Collated Gene Ontology terms

Biological process: transcription coregulator activity(2007, 2024) transcription coactivator activity(2016, 2023)

Molecular function: regulation of transcription by RNA polymerase II2007, 2022, 2024 positive regulation of transcription initiation by RNA polymerase II2014, 2018, 2023 positive regulation of transcription elongation by RNA polymerase II2014, 2018 RNA polymerase II preinitiation complex assembly2014, 2018 transcription initiation at RNA polymerase II promoter2023 positive regulation of transcription by RNA polymerase II2015 mitotic cell cycle2010

Cellular component: mediator complex2005, 2007, 2012, 2020, 2023, 2024 nucleus2009, 2011, 2014, 2018, 2024 core mediator complex2014, 2015, 2018, 2024 nucleoplasm2010, 2013 nucleolus2016 cytoplasm2003 chromatin2016

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 7/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 35/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
W1NER4_AMBTC
EnsemblPlants»
0.0
AMTR_s00137p00031080 Mediator of RNA polymerase
II transcription subunit 22		 Amborella trichopoda
TI:13333 None
 
H9GLT0_ANOCA
Ensembl»
0.0
med22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Anolis carolinensis
TI:28377 None
   
MED22_ANOGA
EnsemblMetazoa»
0.0
MED22 Mediator of RNA polymerase II transcription
subunit 22 (Mediator complex subunit 22)		 Anopheles gambiae
TI:7165 None
 
MD22A_ARATH
TAIR»
0.0
MED22A Mediator of RNA polymerase
II transcription subunit 22a		 Arabidopsis thaliana
TI:3702 None
 
MD22B_ARATH
TAIR»
0.0
MED22B Mediator of RNA polymerase
II transcription subunit 22b		 Arabidopsis thaliana
TI:3702 None
 
Q4X1T1_ASPFU
EnsemblFungi»
0.0
AFUA_2G08880 Mediator of RNA polymerase
II transcription subunit 22		 Aspergillus fumigatus
TI:746128 None
 
F4P5I6_BATDJ
EnsemblBacteria»
0.0
BATDEDRAFT_25758 Mediator of RNA polymerase
II transcription subunit 11		 Batrachochytrium dendrobatidis
TI:109871 None
 
MED22_BOVIN
Ensembl»
0.0
MED22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Bos taurus
TI:9913 None
 
I1HBP5_BRADI
EnsemblPlants»
0.0
BRADI_2g02180v3 Mediator of RNA polymerase
II transcription subunit 22		 Brachypodium distachyon
TI:15368 None
 
C3ZG62_BRAFL
CTD»
0.0
LOC118420545 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Branchiostoma floridae
TI:7739 None
 
A0A078H3V2_BRANA
EnsemblPlants»
0.0
BnaC05g12530D BnaC05g12530D protein Brassica napus
TI:3708 None
 
A0A078HBF6_BRANA
EnsemblPlants»
0.0
BnaA06g11020D BnaA06g11020D protein Brassica napus
TI:3708 None
 
M4EB98_BRACM
EnsemblPlants»
0.0
Uncharacterized protein Brassica campestris
TI:3711 None
   
MED22_CAEBR
WormBase»
0.0
mdt-22 Mediator of RNA polymerase II transcription
subunit 22 (Mediator complex subunit 22)		 Caenorhabditis briggsae
TI:6238 None
 
MED22_CAEEL
WormBase»
0.0
mdt-22 Mediator of RNA polymerase II transcription
subunit 22 (Mediator complex subunit 22)		 Caenorhabditis elegans
TI:6239 None
 
A0A8I3N7W6_CANLF
Ensembl»
0.0
MED22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Canis lupus
TI:9612 None
   
A0A2G2YZP3_CAPAN
EnsemblPlants»
0.0
T459_18633 T459_18755 Mediator of RNA polymerase
II transcription subunit 22b		 Capsicum annuum
TI:4072 None
 
A0A2G2ZZW2_CAPAN
EnsemblPlants»
0.0
T459_09606 Mediator of RNA polymerase
II transcription subunit 22a		 Capsicum annuum
TI:4072 None
 
F6UPP6_CIOIN
Ensembl»
0.0
Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Ciona intestinalis
TI:7719 None
   
A0A067E6N1_CITSI
Ensembl»
0.0
CISIN_1g032069mg Mediator complex subunit 22 Citrus sinensis
TI:2711 None
 
A0A0A0M174_CUCSA
EnsemblPlants»
0.0
Csa_1G701970 Uncharacterized protein Cucumis sativus
TI:3659 None
 
MED22_DANRE
ZFIN»
0.0
med22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Danio rerio
TI:7955 None
 
E9HZH9_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_67650 Mediator of RNA polymerase II transcription
subunit 22 (Mediator complex subunit 22)		 Daphnia pulex
TI:6669 None
 
F0ZDX2_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_76538 Mediator of RNA polymerase
II transcription subunit 22		 Dictyostelium purpureum
TI:5786 None
 
MED22_DICDI
dictyBase»
0.5
med22 Putative mediator of RNA polymerase II transcription
subunit 22 (Putative mediator complex subunit 22)		 Dictyostelium discoideum
TI:44689 None
 
MED22_DROME
FlyBase»
3.3
MED22 Mediator of RNA polymerase II transcription
subunit 22 (Mediator complex subunit 22) (dMED24)		 Drosophila melanogaster
TI:7227 None
 
Q86BK9_DROME
FlyBase»
0.0
Dmel\CG32971 Mediator of RNA polymerase II transcription
subunit 22 (Mediator complex subunit 22)		 Drosophila melanogaster
TI:7227 None
 
Q5B021_EMENI
EnsemblFungi»
0.0
ANIA_06109 Mediator of RNA polymerase
II transcription subunit 22		 Emericella nidulans
TI:162425 None
 
F6SQD1_HORSE
Ensembl»
0.0
MED22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Equus caballus
TI:9796 None
   
A0A022RTG5_ERYGU
EnsemblFungi»
0.0
MIMGU_mgv1a015342mg Mediator of RNA polymerase
II transcription subunit 22		 Erythranthe guttata
TI:4155 None
 
M3W4S0_FELCA
Ensembl»
0.0
MED22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Felis catus
TI:9685 None
 
A0A8V1AFQ2_CHICK
Ensembl»
0.0
MED22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Gallus gallus
TI:9031 None
   
MED22_CHICK
CTD»
0.0
MED22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Gallus gallus
TI:9031 None
 
I1KTS9_SOYBN
EnsemblPlants»
0.0
100787657 Mediator of RNA polymerase
II transcription subunit 22a		 Glycine max
TI:3847 None
 
I1MIE5_SOYBN
EnsemblPlants»
0.0
100807971 Mediator of RNA polymerase
II transcription subunit 22a		 Glycine max
TI:3847 None
 
G3RET4_GORGO
Ensembl»
0.0
MED22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Gorilla gorilla
TI:9593 None
 
A0A1U8JYL3_GOSHI
Ensembl»
0.0
LOC107910490 Mediator of RNA polymerase
II transcription subunit 22b-like		 Gossypium hirsutum
TI:3635 None
   
A0A1U8NVQ0_GOSHI
Ensembl»
0.0
LOC107951581 Mediator of RNA polymerase
II transcription subunit 22b-like		 Gossypium hirsutum
TI:3635 None
   
A0A251SFW1_HELAN
EnsemblPlants»
0.0
HannXRQ_Chr14g0437971 Putative surfeit locus protein 5
subunit 22 of Mediator complex		 Helianthus annuus
TI:4232 None
 
T1ELM6_HELRO
EnsemblMetazoa»
0.0
20197476 Mediator of RNA polymerase II transcription
subunit 22 (Mediator complex subunit 22)		 Helobdella robusta
TI:6412 None
 
MED22_HUMAN
Ensembl»
1.8
MED22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5)		 Homo sapiens
TI:9606 None
 
B7Q522_IXOSC
EnsemblMetazoa»
0.0
8036019 Mediator of RNA polymerase II transcription
subunit 22 (Mediator complex subunit 22)		 Ixodes scapularis
TI:6945 None
 
A0A2I4GB41_JUGRE
EnsemblPlants»
0.0
LOC109006332 Mediator of RNA polymerase
II transcription subunit 22a-like		 Juglans regia
TI:51240 None
 
A0A1Y1IJQ2_KLENI
EnsemblPlants»
0.0
KFL_004650020 Surfeit locus protein 5
subunit 22 of Mediator complex][table7		 Klebsormidium nitens
TI:105231 None
 
W5LWY4_LEPOC
Ensembl»
0.0
Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Lepisosteus oculatus
TI:7918 None
   
A0A251L831_MANES
EnsemblPlants»
0.0
MANES_03G077300 Mediator of RNA polymerase
II transcription subunit 22		 Manihot esculenta
TI:3983 None
 
A0A2R6W3T6_MARPO
EnsemblPlants»
0.0
MARPO_0161s0019 Mediator of RNA polymerase
II transcription subunit 22		 Marchantia polymorpha
TI:3197 None
 
G7IT38_MEDTR
EnsemblPlants»
0.0
11446732 Mediator of RNA polymerase II transcription subunit 22
(Putative mediator of RNA polymerase II transcription subunit 22)		 Medicago truncatula
TI:3880 None
 
F6T0Z7_MONDO
Ensembl»
0.0
MED22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Monodelphis domestica
TI:13616 None
   
MED22_MOUSE
Ensembl»
1.8
Med22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5)		 Mus musculus
TI:10090 None
 
A0A804KGI2_MUSAM
EnsemblPlants»
0.0
103997080 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A1U7Z6E3_NELNU
EnsemblBacteria»
0.0
LOC104586783 Mediator of RNA polymerase II
transcription subunit 22a-like isoform X1		 Nelumbo nucifera
TI:4432 None
   
A7RN15_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g236493 Mediator of RNA polymerase II transcription
subunit 22 (Mediator complex subunit 22)		 Nematostella vectensis
TI:45351 None
 
A0A1S3Y330_TOBAC
EnsemblFungi»
0.0
LOC107771518 Mediator of RNA polymerase
II transcription subunit 22a-like		 Nicotiana tabacum
TI:4097 None
   
A0A1S4CT38_TOBAC
EnsemblFungi»
0.0
LOC107822383 Mediator of RNA polymerase
II transcription subunit 22a-like		 Nicotiana tabacum
TI:4097 None
   
F7EQF8_ORNAN
Ensembl»
0.0
MED22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Ornithorhynchus anatinus
TI:9258 None
   
Q0JQY0_ORYSJ
EnsemblPlants»
0.0
Os01g0132700 Os01g0132700 protein (cDNA, clone:
J065187N12, full insert sequence)		 Oryza sativa
TI:4530 None
 
Q6Z240_ORYSJ
EnsemblPlants»
0.0
Os08g0480500 Os08g0480500 protein (cDNA
clone:J013129G19, full insert sequence)		 Oryza sativa
TI:4530 None
 
A0A3B3HGI5_ORYLA
Ensembl»
0.0
med22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Oryzias latipes
TI:8090 None
   
H2R0M1_PANTR
Ensembl»
0.0
MED22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Pan troglodytes
TI:9598 None
 
A0A2K1IHF3_PHYPA
EnsemblPlants»
0.0
PHYPA_029295 Uncharacterized protein Physcomitrium patens
TI:3218 None
 
A0A2K1ITJ7_PHYPA
EnsemblPlants»
0.0
PHYPA_024542 Mediator complex subunit 22 Physcomitrium patens
TI:3218 None
 
H3GLH8_PHYRM
EnsemblProtists»
0.0
Mediator of RNA polymerase
II transcription subunit 22		 Phytophthora ramorum
TI:164328 None
 
B9HI17_POPTR
EnsemblPlants»
0.0
POPTR_008G080700 Uncharacterized protein Populus trichocarpa
TI:3694 None
 
A0A8R1UAU3_PRIPA
EnsemblMetazoa»
0.0
WBGene00102716 Mediator of RNA polymerase II transcription
subunit 22 (Mediator complex subunit 22)		 Pristionchus pacificus
TI:54126 None
   
M5W3R2_PRUPE
EnsemblPlants»
0.0
PRUPE_7G260300 Mediator of RNA polymerase
II transcription subunit 22		 Prunus persica
TI:3760 None
 
E3KA65_PUCGT
EnsemblFungi»
0.0
PGTG_06999 Uncharacterized protein Puccinia graminis
TI:5297 None
 
MED22_RAT
RGD»
0.0
Med22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Rattus norvegicus
TI:10116 None
 
B9S1N1_RICCO
EnsemblBacteria»
0.0
RCOM_0866610 Surfeit locus protein, putative Ricinus communis
TI:3988 None
 
B9SMJ2_RICCO
EnsemblBacteria»
0.0
RCOM_0988880 Mediator of RNA polymerase
II transcription subunit 22		 Ricinus communis
TI:3988 None
 
MED22_SCHPO
PomBase»
3.2
med22 Mediator of RNA polymerase II transcription subunit 22 (Mediator
complex subunit 22) (Suppressor of RNA polymerase B 6 homolog)		 Schizosaccharomyces pombe
TI:4896 None
 
A7ETZ0_SCLS1
VEuPathDB»
0.0
SS1G_08797 Uncharacterized protein Sclerotinia sclerotiorum
TI:5180 None
 
D8RVA1_SELML
EnsemblPlants»
0.0
SELMODRAFT_102574 Mediator of RNA polymerase
II transcription subunit 22		 Selaginella moellendorffii
TI:88036 None
 
D8S203_SELML
EnsemblPlants»
0.0
SELMODRAFT_232955 Mediator of RNA polymerase
II transcription subunit 22		 Selaginella moellendorffii
TI:88036 None
 
K3XMV5_SETIT
EnsemblPlants»
0.0
101786996 Surfeit locus protein 5 Setaria italica
TI:4555 None
 
A0A3Q7FKU8_SOLLC
EnsemblPlants»
0.0
101257248 Uncharacterized protein Solanum lycopersicum
TI:4081 None
   
M1AIE3_SOLTU
EnsemblPlants»
0.0
102603738 Surfeit locus protein 5 family protein Solanum tuberosum
TI:4113 None
   
C5XJ11_SORBI
EnsemblPlants»
0.0
SORBI_3003G284500 Surfeit locus protein 5 Sorghum bicolor
TI:4558 None
 
C5XQU2_SORBI
EnsemblPlants»
0.0
SORBI_3003G084300 Surfeit locus protein 5 Sorghum bicolor
TI:4558 None
 
A0A7M7HCK9_STRPU
EnsemblMetazoa»
0.0
Mediator of RNA polymerase II transcription
subunit 22 (Mediator complex subunit 22)		 Strongylocentrotus purpuratus
TI:7668 None
   
A0A480S722_PIG
Ensembl»
0.0
MED22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Sus scrofa
TI:9823 None
 
A0A061F1S0_THECC
EnsemblPlants»
0.0
TCM_025935 Surfeit locus protein 5
subunit 22 of Mediator complex		 Theobroma cacao
TI:3641 None
 
A0A061FLB5_THECC
EnsemblPlants»
0.0
TCM_036681 Surfeit locus protein 5
subunit 22 of Mediator complex		 Theobroma cacao
TI:3641 None
 
D6X4N7_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_11045 Mediator of RNA polymerase II transcription
subunit 22 (Mediator complex subunit 22)		 Tribolium castaneum
TI:7070 None
 
B3RP06_TRIAD
EnsemblMetazoa»
0.0
TRIADDRAFT_53358 Mediator of RNA polymerase II transcription
subunit 22 (Mediator complex subunit 22)		 Trichoplax adhaerens
TI:10228 None
 
A0A077RV00_WHEAT
EnsemblPlants»
0.0
CFC21_039338 TRAES_3BF010400390CFD_c1 Surfeit locus protein 5 Triticum aestivum
TI:4565 None
 
A0A3B6EBD0_WHEAT
EnsemblPlants»
0.0
CFC21_033592 Surfeit locus protein 5 Triticum aestivum
TI:4565 None
 
A0A3B6GQ30_WHEAT
EnsemblPlants»
0.0
CFC21_045566 Surfeit locus protein 5 Triticum aestivum
TI:4565 None
 
D7T100_VITVI
EnsemblPlants»
0.0
VIT_19s0085g01120 Mediator of RNA polymerase
II transcription subunit 22a		 Vitis vinifera
TI:29760 None
 
A0A1L8F180_XENLA
Xenbase»
0.0
med22.S Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Xenopus laevis
TI:8355 None
   
A0A8J0T8Q1_XENLA
Xenbase»
0.0
med22.L Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Xenopus laevis
TI:8355 None
   
B1WAV8_XENTR
Xenbase»
0.0
med22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Xenopus tropicalis
TI:8364 None
 
MED22_XENLA
Xenbase»
0.0
med22 Mediator of RNA polymerase II transcription subunit 22
(Mediator complex subunit 22) (Surfeit locus protein 5)		 Xenopus laevis
TI:8355 None
 
MED22_YARLI
EnsemblFungi»
0.0
SRB6 Mediator of RNA polymerase II transcription
subunit 22 (Mediator complex subunit 22)		 Yarrowia lipolytica
TI:4952 None
 
A0A3L6DP29_MAIZE
EnsemblPlants»
0.0
100284536 Surfeit locus protein 5 Zea mays
TI:4577 None
 
A0A804PDF3_MAIZE
EnsemblPlants»
0.0
Mediator of RNA polymerase
II transcription subunit 22a		 Zea mays
TI:4577 None
   
A0A0K9PPF7_ZOSMR
EnsemblPlants»
0.0
ZOSMA_192G00380 Mediator of RNA
polymerase II transcription subunit		 Zostera marina
TI:29655 None