Collated Gene Ontology terms

Biological process: diphthine synthase activity(2007, 2024) methyltransferase activity(2024) diphthine methyl ester synthase activity(2005, 2024) transferase activity(2024)

Molecular function: peptidyl-diphthamide biosynthetic process from peptidyl-histidine2005, 2008, 2013, 2014, 2022, 2024 methylation2024 regulation of cytoplasmic translation2009, 2024 positive regulation of translation2020

Cellular component: cytoplasm2014, 2017, 2018, 2024 nuclear lumen2017 membrane2024 cytosol2009, 2014 ciliary plasm2017 plasma membrane2024 nucleus2009

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 0/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 14/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 3/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 36/39 
Archea: 7/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Key only] GO terms Seq. links Protein domain links
DPH5_HUMAN
Ensembl»
3.4
DPH5 Diphthine methyl ester synthase
(EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)		 Homo sapiens
TI:9606 None
 
H2PZI0_PANTR
Ensembl»
0.0
DPH5 diphthine methyl ester synthase (EC 2.1.1.314) Pan troglodytes
TI:9598 None
 
DPH5_ARATH
TAIR»
0.5
At4g31790 Probable diphthine methyl ester synthase
(EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)		 Arabidopsis thaliana
TI:3702 None
 
DPH5_YEAST
SGD»
3.2
DPH5 Diphthine methyl ester synthase
(EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)		 Saccharomyces cerevisiae
TI:4932 None
 
DPH5_MOUSE
Ensembl»
0.5
Dph5 Diphthine methyl ester synthase
(EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)		 Mus musculus
TI:10090 None
 
Q10L98_ORYSJ
EnsemblPlants»
0.0
LOC_Os03g23970 Os03g0355800 diphthine methyl ester synthase (EC 2.1.1.314) Oryza sativa
TI:4530 None
 
B7P2M4_IXOSC
EnsemblMetazoa»
0.0
8023702 diphthine methyl ester synthase (EC 2.1.1.314) Ixodes scapularis
TI:6945 None
 
F6S1G5_MACMU
Ensembl»
0.0
DPH5 diphthine methyl ester synthase (EC 2.1.1.314) Macaca mulatta
TI:9544 None
 
M5XB26_PRUPE
EnsemblPlants»
0.0
PRUPE_1G367100 diphthine methyl ester synthase (EC 2.1.1.314) Prunus persica
TI:3760 None
 
A0A061GZD5_THECC
EnsemblPlants»
0.0
TCM_040866 diphthine methyl ester synthase (EC 2.1.1.314) Theobroma cacao
TI:3641 None
 
A0A072VQP5_MEDTR
EnsemblPlants»
0.0
25485428 diphthine methyl ester synthase (EC 2.1.1.314) Medicago truncatula
TI:3880 None
 
A0A251UKY7_HELAN
EnsemblPlants»
0.0
HannXRQ_Chr06g0183611 HanXRQr2_Chr06g0276751 diphthine methyl ester synthase (EC 2.1.1.314) Helianthus annuus
TI:4232 None
 
A8BBU1_GIAIC
EnsemblProtists»
0.0
GL50803_0028666 GL50803_28666 diphthine methyl ester synthase (EC 2.1.1.314) Giardia intestinalis
TI:5741 None
 
DPH5_ASPFU
EnsemblFungi»
0.0
dph5 Diphthine methyl ester synthase
(EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)		 Aspergillus fumigatus
TI:746128 None
 
DPH5_BOVIN
Ensembl»
0.0
DPH5 Diphthine methyl ester synthase
(EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)		 Bos taurus
TI:9913 None
 
DPH5_EMENI
EnsemblFungi»
0.0
dph5 Diphthine methyl ester synthase
(EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)		 Emericella nidulans
TI:162425 None
 
G3RMY5_GORGO
Ensembl»
0.0
DPH5 diphthine methyl ester synthase (EC 2.1.1.314) Gorilla gorilla
TI:9593 None
 
G7J4Q4_MEDTR
EnsemblPlants»
0.0
11437114 diphthine methyl ester synthase (EC 2.1.1.314) Medicago truncatula
TI:3880 None
 
I1H5E2_BRADI
EnsemblPlants»
0.0
100846135 diphthine methyl ester synthase (EC 2.1.1.314) Brachypodium distachyon
TI:15368 None
 
Q583F0_TRYB2
VEuPathDB»
0.0
Tb04.3I12.360 diphthine methyl ester synthase (EC 2.1.1.314) Trypanosoma brucei
TI:5691 None
 
Q8IN02_DROME
FlyBase»
1.8
Dph5 diphthine methyl ester synthase (EC 2.1.1.314) Drosophila melanogaster
TI:7227 None
 
T1F274_HELRO
EnsemblMetazoa»
0.0
20202924 diphthine methyl ester synthase (EC 2.1.1.314) Helobdella robusta
TI:6412 None
 
A0A022RCZ9_ERYGU
EnsemblFungi»
0.0
MIMGU_mgv1a011606mg diphthine methyl ester synthase (EC 2.1.1.314) Erythranthe guttata
TI:4155 None
 
A0A067GZ13_CITSI
Ensembl»
0.0
CISIN_1g023387mg diphthine methyl ester synthase (EC 2.1.1.314) Citrus sinensis
TI:2711 None
 
A0A078FTH0_BRANA
EnsemblPlants»
0.0
BnaC08g39960D BnaC08g39960D protein Brassica napus
TI:3708 None
 
A0A078G5B3_BRANA
EnsemblPlants»
0.0
BnaC08g14220D BnaC08g14220D protein Brassica napus
TI:3708 None
 
A0A078I7A7_BRANA
EnsemblPlants»
0.0
BnaCnng14540D BnaCnng14540D protein Brassica napus
TI:3708 None
 
A0A0A0LLL7_CUCSA
EnsemblPlants»
0.0
Csa_2G367220 diphthine methyl ester synthase (EC 2.1.1.314) Cucumis sativus
TI:3659 None
 
A0A0K9PPV9_ZOSMR
EnsemblPlants»
0.0
ZOSMA_1G02340 diphthine methyl ester synthase (EC 2.1.1.314) Zostera marina
TI:29655 None
 
A0A0R0JDS4_SOYBN
EnsemblPlants»
0.0
100784092 diphthine methyl ester synthase (EC 2.1.1.314) Glycine max
TI:3847 None
 
A0A0R4IU56_DANRE
ZFIN»
0.0
zgc:101823 diphthine methyl ester synthase (EC 2.1.1.314) Danio rerio
TI:7955 None
 
A0A0R4J642_SOYBN
EnsemblPlants»
0.0
100787586 diphthine methyl ester synthase (EC 2.1.1.314) Glycine max
TI:3847 None
 
A0A1B6QN52_SORBI
EnsemblPlants»
0.0
SORBI_3001G368700 Uncharacterized protein Sorghum bicolor
TI:4558 None
 
A0A1U7ZAA7_NELNU
EnsemblBacteria»
0.0
LOC104588007 diphthine methyl ester synthase (EC 2.1.1.314) Nelumbo nucifera
TI:4432 None
 
A0A1U8GJU3_CAPAN
EnsemblPlants»
0.0
T459_13379 diphthine methyl ester synthase (EC 2.1.1.314) Capsicum annuum
TI:4072 None
 
A0A1Y1I3P3_KLENI
EnsemblPlants»
0.0
KFL_001210120 diphthine methyl ester synthase (EC 2.1.1.314) Klebsormidium nitens
TI:105231 None
 
A0A2C9V0H6_MANES
EnsemblPlants»
0.0
MANES_11G065900 diphthine methyl ester synthase (EC 2.1.1.314) Manihot esculenta
TI:3983 None
 
A0A2C9VWB6_MANES
EnsemblPlants»
0.0
MANES_05G148600 diphthine methyl ester synthase (EC 2.1.1.314) Manihot esculenta
TI:3983 None
 
A0A2G2Y745_CAPAN
EnsemblPlants»
0.0
T459_29985 Uncharacterized protein Capsicum annuum
TI:4072 None
 
A0A2I2UH15_FELCA
Ensembl»
0.0
DPH5 diphthine methyl ester synthase (EC 2.1.1.314) Felis catus
TI:9685 None
 
A0A2I4HVB7_JUGRE
EnsemblPlants»
0.0
LOC109021810 diphthine methyl ester synthase (EC 2.1.1.314) Juglans regia
TI:51240 None
 
A0A2K2BCA3_POPTR
EnsemblPlants»
0.0
POPTR_002G023700 diphthine methyl ester synthase (EC 2.1.1.314) Populus trichocarpa
TI:3694 None
 
A0A2K3DRT9_CHLRE
EnsemblPlants»
0.0
CHLRE_05g233300v5 diphthine methyl ester synthase (EC 2.1.1.314) Chlamydomonas reinhardtii
TI:3055 None
 
A0A2R6WD27_MARPO
EnsemblPlants»
0.0
MARPO_0107s0028 diphthine methyl ester synthase (EC 2.1.1.314) Marchantia polymorpha
TI:3197 None
 
A0A3B6KE70_WHEAT
EnsemblPlants»
0.0
CFC21_065390 diphthine methyl ester synthase (EC 2.1.1.314) Triticum aestivum
TI:4565 None
 
A0A3B6MPV3_WHEAT
EnsemblPlants»
0.0
CFC21_077134 diphthine methyl ester synthase (EC 2.1.1.314) Triticum aestivum
TI:4565 None
 
A0A804I0R3_MUSAM
EnsemblPlants»
0.0
103976150 diphthine methyl ester synthase (EC 2.1.1.314) Musa acuminata
TI:4641 None
 
A0BGB9_PARTE
EnsemblProtists»
0.0
GSPATT00028621001 diphthine methyl ester synthase (EC 2.1.1.314) Paramecium tetraurelia
TI:5888 None
 
A0EH83_PARTE
EnsemblProtists»
0.0
GSPATT00026998001 diphthine methyl ester synthase (EC 2.1.1.314) Paramecium tetraurelia
TI:5888 None
 
A7EWW9_SCLS1
VEuPathDB»
0.0
SS1G_09828 diphthine methyl ester synthase (EC 2.1.1.314) Sclerotinia sclerotiorum
TI:5180 None
 
A7RTU2_NEMVE
EnsemblMetazoa»
0.0
NEMVEDRAFT_v1g93189 diphthine methyl ester synthase (EC 2.1.1.314) Nematostella vectensis
TI:45351 None
 
A8WT81_CAEBR
WormBase»
0.0
CBG02918 CBG_02918 diphthine methyl ester synthase (EC 2.1.1.314) Caenorhabditis briggsae
TI:6238 None
 
A9A1L4_NITMS
EnsemblBacteria»
0.0
Nmar_1297 Diphthine synthase (EC 2.1.1.98) Nitrosopumilus maritimus
TI:338192 None
 
A9TVZ2_PHYPA
EnsemblPlants»
0.0
PHYPA_029574 diphthine methyl ester synthase (EC 2.1.1.314) Physcomitrium patens
TI:3218 None
 
A9V6F4_MONBE
EnsemblProtists»
0.0
MONBRDRAFT_33663 diphthine methyl ester synthase (EC 2.1.1.314) Monosiga brevicollis
TI:81824 None
 
B4F8L2_MAIZE
EnsemblPlants»
0.0
100191377 diphthine methyl ester synthase (EC 2.1.1.314) Zea mays
TI:4577 None
 
B6K2J6_SCHJY
EnsemblFungi»
0.0
SJAG_02467 diphthine methyl ester synthase (EC 2.1.1.314) Schizosaccharomyces japonicus
TI:4897 None
 
B8BQN6_THAPS
EnsemblProtists»
0.0
THAPSDRAFT_20788 diphthine methyl ester synthase (EC 2.1.1.314) Thalassiosira pseudonana
TI:35128 None
 
B9R875_RICCO
EnsemblBacteria»
0.0
RCOM_1597420 diphthine methyl ester synthase (EC 2.1.1.314) Ricinus communis
TI:3988 None
 
C3YA13_BRAFL
CTD»
0.0
LOC118432428 diphthine methyl ester synthase (EC 2.1.1.314) Branchiostoma floridae
TI:7739 None
 
C4LWZ7_ENTH1
EnsemblProtists»
0.0
EHI_127240 diphthine methyl ester synthase (EC 2.1.1.314) Entamoeba histolytica
TI:5759 None
 
C5WZQ7_SORBI
EnsemblPlants»
0.0
SORBI_3001G368800 diphthine methyl ester synthase (EC 2.1.1.314) Sorghum bicolor
TI:4558 None
 
D6WME0_TRICA
EnsemblMetazoa»
0.0
AUGUSTUS-3.0.2_14546 diphthine methyl ester synthase (EC 2.1.1.314) Tribolium castaneum
TI:7070 None
 
D8RQI7_SELML
EnsemblPlants»
0.0
SELMODRAFT_232025 diphthine methyl ester synthase (EC 2.1.1.314) Selaginella moellendorffii
TI:88036 None
 
D8S0B5_SELML
EnsemblPlants»
0.0
SELMODRAFT_232835 diphthine methyl ester synthase (EC 2.1.1.314) Selaginella moellendorffii
TI:88036 None
 
DPH51_CANAL
EnsemblFungi»
0.0
DPH5 Diphthine methyl ester synthase 1
(EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase 1)		 Candida albicans
TI:5476 None
 
DPH52_CANAL
EnsemblFungi»
0.0
CAALFM_C503700CA Diphthine methyl ester synthase 2
(EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase 2)		 Candida albicans
TI:5476 None
 
DPH5_ASHGO
EnsemblFungi»
0.0
DPH5 Diphthine methyl ester synthase
(EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)		 Ashbya gossypii
TI:33169 None
 
DPH5_DICDI
dictyBase»
1.5
dph5 Diphthine methyl ester synthase
(EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)		 Dictyostelium discoideum
TI:44689 None
 
DPH5_NEUCR
EnsemblFungi»
0.0
dph-5 Diphthine methyl ester synthase
(EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)		 Neurospora crassa
TI:5141 None
 
DPH5_SCHPO
PomBase»
2.5
dph5 Diphthine methyl ester synthase
(EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)		 Schizosaccharomyces pombe
TI:4896 None
 
DPH5_YARLI
EnsemblFungi»
0.0
DPH5 Diphthine methyl ester synthase
(EC 2.1.1.314) (Diphthamide biosynthesis methyltransferase)		 Yarrowia lipolytica
TI:4952 None
 
DPHB_HALSA
EnsemblBacteria»
0.0
dphB Diphthine synthase (EC
2.1.1.98) (Diphthamide biosynthesis methyltransferase)		 Halobacterium salinarum
TI:2242 None
 
DPHB_METAC
EnsemblBacteria»
0.0
dphB Diphthine synthase (EC
2.1.1.98) (Diphthamide biosynthesis methyltransferase)		 Methanosarcina acetivorans
TI:2214 None
 
DPHB_METJA
EnsemblBacteria»
0.0
dphB Diphthine synthase (EC
2.1.1.98) (Diphthamide biosynthesis methyltransferase)		 Methanocaldococcus jannaschii
TI:2190 None
 
DPHB_PYRAE
EnsemblBacteria»
0.0
dphB Diphthine synthase (EC
2.1.1.98) (Diphthamide biosynthesis methyltransferase)		 Pyrobaculum aerophilum
TI:13773 None
 
DPHB_SACS2
EnsemblBacteria»
0.0
dphB Diphthine synthase (EC
2.1.1.98) (Diphthamide biosynthesis methyltransferase)		 Saccharolobus solfataricus
TI:2287 None
 
DPHB_THEKO
EnsemblBacteria»
0.0
dphB Diphthine synthase (EC
2.1.1.98) (Diphthamide biosynthesis methyltransferase)		 Thermococcus kodakarensis
TI:311400 None
 
E0CQ41_VITVI
EnsemblPlants»
0.0
VIT_18s0001g14080 diphthine methyl ester synthase (EC 2.1.1.314) Vitis vinifera
TI:29760 None
 
E3KPU9_PUCGT
EnsemblFungi»
0.0
PGTG_12290 diphthine methyl ester synthase (EC 2.1.1.314) Puccinia graminis
TI:5297 None
 
E9HLA8_DAPPU
EnsemblMetazoa»
0.0
DAPPUDRAFT_331033 diphthine methyl ester synthase (EC 2.1.1.314) Daphnia pulex
TI:6669 None
 
F0ZT50_DICPU
EnsemblProtists»
0.0
DICPUDRAFT_37635 diphthine methyl ester synthase (EC 2.1.1.314) Dictyostelium purpureum
TI:5786 None
 
F1S569_PIG
Ensembl»
0.0
DPH5 diphthine methyl ester synthase (EC 2.1.1.314) Sus scrofa
TI:9823 None
 
F4P9U2_BATDJ
EnsemblBacteria»
0.0
BATDEDRAFT_30589 diphthine methyl ester synthase (EC 2.1.1.314) Batrachochytrium dendrobatidis
TI:109871 None
 
F6YM02_CIOIN
Ensembl»
0.0
LOC100181968 diphthine methyl ester synthase (EC 2.1.1.314) Ciona intestinalis
TI:7719 None
 
G7J5B3_MEDTR
EnsemblPlants»
0.0
MTR_3g114210 Tetrapyrrole (Corrin/porphyrin) methylase Medicago truncatula
TI:3880 None
 
H3GB03_PHYRM
EnsemblProtists»
0.0
diphthine methyl ester synthase (EC 2.1.1.314) Phytophthora ramorum
TI:164328 None
 
M4D494_BRACM
EnsemblPlants»
0.0
BRARA_A00598 diphthine methyl ester synthase (EC 2.1.1.314) Brassica campestris
TI:3711 None
 
Q17514_CAEEL
WormBase»
0.0
dph-5 diphthine methyl ester synthase (EC 2.1.1.314) Caenorhabditis elegans
TI:6239 None
 
Q4Q6A1_LEIMA
EnsemblProtists»
0.0
LMJF_31_1610 diphthine methyl ester synthase (EC 2.1.1.314) Leishmania major
TI:5664 None
 
Q5KEZ6_CRYNJ
EnsemblFungi»
0.0
CNF03650 diphthine methyl ester synthase (EC 2.1.1.314) Cryptococcus neoformans
TI:5207 None
 
Q6DEZ3_XENTR
Xenbase»
0.0
dph5 diphthine methyl ester synthase (EC 2.1.1.314) Xenopus tropicalis
TI:8364 None
 
Q7QA67_ANOGA
EnsemblMetazoa»
0.0
1274556 diphthine methyl ester synthase (EC 2.1.1.314) Anopheles gambiae
TI:7165 None
 
Q8IJV5_PLAF7
EnsemblProtists»
0.0
PF3D7_1009000 diphthine methyl ester synthase (EC 2.1.1.314) Plasmodium falciparum
TI:5833 None
 
W1PK36_AMBTC
EnsemblPlants»
0.0
AMTR_s00284p00011000 diphthine methyl ester synthase (EC 2.1.1.314) Amborella trichopoda
TI:13333 None
 
W1PVU1_AMBTC
EnsemblPlants»
0.0
AMTR_s00287p00014320 diphthine methyl ester synthase (EC 2.1.1.314) Amborella trichopoda
TI:13333 None
 
A0A1L8GGJ2_XENLA
Xenbase»
0.0
dph5.S diphthine methyl ester synthase (EC 2.1.1.314) Xenopus laevis
TI:8355 None
   
A0A1S4CHA3_TOBAC
EnsemblFungi»
0.0
LOC107819004 diphthine methyl ester synthase (EC 2.1.1.314) Nicotiana tabacum
TI:4097 None
   
A0A1S4CQI5_TOBAC
EnsemblFungi»
0.0
LOC107821395 diphthine methyl ester synthase (EC 2.1.1.314) Nicotiana tabacum
TI:4097 None
   
A0A1U8MJL6_GOSHI
Ensembl»
0.0
LOC107938393 diphthine methyl ester synthase (EC 2.1.1.314) Gossypium hirsutum
TI:3635 None
   
A0A3B6LKQ8_WHEAT
EnsemblPlants»
0.0
diphthine methyl ester synthase (EC 2.1.1.314) Triticum aestivum
TI:4565 None
   
A0A3Q7H3C4_SOLLC
EnsemblPlants»
0.0
101259434 diphthine methyl ester synthase (EC 2.1.1.314) Solanum lycopersicum
TI:4081 None
   
A0A7M6UGM0_STRPU
EnsemblMetazoa»
0.0
diphthine methyl ester synthase (EC 2.1.1.314) Strongylocentrotus purpuratus
TI:7668 None
   
A0A803TD74_ANOCA
Ensembl»
0.0
DPH5 diphthine methyl ester synthase (EC 2.1.1.314) Anolis carolinensis
TI:28377 None
   
A0A8I3NBJ4_CANLF
Ensembl»
0.0
DPH5 diphthine methyl ester synthase (EC 2.1.1.314) Canis lupus
TI:9612 None
   
A0A8I6YFM5_HORVV
EnsemblPlants»
0.0
diphthine methyl ester synthase (EC 2.1.1.314) Hordeum vulgare
TI:4513 None
   
A0A8R1Z7P4_PRIPA
EnsemblMetazoa»
0.0
WBGene00304259 diphthine methyl ester synthase (EC 2.1.1.314) Pristionchus pacificus
TI:54126 None
   
F1P418_CHICK
Ensembl»
0.0
DPH5 diphthine methyl ester synthase (EC 2.1.1.314) Gallus gallus
TI:9031 None
   
F6Q8D4_ORNAN
Ensembl»
0.0
DPH5 diphthine methyl ester synthase (EC 2.1.1.314) Ornithorhynchus anatinus
TI:9258 None
   
F6ZPK7_MONDO
Ensembl»
0.0
DPH5 diphthine methyl ester synthase (EC 2.1.1.314) Monodelphis domestica
TI:13616 None
   
F7AIU7_HORSE
Ensembl»
0.0
DPH5 diphthine methyl ester synthase (EC 2.1.1.314) Equus caballus
TI:9796 None
   
H2MGF7_ORYLA
Ensembl»
0.0
dph5 diphthine methyl ester synthase (EC 2.1.1.314) Oryzias latipes
TI:8090 None
   
M0ZWR5_SOLTU
EnsemblPlants»
0.0
102593085 diphthine methyl ester synthase (EC 2.1.1.314) Solanum tuberosum
TI:4113 None
   
Q569A7_RAT
RGD»
0.0
Dph5 diphthine methyl ester synthase (EC 2.1.1.314) Rattus norvegicus
TI:10116 None
   
W5LVQ3_LEPOC
Ensembl»
0.0
diphthine methyl ester synthase (EC 2.1.1.314) Lepisosteus oculatus
TI:7918 None