Standard knownness: 3.5; Custom knownness: None; Num. species: 126; Orthology database: Panther19.0; Protein members: 261
                   Molecular function:
                   
                     glycine decarboxylation via glycine cleavage system2006, 2018, 2019, 2020, 2024
                   
                     protein lipoylation2011, 2017, 2024
                   
                     glycine catabolic process2003, 2013, 2014, 2018, 2021, 2024
                   
                     one-carbon metabolic process2013, 2018, 2024
                   
                     small molecule metabolic process2024
                   
                     response to organic cyclic compound2019, 2024
                   
                     carboxylic acid metabolic process2024
                   
                     translation2021
                   
                     post-transcriptional regulation of gene expression2016
                   
                     negative regulation of transcription by RNA polymerase III2024
                   
                   
                      
                      
                      
                        
                          lipoate biosynthetic process2011
                        
                      
                    
                   
                   Cellular component:
                   
                     mitochondrion2003, 2009, 2011, 2013, 2014, 2017, 2018, 2019, 2021, 2023, 2024
                   
                     glycine cleavage complex2003, 2006, 2018, 2020, 2024
                   
                     cytoplasm2009, 2023, 2024
                   
                     cytosol2014, 2019, 2020
                   
                     mitochondrial matrix2018, 2024
                   
                     oxidoreductase complex2024
                   
                     membrane2024
                   
                     catalytic complex2024
                   
                     nucleus2019, 2021
                   
                     kinetoplast2017
                   
                   
                      
                      
                      
                        
                          thylakoid2021
                        
                          endoplasmic reticulum2019
                        
                      
                    
                    
| Chordates: | 21/21 | ![]()  | 
                   
                 
| Echinoderms: | 0/0 | |
| Hemichordates: | 1/1 | |
| Annelids: | 1/1 | |
| Molluscs: | 0/0 | |
| Bryozoans: | 0/0 | |
| Platyhelminthes: | 0/0 | |
| Rotifers: | 0/0 | |
| Nematodes: | 2/3 | |
| Arthropods: | 5/5 | |
| Tardigrades: | 0/0 | |
| Placozoa: | 1/1 | |
| Cnidaria: | 1/1 | |
| Porifera: | 0/0 | |
| Choanoflagellates+: | 14/1 | |
| Dikarya: | 0/14 | |
| Fungi (other): | 0/1 | |
| Protozoa: | 2/3 | |
| Excavates: | 3/4 | |
| Harosa: | 4/4 | |
| Hacrobia: | 0/0 | |
| Plants: | 37/39 | |
| Archea: | 4/8 | |
| Bacteria: | 30/35 | 
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| UniProt ID Organism DB»  | 
	    
        
          
            Standard knownness | clustom knownness | Gene name | Description | Species [Show all] | GO terms | Seq. links | Protein domain links | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 
        A0A0G2JYW6_RAT RGD»  | 
        
          
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        AABR07067762.1 | Glycine cleavage system H protein | 
        Rattus norvegicus TI:10116 None  | 
        
          
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        A0A1W2PPE4_HUMAN Ensembl»  | 
        
          
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        Glycine cleavage system H protein | 
        Homo sapiens TI:9606 None  | 
        
          
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| 
        A0A8I6GH26_RAT RGD»  | 
        
          
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        ENSRNOG00000069283 | Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein)  | 
        
        Rattus norvegicus TI:10116 None  | 
        
          
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| 
        A0A8V0XYX6_CHICK Ensembl»  | 
        
          
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        GCSH | Glycine cleavage system H protein | 
        Gallus gallus TI:9031 None  | 
        
          
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| 
        GCSH1_ARATH TAIR»  | 
        
          
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        GDH1 | Glycine cleavage system H protein 1, mitochondrial  | 
        
        Arabidopsis thaliana TI:3702 None  | 
        
          
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        GCSH1_DICDI dictyBase»  | 
        
          
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        gcvH1 | Probable glycine cleavage system H protein 1, mitochondrial  | 
        
        Dictyostelium discoideum TI:44689 None  | 
        
          
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| 
        GCSH2_ARATH TAIR»  | 
        
          
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        GDH2 | Glycine cleavage system H protein 2, mitochondrial  | 
        
        Arabidopsis thaliana TI:3702 None  | 
        
          
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        GCSH2_DICDI dictyBase»  | 
        
          
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        gcvH2 | Glycine cleavage system H-like protein gcvH2 | 
        Dictyostelium discoideum TI:44689 None  | 
        
          
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| 
        GCSH3_ARATH TAIR»  | 
        
          
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        GDH3 | Glycine cleavage system H protein 3, mitochondrial  | 
        
        Arabidopsis thaliana TI:3702 None  | 
        
          
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| 
        GCSH3_DICDI dictyBase»  | 
        
          
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        gcvH3 | Putative glycine cleavage system H protein 3 | 
        Dictyostelium discoideum TI:44689 None  | 
        
          
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| 
        GCSH4_DICDI dictyBase»  | 
        
          
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        gcvH4 | Glycine cleavage system H-like protein gcvH4 | 
        Dictyostelium discoideum TI:44689 None  | 
        
          
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        GCSH5_DICDI dictyBase»  | 
        
          
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        gcvH5 | Glycine cleavage system H-like protein gcvH5, mitochondrial  | 
        
        Dictyostelium discoideum TI:44689 None  | 
        
          
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| 
        GCSH_CHICK Ensembl»  | 
        
          
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        GCSH | Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein)  | 
        
        Gallus gallus TI:9031 None  | 
        
          
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        GCSH_DROME FlyBase»  | 
        
          
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        ppl | Glycine cleavage system H protein, mitochondrial (Protein pumpless)  | 
        
        Drosophila melanogaster TI:7227 None  | 
        
          
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| 
        GCSH_ECOLI EnsemblBacteria»  | 
        
          
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        gcvH | Glycine cleavage system H protein | 
        Escherichia coli TI:562 None  | 
        
          
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        GCSH_HUMAN Ensembl»  | 
        
          
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        GCSH | Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein)  | 
        
        Homo sapiens TI:9606 None  | 
        
          
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        GCSH_MOUSE Ensembl»  | 
        
          
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        Gcsh | Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein)  | 
        
        Mus musculus TI:10090 None  | 
        
          
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| 
        GCSH_RAT RGD»  | 
        
          
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        Gcsh | Glycine cleavage system H protein, mitochondrial (Lipoic acid-containing protein)  | 
        
        Rattus norvegicus TI:10116 None  | 
        
          
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        GCSH_SCHPO PomBase»  | 
        
          
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        gcv3 | Putative glycine cleavage system H protein, mitochondrial (Glycine decarboxylase complex subunit H)  | 
        
        Schizosaccharomyces pombe TI:4896 None  | 
        
          
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| 
        GCSH_YEAST SGD»  | 
        
          
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        GCV3 | Glycine cleavage system H protein, mitochondrial (Glycine decarboxylase complex subunit H)  | 
        
        Saccharomyces cerevisiae TI:4932 None  | 
        
          
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        O62122_CAEEL WormBase»  | 
        
          
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        gcsh-1 | Glycine cleavage system H protein | 
        Caenorhabditis elegans TI:6239 None  | 
        
          
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        Q20634_CAEEL WormBase»  | 
        
          
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        gcsh-2 | Glycine cleavage system H protein | 
        Caenorhabditis elegans TI:6239 None  | 
        
          
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| 
        Q5BJB5_DANRE ZFIN»  | 
        
          
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        zgc:112535 | Glycine cleavage system H protein | 
        Danio rerio TI:7955 None  | 
        
          
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        Q6DGX4_DANRE ZFIN»  | 
        
          
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        zgc:92732 | Glycine cleavage system H protein | 
        Danio rerio TI:7955 None  | 
        
          
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