Collated Gene Ontology terms

Biological process: peptidyl-prolyl cis-trans isomerase activity(2025) isomerase activity(2025) DNA binding(2025) double-stranded DNA binding(2009, 2025) bent DNA binding(2009, 2025) RNA binding(2014)

Molecular function: rRNA processing2009, 2025

Cellular component: nucleus2009, 2019, 2024, 2025 spindle2009, 2025 nucleolus2024, 2025 cytoplasm2009, 2017, 2025 nucleoplasm2024, 2025 mitochondrial matrix2009, 2025 preribosome2009, 2025 nuclear lumen2017, 2025 plasma membrane2012 mitochondrion2025
ciliary plasm2017 chromosome2025

Phylogenetic distribution

Chordates: 21/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 2/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 8/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 1/4 
Harosa: 0/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

Click here to switch to the previous version of the database.

Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
PIN4_HUMAN
Ensembl»
2.9
PIN4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14) (Par14) (hPar14) (Parvulin-17) (Par17) (hPar17)
(Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Peptidyl-prolyl cis/trans isomerase EPVH) (hEPVH) (Rotamase Pin4)		 Homo sapiens
TI:9606 None
 
B6T401_MAIZE
EnsemblPlants»
0.0
LOC100286056 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Zea mays
TI:4577 None
 
PIN4_MOUSE
Ensembl»
1.5
Pin4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14)
(Par14) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Rotamase Pin4)		 Mus musculus
TI:10090 None
 
A0A397XYK1_BRACM
EnsemblPlants»
0.0
BRAA09T39492Z BRAPAZ1V2_A09P51670.2 BRARA_I03121 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Brassica campestris
TI:3711 None
 
B7FMQ2_MEDTR
EnsemblPlants»
0.0
MTR_3g037570 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Medicago truncatula
TI:3880 None
 
Q9FE18_ARATH
TAIR»
0.0
At1g26550 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Arabidopsis thaliana
TI:3702 None
 
A0A2K1ZEA5_POPTR
neXtProt»
0.0
POPTR_008G089900 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Populus trichocarpa
TI:3694 None
 
A0A397YHZ4_BRACM
EnsemblPlants»
0.0
BRAA08T34678Z BRAPAZ1V2_A08P30030.2 BRARA_H02141 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Brassica campestris
TI:3711 None
 
C6TKN5_SOYBN
EnsemblPlants»
0.0
LOC100800792 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Glycine max
TI:3847 None
 
G3SDH6_GORGO
Ensembl»
0.0
PIN4 peptidylprolyl isomerase (EC 5.2.1.8) Gorilla gorilla
TI:9593 None
 
Q6ESK5_ORYSJ
neXtProt»
0.0
Os09g0411700 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Oryza sativa
TI:4530 None
 
A0A061G4E9_THECC
neXtProt»
0.0
TCM_014093 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Theobroma cacao
TI:3641 None
 
B7PP75_IXOSC
EnsemblMetazoa»
0.0
8051913 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Ixodes scapularis
TI:6945 None
 
E9FRU0_DAPPU
neXtProt»
0.0
EOG090X0LQS Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Daphnia pulex
TI:6669 None
 
K3ZXU5_SETIT
EnsemblPlants»
0.0
LOC101771555 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Setaria italica
TI:4555 None
 
PIN4_EMENI
EnsemblFungi»
0.0
pin4 Peptidyl-prolyl cis-trans isomerase pin4 (PPIase
pin4) (EC 5.2.1.8) (Parvulin-14) (Par14)		 Emericella nidulans
TI:162425 None
 
PIN4_NEUCR
EnsemblFungi»
0.0
ppi-5 Peptidyl-prolyl cis-trans isomerase pin4 (PPIase
pin4) (EC 5.2.1.8) (Parvulin-14) (Par14)		 Neurospora crassa
TI:5141 None
 
Q57ZK2_TRYB2
TubercuList»
0.0
Tb03.27C5.680 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Trypanosoma brucei
TI:5691 None
 
Q9VBU4_DROME
FlyBase»
0.0
Dmel\CG11858 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Drosophila melanogaster
TI:7227 None
 
T1EUP4_HELRO
EnsemblMetazoa»
0.0
20200294 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Helobdella robusta
TI:6412 None
 
W5NB50_LEPOC
Ensembl»
0.0
Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Lepisosteus oculatus
TI:7918 None
 
A0A022RA69_ERYGU
neXtProt»
0.0
MIMGU_mgv1a014773mg Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Erythranthe guttata
TI:4155 None
 
A0A067EK96_CITSI
neXtProt»
0.0
CISIN_1g043515mg Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Citrus sinensis
TI:2711 None
 
A0A078FTA7_BRANA
neXtProt»
0.0
BnaA09g28980D Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Brassica napus
TI:3708 None
 
A0A078GHN2_BRANA
neXtProt»
0.0
BnaC03g57440D Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Brassica napus
TI:3708 None
 
A0A078J9B4_BRANA
neXtProt»
0.0
BnaA08g19760D Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Brassica napus
TI:3708 None
 
A0A0A0KNJ8_CUCSA
neXtProt»
0.0
Csa_5G472100 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Cucumis sativus
TI:3659 None
 
A0A0K9PS47_ZOSMR
neXtProt»
0.0
ZOSMA_189G00210 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Zostera marina
TI:29655 None
 
A0A0R0JP45_SOYBN
EnsemblPlants»
0.0
GLYMA_06G195800 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Glycine max
TI:3847 None
 
A0A0U9HK92_KLENI
neXtProt»
0.0
KFL_000540040 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Klebsormidium nitens
TI:105231 None
 
A0A1U8EWD8_CAPAN
neXtProt»
0.0
T459_30484 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Capsicum annuum
TI:4072 None
 
A0A251UYJ9_HELAN
neXtProt»
0.0
HannXRQ_Chr04g0107301 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Helianthus annuus
TI:4232 None
 
A0A2C9UJT8_MANES
neXtProt»
0.0
MANES_14G080801v8 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Manihot esculenta
TI:3983 None
 
A0A2I2Z5W4_GORGO
Ensembl»
0.0
peptidylprolyl isomerase (EC 5.2.1.8) Gorilla gorilla
TI:9593 None
 
A0A2I3RE39_PANTR
Ensembl»
0.0
Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Pan troglodytes
TI:9598 None
 
A0A2I3THX7_PANTR
Ensembl»
0.0
PIN4 peptidylprolyl isomerase (EC 5.2.1.8) Pan troglodytes
TI:9598 None
 
A0A2I3TIG4_PANTR
Ensembl»
0.0
peptidylprolyl isomerase (EC 5.2.1.8) Pan troglodytes
TI:9598 None
 
A0A2K1JDR2_PHYPA
EnsemblPlants»
0.0
PHYPA_019943 peptidylprolyl isomerase (EC 5.2.1.8) Physcomitrium patens
TI:3218 None
 
A0A2R6WK15_MARPO
neXtProt»
0.0
MARPO_0082s0039 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Marchantia polymorpha
TI:3197 None
 
A0A7U2NQD0_PHANO
TubercuList»
0.0
JI435_307960 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Phaeosphaeria nodorum
TI:13684 None
 
A0A9K3J6K5_HELAN
neXtProt»
0.0
HanXRQr2_Chr04g0156361 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Helianthus annuus
TI:4232 None
 
A0A9R1WI45_LACSA
neXtProt»
0.0
LSAT_V11C100006100 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Lactuca sativa
TI:4236 None
 
A7SIW4_NEMVE
neXtProt»
0.0
NEMVEDRAFT_v1g119994 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Nematostella vectensis
TI:45351 None
 
A8XYL9_CAEBR
WormBase»
0.0
pinn-4 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Caenorhabditis briggsae
TI:6238 None
 
A9TF41_PHYPA
EnsemblPlants»
0.0
LOC112277653 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Physcomitrium patens
TI:3218 None
 
A9V0Z8_MONBE
neXtProt»
0.0
MONBRDRAFT_25967 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Monosiga brevicollis
TI:81824 None
 
B3SBN5_TRIAD
CTD»
0.0
TRIADDRAFT_51090 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Trichoplax adhaerens
TI:10228 None
 
B6JX24_SCHJY
TubercuList»
0.0
SJAG_00950 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Schizosaccharomyces japonicus
TI:4897 None
 
B9HXX3_POPTR
neXtProt»
0.0
POPTR_010G165600 peptidylprolyl isomerase (EC 5.2.1.8) Populus trichocarpa
TI:3694 None
 
B9RLW3_RICCO
neXtProt»
0.0
RCOM_1471300 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Ricinus communis
TI:3988 None
 
C4LT92_ENTH1
TubercuList»
0.0
EHI_044730 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Entamoeba histolytica
TI:5759 None
 
C5XC88_SORBI
neXtProt»
0.0
SORBI_3002G199100 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Sorghum bicolor
TI:4558 None
 
D6WQF8_TRICA
neXtProt»
0.0
AUGUSTUS-3.0.2_09923 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Tribolium castaneum
TI:7070 None
 
D7SI92_VITVI
neXtProt»
0.0
VIT_17s0000g06430 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Vitis vinifera
TI:29760 None
 
D8QPT0_SELML
neXtProt»
0.0
SELMODRAFT_74131 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Selaginella moellendorffii
TI:88036 None
 
D8SKP6_SELML
neXtProt»
0.0
SELMODRAFT_423141 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Selaginella moellendorffii
TI:88036 None
 
E3L450_PUCGT
TubercuList»
0.0
PGTG_16979 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Puccinia graminis
TI:5297 None
 
F4P849_BATDJ
neXtProt»
0.0
BATDEDRAFT_30473 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Batrachochytrium dendrobatidis
TI:109871 None
 
F5HKU1_ANOGA
EnsemblMetazoa»
0.0
11175657 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Anopheles gambiae
TI:7165 None
 
I1IQ20_BRADI
EnsemblPlants»
0.0
LOC100833005 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Brachypodium distachyon
TI:15368 None
 
M5XNX3_PRUPE
neXtProt»
0.0
PRUPE_1G278400 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Prunus persica
TI:3760 None
 
PIN4_ASPFU
EnsemblFungi»
0.0
pin4 Peptidyl-prolyl cis-trans isomerase pin4 (PPIase
pin4) (EC 5.2.1.8) (Parvulin-14) (Par14)		 Aspergillus fumigatus
TI:746128 None
 
PIN4_BOVIN
Ensembl»
0.0
PIN4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14)
(Par14) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Rotamase Pin4)		 Bos taurus
TI:9913 None
 
PIN4_DANRE
ZFIN»
0.0
pin4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14)
(Par14) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Rotamase Pin4)		 Danio rerio
TI:7955 None
 
PIN4_XENTR
Xenbase»
0.0
pin4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC 5.2.1.8) (Parvulin-14)
(Par14) (Peptidyl-prolyl cis-trans isomerase Pin4) (PPIase Pin4) (Rotamase Pin4)		 Xenopus tropicalis
TI:8364 None
 
Q4KNC9_GOSHI
neXtProt»
0.0
PPI Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Gossypium hirsutum
TI:3635 None
 
Q54Z53_DICDI
dictyBase»
0.0
DDB_G0277775 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Dictyostelium discoideum
TI:44689 None
 
Q9NAF9_CAEEL
WormBase»
0.0
pinn-4 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Caenorhabditis elegans
TI:6239 None
 
W1NHA4_AMBTC
neXtProt»
0.0
AMTR_s00010p00267420 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Amborella trichopoda
TI:13333 None
 
A0A1L8F6N9_XENLA
Xenbase»
0.0
pin4.L Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Xenopus laevis
TI:8355 None
   
A0A1S3WXJ7_TOBAC
neXtProt»
0.0
LOC107759056 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Nicotiana tabacum
TI:4097 None
   
A0A1U8BHI3_NELNU
neXtProt»
0.0
LOC104611166 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Nelumbo nucifera
TI:4432 None
   
A0A1U8LHT5_GOSHI
neXtProt»
0.0
LOC107926585 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Gossypium hirsutum
TI:3635 None
   
A0A2I4H431_JUGRE
neXtProt»
0.0
LOC109013307 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Juglans regia
TI:51240 None
   
A0A3B6KJU4_WHEAT
EnsemblPlants»
0.0
LOC123103905 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Triticum aestivum
TI:4565 None
   
A0A3B6LMU0_WHEAT
EnsemblPlants»
0.0
LOC123112136 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Triticum aestivum
TI:4565 None
   
A0A3B6MTR9_WHEAT
EnsemblPlants»
0.0
LOC123121681 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Triticum aestivum
TI:4565 None
   
A0A3Q7J7T9_SOLLC
EnsemblPlants»
0.0
LOC101255071 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Solanum lycopersicum
TI:4081 None
   
A0A5F5PRL1_HORSE
Ensembl»
0.0
PIN4 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Equus caballus
TI:9796 None
   
A0A5F7ZUR3_MACMU
Ensembl»
0.0
PIN4 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Macaca mulatta
TI:9544 None
   
A0A5F8GMX7_MONDO
Ensembl»
0.0
PIN4 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Monodelphis domestica
TI:13616 None
   
A0A5G2QAJ6_PIG
Ensembl»
0.0
PIN4 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Sus scrofa
TI:9823 None
   
A0A7M7NNB4_STRPU
EnsemblMetazoa»
0.0
Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Strongylocentrotus purpuratus
TI:7668 None
   
A0A804IJE9_MUSAM
EnsemblPlants»
0.0
Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Musa acuminata
TI:4641 None
   
A0A804JYM0_MUSAM
EnsemblPlants»
0.0
Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Musa acuminata
TI:4641 None
   
A0A8I3N0M8_CANLF
Ensembl»
0.0
peptidylprolyl isomerase (EC 5.2.1.8) Canis lupus
TI:9612 None
   
A0A8I3P611_CANLF
Ensembl»
0.0
PIN4 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Canis lupus
TI:9612 None
   
A0A8I6YSL3_HORVV
EnsemblPlants»
0.0
LOC123398333 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Hordeum vulgare
TI:4513 None
   
A0A9R0J388_SPIOL
neXtProt»
0.0
LOC110799602 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Spinacia oleracea
TI:3562 None
   
A0ABI7XRV7_FELCA
Ensembl»
0.0
Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Felis catus
TI:9685 None
   
A0ABI7Y8S3_FELCA
Ensembl»
0.0
Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Felis catus
TI:9685 None
   
A0ABK0LY56_RAT
RGD»
1.5
Pin4 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Rattus norvegicus
TI:10116 None
   
F1NCD7_CHICK
Ensembl»
0.0
PIN4 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Gallus gallus
TI:9031 None
   
F6S4Y6_CIOIN
Ensembl»
0.0
LOC100186662 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Ciona intestinalis
TI:7719 None
   
F7G506_ORNAN
Ensembl»
0.0
PIN4 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Ornithorhynchus anatinus
TI:9258 None
   
H2LST9_ORYLA
Ensembl»
0.0
PIN4 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Oryzias latipes
TI:8090 None
   
H9GE52_ANOCA
Ensembl»
0.0
Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Anolis carolinensis
TI:28377 None
   
M1BZH1_SOLTU
EnsemblPlants»
0.0
LOC102585290 Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8) Solanum tuberosum
TI:4113 None