Cluster UKP04265
- HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED
Standard knownness: 6.3; Custom knownness: None; Num. species: 84; Orthology database: Panther19.0; Protein members: 186
Collated Gene Ontology terms
Molecular function:
mitochondrial respirasome assembly2012, 2013, 2024, 2025
negative regulation of apoptotic process2012, 2020
respiratory electron transport chain2025
regulation of proton transport2019, 2025
mitochondrial respiratory chain complex IV assembly2013, 2014, 2018
cellular response to hypoxia2012, 2015
cellular response to glucose starvation2012, 2015
response to quercetin2024
response to hypoxia2024
positive regulation of protein serine/threonine kinase activity2015
negative regulation of release of cytochrome c from mitochondria2013
copper ion homeostasis2014
Cellular component:
mitochondrial membrane2025
mitochondrion2009, 2013, 2014, 2018, 2024, 2025
mitochondrial inner membrane2012, 2014, 2016, 2022, 2024, 2025
nucleus2013, 2024, 2025
membrane2012, 2025
protein-containing complex2010, 2025
respiratory chain complex2018, 2025
plasma membrane2014
nucleoplasm2025
endoplasmic reticulum2012
cytoplasm2012
Phylogenetic distribution
| Chordates: | 22/21 |  |
| Echinoderms: | 0/0 | |
| Hemichordates: | 1/1 | |
| Annelids: | 1/1 | |
| Molluscs: | 0/0 | |
| Bryozoans: | 0/0 | |
| Platyhelminthes: | 0/0 | |
| Rotifers: | 0/0 | |
| Nematodes: | 3/3 | |
| Arthropods: | 5/5 | |
| Tardigrades: | 0/0 | |
| Placozoa: | 1/1 | |
| Cnidaria: | 1/1 | |
| Porifera: | 0/0 | |
| Choanoflagellates+: | 13/1 | |
| Dikarya: | 0/14 | |
| Fungi (other): | 0/1 | |
| Protozoa: | 2/3 | |
| Excavates: | 0/4 | |
| Harosa: | 1/4 | |
| Hacrobia: | 0/0 | |
| Plants: | 34/39 | |
| Archea: | 0/8 | |
| Bacteria: | 0/35 |
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Proteins
| UniProt ID Organism DB» |
Standard knownness | clustom knownness | Gene name | Description | Species [Show all] | GO terms | Seq. links | Protein domain links | |||||
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HIG1A_MOUSE Ensembl» |
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Higd1a | HIG1 domain family member 1A, mitochondrial (Hypoxia-inducible gene 1 protein) |
Mus musculus TI:10090 None |
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RCF1_YEAST SGD» |
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RCF1 | Respiratory supercomplex factor 1, mitochondrial (Altered inheritance of mitochondria protein 31) |
Saccharomyces cerevisiae TI:4932 None |
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HIG1A_RAT RGD» |
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Higd1a | HIG1 domain family member 1A, mitochondrial (Hypoxia-inducible gene 1 protein) |
Rattus norvegicus TI:10116 None |
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HIG2A_MOUSE Ensembl» |
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Higd2a | HIG1 domain family member 2A |
Mus musculus TI:10090 None |
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B2GV65_RAT RGD» |
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Higd2a | HIG1 hypoxia inducible domain family, member 2A |
Rattus norvegicus TI:10116 None |
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HIG1A_HUMAN Ensembl» |
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HIGD1A | HIG1 domain family member 1A, mitochondrial (Hypoxia-inducible gene 1 protein) (RCF1 homolog A) (RCF1a) |
Homo sapiens TI:9606 None |
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A0A0B4KEI1_DROME FlyBase» |
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Dmel\CG11825 | Uncharacterized protein, isoform C |
Drosophila melanogaster TI:7227 None |
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HIG1C_MOUSE Ensembl» |
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Higd1c | HIG1 domain family member 1C |
Mus musculus TI:10090 None |
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HIG2A_HUMAN Ensembl» |
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HIGD2A | HIG1 domain family member 2A, mitochondrial (RCF1 homolog B) (RCF1b) |
Homo sapiens TI:9606 None |
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A0A8I6AFI4_RAT RGD» |
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Higd1al1 | HIG1 hypoxia inducible domain family, member 1A like 1 |
Rattus norvegicus TI:10116 None |
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M0RBN7_RAT RGD» |
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Higd1c | HIG1 hypoxia inducible domain family, member 1C |
Rattus norvegicus TI:10116 None |
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Q9VXH4_DROME FlyBase» |
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Dmel\CG9921 | RE16337p (Uncharacterized protein, isoform B) (Uncharacterized protein, isoform C) |
Drosophila melanogaster TI:7227 None |
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YL87_SCHPO PomBase» |
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SPAC25B8.07c | HIG1 domain-containing protein C25B8.07c, mitochondrial |
Schizosaccharomyces pombe TI:4896 None |
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D3ZU87_RAT RGD» |
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Higd2al1 | HIG1 hypoxia inducible domain family, member 2A-like 1 |
Rattus norvegicus TI:10116 None |
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F1NUW0_CHICK Ensembl» |
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HIGD2A | HIG1 hypoxia inducible domain family member 2A |
Gallus gallus TI:9031 None |
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HIG1B_HUMAN Ensembl» |
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HIGD1B | HIG1 domain family member 1B (Protein CLST 11240) |
Homo sapiens TI:9606 None |
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HIG1B_MOUSE Ensembl» |
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Higd1b | HIG1 domain family member 1B |
Mus musculus TI:10090 None |
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HIG1C_HUMAN Ensembl» |
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HIGD1C | HIG1 domain family member 1C |
Homo sapiens TI:9606 None |
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HIG2B_HUMAN Ensembl» |
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HIGD2B | HIG1 domain family member 2B |
Homo sapiens TI:9606 None |
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O01257_CAEEL WormBase» |
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CELE_T20D3.6 T20D3.6 | HIG1 domain-containing protein |
Caenorhabditis elegans TI:6239 None |
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Q21524_CAEEL WormBase» |
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CELE_M05D6.5 M05D6.5 | HIG1 domain-containing protein |
Caenorhabditis elegans TI:6239 None |
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Q54XU9_DICDI dictyBase» |
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DDB_G0278571 | Hypoxia induced family protein |
Dictyostelium discoideum TI:44689 None |
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Q566Y4_DANRE ZFIN» |
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higd2a | HIG1 domain family member 2A, mitochondrial (HIG1 hypoxia-inducible domain family, member 2A) (Zgc:112385) |
Danio rerio TI:7955 None |
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Q7ZZZ4_DANRE ZFIN» |
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higd1a | HIG1 domain family member 1A, mitochondrial (HIG1 hypoxia-inducible domain family, member 1A) (Hypoxia induced gene 1) (Putative growth hormone like protein-1) (Yghl1) |
Danio rerio TI:7955 None |
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A0ABK0LKU4_RAT Ensembl» |
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Higd1b | HIG1 hypoxia inducible domain family, member 1B |
Rattus norvegicus TI:10116 None |
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Q5ZJI8_CHICK Ensembl» |
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HIGD1C | HIG1 hypoxia inducible domain family member 1C |
Gallus gallus TI:9031 None |
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