Collated Gene Ontology terms

Biological process: membrane insertase activity(2020, 2022, 2025) protein-folding chaperone binding(2020, 2025)

Molecular function: tail-anchored membrane protein insertion into ER membrane2020, 2022, 2024, 2025 protein insertion into ER membrane by stop-transfer membrane-anchor sequence2020, 2024, 2025 protein folding in endoplasmic reticulum2019, 2025 phospholipid transport2024, 2025 phospholipid metabolic process2024, 2025 wound healing2019 rhodopsin biosynthetic process2015 rhabdomere development2015 retina development in camera-type eye2008 photoreceptor cell maintenance2008

Cellular component: EMC complex2012, 2020, 2024, 2025 membrane2012, 2025 endoplasmic reticulum membrane2020, 2024, 2025 endoplasmic reticulum2015, 2018, 2021, 2025 trans-Golgi network transport vesicle2005, 2025 Golgi apparatus2005, 2025 mitochondrion2021 endomembrane system2014 cytosol2009 cytoplasm2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 2/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
EMC3_HUMAN
Ensembl»
4.2
EMC3 ER membrane protein complex
subunit 3 (Transmembrane protein 111)		 Homo sapiens
TI:9606 None
 
Q9SU27_ARATH
TAIR»
1.0
At4g12590 ER membrane protein complex subunit 3 Arabidopsis thaliana
TI:3702 None
 
B7QCH8_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW022478 ER membrane protein complex subunit 3 Ixodes scapularis
TI:6945 None
 
H2QM15_PANTR
Ensembl»
0.0
EMC3 ER membrane protein complex subunit 3 Pan troglodytes
TI:9598 None
 
A0A397XW05_BRACM
EnsemblPlants»
0.0
BRAA09T38248Z BRAPAZ1V2_A09P29030.2 BRARA_I02255 ER membrane protein complex subunit 3 Brassica campestris
TI:3711 None
 
A5BZU9_VITVI
neXtProt»
0.0
VIT_00s0187g00170 VIT_00s0187g00220 VITISV_022312 ER membrane protein complex subunit 3 Vitis vinifera
TI:29760 None
 
EMC3_DANRE
ZFIN»
4.1
emc3 ER membrane protein complex subunit
3 (Protein pob) (Transmembrane protein 111)		 Danio rerio
TI:7955 None
 
EMC3_MOUSE
Ensembl»
4.0
Emc3 ER membrane protein complex
subunit 3 (Transmembrane protein 111)		 Mus musculus
TI:10090 None
 
EMC3_YEAST
SGD»
5.5
EMC3 ER membrane protein complex subunit 3
(Altered inheritance rate of mitochondria protein 27)		 Saccharomyces cerevisiae
TI:4932 None
 
G7I684_MEDTR
EnsemblPlants»
0.0
11420828 ER membrane protein complex subunit 3 Medicago truncatula
TI:3880 None
 
G7MKR4_MACMU
Ensembl»
0.0
EMC3 ER membrane protein complex subunit 3 Macaca mulatta
TI:9544 None
 
A0A2I2ZL94_GORGO
Ensembl»
0.0
EMC3 ER membrane protein complex subunit 3 Gorilla gorilla
TI:9593 None
 
B0V1B5_DANRE
ZFIN»
1.0
zgc:86609 ER membrane protein complex subunit 3 Danio rerio
TI:7955 None
 
B4FPC9_MAIZE
EnsemblPlants»
0.0
ZEAMMB73_Zm00001d006049 ER membrane protein complex subunit 3 Zea mays
TI:4577 None
 
D8SEY5_SELML
euHCVdb»
0.0
SELMODRAFT_179181 SELMODRAFT_268656 ER membrane protein complex subunit 3 Selaginella moellendorffii
TI:88036 None
 
E3KZ64_PUCGT
TubercuList»
0.0
PGTG_15738 PGTG_18144 ER membrane protein complex subunit 3 Puccinia graminis
TI:5297 None
 
E9HPC6_DAPPU
euHCVdb»
0.0
EOG090X0B72 ER membrane protein complex subunit 3 Daphnia pulex
TI:6669 None
 
I1KYL4_SOYBN
EnsemblPlants»
0.0
LOC100816887 ER membrane protein complex subunit 3 Glycine max
TI:3847 None
 
K3ZWB3_SETIT
EnsemblPlants»
0.0
LOC101785713 ER membrane protein complex subunit 3 Setaria italica
TI:4555 None
 
Q0J0J5_ORYSJ
euHCVdb»
0.0
Os09g0497400 ER membrane protein complex subunit 3 Oryza sativa
TI:4530 None
 
Q9VKR0_DROME
FlyBase»
5.9
EMC3 ER membrane protein complex subunit 3 Drosophila melanogaster
TI:7227 None
 
T1FN13_HELRO
EnsemblMetazoa»
0.0
20210212 ER membrane protein complex subunit 3 Helobdella robusta
TI:6412 None
 
W5NBB8_LEPOC
Ensembl»
0.0
ER membrane protein complex subunit 3 Lepisosteus oculatus
TI:7918 None
 
A0A022QMI2_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a012576mg ER membrane protein complex subunit 3 Erythranthe guttata
TI:4155 None
 
A0A061GG91_THECC
neXtProt»
0.0
TCM_030365 ER membrane protein complex subunit 3 Theobroma cacao
TI:3641 None
 
A0A067GSM3_CITSI
euHCVdb»
0.0
CISIN_1g022876mg ER membrane protein complex subunit 3 Citrus sinensis
TI:2711 None
 
A0A078E1Q0_BRANA
euHCVdb»
0.0
BnaA09g20830D ER membrane protein complex subunit 3 Brassica napus
TI:3708 None
 
A0A078GLH9_BRANA
euHCVdb»
0.0
BnaC03g64900D ER membrane protein complex subunit 3 Brassica napus
TI:3708 None
 
A0A0A0LVU1_CUCSA
neXtProt»
0.0
Csa_1G188170 ER membrane protein complex subunit 3 Cucumis sativus
TI:3659 None
 
A0A0K9NZF1_ZOSMR
euHCVdb»
0.0
ZOSMA_487G00090 ER membrane protein complex subunit 3 Zostera marina
TI:29655 None
 
A0A0K9PPS8_ZOSMR
euHCVdb»
0.0
ZOSMA_18G00640 ER membrane protein complex subunit 3 Zostera marina
TI:29655 None
 
A0A1B6QDF0_SORBI
neXtProt»
0.0
SORBI_3002G252600 ER membrane protein complex subunit 3 Sorghum bicolor
TI:4558 None
 
A0A1D8PR41_CANAL
CGD»
0.0
CAALFM_C702470CA orf19.13820 ER membrane protein complex subunit 3 Candida albicans
TI:5476 None
 
A0A1U8F473_CAPAN
euHCVdb»
0.0
T459_15363 ER membrane protein complex subunit 3 Capsicum annuum
TI:4072 None
 
A0A1Y1HV26_KLENI
neXtProt»
0.0
KFL_001120190 ER membrane protein complex subunit 3 Klebsormidium nitens
TI:105231 None
 
A0A251TI34_HELAN
neXtProt»
0.0
HannXRQ_Chr10g0285161 ER membrane protein complex subunit 3 Helianthus annuus
TI:4232 None
 
A0A251VLA0_HELAN
euHCVdb»
0.0
HannXRQ_Chr01g0006771 ER membrane protein complex subunit 3 Helianthus annuus
TI:4232 None
 
A0A2K1JW57_PHYPA
EnsemblPlants»
0.0
LOC112288570 ER membrane protein complex subunit 3 Physcomitrium patens
TI:3218 None
 
A0A2K1K9U1_PHYPA
EnsemblPlants»
0.0
PHYPA_009728 ER membrane protein complex subunit 3 Physcomitrium patens
TI:3218 None
 
A0A2K1X929_POPTR
neXtProt»
0.0
POPTR_016G013100 ER membrane protein complex subunit 3 Populus trichocarpa
TI:3694 None
 
A0A2K3DCV6_CHLRE
neXtProt»
0.0
CHLRE_09g400400v5 ER membrane protein complex subunit 3 Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6X8W5_MARPO
euHCVdb»
0.0
MARPO_0029s0061 ER membrane protein complex subunit 3 Marchantia polymorpha
TI:3197 None
 
A0A7U2F357_PHANO
TubercuList»
0.0
JI435_152080 ER membrane protein complex subunit 3 Phaeosphaeria nodorum
TI:13684 None
 
A0A804KWE8_MUSAM
EnsemblPlants»
0.0
GSMUA_318130.1 ER membrane protein complex subunit 3 Musa acuminata
TI:4641 None
 
A0A9K3N0P7_HELAN
euHCVdb»
0.0
HanXRQr2_Chr11g0499971 ER membrane protein complex subunit 3 Helianthus annuus
TI:4232 None
 
A0A9K3P188_HELAN
euHCVdb»
0.0
HanXRQr2_Chr01g0007611 ER membrane protein complex subunit 3 Helianthus annuus
TI:4232 None
 
A0A9R1VPL2_LACSA
neXtProt»
0.0
LSAT_V11C400181590 ER membrane protein complex subunit 3 Lactuca sativa
TI:4236 None
 
A0A9R1WUA7_LACSA
euHCVdb»
0.0
LSAT_V11C100050030 ER membrane protein complex subunit 3 Lactuca sativa
TI:4236 None
 
A0BIV9_PARTE
euHCVdb»
0.0
GSPATT00004849001 ER membrane protein complex subunit 3 Paramecium tetraurelia
TI:5888 None
 
A0DYU0_PARTE
neXtProt»
0.0
GSPATT00003175001 ER membrane protein complex subunit 3 Paramecium tetraurelia
TI:5888 None
 
A7EQY7_SCLS1
TubercuList»
0.0
SS1G_07740 ER membrane protein complex subunit 3 Sclerotinia sclerotiorum
TI:5180 None
 
A7SNP4_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g235732 ER membrane protein complex subunit 3 Nematostella vectensis
TI:45351 None
 
A8WQU9_CAEBR
WormBase»
0.0
emc-3 ER membrane protein complex subunit 3 Caenorhabditis briggsae
TI:6238 None
 
A9VE14_MONBE
neXtProt»
0.0
MONBRDRAFT_39355 ER membrane protein complex subunit 3 Monosiga brevicollis
TI:81824 None
 
B3RWY2_TRIAD
CTD»
0.0
TRIADDRAFT_25209 ER membrane protein complex subunit 3 Trichoplax adhaerens
TI:10228 None
 
B5YMH0_THAPS
neXtProt»
0.0
THAPS_23388 ER membrane protein complex subunit 3 Thalassiosira pseudonana
TI:35128 None
 
B6JZT7_SCHJY
TubercuList»
0.0
emc3 ER membrane protein complex subunit 3 Schizosaccharomyces japonicus
TI:4897 None
 
B9HCS0_POPTR
euHCVdb»
0.0
POPTR_006G011500 ER membrane protein complex subunit 3 Populus trichocarpa
TI:3694 None
 
B9S3I8_RICCO
neXtProt»
0.0
RCOM_0669360 ER membrane protein complex subunit 3 Ricinus communis
TI:3988 None
 
C3YB11_BRAFL
euHCVdb»
0.0
LOC118426753 ER membrane protein complex subunit 3 Branchiostoma floridae
TI:7739 None
 
C4LSX6_ENTH1
TubercuList»
0.0
EHI_148060 ER membrane protein complex subunit 3 Entamoeba histolytica
TI:5759 None
 
D6WIR8_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_00094 ER membrane protein complex subunit 3 Tribolium castaneum
TI:7070 None
 
E3L685_PUCGT
TubercuList»
0.0
PGTG_18150 Uncharacterized protein Puccinia graminis
TI:5297 None
 
EMC3_BOVIN
Ensembl»
0.0
EMC3 ER membrane protein complex
subunit 3 (Transmembrane protein 111)		 Bos taurus
TI:9913 None
 
EMC3_DICDI
dictyBase»
2.5
emc3 ER membrane protein complex
subunit 3 (Transmembrane protein 111)		 Dictyostelium discoideum
TI:44689 None
 
EMC3_RAT
RGD»
4.0
Emc3 ER membrane protein complex
subunit 3 (Transmembrane protein 111)		 Rattus norvegicus
TI:10116 None
 
F0ZFR6_DICPU
TubercuList»
0.0
DICPUDRAFT_150216 ER membrane protein complex subunit 3 Dictyostelium purpureum
TI:5786 None
 
F4P5K6_BATDJ
euHCVdb»
0.0
BATDEDRAFT_25775 ER membrane protein complex subunit 3 Batrachochytrium dendrobatidis
TI:109871 None
 
F6VQB3_CIOIN
Ensembl»
0.0
ER membrane protein complex subunit 3 Ciona intestinalis
TI:7719 None
 
H2XML0_CIOIN
Ensembl»
0.0
LOC100182576 ER membrane protein complex subunit 3 Ciona intestinalis
TI:7719 None
 
H3G6F4_PHYRM
EnsemblProtists»
0.0
ER membrane protein complex subunit 3 Phytophthora ramorum
TI:164328 None
 
I1IRE7_BRADI
EnsemblPlants»
0.0
LOC100833630 ER membrane protein complex subunit 3 Brachypodium distachyon
TI:15368 None
 
K7L939_SOYBN
EnsemblPlants»
0.0
GLYMA_08G266600 ER membrane protein complex subunit 3 Glycine max
TI:3847 None
 
K7MQG6_SOYBN
EnsemblPlants»
0.0
LOC100788772 ER membrane protein complex subunit 3 Glycine max
TI:3847 None
 
M5X223_PRUPE
neXtProt»
0.0
PRUPE_4G009900 ER membrane protein complex subunit 3 Prunus persica
TI:3760 None
 
Q38BC5_TRYB2
TubercuList»
0.0
Tb10.70.2450 ER membrane protein complex subunit 3 Trypanosoma brucei
TI:5691 None
 
Q4Q242_LEIMA
TubercuList»
0.0
LMJF_36_0360 ER membrane protein complex subunit 3 Leishmania major
TI:5664 None
 
Q4WC85_ASPFU
TubercuList»
0.0
AFUA_8G05350 ER membrane protein complex subunit 3 Aspergillus fumigatus
TI:746128 None
 
Q5BD54_EMENI
TubercuList»
0.0
ANIA_01526 ER membrane protein complex subunit 3 Emericella nidulans
TI:162425 None
 
Q5KFA1_CRYD1
TubercuList»
0.0
CNF02470 ER membrane protein complex subunit 3 Cryptococcus deneoformans
TI:40410 None
 
Q5PQ81_XENLA
Xenbase»
0.0
tmem111.L ER membrane protein complex subunit 3 Xenopus laevis
TI:8355 None
 
Q6C523_YARLI
TubercuList»
0.0
YALI0_E21670g ER membrane protein complex subunit 3 Yarrowia lipolytica
TI:4952 None
 
Q752Z2_EREGS
euHCVdb»
0.0
AGOS_AFR429C ER membrane protein complex subunit 3 Eremothecium gossypii
TI:33169 None
 
Q7Q3I0_ANOGA
EnsemblMetazoa»
0.0
1278072 ER membrane protein complex subunit 3 Anopheles gambiae
TI:7165 None
 
Q7SGF6_NEUCR
TubercuList»
0.0
NCU00966 ER membrane protein complex subunit 3 Neurospora crassa
TI:5141 None
 
Q7ZY15_XENLA
Xenbase»
0.0
tmem111.S ER membrane protein complex subunit 3 Xenopus laevis
TI:8355 None
 
Q8IDA3_PLAF7
TubercuList»
0.0
PF3D7_1360200 ER membrane protein complex subunit 3 Plasmodium falciparum
TI:5833 None
 
Q9U1X6_CAEEL
WormBase»
1.0
emc-3 ER membrane protein complex subunit 3 Caenorhabditis elegans
TI:6239 None
 
U5D7T8_AMBTC
neXtProt»
0.0
AMTR_s00055p00182870 ER membrane protein complex subunit 3 Amborella trichopoda
TI:13333 None
 
W5MXN8_LEPOC
Ensembl»
0.0
ER membrane protein complex subunit 3 Lepisosteus oculatus
TI:7918 None
 
YNY3_SCHPO
PomBase»
1.8
SPBC1711.03 ER membrane protein complex subunit 3 Schizosaccharomyces pombe
TI:4896 None
 
A0A1L8GLV2_XENLA
CTD»
0.0
LOC121403042 ER membrane protein complex subunit 3 Xenopus laevis
TI:8355 None
   
A0A1L8GP60_XENLA
Xenbase»
0.0
emc3.L ER membrane protein complex subunit 3 Xenopus laevis
TI:8355 None
   
A0A1S3Y1H9_TOBAC
neXtProt»
0.0
LOC107771040 ER membrane protein complex subunit 3 Nicotiana tabacum
TI:4097 None
   
A0A1S3YMU2_TOBAC
euHCVdb»
0.0
LOC107777714 ER membrane protein complex subunit 3 Nicotiana tabacum
TI:4097 None
   
A0A1S4B9M3_TOBAC
euHCVdb»
0.0
LOC107805950 ER membrane protein complex subunit 3 Nicotiana tabacum
TI:4097 None
   
A0A1U7ZLS9_NELNU
euHCVdb»
0.0
LOC104594178 ER membrane protein complex subunit 3 Nelumbo nucifera
TI:4432 None
   
A0A1U8AUG9_NELNU
euHCVdb»
0.0
LOC104606554 ER membrane protein complex subunit 3 Nelumbo nucifera
TI:4432 None
   
A0A1U8L9Q2_GOSHI
euHCVdb»
0.0
LOC107925213 ER membrane protein complex subunit 3 Gossypium hirsutum
TI:3635 None
   
A0A1U8LDU5_GOSHI
neXtProt»
0.0
LOC107925214 ER membrane protein complex subunit 3 Gossypium hirsutum
TI:3635 None
   
A0A1U8LSI1_GOSHI
neXtProt»
0.0
LOC107930393 ER membrane protein complex subunit 3 Gossypium hirsutum
TI:3635 None
   
A0A1U8LSJ9_GOSHI
neXtProt»
0.0
LOC107930392 ER membrane protein complex subunit 3 Gossypium hirsutum
TI:3635 None
   
A0A2I4DQY3_JUGRE
euHCVdb»
0.0
LOC108982597 ER membrane protein complex subunit 3 Juglans regia
TI:51240 None
   
A0A2I4GE96_JUGRE
euHCVdb»
0.0
LOC109007117 ER membrane protein complex subunit 3 Juglans regia
TI:51240 None
   
A0A3B3I3X1_ORYLA
Ensembl»
0.0
zgc:86609 ER membrane protein complex subunit 3 Oryzias latipes
TI:8090 None
   
A0A3B6MU99_WHEAT
EnsemblPlants»
0.0
LOC123121998 ER membrane protein complex subunit 3 Triticum aestivum
TI:4565 None
   
A0A3Q7GNK9_SOLLC
EnsemblPlants»
0.0
ER membrane protein complex subunit 3 Solanum lycopersicum
TI:4081 None
   
A0A4X1UUJ9_PIG
Ensembl»
0.0
EMC3 ER membrane protein complex subunit 3 Sus scrofa
TI:9823 None
   
A0A7M7RFI1_STRPU
EnsemblMetazoa»
0.0
ER membrane protein complex subunit 3 Strongylocentrotus purpuratus
TI:7668 None
   
A0A803JF83_XENTR
Xenbase»
0.0
tmem111 ER membrane protein complex subunit 3 Xenopus tropicalis
TI:8364 None
   
A0A803THP1_ANOCA
Ensembl»
0.0
emc3 ER membrane protein complex subunit 3 Anolis carolinensis
TI:28377 None
   
A0A804JGI9_MUSAM
EnsemblPlants»
0.0
ER membrane protein complex subunit 3 Musa acuminata
TI:4641 None
   
A0A8I3MZ54_CANLF
Ensembl»
0.0
EMC3 ER membrane protein complex subunit 3 Canis lupus
TI:9612 None
   
A0A8I6XPZ2_HORVV
EnsemblPlants»
0.0
LOC123399583 ER membrane protein complex subunit 3 Hordeum vulgare
TI:4513 None
   
A0A8J1L6F9_XENLA
CTD»
0.0
LOC108714228 ER membrane protein complex subunit 3 Xenopus laevis
TI:8355 None
   
A0A8R1Z5J3_PRIPA
EnsemblMetazoa»
0.0
WBGene00304474 ER membrane protein complex subunit 3 Pristionchus pacificus
TI:54126 None
   
A0A9L0S9W8_HORSE
Ensembl»
0.0
EMC3 ER membrane protein complex subunit 3 Equus caballus
TI:9796 None
   
A0A9R0IKV9_SPIOL
neXtProt»
0.0
LOC110789993 ER membrane protein complex subunit 3 Spinacia oleracea
TI:3562 None
   
A0ABI7WZW1_FELCA
Ensembl»
0.0
EMC3 ER membrane protein complex subunit 3 Felis catus
TI:9685 None
   
E1BQV4_CHICK
Ensembl»
1.0
EMC3 ER membrane protein complex subunit 3 Gallus gallus
TI:9031 None
   
F6V3X1_XENTR
Xenbase»
0.0
emc3 ER membrane protein complex subunit 3 Xenopus tropicalis
TI:8364 None
   
F6YL58_MONDO
Ensembl»
0.0
EMC3 ER membrane protein complex subunit 3 Monodelphis domestica
TI:13616 None
   
F7DLA1_ORNAN
Ensembl»
0.0
EMC3 ER membrane protein complex subunit 3 Ornithorhynchus anatinus
TI:9258 None
   
G1KD62_ANOCA
Ensembl»
0.0
LOC100563066 ER membrane protein complex subunit 3 Anolis carolinensis
TI:28377 None
   
H2L630_ORYLA
Ensembl»
0.0
EMC3 ER membrane protein complex subunit 3 Oryzias latipes
TI:8090 None
   
M1AFN4_SOLTU
EnsemblPlants»
0.0
LOC102593120 ER membrane protein complex subunit 3 Solanum tuberosum
TI:4113 None
   
M4DAV7_BRACM
EnsemblPlants»
0.0
ER membrane protein complex subunit 3 Brassica campestris
TI:3711 None
   
M4DWF6_BRACM
EnsemblPlants»
0.0
ER membrane protein complex subunit 3 Brassica campestris
TI:3711 None
   
W5FF45_WHEAT
EnsemblPlants»
0.0
LOC123104232 ER membrane protein complex subunit 3 Triticum aestivum
TI:4565 None
   
W5LWI9_LEPOC
Ensembl»
0.0
ER membrane protein complex subunit 3 Lepisosteus oculatus
TI:7918 None