Collated Gene Ontology terms

Biological process: aminomethyltransferase activity(2003, 2004, 2006) transferase activity(2023) enzyme binding(2007) transaminase activity(2004) glycine dehydrogenase (decarboxylating) activity(2004) ATP binding(2021)

Molecular function: glycine decarboxylation via glycine cleavage system2004, 2006, 2018, 2019, 2020, 2023 glycine catabolic process2003, 2008, 2014, 2018, 2021, 2023 one-carbon metabolic process2008, 2018, 2023 protein lipoylation2009, 2011, 2017 carboxylic acid metabolic process2023 small molecule metabolic process2023 response to organic cyclic compound2019, 2023 translation2021 post-transcriptional regulation of gene expression2016 negative regulation of transcription by RNA polymerase III2023
lipoate biosynthetic process2011

Cellular component: mitochondrion2003, 2009, 2011, 2014, 2015, 2017, 2018, 2019, 2021, 2023 glycine cleavage complex2003, 2006, 2018, 2023 cytoplasm2009, 2023 cytosol2014, 2019, 2020 oxidoreductase complex2023 mitochondrial matrix2015, 2018, 2023 membrane2023 nucleus2019, 2021 kinetoplast2017 thylakoid2021
endoplasmic reticulum2019

Phylogenetic distribution

Chordates: 20/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 16/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 37/39 
Archea: 4/8 
Bacteria: 30/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 0 2 4 6 8 10 Knownness

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
A0A0G2JYW6_RAT
RGD»
0.5
AABR07067762.1 Glycine cleavage system H protein Rattus norvegicus
TI:10116 None
   
A0A0G2JZ02_RAT
RGD»
0.5
RGD1563099 Glycine cleavage system H protein Rattus norvegicus
TI:10116 None
   
A0A1W2PPE4_HUMAN
Ensembl»
0.0
Glycine cleavage system H protein Homo sapiens
TI:9606 None
 
A0A8I6GH26_RAT
RGD»
0.0
ENSRNOG00000069283 Glycine cleavage system H
protein, mitochondrial (Lipoic acid-containing protein)		 Rattus norvegicus
TI:10116 None
   
A0A8V0XYX6_CHICK
Ensembl»
0.0
GCSH Glycine cleavage system H protein Gallus gallus
TI:9031 None
   
GCSH1_ARATH
TAIR»
0.0
GDH1 Glycine cleavage system
H protein 1, mitochondrial		 Arabidopsis thaliana
TI:3702 None
 
GCSH1_DICDI
dictyBase»
2.1
gcvH1 Probable glycine cleavage system
H protein 1, mitochondrial		 Dictyostelium discoideum
TI:44689 None
 
GCSH2_ARATH
TAIR»
0.5
GDH2 Glycine cleavage system
H protein 2, mitochondrial		 Arabidopsis thaliana
TI:3702 None
 
GCSH2_DICDI
dictyBase»
0.5
gcvH2 Glycine cleavage system H-like protein gcvH2 Dictyostelium discoideum
TI:44689 None
 
GCSH3_ARATH
TAIR»
0.0
GDH3 Glycine cleavage system
H protein 3, mitochondrial		 Arabidopsis thaliana
TI:3702 None
 
GCSH3_DICDI
dictyBase»
0.5
gcvH3 Putative glycine cleavage system H protein 3 Dictyostelium discoideum
TI:44689 None
 
GCSH4_DICDI
dictyBase»
0.5
gcvH4 Glycine cleavage system H-like protein gcvH4 Dictyostelium discoideum
TI:44689 None
 
GCSH5_DICDI
dictyBase»
0.5
gcvH5 Glycine cleavage system
H-like protein gcvH5, mitochondrial		 Dictyostelium discoideum
TI:44689 None
 
GCSH_CHICK
Ensembl»
1.3
GCSH Glycine cleavage system H
protein, mitochondrial (Lipoic acid-containing protein)		 Gallus gallus
TI:9031 None
 
GCSH_DROME
FlyBase»
1.0
ppl Glycine cleavage system H
protein, mitochondrial (Protein pumpless)		 Drosophila melanogaster
TI:7227 None
 
GCSH_ECOLI
EnsemblBacteria»
1.7
gcvH Glycine cleavage system H protein Escherichia coli
TI:562 None
 
GCSH_HUMAN
Ensembl»
3.1
GCSH Glycine cleavage system H
protein, mitochondrial (Lipoic acid-containing protein)		 Homo sapiens
TI:9606 None
 
GCSH_MOUSE
Ensembl»
2.0
Gcsh Glycine cleavage system H
protein, mitochondrial (Lipoic acid-containing protein)		 Mus musculus
TI:10090 None
 
GCSH_RAT
RGD»
3.4
Gcsh Glycine cleavage system H
protein, mitochondrial (Lipoic acid-containing protein)		 Rattus norvegicus
TI:10116 None
 
GCSH_SCHPO
PomBase»
2.5
gcv3 Putative glycine cleavage system H protein,
mitochondrial (Glycine decarboxylase complex subunit H)		 Schizosaccharomyces pombe
TI:4896 None
 
GCSH_YEAST
SGD»
3.5
GCV3 Glycine cleavage system H protein,
mitochondrial (Glycine decarboxylase complex subunit H)		 Saccharomyces cerevisiae
TI:4932 None
 
O62122_CAEEL
WormBase»
0.5
gcsh-1 Glycine cleavage system H protein Caenorhabditis elegans
TI:6239 None
 
Q20634_CAEEL
WormBase»
0.5
gcsh-2 Glycine cleavage system H protein Caenorhabditis elegans
TI:6239 None
 
Q5BJB5_DANRE
ZFIN»
0.5
zgc:112535 Glycine cleavage system H protein Danio rerio
TI:7955 None
 
Q6DGX4_DANRE
ZFIN»
0.5
zgc:92732 Glycine cleavage system H protein Danio rerio
TI:7955 None