Collated Gene Ontology terms

Biological process: mRNA binding(2018) C2H2 zinc finger domain binding(2009, 2025) RNA binding(2014, 2025) ubiquitin protein ligase activity(2021)

Molecular function: mRNA processing2025 RNA splicing2025 mRNA splicing, via spliceosome2010, 2011, 2013, 2018, 2025 negative regulation of gene expression2010 ubiquitin-dependent protein catabolic process2021 regulation of metaphase plate congression2014 metamorphosis2013 mRNA cis splicing, via spliceosome2024 female meiosis chromosome segregation2014 alternative mRNA splicing, via spliceosome2019
achiasmate meiosis I2014 DNA-templated transcription2025

Cellular component: nucleus2006, 2009, 2022, 2025 spliceosomal complex2025 cytoplasm2025 nuclear speck2013, 2025 catalytic step 2 spliceosome2010, 2011, 2025 chromatin2013, 2025 U2-type precatalytic spliceosome2019, 2025 U2-type catalytic step 2 spliceosome2018, 2025 Cajal body2009, 2025 nucleoplasm2016, 2022
U2-type spliceosomal complex2013 precatalytic spliceosome2010 polytene chromosome2010 nuclear body2025 chromosome2025 Prp19 complex2024

Phylogenetic distribution

Chordates: 6/21 
Echinoderms: 0/0 
Hemichordates: 0/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 1/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
W1P0P5_AMBTC
euHCVdb»
0.0
AMTR_s00002p00205670 CWF21 domain-containing protein Amborella trichopoda
TI:13333 None
 
W1P2G3_AMBTC
euHCVdb»
0.0
AMTR_s00002p00210460 CWF21 domain-containing protein Amborella trichopoda
TI:13333 None
 
A0A1S4GFQ5_ANOGA
EnsemblMetazoa»
0.0
Uncharacterized protein Anopheles gambiae
TI:7165 None
 
A0A1S4GR31_ANOGA
EnsemblMetazoa»
0.0
CWF21 domain-containing protein Anopheles gambiae
TI:7165 None
 
B3H6J5_ARATH
TAIR»
0.0
At3g49601 Pre-mRNA-splicing factor Arabidopsis thaliana
TI:3702 None
 
CWC21_ASPFU
EnsemblFungi»
0.0
cwc21 Pre-mRNA-splicing factor cwc21 Aspergillus fumigatus
TI:746128 None
 
F4NU85_BATDJ
neXtProt»
0.0
BATDEDRAFT_9270 CWF21 domain-containing protein Batrachochytrium dendrobatidis
TI:109871 None
 
I1J1K4_BRADI
EnsemblPlants»
0.0
LOC100822512 CWF21 domain-containing protein Brachypodium distachyon
TI:15368 None
 
A0A078F4X9_BRANA
neXtProt»
0.0
BnaA06g15740D (rape) hypothetical
protein (BnaA06g15740D protein)		 Brassica napus
TI:3708 None
 
M4DN84_BRACM
EnsemblPlants»
0.0
CWF21 domain-containing protein Brassica campestris
TI:3711 None
   
A8XYY7_CAEBR
WormBase»
0.0
rsr-2 Protein CBR-RSR-2 Caenorhabditis briggsae
TI:6238 None
 
SRRMH_CAEEL
WormBase»
0.0
rsr-2 SRRM2 protein homolog
rsr-2 (SR protein-related rsr-2)		 Caenorhabditis elegans
TI:6239 None
 
CWC21_CANAL
EnsemblFungi»
0.0
CWC21 Pre-mRNA-splicing factor CWC21 Candida albicans
TI:5476 None
 
A0A2G3AGG3_CAPAN
neXtProt»
0.0
T459_01199 CWF21 domain-containing protein Capsicum annuum
TI:4072 None
 
A0A2K3CS30_CHLRE
neXtProt»
0.0
CHLRE_17g745547v5 Pre-mRNA polyadenylation factor
Fip1 domain-containing protein		 Chlamydomonas reinhardtii
TI:3055 None
 
A0A2K3DFH0_CHLRE
euHCVdb»
0.0
CHLRE_09g409200v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A067GK28_CITSI
neXtProt»
0.0
CISIN_1g003900mg CWF21 domain-containing protein Citrus sinensis
TI:2711 None
 
CWC21_CRYD1
EnsemblFungi»
0.0
CWC21 Pre-mRNA-splicing factor CWC21 Cryptococcus deneoformans
TI:40410 None
 
A0A0A0LQ00_CUCSA
neXtProt»
0.0
Csa_2G379180 CWF21 domain-containing protein Cucumis sativus
TI:3659 None
 
F1QLP6_DANRE
ZFIN»
0.0
srrm2 Serine/arginine repetitive matrix 2
(Serine/arginine repetitive matrix protein 2)		 Danio rerio
TI:7955 None
 
E9GK70_DAPPU
neXtProt»
0.0
DAPPUDRAFT_197118 CWF21 domain-containing protein Daphnia pulex
TI:6669 None
 
F0ZR29_DICPU
TubercuList»
0.0
DICPUDRAFT_80636 CWF21 domain-containing protein Dictyostelium purpureum
TI:5786 None
 
Q54EL3_DICDI
dictyBase»
0.0
DDB_G0291670 CWF21 domain-containing protein Dictyostelium discoideum
TI:44689 None
 
A8JNI2_DROME
FlyBase»
1.8
Srrm234 Serine-arginine repetitive matrix
2/3/4, isoform F		 Drosophila melanogaster
TI:7227 None
 
O46048_DROME
FlyBase»
4.8
east EG:133E12.4 protein (Enhanced adult sensory threshold, isoform
E) (Enhanced adult sensory threshold, isoform F)		 Drosophila melanogaster
TI:7227 None
 
Q9VWH5_DROME
FlyBase»
0.0
Dmel\CG14200 Uncharacterized protein, isoform A Drosophila melanogaster
TI:7227 None
 
Q5AYP4_EMENI
TubercuList»
0.0
ANIA_06586 RNA binding protein,
putative (AFU_orthologue AFUA_6G04320)		 Emericella nidulans
TI:162425 None
 
C4M4I2_ENTH1
TubercuList»
0.0
EHI_138760 Uncharacterized protein Entamoeba histolytica
TI:5759 None
 
C4M650_ENTH1
TubercuList»
0.0
EHI_179990 CWF21 domain-containing protein Entamoeba histolytica
TI:5759 None 		 
 
CWC21_EREGS
EnsemblFungi»
0.0
CWC21 Pre-mRNA-splicing factor CWC21 Eremothecium gossypii
TI:33169 None
 
A0A022QP80_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a021049mg CWF21 domain-containing protein Erythranthe guttata
TI:4155 None
 
A0A022QPC9_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a001099mg CWF21 domain-containing protein Erythranthe guttata
TI:4155 None
 
A0A022QRD5_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a0233651mg CWF21 domain-containing protein Erythranthe guttata
TI:4155 None
 
A0A0R0FPC6_SOYBN
EnsemblPlants»
0.0
GLYMA_17G200600 CWF21 domain-containing protein Glycine max
TI:3847 None
 
K7M6I8_SOYBN
EnsemblPlants»
0.0
LOC100792927 CWF21 domain-containing protein Glycine max
TI:3847 None
 
G3RMK9_GORGO
Ensembl»
0.0
SRRM2 Serine/arginine repetitive matrix 2 Gorilla gorilla
TI:9593 None
 
A0A1U8L8N2_GOSHI
neXtProt»
0.0
LOC107923866 Serine/arginine repetitive matrix protein 2-like Gossypium hirsutum
TI:3635 None
   
A0ABM3A9P1_GOSHI
neXtProt»
0.0
LOC107923427 Serine/arginine repetitive matrix protein 2 Gossypium hirsutum
TI:3635 None
   
A0ABM3AB16_GOSHI
euHCVdb»
0.0
LOC121218610 Pre-mRNA-splicing factor cwc-21 Gossypium hirsutum
TI:3635 None
   
A0ABM3BWH5_GOSHI
euHCVdb»
0.0
LOC107956862 Pre-mRNA-splicing factor CWC21-like Gossypium hirsutum
TI:3635 None
   
A0ABM3BYH3_GOSHI
euHCVdb»
0.0
LOC107955360 Protein starmaker Gossypium hirsutum
TI:3635 None
   
A0A251TK18_HELAN
neXtProt»
0.0
HannXRQ_Chr10g0299041 Putative mRNA splicing
factor Cwf21 domain-containing protein		 Helianthus annuus
TI:4232 None
 
A0A9K3HWS3_HELAN
neXtProt»
0.0
HanXRQr2_Chr10g0439271 mRNA splicing factor
Cwf21 domain-containing protein		 Helianthus annuus
TI:4232 None
 
A0A9K3JZ12_HELAN
euHCVdb»
0.0
HanXRQr2_Chr01g0037341 mRNA splicing factor
Cwf21 domain-containing protein		 Helianthus annuus
TI:4232 None
 
T1FZD9_HELRO
EnsemblMetazoa»
0.0
20214187 CWF21 domain-containing protein Helobdella robusta
TI:6412 None
 
SRRM2_HUMAN
Ensembl»
4.2
SRRM2 Serine/arginine repetitive matrix protein 2 (300 kDa nuclear matrix antigen) (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear
matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803)		 Homo sapiens
TI:9606 None
 
A0A8I6WHN5_HORVV
EnsemblPlants»
0.0
LOC123427665 CWF21 domain-containing protein Hordeum vulgare
TI:4513 None
   
A0A8I7BAC7_HORVV
EnsemblPlants»
0.0
CWF21 domain-containing protein Hordeum vulgare
TI:4513 None
   
B7PZH0_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW020191 Nucleolar GTPase/ATPase p130, putative Ixodes scapularis
TI:6945 None 		 
 
B7PZH1_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW020192 Pre-mRNA-splicing factor CWC21, putative Ixodes scapularis
TI:6945 None
 
A0A2I4EXB7_JUGRE
euHCVdb»
0.0
LOC108993535 Serine/arginine repetitive matrix protein 2-like Juglans regia
TI:51240 None
   
A0A2I4GP63_JUGRE
euHCVdb»
0.0
LOC109009599 Protein starmaker-like Juglans regia
TI:51240 None
   
A0A1Y1HQH6_KLENI
neXtProt»
0.0
KFL_000650130 CWF21 domain-containing protein Klebsormidium nitens
TI:105231 None
 
A0A9R1VUF5_LACSA
euHCVdb»
0.0
LSAT_V11C400186150 CWF21 domain-containing protein Lactuca sativa
TI:4236 None
 
A0A1D5RIX1_MACMU
Ensembl»
0.0
SRRM2 Serine/arginine repetitive matrix 2 Macaca mulatta
TI:9544 None
   
A0A251L6V2_MANES
neXtProt»
0.0
MANES_03G046500 CWF21 domain-containing protein Manihot esculenta
TI:3983 None
 
A0A2R6WUA4_MARPO
euHCVdb»
0.0
MARPO_0057s0051 CWF21 domain-containing protein Marchantia polymorpha
TI:3197 None
 
A0A2R6WUB9_MARPO
euHCVdb»
0.0
MARPO_0057s0059 CWF21 domain-containing protein Marchantia polymorpha
TI:3197 None
 
A0A2R6XFC8_MARPO
euHCVdb»
0.0
MARPO_0018s0007 CWF21 domain-containing protein Marchantia polymorpha
TI:3197 None
 
A0A072VNT0_MEDTR
EnsemblPlants»
0.0
MTR_1g010100 Pre-mRNA-splicing factor cwc-21, putative Medicago truncatula
TI:3880 None
 
A0A804HVP3_MUSAM
EnsemblPlants»
0.0
GSMUA_302270.1 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A1U8A3X5_NELNU
neXtProt»
0.0
LOC104596821 Sarcoplasmic reticulum
histidine-rich calcium-binding protein-like		 Nelumbo nucifera
TI:4432 None
   
A0A1U8BEQ2_NELNU
euHCVdb»
0.0
LOC104612650 Uncharacterized protein LOC104612650 Nelumbo nucifera
TI:4432 None
   
A7RM21_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g86218 CWF21 domain-containing protein Nematostella vectensis
TI:45351 None
 
A7RM22_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g86498 Uncharacterized protein Nematostella vectensis
TI:45351 None 		 
 
CWC21_NEUCR
EnsemblFungi»
0.0
cwc-21 Pre-mRNA-splicing factor cwc-21 Neurospora crassa
TI:5141 None
 
A0A1S4DDZ6_TOBAC
euHCVdb»
0.0
LOC107828793 Uncharacterized protein LOC107828793 Nicotiana tabacum
TI:4097 None
   
A0A3B3IHN2_ORYLA
Ensembl»
0.0
srrm2 CWF21 domain-containing protein Oryzias latipes
TI:8090 None
   
A0A2I3SBS9_PANTR
Ensembl»
0.0
SRRM2 Serine/arginine repetitive matrix 2 Pan troglodytes
TI:9598 None
 
A0DKG3_PARTE
euHCVdb»
0.0
GSPATT00017860001 CWF21 domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0E0Y9_PARTE
neXtProt»
0.0
GSPATT00022125001 CWF21 domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A0A7U2HYJ8_PHANO
TubercuList»
0.0
JI435_015750 CWF21 domain-containing protein Phaeosphaeria nodorum
TI:13684 None
 
A0A2K1KTW1_PHYPA
EnsemblPlants»
0.0
LOC112280715 CWF21 domain-containing protein Physcomitrium patens
TI:3218 None
 
A0A7I4AK01_PHYPA
EnsemblPlants»
0.0
CWF21 domain-containing protein Physcomitrium patens
TI:3218 None
 
H3G6V0_PHYRM
EnsemblProtists»
0.0
CWF21 domain-containing protein Phytophthora ramorum
TI:164328 None
 
H3GQA4_PHYRM
EnsemblProtists»
0.0
CWF21 domain-containing protein Phytophthora ramorum
TI:164328 None
 
Q8IKW9_PLAF7
TubercuList»
0.0
PF3D7_1450700 CWF21 domain-containing protein Plasmodium falciparum
TI:5833 None
 
A0A2K2A715_POPTR
euHCVdb»
0.0
POPTR_006G233000 CWF21 domain-containing protein Populus trichocarpa
TI:3694 None
 
A0A2A6CX27_PRIPA
EnsemblMetazoa»
0.0
WBGene00274830 Cwf21 domain-containing protein Pristionchus pacificus
TI:54126 None
   
A0A2A6CXN4_PRIPA
EnsemblMetazoa»
0.0
WBGene00282618 SPX domain-containing protein Pristionchus pacificus
TI:54126 None 		     
A0A251RDQ2_PRUPE
euHCVdb»
0.0
PRUPE_1G463200 CWF21 domain-containing protein Prunus persica
TI:3760 None
 
E3KF08_PUCGT
TubercuList»
0.0
PGTG_10008 CWF21 domain-containing protein Puccinia graminis
TI:5297 None
 
B9RRV5_RICCO
euHCVdb»
0.0
RCOM_0798440 CWF21 domain-containing protein Ricinus communis
TI:3988 None
 
CWC21_YEAST
SGD»
2.2
CWC21 Pre-mRNA-splicing factor CWC21 (Complexed
with CEF1 protein 21)		 Saccharomyces cerevisiae
TI:4932 None
 
B6K894_SCHJY
TubercuList»
0.0
cwf21 Complexed with Cdc5 protein Cwf21 Schizosaccharomyces japonicus
TI:4897 None
 
CWC21_SCHPO
PomBase»
0.8
cwf21 Pre-mRNA-splicing factor cwf21 (Complexed
with cdc5 protein 21)		 Schizosaccharomyces pombe
TI:4896 None
 
A7EUE7_SCLS1
TubercuList»
0.0
SS1G_08954 CWF21 domain-containing protein Sclerotinia sclerotiorum
TI:5180 None
 
K3XS18_SETIT
EnsemblPlants»
0.0
CWF21 domain-containing protein Setaria italica
TI:4555 None
 
K3YQ10_SETIT
EnsemblPlants»
0.0
CWF21 domain-containing protein Setaria italica
TI:4555 None
 
A0A3Q7HQI0_SOLLC
EnsemblPlants»
0.0
LOC101245685 CWF21 domain-containing protein Solanum lycopersicum
TI:4081 None
   
M1CW32_SOLTU
EnsemblPlants»
0.0
CWF21 domain-containing protein Solanum tuberosum
TI:4113 None
   
A0A194YPW1_SORBI
euHCVdb»
0.0
SORBI_3004G102000 CWF21 domain-containing protein Sorghum bicolor
TI:4558 None
 
A0A1B6Q4N6_SORBI
euHCVdb»
0.0
SORBI_3003G213700 CWF21 domain-containing protein Sorghum bicolor
TI:4558 None
 
A0ABM3RPC0_SPIOL
euHCVdb»
0.0
LOC110783942 CWF21 domain-containing protein Spinacia oleracea
TI:3562 None
   
B8BXH8_THAPS
euHCVdb»
0.0
THAPSDRAFT_21700 CWF21 domain-containing protein Thalassiosira pseudonana
TI:35128 None
 
A0A061FQT0_THECC
euHCVdb»
0.0
TCM_044549 Cwf21 Theobroma cacao
TI:3641 None
 
A0A061FRZ2_THECC
euHCVdb»
0.0
TCM_044552 Cwf21 Theobroma cacao
TI:3641 None
 
A0A061FX87_THECC
euHCVdb»
0.0
TCM_044534 Uncharacterized protein isoform 1 Theobroma cacao
TI:3641 None
 
D2A2G4_TRICA
neXtProt»
0.0
AUGUSTUS-3.0.2_07655 Uncharacterized protein Tribolium castaneum
TI:7070 None
 
D6WZL8_TRICA
neXtProt»
0.0
AUGUSTUS-3.0.2_11813 CWF21 domain-containing protein Tribolium castaneum
TI:7070 None
 
A2FC84_TRIV3
TubercuList»
0.0
TVAG_335570 Virulent strain associated lipoprotein, putative Trichomonas vaginalis
TI:5722 None
 
A2FUP7_TRIV3
TubercuList»
0.0
TVAG_311150 Cell cycle control protein, putative Trichomonas vaginalis
TI:5722 None
 
A0A1D6DCZ9_WHEAT
EnsemblPlants»
0.0
LOC123054360 CWF21 domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6B5A4_WHEAT
EnsemblPlants»
0.0
LOC123190237 CWF21 domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6CBX8_WHEAT
EnsemblPlants»
0.0
LOC123046503 CWF21 domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6I423_WHEAT
EnsemblPlants»
0.0
LOC123087842 CWF21 domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6LVM0_WHEAT
EnsemblPlants»
0.0
LOC123114076 CWF21 domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B6N1D7_WHEAT
EnsemblPlants»
0.0
LOC123123575 CWF21 domain-containing protein Triticum aestivum
TI:4565 None
   
F6H2X4_VITVI
euHCVdb»
0.0
VIT_04s0008g03130 CWF21 domain-containing protein Vitis vinifera
TI:29760 None
 
CWC21_YARLI
EnsemblFungi»
0.0
CWC21 Pre-mRNA-splicing factor CWC21 Yarrowia lipolytica
TI:4952 None
 
A0A1D6FL01_MAIZE
EnsemblPlants»
0.0
LOC103635373 Cwf21 Zea mays
TI:4577 None
 
A0A1D6QPY2_MAIZE
EnsemblPlants»
0.0
ZEAMMB73_Zm00001d053533 Cwf21 Zea mays
TI:4577 None
 
A0A1D6QPY4_MAIZE
EnsemblPlants»
0.0
LOC103655975 Cwf21 Zea mays
TI:4577 None
 
A0A804P2V8_MAIZE
EnsemblPlants»
0.0
CWF21 domain-containing protein Zea mays
TI:4577 None
   
A0A804P2V9_MAIZE
EnsemblPlants»
0.0
CWF21 domain-containing protein Zea mays
TI:4577 None
   
A0A804P2W4_MAIZE
EnsemblPlants»
0.0
LOC103654771 CWF21 domain-containing protein Zea mays
TI:4577 None
   
A0A804QU61_MAIZE
EnsemblPlants»
0.0
CWF21 domain-containing protein Zea mays
TI:4577 None
   
B6T6E6_MAIZE
EnsemblPlants»
0.0
LOC100276189 Cwf21 Zea mays
TI:4577 None
 
B6UF23_MAIZE
EnsemblPlants»
0.0
LOC100278881 Cwf21 Zea mays
TI:4577 None
 
K7U6L0_MAIZE
EnsemblPlants»
0.0
LOC103654772 Cwf21 Zea mays
TI:4577 None
 
K7V5J0_MAIZE
EnsemblPlants»
0.0
LOC103654761 Cwf21 Zea mays
TI:4577 None
 
K7V5J4_MAIZE
EnsemblPlants»
0.0
LOC103654766 Cwf21 Zea mays
TI:4577 None
 
A0A0K9PPU0_ZOSMR
euHCVdb»
0.0
ZOSMA_189G00490 CWF21 domain-containing protein Zostera marina
TI:29655 None