
A0A251PBZ4_PRUPE
euHCVdb»
0.0
PRUPE_5G217600 UDENN domain-containing protein Prunus persica
TI:3760 None
 
B9RE36_RICCO
neXtProt»
0.0
RCOM_1617730 UDENN domain-containing protein Ricinus communis
TI:3988 None
 
D8SKH1_SELML
euHCVdb»
0.0
SELMODRAFT_119416 UDENN domain-containing protein Selaginella moellendorffii
TI:88036 None
 
D8QQ04_SELML
euHCVdb»
0.0
SELMODRAFT_163686 UDENN domain-containing protein Selaginella moellendorffii
TI:88036 None
 
D8TDF8_SELML
euHCVdb»
0.0
SELMODRAFT_431683 UDENN domain-containing protein Selaginella moellendorffii
TI:88036 None
 
D8RQ96_SELML
euHCVdb»
0.0
SELMODRAFT_98817 UDENN domain-containing protein Selaginella moellendorffii
TI:88036 None
 
C5WQS4_SORBI
euHCVdb»
0.0
SORBI_3001G430800 UDENN domain-containing protein Sorghum bicolor
TI:4558 None
 
A0A2G3A3E9_CAPAN
euHCVdb»
0.0
T459_10826 UDENN domain-containing protein Capsicum annuum
TI:4072 None
 
A0A061FUK1_THECC
euHCVdb»
0.0
TCM_012260 Uncharacterized protein isoform 1 Theobroma cacao
TI:3641 None
 
B3RUN7_TRIAD
CTD»
0.0
TRIADDRAFT_23603 UDENN domain-containing protein Trichoplax adhaerens
TI:10228 None
 
A2ET75_TRIV3
TubercuList»
0.0
TVAG_125680 UDENN domain-containing protein Trichomonas vaginalis
TI:5722 None
 
A2FVH9_TRIV3
TubercuList»
0.0
TVAG_175210 UDENN domain-containing protein Trichomonas vaginalis
TI:5722 None
 
A2FG30_TRIV3
TubercuList»
0.0
TVAG_301900 UDENN domain-containing protein Trichomonas vaginalis
TI:5722 None
 
A2FGR5_TRIV3
TubercuList»
0.0
TVAG_304310 UDENN domain-containing protein Trichomonas vaginalis
TI:5722 None
 
A2E623_TRIV3
TubercuList»
0.0
TVAG_362450 Uncharacterized protein Trichomonas vaginalis
TI:5722 None
 
A2DFU0_TRIV3
TubercuList»
0.0
TVAG_391770 UDENN domain-containing protein Trichomonas vaginalis
TI:5722 None
 
A2DYS8_TRIV3
TubercuList»
0.0
TVAG_426620 UDENN domain-containing protein Trichomonas vaginalis
TI:5722 None
 
A2FRX2_TRIV3
TubercuList»
0.0
TVAG_444740 UDENN domain-containing protein Trichomonas vaginalis
TI:5722 None
 
A2FW65_TRIV3
TubercuList»
0.0
TVAG_445710 Uncharacterized protein Trichomonas vaginalis
TI:5722 None
 
Q38AU7_TRYB2
TubercuList»
0.0
Tb10.70.0190 UDENN domain-containing protein Trypanosoma brucei
TI:5691 None
 
F6GTI4_VITVI
euHCVdb»
0.0
VIT_17s0000g04140 UDENN domain-containing protein Vitis vinifera
TI:29760 None
 
A0A8R1U7B8_PRIPA
EnsemblMetazoa»
0.0
WBGene00096006 UDENN domain-containing protein Pristionchus pacificus
TI:54126 None
   
Q6CD27_YARLI
TubercuList»
0.0
YALI0_C04301g YALI0C04301p Yarrowia lipolytica
TI:4952 None
 
A0AB13ABJ6_DANRE
ZFIN»
0.0
dennd6a DENN/MADD domain containing 6Aa Danio rerio
TI:7955 None
   
F6S962_XENTR
Xenbase»
0.0
dennd6a DENN/MADD domain-containing 6A
(Protein DENND6A isoform X1)		 Xenopus tropicalis
TI:8364 None
   
A0A8J0U669_XENLA
CTD»
0.0
dennd6a.L Protein DENND6A Xenopus laevis
TI:8355 None
   
A0A6I8RAB9_XENTR
Xenbase»
0.0
dennd6b DENN/MADD domain-containing 6B (Protein DENND6B) Xenopus tropicalis
TI:8364 None
   
Q803T4_DANRE
ZFIN»
0.5
dennd6b Family with sequence similarity
116, member B (Protein DENND6B)		 Danio rerio
TI:7955 None
 
A0A8J1MLE0_XENLA
CTD»
0.0
dennd6b.L Protein DENND6B isoform X1 Xenopus laevis
TI:8355 None