Collated Gene Ontology terms

Biological process: isoleucine-tRNA ligase activity(2013, 2014, 2016, 2017, 2025) ATP binding(2004, 2025) nucleotide binding(2025) ligase activity(2025) aminoacyl-tRNA ligase activity(2025) aminoacyl-tRNA deacylase activity(2025) tRNA binding(2025) metal ion binding(2025) zinc ion binding(2014, 2022, 2025)

Molecular function: isoleucyl-tRNA aminoacylation2013, 2014, 2016, 2017, 2025 tRNA aminoacylation for protein translation2023, 2025 translation2024, 2025 aminoacyl-tRNA metabolism involved in translational fidelity2025 mitochondrial translation2013, 2017, 2024, 2025 reproductive structure development2025 post-embryonic development2025 defense response2025 response to antibiotic2025 plant ovule development2005
DNA-templated transcription2025

Cellular component: mitochondrion2005, 2009, 2013, 2016, 2018, 2024, 2025 cytoplasm2025 mitochondrial matrix2013, 2018, 2025 cytosol2009, 2014, 2021, 2025 chloroplast2018, 2021, 2025 membrane2025 nucleus2025 chloroplast stroma2021

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 0/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 0/4 
Harosa: 3/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 1/8 
Bacteria: 26/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
SYIM_ARATH
TAIR»
2.3
OVA2 Isoleucine--tRNA ligase, chloroplastic/mitochondrial (EC 6.1.1.5) (Isoleucyl-tRNA
synthetase) (IleRS) (Protein OVULE ABORTION 2)		 Arabidopsis thaliana
TI:3702 None
 
SYIM_YEAST
SGD»
3.9
ISM1 Isoleucine--tRNA ligase, mitochondrial (EC
6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)		 Saccharomyces cerevisiae
TI:4932 None
 
SYI_ECOLI
EnsemblBacteria»
3.4
ileS Isoleucine--tRNA ligase (EC
6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)		 Escherichia coli
TI:562 None
 
SYIM_HUMAN
Ensembl»
3.3
IARS2 Isoleucine--tRNA ligase, mitochondrial (EC
6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)		 Homo sapiens
TI:9606 None
 
SYIM_SCHPO
PomBase»
2.0
ism1 Isoleucine--tRNA ligase, mitochondrial (EC
6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)		 Schizosaccharomyces pombe
TI:4896 None
 
SYIM_MOUSE
Ensembl»
1.5
Iars2 Isoleucine--tRNA ligase, mitochondrial (EC
6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)		 Mus musculus
TI:10090 None
 
A0A0G2K261_RAT
RGD»
1.5
Iars2 Isoleucine--tRNA ligase, mitochondrial
(EC 6.1.1.5) (Isoleucyl-tRNA synthetase)		 Rattus norvegicus
TI:10116 None
   
Q9VUY4_DROME
FlyBase»
3.3
IleRS-m isoleucine--tRNA ligase (EC
6.1.1.5) (Isoleucyl-tRNA synthetase)		 Drosophila melanogaster
TI:7227 None
 
SYIM_CHICK
Ensembl»
1.5
IARS2 Isoleucine--tRNA ligase, mitochondrial (EC
6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)		 Gallus gallus
TI:9031 None
 
SYIM_DICDI
dictyBase»
1.5
mileS Probable isoleucine--tRNA ligase, mitochondrial
(EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS)		 Dictyostelium discoideum
TI:44689 None
 
E2JL04_CAEEL
WormBase»
1.5
iars-2 isoleucine--tRNA ligase (EC
6.1.1.5) (Isoleucyl-tRNA synthetase)		 Caenorhabditis elegans
TI:6239 None
 
F1QUQ0_DANRE
ZFIN»
0.0
iars2 isoleucine--tRNA ligase (EC
6.1.1.5) (Isoleucyl-tRNA synthetase)		 Danio rerio
TI:7955 None