Collated Gene Ontology terms

Biological process: SUMO transferase activity(2019) ATP-dependent topological DNA co-entrapment activity(2022)

Molecular function: DNA repair2013, 2014, 2023, 2025 DNA damage response2023, 2025 DNA recombination2025 double-strand break repair via homologous recombination2022, 2024, 2025 DNA-templated transcription2025 chromatin looping2024, 2025 regulation of telomere maintenance2024, 2025 protein sumoylation2024 sorocarp development2015 response to UV2015
positive regulation of gene expression2015 meiotic cell cycle2025

Cellular component: Smc5-Smc6 complex2004, 2012, 2013, 2014, 2017, 2025 nucleus2014, 2015, 2018, 2024, 2025 chromosome2025 chromosome, telomeric region2024, 2025 nucleoplasm2013, 2024, 2025 nucleolus2024, 2025 cytoplasm2025 rDNA heterochromatin2015, 2025 pericentric heterochromatin2015, 2025 chromosome, subtelomeric region2015, 2025
CENP-A containing chromatin2015, 2025 euchromatin2019

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 0/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 15/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 3/3 
Excavates: 1/4 
Harosa: 1/4 
Hacrobia: 0/0 
Plants: 39/39 
Archea: 0/8 
Bacteria: 0/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
NSE4_SCHPO
PomBase»
3.9
nse4 Non-structural maintenance of chromosome element 4
(Non-SMC element 4) (DNA repair protein rad62)		 Schizosaccharomyces pombe
TI:4896 None
 
NSE4_YEAST
SGD»
3.9
NSE4 Non-structural maintenance of chromosome element
4 (Non-SMC element 4) (Protein QRI2)		 Saccharomyces cerevisiae
TI:4932 None
 
NSE4A_HUMAN
Ensembl»
3.7
NSMCE4A Non-structural maintenance of chromosomes element 4 homolog
A (NS4EA) (Non-SMC element 4 homolog A)		 Homo sapiens
TI:9606 None
 
EID3_HUMAN
Ensembl»
2.9
EID3 EP300-interacting inhibitor of differentiation 3 (EID-3) (E1A-like inhibitor of differentiation 3) (EID-1-like inhibitor of differentiation
3) (Non-structural maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B)		 Homo sapiens
TI:9606 None
 
Q54T56_DICDI
dictyBase»
2.9
DDB_G0281991 Non-structural maintenance of
chromosomes element 4		 Dictyostelium discoideum
TI:44689 None
 
Q9VKV4_DROME
FlyBase»
2.2
Nse4 Non-structural maintenance of
chromosomes element 4		 Drosophila melanogaster
TI:7227 None
 
D3Z9K8_RAT
RGD»
1.0
Nsmce4a Non-structural maintenance of
chromosomes element 4		 Rattus norvegicus
TI:10116 None
   
G3XA30_MOUSE
Ensembl»
1.0
Nsmce4a Non-structural maintenance of
chromosomes element 4		 Mus musculus
TI:10090 None
   
A0A8V0X2D1_CHICK
Ensembl»
0.5
NSMCE4A Non-structural maintenance of
chromosomes element 4		 Gallus gallus
TI:9031 None
   
EID3_MOUSE
Ensembl»
0.5
Eid3 EP300-interacting inhibitor of differentiation 3 (EID-3) (EID-1-like inhibitor of differentiation 3) (Non-structural
maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B)		 Mus musculus
TI:10090 None
 
EID3_RAT
RGD»
0.5
Eid3 EP300-interacting inhibitor of differentiation 3 (EID-3) (E1A-like inhibitor of differentiation 3) (EID-1-like inhibitor of differentiation
3) (Non-structural maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B)		 Rattus norvegicus
TI:10116 None
 
NSE4A_ARATH
TAIR»
0.5
NSE4A Non-structural maintenance of chromosomes element 4
homolog A (Non-SMC element 4 homolog A)		 Arabidopsis thaliana
TI:3702 None
 
NSE4B_ARATH
TAIR»
0.5
NSE4B Non-structural maintenance of chromosomes element 4
homolog B (Non-SMC element 4 homolog B)		 Arabidopsis thaliana
TI:3702 None
 
Q504G2_DANRE
ZFIN»
0.5
nsmce4a Non-structural maintenance of
chromosomes element 4		 Danio rerio
TI:7955 None
 
Q9XTV3_CAEEL
WormBase»
0.5
nse-4 Non-structural maintenance of
chromosomes element 4		 Caenorhabditis elegans
TI:6239 None
 
A0ABK0LFN0_RAT
Ensembl»
0.0
Eid3 Non-structural maintenance of
chromosomes element 4		 Rattus norvegicus
TI:10116 None