• Cluster UKP04350

• GUANYLYL CYCLASE DOMAIN CONTAINING PROTEIN 1 GUCD1

• Standard knownness: 1.6; Custom knownness: None; Num. species: 69; Orthology database: Panther19.0; Protein members: 88

Phylogenetic distribution

Chordates:	21/21
Echinoderms:	0/0
Hemichordates:	1/1
Annelids:	1/1
Molluscs:	0/0
Bryozoans:	0/0
Platyhelminthes:	0/0
Rotifers:	0/0
Nematodes:	0/3
Arthropods:	4/5
Tardigrades:	0/0
Placozoa:	1/1
Cnidaria:	1/1
Porifera:	0/0
Choanoflagellates+:	1/1
Dikarya:	0/14
Fungi (other):	0/1
Protozoa:	2/3
Excavates:	0/4
Harosa:	1/4
Hacrobia:	0/0
Plants:	36/39
Archea:	0/8
Bacteria:	0/35

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Proteins

UniProt ID Organism DB»	Standard knownness	clustom knownness	Gene name	Description	Species  [Key only]	GO terms	Seq. links	Protein domain links
GUCD1_HUMAN Ensembl»	0.0		GUCD1	Protein GUCD1 (Guanylyl cyclase domain-containing protein 1) (Protein LLN4)	Homo sapiens TI:9606 None	GO (2) P:IEA - liver regeneration P:IEA - response to cAMP	EMBL (7) AK054681 AK098754 AP000356 CH471095 BC002924 BC070109 AB049215		InterPro (1) IPR018616 -
GCC1_ARATH TAIR»	1.6		GC1	Guanylyl cyclase 1 (AtGC1) (EC 4.6.1.2)	Arabidopsis thaliana TI:3702 None	GO (5) F:IDA - guanylate cyclase activity P:IDA - cGMP biosynthetic process F:IEA - lyase activity P:IEA - cGMP biosynthetic process F:IEA - guanylate cyclase activity	EMBL (6) AY118140 AB017060 CP002688 BT024499 AK229272 AY084807		InterPro (1) IPR018616 -
GUCD1_MOUSE Ensembl»	0.0		Gucd1	Protein GUCD1 (Guanylyl cyclase domain-containing protein 1) (Protein LLN4)	Mus musculus TI:10090 None		EMBL (6) AK034509 AK040832 AK157404 BC043463 BC118613 BC119795		InterPro (1) IPR018616 -
A0A067FPD1_CITSI Ensembl»	0.0		CISIN_1g0243821mg	Peptidase C39-like domain-containing protein	Citrus sinensis TI:2711 None		EMBL (5) KK784893 KK784893 KK784893 KK784893 KK784893		InterPro (1) IPR018616 -
A0A067G0M6_CITSI Ensembl»	0.0		CISIN_1g0243822mg	Guanylyl cyclase	Citrus sinensis TI:2711 None		EMBL (3) KK784893 KK784893 KK784893		InterPro (1) IPR018616 -
B8A1L7_MAIZE EnsemblPlants»	0.0		ZEAMMB73_Zm00001d038348	Guanylyl cyclase 1	Zea mays TI:4577 None		EMBL (3) BT055459 CM000782 CM000782		InterPro (1) IPR018616 -
Q28HB1_XENTR Xenbase»	0.0		gucd1	Novel protein (Protein GUCD1)	Xenopus tropicalis TI:8364 None		EMBL (3) BC170918 BC170920 CR760957		InterPro (1) IPR018616 -
A0A251TSW0_HELAN EnsemblPlants»	0.0		HannXRQ_Chr09g0246921 HanXRQr2_Chr09g0381861	Guanylate cyclase (EC 4.6.1.2) (Putative guanylyl cyclase)	Helianthus annuus TI:4232 None	GO (1) F:IEA - lyase activity	EMBL (2) MNCJ02000324 CM007898		InterPro (1) IPR018616 -
A0A251UG19_HELAN EnsemblPlants»	0.0		ATGC1	Guanylate cyclase (EC 4.6.1.2) (Putative guanylyl cyclase 1)	Helianthus annuus TI:4232 None	GO (1) F:IEA - lyase activity	EMBL (2) MNCJ02000322 CM007896		InterPro (1) IPR018616 -
B7QLQ0_IXOSC EnsemblMetazoa»	0.0		8043144	Protein GUCD1	Ixodes scapularis TI:6945 None		EMBL (2) ABJB010640860 DS967150		InterPro (1) IPR018616 -
G7JAJ6_MEDTR EnsemblPlants»	0.0		11409737	Guanylyl cyclase (Putative guanylate cyclase (EC 4.6.1.2))	Medicago truncatula TI:3880 None	GO (3) F:IEA - lyase activity F:IEA - guanylate cyclase activity P:IEA - cGMP biosynthetic process	EMBL (2) CM001219 PSQE01000003		InterPro (1) IPR018616 -
H9ZE64_MACMU Ensembl»	0.0		GUCD1	Chromosome 22 open reading frame 13 (Guanylyl cyclase domain containing 1)	Macaca mulatta TI:9544 None		EMBL (2) JU477426 JV048387		InterPro (1) IPR018616 -
K3Z8T5_SETIT EnsemblPlants»	0.0		101767961	Guanylyl cyclase	Setaria italica TI:4555 None	GO (2) F:IEA - guanylate cyclase activity P:IEA - cGMP biosynthetic process	EMBL (2) AGNK02001671 CM003530		InterPro (1) IPR018616 -
M5X244_PRUPE EnsemblPlants»	0.0		PRUPE_2G243100	Guanylyl cyclase	Prunus persica TI:3760 None	GO (2) F:IEA - guanylate cyclase activity P:IEA - cGMP biosynthetic process	EMBL (2) CM007652 CM007652		InterPro (1) IPR018616 -
Q08CN7_DANRE ZFIN»	0.0		zgc:152874	Guanylyl cyclase domain-containing 1 (Protein GUCD1) (Zgc:152874)	Danio rerio TI:7955 None		EMBL (2) CR848681 BC124161		InterPro (1) IPR018616 -
Q9W4Y0_DROME FlyBase»	0.0		EG:BACR25B3.6	RE44620p (Uncharacterized protein, isoform C)	Drosophila melanogaster TI:7227 None		EMBL (2) AE014298 BT031159		InterPro (1) IPR018616 -
T1FNC8_HELRO EnsemblMetazoa»	0.0		20210325	Protein GUCD1	Helobdella robusta TI:6412 None		EMBL (2) AMQM01005908 KB097144		InterPro (1) IPR018616 -
A0A022R8Q3_ERYGU EnsemblFungi»	0.0		MIMGU_mgv1a011515mg	Guanylyl cyclase	Erythranthe guttata TI:4155 None		EMBL (1) KI630628		InterPro (1) IPR018616 -
A0A058ZT12_EUCGR EnsemblPlants»	0.0		EUGRSUZ_L02372	Guanylyl cyclase	Eucalyptus grandis TI:71139 None		EMBL (1) KK199588		InterPro (1) IPR018616 -
A0A061FM01_THECC EnsemblPlants»	0.0		TCM_042643	C22orf13, putative isoform 1	Theobroma cacao TI:3641 None	GO (2) F:IEA - guanylate cyclase activity P:IEA - cGMP biosynthetic process	EMBL (1) CM001888		InterPro (1) IPR018616 -
A0A0A0K8F6_CUCSA EnsemblPlants»	0.0		Csa_6G009370	Guanylyl cyclase	Cucumis sativus TI:3659 None	GO (2) F:IEA - guanylate cyclase activity P:IEA - cGMP biosynthetic process	EMBL (1) CM002927		InterPro (1) IPR018616 -
A0A0K9PU54_ZOSMR EnsemblPlants»	0.0		ZOSMA_162G00270	Guanylyl cyclase	Zostera marina TI:29655 None		EMBL (1) LFYR01000625		InterPro (1) IPR018616 -
A0A1D6IXR7_MAIZE EnsemblPlants»	0.0		103642433	Guanylyl cyclase 1	Zea mays TI:4577 None		EMBL (1) CM000786		InterPro (1) IPR018616 -
A0A1S4H619_ANOGA EnsemblMetazoa»	0.0			Uncharacterized protein	Anopheles gambiae TI:7165 None		EMBL (1) AAAB01008816		InterPro (1) IPR018616 -
A0A1U8GAG9_CAPAN EnsemblPlants»	0.0		T459_08999	Protein GUCD1	Capsicum annuum TI:4072 None		EMBL (1) AYRZ02000003		InterPro (1) IPR018616 -
A0A1U8Q798_NELNU EnsemblBacteria»	0.0		LOC104601147	Protein GUCD1 isoform X1	Nelumbo nucifera TI:4432 None		EMBL (1) DUZY01000002		InterPro (1) IPR018616 -
A0A1Y1INU5_KLENI EnsemblPlants»	0.0		KFL_007360080	Guanylyl cyclase domain containing protein	Klebsormidium nitens TI:105231 None		EMBL (1) DF237685		InterPro (1) IPR018616 -
A0A287B1P5_PIG Ensembl»	0.0		GUCD1	Guanylyl cyclase domain containing 1 (Protein GUCD1)	Sus scrofa TI:9823 None		EMBL (1) DQIR01226849		InterPro (1) IPR018616 -
A0A2C9VKQ5_MANES EnsemblPlants»	0.0		MANES_07G122900	Guanylyl cyclase	Manihot esculenta TI:3983 None		EMBL (1) CM004393		InterPro (1) IPR018616 -
A0A2I2ZTB9_GORGO Ensembl»	0.0			Guanylyl cyclase domain containing 1	Gorilla gorilla TI:9593 None		EMBL (1) CABD030120430		InterPro (1) IPR018616 -
A0A2I3T318_PANTR Ensembl»	0.0		GUCD1	Guanylyl cyclase domain containing 1	Pan troglodytes TI:9598 None		EMBL (1) AC194994		InterPro (1) IPR018616 -
A0A2K1IM41_PHYPA EnsemblPlants»	0.0		PHYPA_026656	Guanylyl cyclase	Physcomitrium patens TI:3218 None		EMBL (1) ABEU02000022		InterPro (1) IPR018616 -
A0A2K3DBN7_CHLRE EnsemblPlants»	0.0		CHLRE_10g457450v5	Guanylyl cyclase	Chlamydomonas reinhardtii TI:3055 None		EMBL (1) CM008971		InterPro (1) IPR018616 -
A0A2R6XW31_MARPO EnsemblPlants»	0.0		MARPO_0001s0310	Guanylyl cyclase	Marchantia polymorpha TI:3197 None		EMBL (1) KZ772673		InterPro (1) IPR018616 -
A0A337S624_FELCA Ensembl»	0.0		LOC101100863	Guanylyl cyclase domain containing 1	Felis catus TI:9685 None		EMBL (1) AANG04003518		InterPro (1) IPR018616 -
A0A337SRL1_FELCA Ensembl»	0.0		GUCD1	Guanylyl cyclase domain containing 1	Felis catus TI:9685 None		EMBL (1) AANG04002472		InterPro (1) IPR018616 -
A0A3B5YZQ4_WHEAT EnsemblPlants»	0.0		CFC21_007622	Guanylyl cyclase	Triticum aestivum TI:4565 None		EMBL (1) CM022212		InterPro (1) IPR018616 -
A0A3B5ZWR3_WHEAT EnsemblPlants»	0.0		CFC21_012532	Guanylyl cyclase	Triticum aestivum TI:4565 None		EMBL (1) CM022213		InterPro (1) IPR018616 -
A0A7I4FA67_PHYPA EnsemblPlants»	0.0			Guanylyl cyclase	Physcomitrium patens TI:3218 None		EMBL (1) ABEU02000019		InterPro (1) IPR018616 -
A1L3M7_XENLA Xenbase»	0.0		gucd1.L	LOC100037048 protein (Uncharacterized protein LOC100037048)	Xenopus laevis TI:8355 None		EMBL (1) BC130200		InterPro (1) IPR018616 -
A7RM91_NEMVE EnsemblMetazoa»	0.0		NEMVEDRAFT_v1g86655	Protein GUCD1	Nematostella vectensis TI:45351 None		EMBL (1) DS469519		InterPro (1) IPR018616 -
B3RYX5_TRIAD EnsemblMetazoa»	0.0		TRIADDRAFT_57249	Guanylyl cyclase	Trichoplax adhaerens TI:10228 None		EMBL (1) DS985246		InterPro (1) IPR018616 -
B8C5L3_THAPS EnsemblProtists»	0.0		THAPSDRAFT_6114	Ubiquitinyl hydrolase 1	Thalassiosira pseudonana TI:35128 None		EMBL (1) CM000643		InterPro (1) IPR018616 -
B9HHJ1_POPTR EnsemblPlants»	0.0		POPTR_008G062100	Guanylyl cyclase	Populus trichocarpa TI:3694 None		EMBL (1) CM009297		InterPro (1) IPR018616 -
B9SE40_RICCO EnsemblBacteria»	0.0		RCOM_1483470	Protein C22orf13, putative	Ricinus communis TI:3988 None		EMBL (1) EQ973933		InterPro (1) IPR018616 -
C5YZ62_SORBI EnsemblPlants»	0.0		SORBI_3009G159200	Guanylyl cyclase	Sorghum bicolor TI:4558 None	GO (2) F:IEA - guanylate cyclase activity P:IEA - cGMP biosynthetic process	EMBL (1) CM000768		InterPro (1) IPR018616 -
D2A5H0_TRICA EnsemblMetazoa»	0.0		AUGUSTUS-3.0.2_15537	Protein GUCD1-like Protein	Tribolium castaneum TI:7070 None		EMBL (1) KQ971345		InterPro (1) IPR018616 -
D7TML6_VITVI EnsemblPlants»	0.0		VIT_13s0019g02720	Protein GUCD1	Vitis vinifera TI:29760 None		EMBL (1) FN595998		InterPro (1) IPR018616 -
D8RMK6_SELML EnsemblPlants»	0.0		SELMODRAFT_97002	Guanylyl cyclase	Selaginella moellendorffii TI:88036 None		EMBL (1) GL377584		InterPro (1) IPR018616 -
D8SLN8_SELML EnsemblPlants»	0.0		SELMODRAFT_119770	Guanylyl cyclase	Selaginella moellendorffii TI:88036 None		EMBL (1) GL377626		InterPro (1) IPR018616 -
F0Z707_DICPU EnsemblProtists»	0.0		DICPUDRAFT_146833	Guanylyl cyclase	Dictyostelium purpureum TI:5786 None		EMBL (1) GL870944		InterPro (1) IPR018616 -
F4P887_BATDJ EnsemblBacteria»	0.0		BATDEDRAFT_12878	Guanylyl cyclase	Batrachochytrium dendrobatidis TI:109871 None		EMBL (1) GL882888		InterPro (1) IPR018616 -
F6YTC9_CIOIN Ensembl»	0.0			Uncharacterized protein	Ciona intestinalis TI:7719 None		EMBL (1) EAAA01000897		InterPro (1) IPR018616 -
I1HIV1_BRADI EnsemblPlants»	0.0		100824072	Guanylyl cyclase	Brachypodium distachyon TI:15368 None	GO (2) F:IEA - guanylate cyclase activity P:IEA - cGMP biosynthetic process	EMBL (1) CM000881		InterPro (1) IPR018616 -
I1LML3_SOYBN EnsemblPlants»	0.0		GLYMA_11G225300	Guanylyl cyclase	Glycine max TI:3847 None		EMBL (1) CM000844		InterPro (1) IPR018616 -
K7MPM8_SOYBN EnsemblPlants»	0.0		100037468	Guanylyl cyclase	Glycine max TI:3847 None		EMBL (1) CM000851		InterPro (1) IPR018616 -
Q54TH3_DICDI dictyBase»	0.0		DDB_G0281749	Guanylyl cyclase	Dictyostelium discoideum TI:44689 None		EMBL (1) AAFI02000042		InterPro (1) IPR018616 -
Q6I642_ORYSJ EnsemblPlants»	0.0		Os05g0453500	Os05g0453500 protein	Oryza sativa TI:4530 None		EMBL (1) AP014961		InterPro (1) IPR018616 -
W1PVZ4_AMBTC EnsemblPlants»	0.0		AMTR_s00165p00042340	Guanylyl cyclase	Amborella trichopoda TI:13333 None	GO (2) F:IEA - guanylate cyclase activity P:IEA - cGMP biosynthetic process	EMBL (1) KI392640		InterPro (1) IPR018616 -
W5MJC5_LEPOC Ensembl»	0.0			Guanylyl cyclase domain containing 1	Lepisosteus oculatus TI:7918 None		EMBL (1) AHAT01005183		InterPro (1) IPR018616 -
A0A1S3XHT3_TOBAC EnsemblFungi»	0.0		LOC107765333	Protein GUCD1-like isoform X4	Nicotiana tabacum TI:4097 None				InterPro (1) IPR018616 -
A0A1S4A6D4_TOBAC EnsemblFungi»	0.0		LOC107794197	Protein GUCD1-like isoform X1	Nicotiana tabacum TI:4097 None				InterPro (1) IPR018616 -
A0A1U8KGG2_GOSHI Ensembl»	0.0		LOC107916717	Protein GUCD1-like isoform X1	Gossypium hirsutum TI:3635 None				InterPro (1) IPR018616 -
A0A1U8LPX3_GOSHI Ensembl»	0.0		LOC107929619	Protein GUCD1-like isoform X1	Gossypium hirsutum TI:3635 None				InterPro (1) IPR018616 -
A0A1U8N6V6_GOSHI Ensembl»	0.0		LOC107944280	Protein GUCD1-like	Gossypium hirsutum TI:3635 None				InterPro (1) IPR018616 -
A0A1U8NTJ7_GOSHI Ensembl»	0.0		LOC107951688	Protein GUCD1-like isoform X1	Gossypium hirsutum TI:3635 None				InterPro (1) IPR018616 -
A0A3B5Y3G4_WHEAT EnsemblPlants»	0.0			Guanylyl cyclase	Triticum aestivum TI:4565 None				InterPro (1) IPR018616 -
A0A3Q1LUU6_BOVIN Ensembl»	0.0		GUCD1	Guanylyl cyclase domain containing 1	Bos taurus TI:9913 None				InterPro (1) IPR018616 -
A0A3Q2LB50_HORSE Ensembl»	0.0		GUCD1	Guanylyl cyclase domain containing 1	Equus caballus TI:9796 None				InterPro (1) IPR018616 -
A0A3Q7G9A7_SOLLC EnsemblPlants»	0.0			Guanylyl cyclase	Solanum lycopersicum TI:4081 None				InterPro (1) IPR018616 -
A0A5F8HLE7_MONDO Ensembl»	0.0		GUCD1	Guanylyl cyclase domain containing 1	Monodelphis domestica TI:13616 None				InterPro (1) IPR018616 -
A0A6P9EVQ9_JUGRE EnsemblPlants»	0.0		LOC108991914	LOW QUALITY PROTEIN: guanylyl cyclase 1	Juglans regia TI:51240 None				InterPro (1) IPR018616 -
A0A7M7P7E3_STRPU EnsemblMetazoa»	0.0			Protein GUCD1	Strongylocentrotus purpuratus TI:7668 None				InterPro (1) IPR018616 -
A0A7M7RF64_STRPU EnsemblMetazoa»	0.0			Protein GUCD1	Strongylocentrotus purpuratus TI:7668 None				InterPro (1) IPR018616 -
A0A804JP65_MUSAM EnsemblPlants»	0.0			Guanylyl cyclase	Musa acuminata TI:4641 None				InterPro (1) IPR018616 -
A0A804N5P5_MAIZE EnsemblPlants»	0.0			Guanylyl cyclase 1	Zea mays TI:4577 None				InterPro (1) IPR018616 -
A0A804PCH8_MAIZE EnsemblPlants»	0.0			eRF1 domain-containing protein	Zea mays TI:4577 None				InterPro (3) IPR005142 - IPR018616 - IPR029064 -
A0A804PTX5_MAIZE EnsemblPlants»	0.0			Ubiquitin-like protease family profile domain-containing protein	Zea mays TI:4577 None				InterPro (2) IPR018616 - IPR037239 -
A0A8I3P4Q5_CANLF Ensembl»	0.0			Uncharacterized protein	Canis lupus TI:9612 None				InterPro (1) IPR018616 -
A0A8I3PRX5_CANLF Ensembl»	0.0		GUCD1	Uncharacterized protein	Canis lupus TI:9612 None				InterPro (1) IPR018616 -
A0A8I5ZSK9_RAT RGD»	1.6		Gucd1	Guanylyl cyclase domain containing 1	Rattus norvegicus TI:10116 None	GO (2) P:IEP - liver regeneration P:IEP - response to cAMP			InterPro (1) IPR018616 -
A0A8I6WHZ1_HORVV EnsemblPlants»	0.0			Guanylyl cyclase	Hordeum vulgare TI:4513 None				InterPro (1) IPR018616 -
A0A8J0U2K8_XENLA Xenbase»	0.0		gucd1.S	Guanylyl cyclase domain containing 1 S homeolog isoform X1	Xenopus laevis TI:8355 None				InterPro (1) IPR018616 -
A0A8V1A8C8_CHICK Ensembl»	0.0		GUCD1	Guanylyl cyclase domain containing 1	Gallus gallus TI:9031 None				InterPro (1) IPR018616 -
A0A9J7LKV4_BRAFL CTD»	0.0		LOC118421547	Protein GUCD1-like	Branchiostoma floridae TI:7739 None				InterPro (1) IPR018616 -
H2MLY8_ORYLA Ensembl»	0.0		gucd1	Guanylyl cyclase domain containing 1	Oryzias latipes TI:8090 None				InterPro (1) IPR018616 -
K7E8L5_ORNAN Ensembl»	0.0			Guanylyl cyclase domain containing 1	Ornithorhynchus anatinus TI:9258 None				InterPro (1) IPR018616 -
M4CY54_BRACM EnsemblPlants»	0.0			Protein GUCD1	Brassica campestris TI:3711 None				InterPro (1) IPR018616 -