Collated Gene Ontology terms

Biological process: transferase activity(2025) acyltransferase activity(2025) dihydrolipoamide branched chain acyltransferase activity(2025) dihydrolipoyllysine-residue acetyltransferase activity(2009, 2025) dihydrolipoyllysine-residue succinyltransferase activity(2025) ubiquitin protein ligase binding(2015, 2025) lipoic acid binding(2009, 2010, 2025) acyltransferase activity, transferring groups other than amino-acyl groups(2024, 2025) acetyltransferase activity(2025) zinc ion binding(2021)
pyruvate dehydrogenase (acetyl-transferring) activity2010 oxoglutarate dehydrogenase (succinyl-transferring) activity2010 oxidoreductase activity2025 nuclease activity2025 hydroxycinnamoyltransferase activity2025 hydrolase activity2025 endonuclease activity2025 disulfide oxidoreductase activity2024 dihydrolipoyl dehydrogenase (NADH) activity2011 antioxidant activity2025 DNA binding2025

Molecular function: pyruvate decarboxylation to acetyl-CoA2009, 2017, 2025 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA2025 tricarboxylic acid cycle2025 response to sucrose2013, 2025 response to absence of light2013, 2025 cellular response to sucrose starvation2013, 2025 branched-chain amino acid catabolic process2025 aerobic respiration2025 cellular respiration2025 lipid metabolic process2025
fatty acid metabolic process2025 fatty acid biosynthetic process2025 cell redox homeostasis2010, 2023 stress response to acid chemical2024 pyruvate catabolic process2025 post-transcriptional regulation of gene expression2016 positive regulation of nematode larval development2016 positive regulation of fatty acid biosynthetic process2016 positive regulation of embryonic development2016 positive regulation of egg-laying behavior2016 cellular oxidant detoxification2025 cellular detoxification2022 carboxylic acid metabolic process2025 branched-chain amino acid metabolic process2012 acetoin catabolic process2025 L-valine catabolic process2025 L-leucine catabolic process2025 L-isoleucine catabolic process2025 DNA repair2025 DNA damage response2025

Cellular component: mitochondrion2004, 2005, 2009, 2014, 2021, 2024, 2025 branched-chain alpha-ketoacid dehydrogenase complex2024, 2025 mitochondrial matrix2024, 2025 cytosol2010, 2016, 2022, 2024, 2025 cytoplasm2009, 2011, 2017, 2025 pyruvate dehydrogenase complex2010, 2011, 2018, 2025 mitochondrial nucleoid2009, 2025 plasma membrane2010 peptidoglycan-based cell wall2012 cilium2016, 2025
nucleus2025 neuron projection2016 microtubule cytoskeleton2025 dendrite2025 chloroplast2018

Phylogenetic distribution

Chordates: 22/21 
Echinoderms: 0/0 
Hemichordates: 1/1 
Annelids: 1/1 
Molluscs: 0/0 
Bryozoans: 0/0 
Platyhelminthes: 0/0 
Rotifers: 0/0 
Nematodes: 3/3 
Arthropods: 5/5 
Tardigrades: 0/0 
Placozoa: 1/1 
Cnidaria: 1/1 
Porifera: 0/0 
Choanoflagellates+: 10/1 
Dikarya: 0/14 
Fungi (other): 0/1 
Protozoa: 2/3 
Excavates: 2/4 
Harosa: 4/4 
Hacrobia: 0/0 
Plants: 38/39 
Archea: 3/8 
Bacteria: 28/35 

Find a cluster

Protein ID:
UniProt ID, accession, gene name or model org. database name
Cluster ID:
e.g. "UKP00123" or "123"

Download

Protein sequences (FASTA format)

Knownness history

2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 0 2 4 6 8 10 Knownness

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Proteins

UniProt ID
Organism DB»		 Standard knownness clustom knownness Gene name Description Species  [Show all] GO terms Seq. links Protein domain links
ODB2_HUMAN
Ensembl»
4.7
DBT Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component
E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (BCKDH-E2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)		 Homo sapiens
TI:9606 None
 
ODB2_ARATH
TAIR»
3.7
BCE2 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCE2)
(BCKAD-E2) (BCKADE2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (Protein DARK INDUCIBLE 3)		 Arabidopsis thaliana
TI:3702 None
 
ODB2_MOUSE
Ensembl»
2.5
Dbt Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (Branched-chain alpha-keto acid dehydrogenase complex component
E2) (BCKAD-E2) (BCKADE2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)		 Mus musculus
TI:10090 None
 
ODP2_ECOLI
EnsemblBacteria»
4.8
aceF Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (EC
2.3.1.12) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (E2)		 Escherichia coli
TI:562 None
 
Q5BKV3_DANRE
ZFIN»
0.8
dbt Dihydrolipoamide acetyltransferase component of
pyruvate dehydrogenase complex (EC 2.3.1.-)		 Danio rerio
TI:7955 None
 
Q9VXY3_DROME
FlyBase»
4.6
Dbct Dihydrolipoamide acetyltransferase component of
pyruvate dehydrogenase complex (EC 2.3.1.-)		 Drosophila melanogaster
TI:7227 None
 
ODB2_CAEEL
WormBase»
3.2
dbt-1 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC
2.3.1.168) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (Dihydrolipoamide branched-chain transacylase E2)		 Caenorhabditis elegans
TI:6239 None
 
Q54TR7_DICDI
dictyBase»
0.0
bkdC Dihydrolipoamide acetyltransferase component of
pyruvate dehydrogenase complex (EC 2.3.1.-)		 Dictyostelium discoideum
TI:44689 None
 
A0A8V1A234_CHICK
Ensembl»
0.0
DBT Dihydrolipoamide acetyltransferase component of
pyruvate dehydrogenase complex (EC 2.3.1.-)		 Gallus gallus
TI:9031 None
   
B2GV15_RAT
RGD»
1.5
Dbt Dihydrolipoamide acetyltransferase component of
pyruvate dehydrogenase complex (EC 2.3.1.-)		 Rattus norvegicus
TI:10116 None