Collated Gene Ontology terms

Biological process: guanyl-nucleotide exchange factor activity(2025) guanyl-nucleotide exchange factor adaptor activity(2023)

Molecular function: regulation of autophagy2017, 2020, 2025 autophagy2025 late endosome to vacuole transport via multivesicular body sorting pathway2024

Cellular component: Mon1-Ccz1 complex2017, 2020, 2023, 2025 late endosome membrane2017, 2020, 2025 late endosome2024, 2025 lysosomal membrane2013, 2025

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 2/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 2/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
RMC1_HUMAN
Ensembl»
1.8
RMC1 Regulator of MON1-CCZ1 complex (Colon cancer-associated
protein Mic1) (Mic-1) (WD repeat-containing protein 98)		 Homo sapiens
TI:9606 None
 
B7QG37_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW013040 Uncharacterized protein Ixodes scapularis
TI:6945 None
 
A0A061EY06_THECC
euHCVdb»
0.0
TCM_024967 Cultured cell, putative isoform 1 Theobroma cacao
TI:3641 None
 
A0A1D6KVU4_MAIZE
EnsemblPlants»
0.0
LOC100193040 Colon cancer-associated protein
Mic1-like containing protein expressed		 Zea mays
TI:4577 None
 
A0A251SRD5_HELAN
neXtProt»
0.0
HannXRQ_Chr13g0398361 HanXRQr2_Chr13g0582201 Regulator of MON1-CCZ1 complex Helianthus annuus
TI:4232 None
 
A0A287A4H7_PIG
Ensembl»
0.0
RMC1 Regulator of MON1-CCZ1 (Uncharacterized
protein C18orf8 homolog isoform X1)		 Sus scrofa
TI:9823 None
 
G7KWB7_MEDTR
EnsemblPlants»
0.0
11437341 Colon cancer-associated Mic1-like protein
(Putative colon cancer-associated Mic1)		 Medicago truncatula
TI:3880 None
 
K4A6A9_SETIT
EnsemblPlants»
0.0
LOC101763505 Uncharacterized protein Setaria italica
TI:4555 None
 
Q338I5_ORYSJ
neXtProt»
0.0
LOC_Os10g26140 Os10g0400900 Colon cancer-associated protein Mic1-like
containing protein, expressed (Os10g0400900 protein)		 Oryza sativa
TI:4530 None
 
Q57Y64_TRYB2
TubercuList»
0.0
Tb07.15M23.310 Mic1 domain-containing protein Trypanosoma brucei
TI:5691 None
 
RMC1_DROME
FlyBase»
2.4
Bulli Regulator of MON1-CCZ1 complex (Protein Bulli) Drosophila melanogaster
TI:7227 None
 
RMC1_MOUSE
Ensembl»
2.0
Rmc1 Regulator of MON1-CCZ1 complex
(Colon cancer-associated protein Mic1) (Mic-1)		 Mus musculus
TI:10090 None
 
T1EWG2_HELRO
EnsemblMetazoa»
0.0
20200912 Mic1 domain-containing protein Helobdella robusta
TI:6412 None
 
A0A022RIH7_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a001809mg Uncharacterized protein Erythranthe guttata
TI:4155 None
 
A0A067DCS4_CITSI
euHCVdb»
0.0
CISIN_1g043355mg Regulator of MON1-CCZ1
complex N-terminal domain-containing protein		 Citrus sinensis
TI:2711 None
 
A0A067FU04_CITSI
neXtProt»
0.0
CISIN_1g007885mg Mic1 domain-containing protein Citrus sinensis
TI:2711 None
 
A0A0A0LEC9_CUCSA
neXtProt»
0.0
Csa_3G799630 Uncharacterized protein Cucumis sativus
TI:3659 None
 
A0A0K9NM82_ZOSMR
neXtProt»
0.0
ZOSMA_81G01200 Colon cancer-associated protein
Mic1-like containing protein,expressed		 Zostera marina
TI:29655 None
 
A0A139WKS6_TRICA
neXtProt»
0.0
AUGUSTUS-3.0.2_32487 Uncharacterized protein
C18orf8 homolog-like Protein		 Tribolium castaneum
TI:7070 None
 
A0A1S4GVI3_ANOGA
EnsemblMetazoa»
0.0
Mic1 domain-containing protein Anopheles gambiae
TI:7165 None
 
A0A1U8G1K0_CAPAN
neXtProt»
0.0
T459_09041 Uncharacterized protein Capsicum annuum
TI:4072 None
 
A0A1Y1I2S0_KLENI
euHCVdb»
0.0
KFL_002240160 Uncharacterized protein Klebsormidium nitens
TI:105231 None
 
A0A251N8H3_PRUPE
euHCVdb»
0.0
PRUPE_7G082700 Uncharacterized protein Prunus persica
TI:3760 None
 
A0A2C9V9U7_MANES
euHCVdb»
0.0
MANES_09G038300v8 Uncharacterized protein Manihot esculenta
TI:3983 None
 
A0A2K1KHF7_PHYPA
EnsemblPlants»
0.0
LOC112283539 Uncharacterized protein Physcomitrium patens
TI:3218 None
 
A0A2K1XBF3_POPTR
neXtProt»
0.0
POPTR_016G060500 Uncharacterized protein Populus trichocarpa
TI:3694 None
 
A0A2K3DH82_CHLRE
euHCVdb»
0.0
CHLRE_08g370250v5 Regulator of MON1-CCZ1
complex N-terminal domain-containing protein		 Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6XQZ0_MARPO
euHCVdb»
0.0
MARPO_0005s0167 Uncharacterized protein Marchantia polymorpha
TI:3197 None
 
A0A9R1VB51_LACSA
euHCVdb»
0.0
LSAT_V11C600312710 Mic1 domain-containing protein Lactuca sativa
TI:4236 None
 
A0CUZ1_PARTE
euHCVdb»
0.0
GSPATT00010776001 Uncharacterized protein Paramecium tetraurelia
TI:5888 None
 
A0D8F6_PARTE
euHCVdb»
0.0
GSPATT00014269001 Mic1 domain-containing protein Paramecium tetraurelia
TI:5888 None
 
A4IHS1_XENTR
Xenbase»
0.0
rmc1 LOC100124886 protein (Uncharacterized
protein C18orf8 homolog)		 Xenopus tropicalis
TI:8364 None
 
A7RLZ3_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g86197 Mic1 domain-containing protein Nematostella vectensis
TI:45351 None
 
A8WPJ0_CAEBR
WormBase»
0.0
CBG01087 CBG_01087 Protein CBG01087 Caenorhabditis briggsae
TI:6238 None
 
A9V7U8_MONBE
euHCVdb»
0.0
MONBRDRAFT_33838 Mic1 domain-containing protein Monosiga brevicollis
TI:81824 None
 
B1N2I0_ENTH1
TubercuList»
0.0
EHI_011860 Mic1 domain-containing protein Entamoeba histolytica
TI:5759 None
 
B3S193_TRIAD
CTD»
0.0
TRIADDRAFT_58243 Uncharacterized protein Trichoplax adhaerens
TI:10228 None
 
B8BYM6_THAPS
euHCVdb»
0.0
THAPSDRAFT_21901 Mic1 domain-containing protein Thalassiosira pseudonana
TI:35128 None
 
B9T869_RICCO
euHCVdb»
0.0
RCOM_0033380 Uncharacterized protein Ricinus communis
TI:3988 None
 
C4LYF0_ENTH1
TubercuList»
0.0
EHI_008170 Mic1 domain-containing protein Entamoeba histolytica
TI:5759 None
 
C4M1Q9_ENTH1
TubercuList»
0.0
EHI_062850 Mic1 domain-containing protein Entamoeba histolytica
TI:5759 None
 
C4M527_ENTH1
TubercuList»
0.0
EHI_128130 Mic1 domain-containing protein Entamoeba histolytica
TI:5759 None
 
C4M778_ENTH1
TubercuList»
0.0
EHI_199710 Mic1 domain-containing protein Entamoeba histolytica
TI:5759 None
 
C5WMB4_SORBI
euHCVdb»
0.0
SORBI_3001G255800 Uncharacterized protein Sorghum bicolor
TI:4558 None
 
D8RT72_SELML
euHCVdb»
0.0
SELMODRAFT_174040 Uncharacterized protein Selaginella moellendorffii
TI:88036 None
 
D8SQL7_SELML
neXtProt»
0.0
SELMODRAFT_181873 Uncharacterized protein Selaginella moellendorffii
TI:88036 None
 
E9FQM0_DAPPU
neXtProt»
0.0
DAPPUDRAFT_309723 Uncharacterized protein Daphnia pulex
TI:6669 None
 
F0ZEU2_DICPU
TubercuList»
0.0
DICPUDRAFT_76852 Uncharacterized protein Dictyostelium purpureum
TI:5786 None
 
F4J8L1_ARATH
TAIR»
1.0
At3g12010 C18orf8 Arabidopsis thaliana
TI:3702 None
 
F4NZQ6_BATDJ
euHCVdb»
0.0
BATDEDRAFT_87483 Uncharacterized protein Batrachochytrium dendrobatidis
TI:109871 None
 
F6HLH1_VITVI
euHCVdb»
0.0
VIT_08s0007g06830 Uncharacterized protein Vitis vinifera
TI:29760 None
 
G3QQX7_GORGO
Ensembl»
0.0
RMC1 Regulator of MON1-CCZ1 complex
(Colon cancer-associated protein Mic1)		 Gorilla gorilla
TI:9593 None
 
H2QEC4_PANTR
Ensembl»
0.0
RMC1 Regulator of MON1-CCZ1 complex
(Colon cancer-associated protein Mic1)		 Pan troglodytes
TI:9598 None
 
H3HE60_PHYRM
EnsemblProtists»
0.0
Regulator of MON1-CCZ1
complex N-terminal domain-containing protein		 Phytophthora ramorum
TI:164328 None
 
I1I3U0_BRADI
EnsemblPlants»
0.0
LOC100839726 Uncharacterized protein Brachypodium distachyon
TI:15368 None
 
I1N9B7_SOYBN
EnsemblPlants»
0.0
LOC100500389 Uncharacterized protein Glycine max
TI:3847 None
 
K7KF38_SOYBN
EnsemblPlants»
0.0
LOC100788425 Uncharacterized protein Glycine max
TI:3847 None
 
Q4QEE9_LEIMA
TubercuList»
0.0
LMJF_17_0450 Uncharacterized protein Leishmania major
TI:5664 None
 
Q5PPI8_RAT
RGD»
1.5
Rmc1 Regulator of MON1-CCZ1 complex
(Colon cancer-associated protein Mic1)		 Rattus norvegicus
TI:10116 None
 
Q8I5F3_PLAF7
TubercuList»
0.0
PF3D7_1226400 Mic1 domain-containing protein Plasmodium falciparum
TI:5833 None
 
Q95Y58_CAEEL
WormBase»
1.0
CELE_Y50D4A.4 Y50D4A.4 Mic1 domain-containing protein Caenorhabditis elegans
TI:6239 None
 
RMC1_DICDI
dictyBase»
1.0
DDB_G0286707 Regulator of MON1-CCZ1 complex
homolog (Mic1 domain-containing protein DDB_G0286707)		 Dictyostelium discoideum
TI:44689 None
 
U5G851_POPTR
euHCVdb»
0.0
POPTR_006G195000 Uncharacterized protein Populus trichocarpa
TI:3694 None
 
W1PTY0_AMBTC
neXtProt»
0.0
AMTR_s00024p00184500 Uncharacterized protein Amborella trichopoda
TI:13333 None
 
W5M0I6_LEPOC
Ensembl»
0.0
Regulator of MON1-CCZ1 Lepisosteus oculatus
TI:7918 None
 
A0A1L8H8A2_XENLA
CTD»
0.0
rmc1.S Regulator of MON1-CCZ1 complex isoform X1 Xenopus laevis
TI:8355 None
   
A0A1L8HG57_XENLA
Xenbase»
0.0
rmc1.L Uncharacterized protein LOC100137621 isoform X1 Xenopus laevis
TI:8355 None
   
A0A1S3X157_TOBAC
euHCVdb»
0.0
LOC107759930 Mic1 domain-containing protein Nicotiana tabacum
TI:4097 None
   
A0A1U8KYC6_GOSHI
euHCVdb»
0.0
LOC107922106 Mic1 domain-containing protein Gossypium hirsutum
TI:3635 None
   
A0A1U8MQX9_GOSHI
euHCVdb»
0.0
LOC107939153 Uncharacterized protein LOC107939153 isoform
X1 (Uncharacterized protein isoform X1)		 Gossypium hirsutum
TI:3635 None
   
A0A1U8Q5P3_NELNU
euHCVdb»
0.0
LOC104597599 Uncharacterized protein C18orf8 isoform X1 Nelumbo nucifera
TI:4432 None
   
A0A2A6CRI8_PRIPA
EnsemblMetazoa»
0.0
WBGene00102208 Uncharacterized protein Pristionchus pacificus
TI:54126 None
   
A0A2I4DRB9_JUGRE
euHCVdb»
0.0
LOC108982710 Uncharacterized protein LOC108982710 isoform X1 Juglans regia
TI:51240 None
   
A0A2I4GY88_JUGRE
euHCVdb»
0.0
LOC109011929 Uncharacterized protein LOC109011929 Juglans regia
TI:51240 None
   
A0A3B5Y4H4_WHEAT
EnsemblPlants»
0.0
LOC123062436 Mic1 domain-containing protein Triticum aestivum
TI:4565 None
   
A0A3B5Z2W8_WHEAT
EnsemblPlants»
0.0
LOC123139696 Uncharacterized protein Triticum aestivum
TI:4565 None
   
A0A3B5ZYH2_WHEAT
EnsemblPlants»
0.0
Uncharacterized protein Triticum aestivum
TI:4565 None
   
A0A3Q7FK38_SOLLC
EnsemblPlants»
0.0
LOC101263794 Uncharacterized protein Solanum lycopersicum
TI:4081 None
   
A0A6I8NFP2_ORNAN
Ensembl»
0.0
RMC1 Regulator of MON1-CCZ1 Ornithorhynchus anatinus
TI:9258 None
   
A0A7M7SXL6_STRPU
EnsemblMetazoa»
0.0
Mic1 domain-containing protein Strongylocentrotus purpuratus
TI:7668 None
   
A0A804HUF5_MUSAM
EnsemblPlants»
0.0
Mic1 domain-containing protein Musa acuminata
TI:4641 None
   
A0A8I3NLR6_CANLF
Ensembl»
0.0
RMC1 Regulator of MON1-CCZ1 Canis lupus
TI:9612 None
   
A0A8V0XNE9_CHICK
Ensembl»
1.0
C18orf8 Regulator of MON1-CCZ1 Gallus gallus
TI:9031 None
   
A0A9J7MGK8_BRAFL
euHCVdb»
0.0
LOC118409858 Regulator of MON1-CCZ1 complex-like Branchiostoma floridae
TI:7739 None
   
A0A9L0TI23_HORSE
Ensembl»
0.0
RMC1 Regulator of MON1-CCZ1 Equus caballus
TI:9796 None
   
A0A9R0JHT3_SPIOL
euHCVdb»
0.0
LOC110805462 Mic1 domain-containing protein Spinacia oleracea
TI:3562 None
   
A0AB13A9C8_DANRE
ZFIN»
0.0
rmc1 Regulator of MON1-CCZ1 complex Danio rerio
TI:7955 None
   
A0ABI7WHG7_FELCA
Ensembl»
0.0
RMC1 Regulator of MON1-CCZ1 Felis catus
TI:9685 None
   
E1BHW7_BOVIN
Ensembl»
0.0
RMC1 Regulator of MON1-CCZ1 Bos taurus
TI:9913 None
   
F6UQM6_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None
   
F7E5Z1_MACMU
Ensembl»
0.0
RMC1 Regulator of MON1-CCZ1 complex
(Colon cancer-associated protein Mic1)		 Macaca mulatta
TI:9544 None
   
F7G2S1_MONDO
Ensembl»
0.0
RMC1 Regulator of MON1-CCZ1 Monodelphis domestica
TI:13616 None
   
G1K8D6_ANOCA
Ensembl»
0.0
RMC1 Regulator of MON1-CCZ1 Anolis carolinensis
TI:28377 None
   
H2LDZ6_ORYLA
Ensembl»
0.0
RMC1 Regulator of MON1-CCZ1 Oryzias latipes
TI:8090 None
   
M0VTM7_HORVV
EnsemblPlants»
0.0
LOC123447376 Uncharacterized protein Hordeum vulgare
TI:4513 None
   
M4CB56_BRACM
EnsemblPlants»
0.0
Uncharacterized protein Brassica campestris
TI:3711 None