Collated Gene Ontology terms

Biological process: zinc ion binding(2025) transcription coactivator activity(2022) RNA binding(2013, 2014) transferase activity(2025) protein-lysine-acetyltransferase activity(2025) nucleic acid binding(2025) metal ion binding(2025) hydrolase activity(2025) acyltransferase activity(2025) AMP kinase activity(2025)

Molecular function: mRNA 3'-end processing2025 mRNA processing2023, 2025 chromosome segregation2025 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway2015, 2025 termination of RNA polymerase II transcription, poly(A)-coupled2025 positive regulation of transcription by RNA polymerase II2022 spermatogenesis2001 regulation of flower development2003 nucleoside monophosphate phosphorylation2025 flower development2025
embryo development ending in seed dormancy2005 cell differentiation2025 DNA damage tolerance2001

Cellular component: nucleus2001, 2004, 2009, 2015, 2017, 2018, 2025 mRNA cleavage and polyadenylation specificity factor complex2004, 2013, 2017, 2023, 2025 nucleoplasm2016, 2017, 2024, 2025 fibrillar center2024, 2025 chromatin2014, 2025 nuclear speck2014, 2025 ribosome2025 ribonucleoprotein complex2025 mediator complex2022 cytosol2009, 2025
nucleolus2015 cytoplasm2025 apicoplast2015 Cul4-RING E3 ubiquitin ligase complex2008

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 4/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
PFS2_SCHPO
PomBase»
1.4
pfs2 Polyadenylation factor subunit 2 Schizosaccharomyces pombe
TI:4896 None
 
WDR33_HUMAN
Ensembl»
2.5
WDR33 pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Homo sapiens
TI:9606 None
 
WDR33_MOUSE
Ensembl»
0.5
Wdr33 pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Mus musculus
TI:10090 None
 
PFS2_YEAST
SGD»
3.2
PFS2 Polyadenylation factor subunit 2 Saccharomyces cerevisiae
TI:4932 None
 
FY_ARATH
TAIR»
1.6
FY Flowering time control protein FY Arabidopsis thaliana
TI:3702 None
 
Q585M8_TRYB2
TubercuList»
0.0
Tb06.28P18.830 Uncharacterized protein Trypanosoma brucei
TI:5691 None
 
B6JZY6_SCHJY
TubercuList»
0.0
pfs2 Polyadenylation factor subunit 2 Schizosaccharomyces japonicus
TI:4897 None
 
O97242_PLAF7
TubercuList»
0.0
PF3D7_0305800 P-loop containing nucleoside
triphosphate hydrolase, putative		 Plasmodium falciparum
TI:5833 None
 
PFS2_ASPFU
EnsemblFungi»
0.0
pfs2 Polyadenylation factor subunit 2 Aspergillus fumigatus
TI:746128 None
 
PFS2_CANAL
EnsemblFungi»
0.0
PFS2 Polyadenylation factor subunit 2 Candida albicans
TI:5476 None
 
PFS2_EMENI
EnsemblFungi»
0.0
pfs2 Polyadenylation factor subunit 2 Emericella nidulans
TI:162425 None
 
PFS2_EREGS
EnsemblFungi»
0.0
PSF2 Polyadenylation factor subunit 2 Eremothecium gossypii
TI:33169 None
 
PFS2_YARLI
EnsemblFungi»
0.0
PFS2 Polyadenylation factor subunit 2 Yarrowia lipolytica
TI:4952 None
 
A0ABK0M1Z4_RAT
RGD»
0.5
Wdr33 WD repeat domain 33 Rattus norvegicus
TI:10116 None
   
A0A5F7ZAP7_MACMU
Ensembl»
0.0
WDR33 pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Macaca mulatta
TI:9544 None
   
A0A8I3PAI9_CANLF
Ensembl»
0.0
WDR33 pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Canis lupus
TI:9612 None
   
A0A8V0ZXY5_CHICK
Ensembl»
0.0
WDR33 pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Gallus gallus
TI:9031 None
   
B9RGB3_RICCO
euHCVdb»
0.0
RCOM_1452660 WD-repeat protein, putative (EC 2.3.1.48) Ricinus communis
TI:3988 None
 
E1BCT7_BOVIN
Ensembl»
0.0
WDR33 pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Bos taurus
TI:9913 None
   
F7AFC4_MONDO
Ensembl»
0.0
WDR33 pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Monodelphis domestica
TI:13616 None
   
F7G861_ORNAN
Ensembl»
0.0
WDR33 pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Ornithorhynchus anatinus
TI:9258 None
   
G3QQ06_GORGO
Ensembl»
0.0
WDR33 pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Gorilla gorilla
TI:9593 None
 
H2QIP3_PANTR
Ensembl»
0.0
WDR33 pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Pan troglodytes
TI:9598 None
 
H3GU25_PHYRM
EnsemblProtists»
0.0
CCHC-type domain-containing protein Phytophthora ramorum
TI:164328 None
 
I3L6Y7_PIG
Ensembl»
0.0
WDR33 pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Sus scrofa
TI:9823 None
 
Q4Q7R7_LEIMA
TubercuList»
0.0
LMJF_30_0410 WD-40 repeat protein Leishmania major
TI:5664 None
 
Q55GF7_DICDI
dictyBase»
1.0
DDB_G0268502 C2H2-type domain-containing protein Dictyostelium discoideum
TI:44689 None
 
WDR33_CAEEL
WormBase»
0.0
pfs-2 pre-mRNA 3' end processing protein
pfs-2 (Polyadenylation factor subunit homolog 2)		 Caenorhabditis elegans
TI:6239 None
 
A0A1L8G4F1_XENLA
Xenbase»
0.0
wdr33.S pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Xenopus laevis
TI:8355 None
   
A0A1L8GAN7_XENLA
Xenbase»
0.0
wdr33.L pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Xenopus laevis
TI:8355 None
   
A7F7I8_SCLS1
TubercuList»
0.0
SS1G_13568 Polyadenylation factor subunit 2 Sclerotinia sclerotiorum
TI:5180 None
 
PFS2_CRYD1
EnsemblFungi»
0.0
PFS2 Polyadenylation factor subunit 2 Cryptococcus deneoformans
TI:40410 None
 
PFS2_NEUCR
EnsemblFungi»
0.0
paa-1 Polyadenylation factor subunit 2 Neurospora crassa
TI:5141 None
 
Y9197_DICDI
dictyBase»
1.0
DDB_G0290989 Putative uncharacterized protein DDB_G0290989 Dictyostelium discoideum
TI:44689 None
 
A0A1S4BYA4_TOBAC
euHCVdb»
0.0
LOC107813173 Flowering time control protein FY Nicotiana tabacum
TI:4097 None
   
A0A2A6B709_PRIPA
EnsemblMetazoa»
0.0
WBGene00273963 Translation initiation factor eIF2A Pristionchus pacificus
TI:54126 None
   
A0A3Q2HDP2_HORSE
Ensembl»
0.0
WDR33 pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Equus caballus
TI:9796 None
   
A0A6I8PTU4_XENTR
Xenbase»
0.0
wdr33 pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Xenopus tropicalis
TI:8364 None
   
A0A9R0IRF4_SPIOL
euHCVdb»
0.0
LOC110793119 Flowering time control protein FY isoform X1 Spinacia oleracea
TI:3562 None
   
A8XCF1_CAEBR
WormBase»
0.0
pfs-2 Protein CBR-PFS-2 Caenorhabditis briggsae
TI:6238 None
 
E3JUN0_PUCGT
TubercuList»
0.0
PGTG_01086 Polyadenylation factor subunit 2 Puccinia graminis
TI:5297 None
 
E9GF06_DAPPU
neXtProt»
0.0
DAPPUDRAFT_195849 Uncharacterized protein Daphnia pulex
TI:6669 None
 
F4NVX5_BATDJ
euHCVdb»
0.0
BATDEDRAFT_9537 Polyadenylation factor subunit 2 (WD repeat-containing protein 33) (WD repeat-containing
protein of 146 kDa) (pre-mRNA 3' end processing protein WDR33)		 Batrachochytrium dendrobatidis
TI:109871 None
 
G1KDY3_ANOCA
Ensembl»
0.0
wdr33 pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Anolis carolinensis
TI:28377 None
   
H2LS99_ORYLA
Ensembl»
0.0
WDR33 pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Oryzias latipes
TI:8090 None
   
W5MRX1_LEPOC
Ensembl»
0.0
pre-mRNA 3' end processing protein WDR33 (WD repeat-containing
protein 33) (WD repeat-containing protein of 146 kDa)		 Lepisosteus oculatus
TI:7918 None
 
A0A022RD51_ERYGU
euHCVdb»
0.0
MIMGU_mgv1a002095mg Uncharacterized protein Erythranthe guttata
TI:4155 None
 
A0A061FYJ3_THECC
neXtProt»
0.0
TCM_045257 Transducin/WD40 repeat-like superfamily protein Theobroma cacao
TI:3641 None
 
A0A067ECX1_CITSI
euHCVdb»
0.0
CISIN_1g0050962mg Uncharacterized protein Citrus sinensis
TI:2711 None
 
A0A0A0KTQ4_CUCSA
neXtProt»
0.0
Csa_5G431540 Uncharacterized protein Cucumis sativus
TI:3659 None
 
A0A0K9NWS0_ZOSMR
euHCVdb»
0.0
ZOSMA_545G00070 Putative WD-repeat protein Zostera marina
TI:29655 None
 
A0A0R0GCH5_SOYBN
EnsemblPlants»
0.0
LOC100791889 Uncharacterized protein Glycine max
TI:3847 None
   
A0A0R0GQZ5_SOYBN
EnsemblPlants»
0.0
LOC100788493 Uncharacterized protein Glycine max
TI:3847 None
 
A0A0U9HIG6_KLENI
euHCVdb»
0.0
KFL_000610060 Polyadenylation factor I complex Klebsormidium nitens
TI:105231 None
 
A0A1U8B6D8_NELNU
euHCVdb»
0.0
LOC104611289 Flowering time control protein FY Nelumbo nucifera
TI:4432 None
   
A0A251QAG9_PRUPE
neXtProt»
0.0
PRUPE_2G034300 Uncharacterized protein Prunus persica
TI:3760 None
 
A0A251S403_HELAN
euHCVdb»
0.0
HannXRQ_Chr15g0463071 Putative WD40/YVTN
repeat-like-containing domain-containing protein		 Helianthus annuus
TI:4232 None
 
A0A251VM76_HELAN
euHCVdb»
0.0
FY Putative transducin/WD40 repeat-like superfamily
protein (Transcription factor WD40-like family)		 Helianthus annuus
TI:4232 None
 
A0A2C9W2Z2_MANES
euHCVdb»
0.0
MANES_04G160100v8 Uncharacterized protein Manihot esculenta
TI:3983 None
 
A0A2I4EF34_JUGRE
euHCVdb»
0.0
LOC108989020 Flowering time control
protein FY-like isoform X1		 Juglans regia
TI:51240 None
   
A0A2K2B9T0_POPTR
euHCVdb»
0.0
POPTR_003G197900 Uncharacterized protein Populus trichocarpa
TI:3694 None
 
A0A2K2BRD6_POPTR
neXtProt»
0.0
POPTR_001G026800 Uncharacterized protein Populus trichocarpa
TI:3694 None
 
A0A2K3DM00_CHLRE
euHCVdb»
0.0
CHLRE_06g251951v5 Uncharacterized protein Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6X920_MARPO
euHCVdb»
0.0
MARPO_0029s0111 Uncharacterized protein Marchantia polymorpha
TI:3197 None
 
A0A3B6KLF5_WHEAT
EnsemblPlants»
0.0
LOC123104354 IFT140 first
beta-propeller domain-containing protein		 Triticum aestivum
TI:4565 None
   
A0A3B6LNJ5_WHEAT
EnsemblPlants»
0.0
LOC123112633 IFT140 first
beta-propeller domain-containing protein		 Triticum aestivum
TI:4565 None
   
A0A3B6MTC0_WHEAT
EnsemblPlants»
0.0
LOC123122123 IFT140 first
beta-propeller domain-containing protein		 Triticum aestivum
TI:4565 None
   
A0A3Q7HNU6_SOLLC
EnsemblPlants»
0.0
LOC101263044 IFT140 first
beta-propeller domain-containing protein		 Solanum lycopersicum
TI:4081 None
   
A0A6P9DZT5_JUGRE
euHCVdb»
0.0
LOC109012326 Flowering time control protein FY-like Juglans regia
TI:51240 None
   
A0A7I4B3Z3_PHYPA
EnsemblPlants»
0.0
LOC112293796 Anaphase-promoting complex subunit
4 WD40 domain-containing protein		 Physcomitrium patens
TI:3218 None
 
A0A7M7NYD2_STRPU
EnsemblMetazoa»
0.0
Pre-mRNA 3' end processing protein WDR33 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7M7RCI6_STRPU
EnsemblMetazoa»
0.0
Pre-mRNA 3' end processing protein WDR33 Strongylocentrotus purpuratus
TI:7668 None
   
A0A7U2FEM0_PHANO
TubercuList»
0.0
JI435_137120 Polyadenylation factor subunit 2 Phaeosphaeria nodorum
TI:13684 None
 
A0A803TCU9_ANOCA
Ensembl»
0.0
WD repeat domain 33 Anolis carolinensis
TI:28377 None
   
A0A804IXM6_MUSAM
EnsemblPlants»
0.0
GSMUA_141840.1 (wild Malaysian banana) hypothetical protein Musa acuminata
TI:4641 None
 
A0A804N7I4_MAIZE
EnsemblPlants»
0.0
LOC100381986 Flowering time control protein FY Zea mays
TI:4577 None
   
A0A8I6XHI5_HORVV
EnsemblPlants»
0.0
LOC123399837 IFT140 first
beta-propeller domain-containing protein		 Hordeum vulgare
TI:4513 None
   
A0A9J7MBD4_BRAFL
euHCVdb»
0.0
LOC118430865 Pre-mRNA 3' end processing protein WDR33-like Branchiostoma floridae
TI:7739 None
   
A0A9K3E3K6_HELAN
neXtProt»
0.0
HanXRQr2_Chr15g0703491 Transcription factor WD40-like family Helianthus annuus
TI:4232 None
 
A0A9R1WK38_LACSA
euHCVdb»
0.0
LSAT_V11C100045120 Anaphase-promoting complex subunit
4 WD40 domain-containing protein		 Lactuca sativa
TI:4236 None
 
A0ABM2YWU3_GOSHI
euHCVdb»
0.0
LOC107939237 Flowering time control protein FY isoform X1 Gossypium hirsutum
TI:3635 None
   
A0ABM3AWP4_GOSHI
euHCVdb»
0.0
LOC107915529 Flowering time control protein FY isoform X1 Gossypium hirsutum
TI:3635 None
   
A0C8Q1_PARTE
euHCVdb»
0.0
GSPATT00036303001 Translation initiation factor
beta propellor-like domain-containing protein		 Paramecium tetraurelia
TI:5888 None
 
A0E1V8_PARTE
neXtProt»
0.0
GSPATT00022446001 Translation initiation factor
beta propellor-like domain-containing protein		 Paramecium tetraurelia
TI:5888 None
 
A2D7P9_TRIV3
TubercuList»
0.0
TVAG_121040 WD repeat protein, putative Trichomonas vaginalis
TI:5722 None
 
A4Q377_MEDTR
EnsemblPlants»
0.0
11443981 Flowering time control
FY-like protein (WD40-like)		 Medicago truncatula
TI:3880 None
 
A7S5J4_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g105436 Uncharacterized protein Nematostella vectensis
TI:45351 None
 
A8BHU7_GIAIC
TubercuList»
0.0
GL50803_0016900 Collagen alpha 1 chain Giardia intestinalis
TI:5741 None
 
A9V9K0_MONBE
neXtProt»
0.0
MONBRDRAFT_34049 Anaphase-promoting complex subunit
4 WD40 domain-containing protein		 Monosiga brevicollis
TI:81824 None
 
B3RZA6_TRIAD
CTD»
0.0
TRIADDRAFT_26233 Uncharacterized protein Trichoplax adhaerens
TI:10228 None
 
C4M1D0_ENTH1
TubercuList»
0.0
EHI_170080 WD domain containing protein Entamoeba histolytica
TI:5759 None
 
C5XHW5_SORBI
euHCVdb»
0.0
SORBI_3003G427100 Uncharacterized protein Sorghum bicolor
TI:4558 None
 
C7G084_DICDI
dictyBase»
0.0
DDB_G0295793 WD40 repeat-containing protein Dictyostelium discoideum
TI:44689 None
 
D6WNM4_TRICA
euHCVdb»
0.0
AUGUSTUS-3.0.2_13939 Pre-mRNA 3' end
processing protein WDR33-like Protein		 Tribolium castaneum
TI:7070 None
 
D8R1B2_SELML
neXtProt»
0.0
FY-1 Uncharacterized protein FY-1 Selaginella moellendorffii
TI:88036 None
 
D8S1I6_SELML
euHCVdb»
0.0
FY-2 Uncharacterized protein FY-2 Selaginella moellendorffii
TI:88036 None
 
F0ZBF1_DICPU
TubercuList»
0.0
DICPUDRAFT_148551 Uncharacterized protein Dictyostelium purpureum
TI:5786 None
 
F6I5T1_VITVI
euHCVdb»
0.0
VIT_13s0019g00220 Uncharacterized protein Vitis vinifera
TI:29760 None
 
F7A7C3_CIOIN
Ensembl»
0.0
Uncharacterized protein Ciona intestinalis
TI:7719 None
 
I1HV81_BRADI
EnsemblPlants»
0.0
LOC100834292 IFT140 first
beta-propeller domain-containing protein		 Brachypodium distachyon
TI:15368 None
 
K3YQF3_SETIT
EnsemblPlants»
0.0
LOC101780563 Uncharacterized protein Setaria italica
TI:4555 None
 
M4CPR3_BRACM
EnsemblPlants»
0.0
Uncharacterized protein Brassica campestris
TI:3711 None
   
M4E3R3_BRACM
EnsemblPlants»
0.0
Uncharacterized protein Brassica campestris
TI:3711 None
   
Q7PXE0_ANOGA
EnsemblMetazoa»
0.0
1281820 AGAP001362-PA Anopheles gambiae
TI:7165 None
 
Q8I518_PLAF7
TubercuList»
0.0
PF3D7_1241100 Polyadenylation factor subunit 2, putative Plasmodium falciparum
TI:5833 None
 
Q9VNG2_DROME
FlyBase»
0.0
Wdr33 LD24014p (WD repeat domain 33, isoform
A) (WD repeat domain 33, isoform B)		 Drosophila melanogaster
TI:7227 None
 
T1EGA4_HELRO
EnsemblMetazoa»
0.0
20195606 Uncharacterized protein Helobdella robusta
TI:6412 None
 
U5D1B5_AMBTC
euHCVdb»
0.0
AMTR_s00063p00034480 Uncharacterized protein Amborella trichopoda
TI:13333 None
 
A0A078F4I4_BRANA
euHCVdb»
0.0
BnaC03g35740D BnaC03g35740D protein Brassica napus
TI:3708 None
 
A0A0N7KEF1_ORYSJ
euHCVdb»
0.0
Os01g0951000 Os01g0951000 protein Oryza sativa
TI:4530 None
 
A0A2G2Y5S8_CAPAN
neXtProt»
0.0
T459_29509 Uncharacterized protein Capsicum annuum
TI:4072 None
 
A0ABI7YMF2_FELCA
Ensembl»
0.0
WDR33 WD repeat domain 33 Felis catus
TI:9685 None
   
A7S5J3_NEMVE
euHCVdb»
0.0
NEMVEDRAFT_v1g207136 Uncharacterized protein Nematostella vectensis
TI:45351 None
 
B7PE45_IXOSC
EnsemblMetazoa»
0.0
IscW_ISCW005214 WD-repeat protein, putative Ixodes scapularis
TI:6945 None
 
B8CEM0_THAPS
neXtProt»
0.0
THAPSDRAFT_38469 Uncharacterized protein Thalassiosira pseudonana
TI:35128 None
 
D8SI46_SELML
neXtProt»
0.0
SELMODRAFT_422350 Uncharacterized protein Selaginella moellendorffii
TI:88036 None
 
W1NHA1_AMBTC
euHCVdb»
0.0
AMTR_s00011p00028190 Uncharacterized protein Amborella trichopoda
TI:13333 None