Collated Gene Ontology terms

Biological process: lipoic acid binding(2020, 2025) transferase activity(2025) molecular carrier activity(2025) enzyme binding(2007, 2025) aminomethyltransferase activity(2006, 2025) ATP binding(2021)

Molecular function: glycine decarboxylation via glycine cleavage system2006, 2019, 2024, 2025 protein lipoylation2011, 2013, 2017, 2025 glycine catabolic process2013, 2014, 2021, 2025 one-carbon metabolic process2013, 2025 small molecule metabolic process2025 carboxylic acid metabolic process2025 post-transcriptional regulation of gene expression2016 lipoate biosynthetic process2011

Cellular component: glycine cleavage complex2003, 2006, 2020, 2024, 2025 mitochondrion2003, 2009, 2011, 2013, 2014, 2017, 2018, 2019, 2021, 2024, 2025 cytosol2014, 2019, 2020 cytoplasm2009, 2025 mitochondrial matrix2018, 2024, 2025 kinetoplast2017, 2025 nucleus2019, 2021 thylakoid2021 endoplasmic reticulum2019

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 3/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 4/8 
Bacteria: 30/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
A0A1W2PPE4_HUMAN
Ensembl»
0.0
Glycine cleavage system H protein Homo sapiens
TI:9606 None
 
A0A0G2JYW6_RAT
RGD»
0.5
AABR07067762.1 Glycine cleavage system H protein Rattus norvegicus
TI:10116 None
   
A0A8I6GH26_RAT
RGD»
0.5
ENSRNOG00000069283 Glycine cleavage system H
protein, mitochondrial (Lipoic acid-containing protein)		 Rattus norvegicus
TI:10116 None
   
A0A8V0XYX6_CHICK
Ensembl»
0.5
GCSH Glycine cleavage system H protein Gallus gallus
TI:9031 None
   
GCSH_CHICK
CTD»
2.1
GCSH Glycine cleavage system H
protein, mitochondrial (Lipoic acid-containing protein)		 Gallus gallus
TI:9031 None
 
GCSH_HUMAN
Ensembl»
1.4
GCSH Glycine cleavage system H
protein, mitochondrial (Lipoic acid-containing protein)		 Homo sapiens
TI:9606 None
 
GCSH_YEAST
SGD»
4.3
GCV3 Glycine cleavage system H protein,
mitochondrial (Glycine decarboxylase complex subunit H)		 Saccharomyces cerevisiae
TI:4932 None
 
GCSH1_ARATH
TAIR»
0.5
GDH1 Glycine cleavage system
H protein 1, mitochondrial		 Arabidopsis thaliana
TI:3702 None
 
GCSH2_ARATH
TAIR»
1.0
GDH2 Glycine cleavage system
H protein 2, mitochondrial		 Arabidopsis thaliana
TI:3702 None
 
GCSH3_ARATH
TAIR»
0.5
GDH3 Glycine cleavage system
H protein 3, mitochondrial		 Arabidopsis thaliana
TI:3702 None
 
GCSH_MOUSE
Ensembl»
1.5
Gcsh Glycine cleavage system H
protein, mitochondrial (Lipoic acid-containing protein)		 Mus musculus
TI:10090 None
 
GCSH_RAT
RGD»
2.9
Gcsh Glycine cleavage system H
protein, mitochondrial (Lipoic acid-containing protein)		 Rattus norvegicus
TI:10116 None
 
O62122_CAEEL
WormBase»
0.5
gcsh-1 Glycine cleavage system H protein Caenorhabditis elegans
TI:6239 None
 
Q20634_CAEEL
WormBase»
0.5
gcsh-2 Glycine cleavage system H protein Caenorhabditis elegans
TI:6239 None
 
Q5BJB5_DANRE
ZFIN»
0.5
gcsha Glycine cleavage system H protein Danio rerio
TI:7955 None
 
Q6DGX4_DANRE
ZFIN»
0.5
gcshb Glycine cleavage system H protein Danio rerio
TI:7955 None
 
GCSH_SCHPO
PomBase»
0.5
gcv3 Putative glycine cleavage system H protein,
mitochondrial (Glycine decarboxylase complex subunit H)		 Schizosaccharomyces pombe
TI:4896 None
 
GCSH_ECOLI
EnsemblBacteria»
1.2
gcvH Glycine cleavage system H protein Escherichia coli
TI:562 None
 
GCSH1_DICDI
dictyBase»
1.3
gcvH1 Probable glycine cleavage system
H protein 1, mitochondrial		 Dictyostelium discoideum
TI:44689 None
 
GCSH2_DICDI
dictyBase»
0.5
gcvH2 Glycine cleavage system H-like protein gcvH2 Dictyostelium discoideum
TI:44689 None
 
GCSH3_DICDI
dictyBase»
0.5
gcvH3 Putative glycine cleavage system H protein 3 Dictyostelium discoideum
TI:44689 None
 
GCSH4_DICDI
dictyBase»
0.5
gcvH4 Glycine cleavage system H-like protein gcvH4 Dictyostelium discoideum
TI:44689 None
 
GCSH5_DICDI
dictyBase»
0.5
gcvH5 Glycine cleavage system
H-like protein gcvH5, mitochondrial		 Dictyostelium discoideum
TI:44689 None
 
GCSH_DROME
FlyBase»
2.0
ppl Glycine cleavage system H
protein, mitochondrial (Protein pumpless)		 Drosophila melanogaster
TI:7227 None